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Current Diabetes Reports
Erschienen in: Current Diabetes Reports 5/2012

01.10.2012 | Transplantation (A Pileggi, Section Editor)

No Islets Left Behind: Islet Autotransplantation for Surgery-Induced Diabetes

verfasst von: Melena D. Bellin, A. N. Balamurugan, Timothy L. Pruett, David E. R. Sutherland

Erschienen in: Current Diabetes Reports | Ausgabe 5/2012

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Abstract

For patients with severe chronic pancreatitis refractory to medical interventions, total pancreatectomy can be considered to relieve the root cause of pain. The goal of a simultaneous islet autotransplant is to prevent or minimize the otherwise inevitable surgical diabetes. Islet autotransplant can successfully preserve some endogenous islet function in the majority of recipients, which mediates protection against brittle diabetes. Most maintain reasonably good glycemic control, while 30 %–40 % successfully discontinue insulin therapy. With islet autotransplants reaching a wider clinical audience, refinements in islet isolation techniques and strategies to protect islet grafts post-transplant may further improve the success of this procedure.
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Metadaten
Titel
No Islets Left Behind: Islet Autotransplantation for Surgery-Induced Diabetes
verfasst von
Melena D. Bellin
A. N. Balamurugan
Timothy L. Pruett
David E. R. Sutherland
Publikationsdatum
01.10.2012
Verlag
Current Science Inc.
Erschienen in
Current Diabetes Reports / Ausgabe 5/2012
Print ISSN: 1534-4827
Elektronische ISSN: 1539-0829
DOI
https://doi.org/10.1007/s11892-012-0296-1

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