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Current Allergy and Asthma Reports

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01.09.2014 | BASIC AND APPLIED SCIENCE (M FRIERI AND PJ BRYCE, SECTION EDITORS)

Mechanisms Controlling Mast Cell and Basophil Lineage Decisions

verfasst von: Hua Huang, Yapeng Li

Erschienen in: Current Allergy and Asthma Reports | Ausgabe 9/2014

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Abstract

Basophils and mast cells have long been known to play critical roles in allergic disease and host defense against parasitic infections. Recent recognition of these effector cells in immune regulations, host defense against bacteria and virus, and autoimmune diseases entices increased interest in studying these cells. However, origin and molecular regulation of basophil and mast cell differentiation remain incompletely understood. In this review, we focus on recent advances of the understanding the origin and molecular regulation of mouse basophil and mast cell development. We also summarize progress in the understanding of the origin and molecular regulation of human basophil and mast cell development. A more complete understanding of molecular regulation of basophils and mast cells will lead to the development of interventions that are more effective in achieving long-term success.

Karasuyama H, Mukai K, Obata K, Tsujimura Y, Wada T. Nonredundant roles of basophils in immunity. Annu Rev Immunol. 2011;29:45–69. doi:10.1146/annurev-immunol-031210-101257.PubMedCrossRef

Kim HY, DeKruyff RH, Umetsu DT. The many paths to asthma: phenotype shaped by innate and adaptive immunity. Nat Immunol. 2010;11(7):577–84. doi:10.1038/ni.1892.PubMedCentralPubMedCrossRef

Voehringer D. Protective and pathological roles of mast cells and basophils. Nat Rev Immunol. 2013;13(5):362–75. doi:10.1038/nri3427.PubMedCrossRef

Wedemeyer J, Tsai M, Galli SJ. Roles of mast cells and basophils in innate and acquired immunity. Curr Opin Immunol. 2000;12(6):624–31.PubMedCrossRef

Arock M, Schneider E, Boissan M, Tricottet V, Dy M. Differentiation of human basophils: an overview of recent advances and pending questions. J Leukoc Biol. 2002;71(4):557–64.PubMed

Frieri M, Patel R, Celestin J. Mast cell activation syndrome: a review. Curr Allergy Asthma Rep. 2013;13(1):27–32. doi:10.1007/s11882-012-0322-z.PubMedCrossRef

Anthony RM, Rutitzky LI, Urban Jr JF, Stadecker MJ, Gause WC. Protective immune mechanisms in helminth infection. Nat Rev Immunol. 2007;7(12):975–87. doi:10.1038/nri2199.PubMedCentralPubMedCrossRef

Barnes PJ. Severe asthma: advances in current management and future therapy. J Allergy Clin Immunol. 2012;129(1):48–59. doi:10.1016/j.jaci.2011.11.006.PubMedCrossRef

Galli SJ, Tsai M. Mast cells in allergy and infection: versatile effector and regulatory cells in innate and adaptive immunity. Eur J Immunol. 2010;40(7):1843–51. doi:10.1002/eji.201040559.PubMedCentralPubMedCrossRef

10.

Kumamoto Y, Linehan M, Weinstein JS, Laidlaw BJ, Craft JE, Iwasaki A. CD301b(+) dermal dendritic cells drive T helper 2 cell-mediated immunity. Immunity. 2013;39(4):733–43. doi:10.1016/j.immuni.2013.08.029.PubMedCrossRef

11.

Otsuka A, Nakajima S, Kubo M, Egawa G, Honda T, Kitoh A, et al. Basophils are required for the induction of Th2 immunity to haptens and peptide antigens. Nat Commun. 2013;4:1739. doi:10.1038/ncomms2740.PubMedCrossRef

12.

Tang H, Cao W, Kasturi SP, Ravindran R, Nakaya HI, Kundu K, et al. The T helper type 2 response to cysteine proteases requires dendritic cell-basophil cooperation via ROS-mediated signaling. Nat Immunol. 2010;11(7):608–17. doi:10.1038/ni.1883.PubMedCentralPubMedCrossRef

13.

Guermonprez P, Helft J, Claser C, Deroubaix S, Karanje H, Gazumyan A, et al. Inflammatory Flt3l is essential to mobilize dendritic cells and for T cell responses during Plasmodium infection. Nat Med. 2013;19(6):730–8. doi:10.1038/nm.3197.PubMedCentralPubMedCrossRef

14.

