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Current Allergy and Asthma Reports
Erschienen in: Current Allergy and Asthma Reports 9/2014

01.09.2014 | Pediatric Allergy and Immunology (JM Portnoy and CE Ciaccio, Section Editors)

Vitamin D and Asthma—Life After VIDA?

verfasst von: John M. Brehm

Erschienen in: Current Allergy and Asthma Reports | Ausgabe 9/2014

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Abstract

The vitamin D hypothesis postulates that lower vitamin D levels are causally associated with increased asthma risk and asthma severity. Multiple epidemiological studies have shown an inverse relationship between circulating vitamin D levels (in the form of 25-hydroxy vitamin D) and asthma severity and control and lung function. However, in the recently published vitamin D and asthma (VIDA) study, vitamin D supplementation failed to show an improvement in asthma control in adults. This article reviews the current epidemiological and trial evidence for vitamin D and asthma and explores some of the possible alternative explanations for previous findings (including “reverse causation” and the importance of studying children and adults). We also address some of the unique challenges of conducting vitamin D trials and potential ways to address them. Finally, I will argue for further clinical trials of vitamin D in asthma, especially in children, using knowledge gained from the VIDA trial.
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Metadaten
Titel
Vitamin D and Asthma—Life After VIDA?
verfasst von
John M. Brehm
Publikationsdatum
01.09.2014
Verlag
Springer US
Erschienen in
Current Allergy and Asthma Reports / Ausgabe 9/2014
Print ISSN: 1529-7322
Elektronische ISSN: 1534-6315
DOI
https://doi.org/10.1007/s11882-014-0461-5

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