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Journal of Cancer Survivorship

Erschienen in:

11.02.2022

Effects of exercise on chemotherapy-induced peripheral neuropathy in cancer patients: a systematic review and meta-analysis

verfasst von: Shaoning Guo, Wenwen Han, Pengju Wang, Xue Wang, Xuedong Fang

Erschienen in: Journal of Cancer Survivorship | Ausgabe 2/2023

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Abstract

Purpose

Summarize and critically evaluate the existing studies to determine the effects of exercise on chemotherapy-induced peripheral neuropathy in cancer patients.

Methods

We searched PubMed, Scopus, Web of Science, and Cochrane Library databases for randomized controlled trials reporting exercise intervention in cancer patients with chemotherapy-induced peripheral neuropathy. The outcomes of interest included chemotherapy-induced peripheral neuropathy symptoms, physical function (balance control, muscle strength, and functional status), and quality of life. The Cochrane Collaboration’s tool was employed to assess the risk of bias.

Results

The search identified 1309 studies, 16 of which eligible. Our meta-analysis revealed that exercise intervention significantly improved the quality of life (SMD = 0.83, 95% CI = 0.58 to 1.08, I² = 0%, P < 0.00001) and relieved neuropathic pain (MD = − 4.93, 95% CI = − 5.60 to − 4.26, I² = 0%, P < 0.00001). The muscular strength of the upper (SMD = 1.10, 95% CI = 0.68 to 1.51, I² = 25%, P < 0.00001) and the lower limbs (SMD = 0.84, 95% CI = 0.42 to 1.26, I² = 36%, P < 0.00001) increased and balance performance (SMD = 1.05, 95% CI = 0.62 to1.48, I² = 0%, P < 0.00001) was better in the exercise group than in the group with usual care. However, no evidence was found that exercise intervention could improve CIPN symptoms.

Conclusions

The results of this study showed that combined exercise could be an effective option for improving quality of life, physical function (balance control and muscle strength), and neuropathic pain in cancer patients with chemotherapy-induced peripheral neuropathy. Further exploration of appropriate exercise prescriptions is needed to improve other outcomes.

Implications for Cancer Survivors

Specific and appropriate exercise intervention for cancer patients with chemotherapy-induced peripheral neuropathy should be recommended because these interventions can improve their quality of life and physical function.

Ferlay J, Colombet M, Soerjomataram I, Parkin D, Piñeros M, Znaor A, Bray F. Cancer statistics for the year 2020: an overview. International J Cancer. 2021;149(4):778–89. https://doi.org/10.1002/ijc.33588.CrossRef

Arnold M, Rutherford M, Bardot A, Ferlay J, Andersson T, Myklebust T, Tervonen H, Thursfield V, Ransom D, Shack L, et al. Progress in cancer survival, mortality, and incidence in seven high-income countries 1995–2014 (ICBP SURVMARK-2): a population-based study. Lancet Oncol. 2019;20(11):1493–505.PubMedPubMedCentralCrossRef

Brown M, Farquhar-Smith P. Pain in cancer survivors; filling in the gaps. Br J Anaesth. 2017;119(4):723–36.PubMedCrossRef

Derksen T, Bours M, Mols F, Weijenberg M. Lifestyle-related factors in the self-management of chemotherapy-induced peripheral neuropathy in colorectal cancer: a systematic review. Evid Based Complement Alternat Med. 2017;2017:7916031.PubMedPubMedCentralCrossRef

Staff N, Grisold A, Grisold W, Windebank A. Chemotherapy-induced peripheral neuropathy: a current review. Ann Neurol. 2017;81(6):772–81.PubMedPubMedCentralCrossRef

Seretny M, Currie G, Sena E, Ramnarine S, Grant R, MacLeod M, Colvin L, Fallon M. Incidence, prevalence, and predictors of chemotherapy-induced peripheral neuropathy: a systematic review and meta-analysis. Pain. 2014;155(12):2461–70.PubMedCrossRef

Hershman D, Weimer L, Wang A, Kranwinkel G, Brafman L, Fuentes D, Awad D, Crew K. Association between patient reported outcomes and quantitative sensory tests for measuring long-term neurotoxicity in breast cancer survivors treated with adjuvant paclitaxel chemotherapy. Breast Cancer Res Treat. 2011;125(3):767–74.PubMedCrossRef

Beijers A, Mols F, Dercksen W, Driessen C, Vreugdenhil G. Chemotherapy-induced peripheral neuropathy and impact on quality of life 6 months after treatment with chemotherapy. J Community Support Oncol. 2014;12(11):401–6.PubMedCrossRef

Kırca K, Kutlutürkan S. Symptoms experience and quality of life in the patients with breast cancer receiving the taxane class of drugs. Eur J Breast Health. 2018;14(3):148–55.PubMedPubMedCentral

10.