Lu LF, Lind EF, Gondek DC, Bennett KA, Gleeson MW, Pino-Lagos K, et al. Mast cells are essential intermediaries in regulatory T-cell tolerance. Nature. 2006;442(7106):997–1002. doi:10.1038/nature05010.PubMedCrossRef

15.

Chen CC, Grimbaldeston MA, Tsai M, Weissman IL, Galli SJ. Identification of mast cell progenitors in adult mice. Proc Natl Acad Sci U S A. 2005;102(32):11408–13. doi:10.1073/pnas.0504197102.PubMedCentralPubMedCrossRef

16.

Franco CB, Chen CC, Drukker M, Weissman IL, Galli SJ. Distinguishing mast cell and granulocyte differentiation at the single-cell level. Cell Stem Cell. 2010;6(4):361–8. doi:10.1016/j.stem.2010.02.013.PubMedCentralPubMedCrossRef

17.

Arinobu Y, Iwasaki H, Gurish MF, Mizuno S, Shigematsu H, Ozawa H, et al. Developmental checkpoints of the basophil/mast cell lineages in adult murine hematopoiesis. Proc Natl Acad Sci U S A. 2005;102(50):18105–10.PubMedCentralPubMedCrossRef

18.

Mukai K, Benbarak MJ, Tachibana M, Nishida K, Karasuyama H, Taniuchi I, et al. Critical role of P1-Runx1 in mouse basophil development. Blood. 2012;120(1):76–85. doi:10.1182/blood-2011-12-399113.PubMedCentralPubMedCrossRef

19.

Qi X, Hong J, Chaves L, Zhuang Y, Chen Y, Wang D, et al. Antagonistic regulation by the transcription factors C/EBPalpha and MITF specifies basophil and mast cell fates. Immunity. 2013;39(1):97–110. doi:10.1016/j.immuni.2013.06.012.PubMedCentralPubMedCrossRef

20.

Ohnmacht C, Voehringer D. Basophil effector function and homeostasis during helminth infection. Blood. 2009;113(12):2816–25. doi:10.1182/blood-2008-05-154773.PubMedCrossRef

21.

Metcalf D, Ng AP, Baldwin TM, Di Rago L, Mifsud S. Concordant mast cell and basophil production by individual hematopoietic blast colony-forming cells. Proc Natl Acad Sci U S A. 2013;110(22):9031–5. doi:10.1073/pnas.1307711110.PubMedCentralPubMedCrossRef

22.

Shelburne CP, McCoy ME, Piekorz R, Sexl V, Roh KH, Jacobs-Helber SM, et al. Stat5 expression is critical for mast cell development and survival. Blood. 2003;102(4):1290–7. doi:10.1182/blood-2002-11-3490.PubMedCrossRef

23.

Migliaccio AR, Rana RA, Sanchez M, Lorenzini R, Centurione L, Bianchi L, et al. GATA-1 as a regulator of mast cell differentiation revealed by the phenotype of the GATA-1low mouse mutant. J Exp Med. 2003;197(3):281–96.PubMedCentralPubMedCrossRef

24.

Tsai FY, Orkin SH. Transcription factor GATA-2 is required for proliferation/survival of early hematopoietic cells and mast cell formation, but not for erythroid and myeloid terminal differentiation. Blood. 1997;89(10):3636–43.PubMed

25.

Takemoto CM, Lee Y-N, Jegga AG, Zablocki D, Brandal S, Shahlaee A, et al. Mast cell transcriptional networks. Blood Cell Mol Dis. 2008;41(1):82–90.CrossRef

26.

Kitamura Y, Morii E, Jippo T, Ito A. Regulation of mast cell phenotype by MITF. Int Arch Allergy Immunol. 2002;127(2):106–9.PubMedCrossRef

27.

Ohmori K, Luo Y, Jia Y, Nishida J, Wang Z, Bunting KD, et al. IL-3 induces basophil expansion in vivo by directing granulocyte-monocyte progenitors to differentiate into basophil lineage-restricted progenitors in the bone marrow and by increasing the number of basophil/mast cell progenitors in the spleen. J Immunol. 2009;182(5):2835–41. doi:10.4049/jimmunol.0802870.PubMedCentralPubMedCrossRef

28.

Iwasaki H, Mizuno S, Arinobu Y, Ozawa H, Mori Y, Shigematsu H, et al. The order of expression of transcription factors directs hierarchical specification of hematopoietic lineages. Genes Dev. 2006;20(21):3010–21. doi:10.1101/gad.1493506.PubMedCentralPubMedCrossRef

29.

