Erschienen in:
01.10.2014 | Review
The Effects of Bariatric Surgery on Colorectal Cancer Risk: Systematic Review and Meta-analysis
verfasst von:
Sorena Afshar, Seamus B. Kelly, Keith Seymour, Jose Lara, Sean Woodcock, John C. Mathers
Erschienen in:
Obesity Surgery
|
Ausgabe 10/2014
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Abstract
Obesity is an established risk factor for colorectal cancer (CRC) but the effects of bariatric surgery on CRC incidence are uncertain. A systematic review of six electronic databases identified 3691 articles. Four observational studies met our inclusion criteria and results were pooled using a random effects model. Meta-analysis of these four studies revealed that bariatric surgery was associated with a significantly (p = 0.004) lower CRC incidence (RR = 0.73, 95 % confidence interval, 0.58–0.90) when compared with obese non-operated individuals, i.e., bariatric surgery is associated with a 27 % lower CRC risk. However the evidence base is limited and these findings should be confirmed by future studies with improved designs.