Bao T, Basal C, Seluzicki C, Li S, Seidman A, Mao J. Long-term chemotherapy-induced peripheral neuropathy among breast cancer survivors: prevalence, risk factors, and fall risk. Breast Cancer Res Treat. 2016;159(2):327–33.PubMedPubMedCentralCrossRef

11.

Kolb NA, Smith AG, Singleton JR, Beck SL, Stoddard GJ, Brown S, Mooney K. The association of chemotherapy-induced peripheral neuropathy symptoms and the risk of falling. JAMA Neurol. 2016;73(7):860–6.PubMedPubMedCentralCrossRef

12.

Winters-Stone K, Horak F, Jacobs P, Trubowitz P, Dieckmann N, Stoyles S, Faithfull S. Falls, functioning, and disability among women with persistent symptoms of chemotherapy-induced peripheral neuropathy. J Clin Oncol. 2017;35(23):2604–12.PubMedPubMedCentralCrossRef

13.

Iżycki D, Niezgoda A, Kaźmierczak M, Nowak-Markwitz E. Chemotherapy-induced peripheral neuropathy - epidemiology and pathogenesis. Ginekol Pol. 2016;87(4):293–9.PubMedCrossRef

14.

Tanay M, Armes J. Lived experiences and support needs of women who developed chemotherapy-induced peripheral neuropathy following treatment for breast and ovarian cancer. Eur J Cancer Care (Engl). 2019;28(3):e13011.PubMedCrossRef

15.

Duregon F, Vendramin B, Bullo V, Gobbo S, Cugusi L, Blasio A, Neunhaeuserer Di D, Zaccaria M, Bergamin M, Ermolao A. Effects of exercise on cancer patients suffering chemotherapy-induced peripheral neuropathy undergoing treatment: a systematic review. Crit Rev Oncol Hematol. 2018;121:90–100.PubMedCrossRef

16.

Kanzawa-Lee GA. Chemotherapy-induced peripheral neuropathy: nursing implications. J Infus Nurs. 2020;43(3):155–66.PubMedCrossRef

17.

Hershman DL, Lacchetti C, Loprinzi C. Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: American Society of Clinical Oncology clinical practice guideline. J Oncol Pract. 2014;10(6):421–4.CrossRef

18.

Loprinzi C, Lacchetti C, Bleeker J, Cavaletti G, Chauhan C, Hertz D, Kelley M, Lavino A, Lustberg M, Paice J, et al. Prevention and management of chemotherapy-induced peripheral neuropathy in survivors of adult cancers: ASCO guideline update. J Clin Oncol. 2020;38(28):3325–48.PubMedCrossRef

19.

Dhawan S, Andrews R, Kumar L, Wadhwa S, Shukla G. A randomized controlled trial to assess the effectiveness of muscle strengthening and balancing exercises on chemotherapy-induced peripheral neuropathic pain and quality of life among cancer patients. Cancer Nurs. 2020;43(4):269–80.PubMedCrossRef

20.

Zimmer P, Trebing S, Timmers-Trebing U, Schenk A, Paust R, Bloch W, Rudolph R, Streckmann F, Baumann FT. Eight-week, multimodal exercise counteracts a progress of chemotherapy-induced peripheral neuropathy and improves balance and strength in metastasized colorectal cancer patients: a randomized controlled trial. Support Care Cancer. 2018;26(2):615–24.PubMedCrossRef

21.

Kleckner IR, Kamen C, Gewandter JS, Mohile NA, Heckler CE, Culakova E, Fung C, Janelsins MC, Asare M, Lin PJ, et al. Effects of exercise during chemotherapy on chemotherapy-induced peripheral neuropathy: a multicenter, randomized controlled trial. Support Care Cancer. 2018;26(4):1019–28.PubMedCrossRef

22.

Streckmann F, Kneis S, Leifert J, Baumann F, Kleber M, Ihorst G, Herich L, Grüssinger V, Gollhofer A, Bertz H. Exercise program improves therapy-related side-effects and quality of life in lymphoma patients undergoing therapy. Ann Oncol. 2014;25(2):493–9.PubMedCrossRef

23.

Bland KA, Kirkham AA, Bovard J, Shenkier T, Zucker D, McKenzie DC, Davis MK, Gelmon KA, Campbell KL. Effect of exercise on taxane chemotherapy–induced peripheral neuropathy in women with breast cancer: a randomized controlled trial. Clin Breast Cancer. 2019;19(6):411–22.PubMedCrossRef

24.