Lilla JN, Chen CC, Mukai K, BenBarak MJ, Franco CB, Kalesnikoff J, et al. Reduced mast cell and basophil numbers and function in Cpa3-Cre; Mcl-1fl/fl mice. Blood. 2011;118(26):6930–8. doi:10.1182/blood-2011-03-343962.PubMedCentralPubMedCrossRef

30.

Rao KN, Smuda C, Gregory GD, Min B, Brown MA. Ikaros limits basophil development by suppressing C/EBP-alpha expression. Blood. 2013;122(15):2572–81. doi:10.1182/blood-2013-04-494625.PubMedCrossRef

31.

Kitamura Y, Oboki K, Ito A. Development of mast cells. Proceedings Japan Acad Ser B Phys Biol Sci. 2007;83(6):164–74.CrossRef

32.

Langdon JM, Schroeder JT, Vonakis BM, Bieneman AP, Chichester K, Macdonald SM. Histamine-releasing factor/translationally controlled tumor protein (HRF/TCTP)-induced histamine release is enhanced with SHIP-1 knockdown in cultured human mast cell and basophil models. J Leukoc Biol. 2008;84(4):1151–8. doi:10.1189/jlb.0308172.PubMedCentralPubMedCrossRef

33.

Gorgens A, Radtke S, Mollmann M, Cross M, Durig J, Horn PA, et al. Revision of the human hematopoietic tree: granulocyte subtypes derive from distinct hematopoietic lineages. Cell Rep. 2013;3(5):1539–52. doi:10.1016/j.celrep.2013.04.025.PubMedCrossRef

34.

Schroeder JT. Basophils: emerging roles in the pathogenesis of allergic disease. Immunol Rev. 2011;242(1):144–60. doi:10.1111/j.1600-065X.2011.01023.x.PubMedCrossRef

35.

Kirshenbaum AS, Goff JP, Kessler SW, Mican JM, Zsebo KM, Metcalfe DD. Effect of IL-3 and stem cell factor on the appearance of human basophils and mast cells from CD34+ pluripotent progenitor cells. J Immunol. 1992;148(3):772–7.PubMed

36.

Agis H, Willheim M, Sperr WR, Wilfing A, Kromer E, Kabrna E, et al. Monocytes do not make mast cells when cultured in the presence of SCF. Characterization of the circulating mast cell progenitor as a c-kit+, CD34+, Ly-, CD14-, CD17-, colony-forming cell. J Immunol. 1993;151(8):4221–7.PubMed

37.

Kirshenbaum AS, Goff JP, Semere T, Foster B, Scott LM, Metcalfe DD. Demonstration that human mast cells arise from a progenitor cell population that is CD34(+), c-kit(+), and expresses aminopeptidase N (CD13). Blood. 1999;94(7):2333–42.PubMed

38.

Kirshenbaum AS, Metcalfe DD. Growth of human mast cells from bone marrow and peripheral blood-derived CD34+ pluripotent progenitor cells. Methods Mol Biol. 2006;315:105–12.PubMed

39.

Chan EC, Bai Y, Kirshenbaum AS, Fischer ER, Simakova O, Bandara G, et al. Mastocytosis associated with a rare germline KIT K509I mutation displays a well-differentiated mast cell phenotype. J Allergy Clin Immunol. 2014. doi:10.1016/j.jaci.2013.12.1090.

40.

Kempuraj D, Saito H, Kaneko A, Fukagawa K, Nakayama M, Toru H, et al. Characterization of mast cell-committed progenitors present in human umbilical cord blood. Blood. 1999;93(10):3338–46.PubMed

41.

Maaninka K, Lappalainen J, Kovanen PT. Human mast cells arise from a common circulating progenitor. J Allergy Clin Immunol. 2013;132(2):463–9. doi:10.1016/j.jaci.2013.02.011. e3.PubMedCrossRef

42.

Leary AG, Ogawa M. Identification of pure and mixed basophil colonies in culture of human peripheral blood and marrow cells. Blood. 1984;64(1):78–83.PubMed

43.

Denburg JA, Telizyn S, Messner H, Lim B, Jamal N, Ackerman SJ, et al. Heterogeneity of human peripheral blood eosinophil-type colonies: evidence for a common basophil-eosinophil progenitor. Blood. 1985;66(2):312–8.PubMed

44.

Poch T, Hermansky F, Lodrova V. A contribution to the simultaneous appearance of basophilic and eosinophilic granules in chronic myelocytic leukemia. Neoplasma. 1973;20(4):413–7.PubMed

45.

