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Current Diabetes Reports

Erschienen in:

01.10.2012 | Pathogenesis of Type 1 Diabetes (AG Ziegler, Section Editor)

Anti-Inflammatory Therapy in Type 1 Diabetes

verfasst von: Bernd Baumann, Heba H. Salem, Bernhard O. Boehm

Erschienen in: Current Diabetes Reports | Ausgabe 5/2012

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Abstract

Type 1 diabetes (T1D) is a multi-factorial, organ-specific autoimmune disease in genetically susceptible individuals, which is characterized by a selective and progressive loss of insulin-producing β-cells. Cells mediating innate as well as adaptive immunity infiltrate pancreatic islets, thereby generating an aberrant inflammatory process called insulitis that can be mirrored by a pathologic autoantibody production and autoreactive T-cells. In tight cooperation with infiltrating innate immune cells, which secrete high levels of pro-inflammatory cytokines like IL-1β, TNFα, and INFγ effector T-cells trigger the fatal destruction process of β-cells. There is ongoing discussion on the contribution of inflammation in T1D pathogenesis, ranging from a bystander reaction of autoimmunity to a dysregulation of immune responses that initiate inflammatory processes and thereby actively promoting β-cell death. Here, we review recent advances in anti-inflammatory interventions in T1D animal models and preclinical studies and discuss their mode of action as well as their capacity to interfere with T1D development.

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Titel: Anti-Inflammatory Therapy in Type 1 Diabetes
verfasst von: Bernd Baumann
Heba H. Salem
Bernhard O. Boehm
Publikationsdatum: 01.10.2012
Verlag: Current Science Inc.
Erschienen in: Current Diabetes Reports / Ausgabe 5/2012
Print ISSN: 1534-4827
Elektronische ISSN: 1539-0829
DOI: https://doi.org/10.1007/s11892-012-0299-y

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