Schönsteiner SS, Bauder Mißbach H, Benner A, Mack S, Hamel T, Orth M, Landwehrmeyer B, Süßmuth SD, Geitner C, Mayer-Steinacker R, et al. A randomized exploratory phase 2 study in patients with chemotherapy-related peripheral neuropathy evaluating whole-body vibration training as adjunct to an integrated program including massage, passive mobilization and physical exercises. Exp Hematol Oncol. 2017;6:5.PubMedPubMedCentralCrossRef

25.

Moher, Medicine DJP, Altman DG, PRISMA Group. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. J Clin Epidemiol. 2009;62(10):1006–12.

26.

Higgins PT, Green S. Cochrane handbook for systematic reviews of interventions. Version 5.1.0 [2021-12-2]. The Cochrane Collaboration. Available at: http://www.cochrane-handbook.org. Accessed Mar 2011.

27.

Higgins J, Altman D, Gøtzsche P, Jüni P, Moher D, Oxman A, Savovic J, Schulz K, Weeks L, Sterne J, et al. The Cochrane Collaboration’s tool for assessing risk of bias in randomised trials. BMJ. 2011;343:d5928.PubMedPubMedCentralCrossRef

28.

Durlak JA. How to select, calculate, and interpret effect sizes. J Pediatr Psychol. 2009;34(9):917–28.PubMedCrossRef

29.

Higgins J, Thompson S, Deeks J, Altman DJB. Measuring inconsistency in meta-analyses. BMJ. 2003;327(7414):557–60.PubMedPubMedCentralCrossRef

30.

Fiona S, Lehmann HC, Balke M, Schenk A, Oberste M, Heller A, Schurhorster A, Elter T, Bloch W, Baumann FT. Sensorimotor training and whole-body vibration training have the potential to reduce motor and sensory symptoms of chemotherapy-induced peripheral neuropathy-a randomized controlled pilot trial. Support Care Cancer. 2018;27(7):2471–8.

31.

Henke C, Cabri J, Fricke L, Pankow W, Kandilakis G, Feyer P, de Wit M. Strength and endurance training in the treatment of lung cancer patients in stages IIIA/IIIB/IV. Support Care Cancer. 2014;22(1):95–101.PubMedCrossRef

32.

Kneis S, Wehrle A, Müller J, Maurer C, Ihorst G, Gollhofer A, Bertz H. It’s never too late - balance and endurance training improves functional performance, quality of life, and alleviates neuropathic symptoms in cancer survivors suffering from chemotherapy-induced peripheral neuropathy: results of a randomized controlled trial. BMC Cancer. 2019;19(1):414.PubMedPubMedCentralCrossRef

33.

Stuecher K, Bolling C, Vogt L, Niederer D, Schmidt K, Dignaß A, Banzer W. Exercise improves functional capacity and lean body mass in patients with gastrointestinal cancer during chemotherapy: a single-blind RCT. Support Care Cancer. 2019;27(6):2159–69.PubMedCrossRef

34.

Vollmers PL, Mundhenke C, Maass N, Bauerschlag D, Kratzenstein S, Röcken C, Schmidt T. Evaluation of the effects of sensorimotor exercise on physical and psychological parameters in breast cancer patients undergoing neurotoxic chemotherapy. J Cancer Res Clin Oncol. 2018;44(9):1785–92.CrossRef

35.

Müller J, Weiler M, Schneeweiss A, Haag GM, Steindorf K, Wick W, Wiskemann J. Preventive effect of sensorimotor exercise and resistance training on chemotherapy-induced peripheral neuropathy: a randomised-controlled trial. Br J Cancer. 2021;125(7):955–65.PubMedPubMedCentralCrossRef

36.

Schwenk M, Grewal GS, Holloway D, Muchna A, Garland L, Najafi B. Interactive sensor-based balance training in older cancer patients with chemotherapy-induced peripheral neuropathy: a randomized controlled trial. Gerontology. 2016;62(5):553–63.PubMedCrossRef

37.

Andersen Hammond E, Pitz M, Steinfeld K, Lambert P, Shay B. An exploratory randomized trial of physical therapy for the treatment of chemotherapy-induced peripheral neuropathy. Neurorehabil Neural Repair. 2020;34(3):235–46.PubMedCrossRef

38.

Lin KY, Cheng HC, Yen CJ, Hung CH, Huang YT, Yang HL, Cheng WT, Tsai KL. Effects of exercise in patients undergoing chemotherapy for head and neck cancer: a pilot randomized controlled trial. Int J Environ Res Public Health. 2021;18(3):1291–304.PubMedPubMedCentralCrossRef

39.