Weil SC, Hrisinko MA. A hybrid eosinophilic-basophilic granulocyte in chronic granulocytic leukemia. Am J Clin Pathol. 1987;87(1):66–70.PubMed

46.

Lindner PS, Pardanani B, Angadi C, Frieri M. Acute nonlymphocytic leukemia in systemic mastocytosis with biclonal gammopathy. J Allergy Clin Immunol. 1992;90(3 Pt 1):410–2.PubMedCrossRef

47.

Frieri M, Quershi M. Pediatric mastocytosis: a review of the literature. Pediatr Allergy Immunol Pulmonol. 2013;26(4):175–80. doi:10.1089/ped.2013.0275.PubMedCentralPubMedCrossRef

48.

Valent P, Sotlar K, Sperr WR, Escribano L, Yavuz S, Reiter A, et al. Refined diagnostic criteria and classification of mast cell leukemia (MCL) and myelomastocytic leukemia (MML): a consensus proposal. Ann Oncol. 2014. doi:10.1093/annonc/mdu047.PubMed

49.

Cruse G, Metcalfe DD, Olivera A. Functional deregulation of KIT: link to mast cell proliferative diseases and other neoplasms. Immunol Allergy Clin North Am. 2014;34(2):219–37. doi:10.1016/j.iac.2014.01.002.PubMedCrossRef

50.

Boyce JA, Friend D, Matsumoto R, Austen KF, Owen WF. Differentiation in vitro of hybrid eosinophil/basophil granulocytes: autocrine function of an eosinophil developmental intermediate. J Exp Med. 1995;182(1):49–57.PubMedCrossRef

51.

Celestin J, Frieri M. Eosinophilic disorders in various diseases. Curr Allergy Asthma Rep. 2012;12(1):18–24. doi:10.1007/s11882-011-0240-5.PubMedCrossRef

52.

Kocabas CN, Yavuz AS, Lipsky PE, Metcalfe DD, Akin C. Analysis of the lineage relationship between mast cells and basophils using the c-kit D816V mutation as a biologic signature. J Allergy Clin Immunol. 2005;115(6):1155–61. doi:10.1016/j.jaci.2005.02.030.PubMedCrossRef

53.

Buhring HJ, Simmons PJ, Pudney M, Muller R, Jarrossay D, van Agthoven A, et al. The monoclonal antibody 97A6 defines a novel surface antigen expressed on human basophils and their multipotent and unipotent progenitors. Blood. 1999;94(7):2343–56.PubMed

54.

Andoh K, Piao JH, Terashima K, Nakamura H, Sano K. Genomic structure and promoter analysis of the ecto-phosphodiesterase I gene (PDNP3) expressed in glial cells. Biochim Biophys Acta. 1999;1446(3):213–24.PubMedCrossRef

55.

Buhring HJ, Streble A, Valent P. The basophil-specific ectoenzyme E-NPP3 (CD203c) as a marker for cell activation and allergy diagnosis. Int Arch Allergy Immunol. 2004;133(4):317–29. doi:10.1159/000077351.PubMedCrossRef

56.

Ono E, Taniguchi M, Higashi N, Mita H, Kajiwara K, Yamaguchi H, et al. CD203c expression on human basophils is associated with asthma exacerbation. J Allergy Clin Immunol. 2010;125(2):483–9. doi:10.1016/j.jaci.2009.10.074. e3.PubMedCrossRef

57.

Buhring HJ, Seiffert M, Giesert C, Marxer A, Kanz L, Valent P, et al. The basophil activation marker defined by antibody 97A6 is identical to the ectonucleotide pyrophosphatase/phosphodiesterase 3. Blood. 2001;97(10):3303–5.PubMedCrossRef

58.

Frieri M. Mechanisms of disease for the clinician: systemic lupus erythematosus. Ann Allergy Asthma Immunol. 2013;110(4):228–32. doi:10.1016/j.anai.2012.12.010.PubMedCrossRef

Titel: Mechanisms Controlling Mast Cell and Basophil Lineage Decisions
verfasst von: Hua Huang
Yapeng Li
Publikationsdatum: 01.09.2014
Verlag: Springer US
Erschienen in: Current Allergy and Asthma Reports / Ausgabe 9/2014
Print ISSN: 1529-7322
Elektronische ISSN: 1534-6315
DOI: https://doi.org/10.1007/s11882-014-0457-1

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