Saraboon C, Siriphorn A. Effects of foam pad balance exercises on cancer patients undergoing chemotherapy: a randomized control trial. J Bodyw Mov Ther. 2021;28:164–71.PubMedCrossRef

40.

Dhawan S, Andrews R, Kumar L, Wadhwa S, Garima S. A randomized controlled trial to assess the effectiveness of muscle strengthening and balancing exercises on chemotherapy-induced peripheral neuropathic pain and quality of life among cancer patients. Cancer Nurs. 2019;43(4):269-280.

41.

Carozzi VA, Canta A, Chiorazzi A. Chemotherapy-induced peripheral neuropathy: what do we know about mechanisms? Neurosci Lett. 2015;596:90–107.PubMedCrossRef

42.

Lin WL, Wang RH, Chou FH, Feng IJ, Fang CJ, Wang HH. The effects of exercise on chemotherapy-induced peripheral neuropathy symptoms in cancer patients: a systematic review and meta-analysis. Support Care Cancer. 2021;29(9):5303–11. https://doi.org/10.1007/s00520-021-06082-3.CrossRefPubMed

43.

Wonders KY, Drury DG. Current exercise behaviors of breast cancer patients diagnosed with chemotherapy-induced peripheral neuropathy. J Integr Oncol. 2012;1(1):1–4.CrossRef

44.

Winters-Stone KM, Horak F, Jacobs PG, Trubowitz P, Dieckmann NF, Stoyles S, Faithfull S. Falls, functioning, and disability among women with persistent symptoms of chemotherapy-induced peripheral neuropathy. J Clin Oncol. 2017;35(23):2604–12. https://doi.org/10.1200/JCO.2016.71.3552.CrossRefPubMedPubMedCentral

45.

Kanzawa-Lee GA, Larson JL, Resnicow K, Smith EML. Exercise effects on chemotherapy-induced peripheral neuropathy: a comprehensive integrative review. Cancer Nurs. 2020;43(3):E172-e185.PubMedCrossRef

46.

Cammisuli S, Cavazzi E, Baldissarro E, Leandri M. Rehabilitation of balance disturbances due to chemotherapy-induced peripheral neuropathy: a pilot study. Eur J Phys Rehabil Med. 2016;52(4):479–88.PubMed

47.

Gao R, Yu T, Liu L, Bi J, Guo L. Exercise intervention for post-treatment colorectal cancer survivors: a systematic review and meta-analysis. J Cancer Surviv. 2020;14(6):878–93. https://doi.org/10.1007/s11764-020-00900-z.CrossRefPubMed

48.

Okuma K, Shiraishi K, Kanai Y, Nakagawa K. Improvement in quality of life by using duloxetine for chemotherapy-induced peripheral neuropathy (CIPN): a case report. Support Care Cancer. 2016;24(11):4483–5. https://doi.org/10.1007/s00520-016-3349-1.CrossRefPubMed

49.

Tanay M, Armes J, Ream E. The experience of chemotherapy-induced peripheral neuropathy in adult cancer patients: a qualitative thematic synthesis. Eur J Cancer Care. 2017;26(5):e12443. https://doi.org/10.1111/ecc.12443.CrossRef

50.

Duregon F, Vendramin B, Bullo V, Gobbo S, Cugusi L, Di Blasio A, Neunhaeuserer D, Zaccaria M, Bergamin M, Ermolao A. Effects of exercise on cancer patients suffering chemotherapy-induced peripheral neuropathy undergoing treatment: a systematic review. Crit Rev Oncol Hematol. 2018;121:90–100.PubMedCrossRef

Titel: Effects of exercise on chemotherapy-induced peripheral neuropathy in cancer patients: a systematic review and meta-analysis
verfasst von: Shaoning Guo
Wenwen Han
Pengju Wang
Xue Wang
Xuedong Fang
Publikationsdatum: 11.02.2022
Verlag: Springer US
Erschienen in: Journal of Cancer Survivorship / Ausgabe 2/2023
Print ISSN: 1932-2259
Elektronische ISSN: 1932-2267
DOI: https://doi.org/10.1007/s11764-022-01182-3

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25.04.2024 | Nierenkarzinom | Nachrichten

Springer Medizin

Effects of exercise on chemotherapy-induced peripheral neuropathy in cancer patients: a systematic review and meta-analysis

Abstract

Purpose

Methods

Results

Conclusions

Implications for Cancer Survivors

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Abstract

Purpose

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Conclusions

Implications for Cancer Survivors

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