Skip to main content
Erschienen in: Current Diabetes Reports 8/2019

01.08.2019 | Pediatric Type 2 and Monogenic Diabetes (O Pinhas-Hamiel, Section Editor)

Attention Deficit/Hyperactivity, the Metabolic Syndrome, and Type 2 Diabetes

verfasst von: Zohar Landau, Orit Pinhas-Hamiel

Erschienen in: Current Diabetes Reports | Ausgabe 8/2019

Einloggen, um Zugang zu erhalten

Abstract

Purpose of Review

To present current data on the coexistence of attention deficit hyperactivity disorder (ADHD) and the metabolic syndrome and type 2 diabetes mellitus in adults and children and to discuss possible mechanisms.

Recent Findings

Emerging data suggest that risk factors for obesity and insulin resistance such as diabetes during pregnancy and intrauterine growth failure may also have a role in the development of ADHD. Furthermore, ADHD and obesity share lifestyle factors, such as abnormal eating patterns, binge eating, and a sedentary lifestyle. ADHD is a risk factor for components of the metabolic syndrome, particularly obesity and type 2 diabetes mellitus, and also hypertension, both in adults and youth.

Summary

Associations of ADHD with obesity, diabetes, and hypertension have been ascertained, and various mechanisms have been proposed. Research is needed to decipher the shared genetic, pharmacological, and lifestyle risk factors. Individuals with ADHD should be treated as a high-risk group for cardiometabolic complications.
Literatur
1.
Zurück zum Zitat Bielorai B, Pinhas-Hamiel O. Type 2 diabetes mellitus, the metabolic syndrome, and its components in adult survivors of acute lymphoblastic leukemia and hematopoietic stem cell transplantations. Curr Diab Rep. 2018;18:32.CrossRef Bielorai B, Pinhas-Hamiel O. Type 2 diabetes mellitus, the metabolic syndrome, and its components in adult survivors of acute lymphoblastic leukemia and hematopoietic stem cell transplantations. Curr Diab Rep. 2018;18:32.CrossRef
2.
Zurück zum Zitat Pinhas-Hamiel O, Levek-Motola N, Kaidar K, Boyko V, Tisch E, Mazor-Aronovitch K, et al. Prevalence of overweight, obesity and metabolic syndrome components in children, adolescents and young adults with type 1 diabetes mellitus. Diabetes Metab Res Rev. 2015;31:76–84.CrossRef Pinhas-Hamiel O, Levek-Motola N, Kaidar K, Boyko V, Tisch E, Mazor-Aronovitch K, et al. Prevalence of overweight, obesity and metabolic syndrome components in children, adolescents and young adults with type 1 diabetes mellitus. Diabetes Metab Res Rev. 2015;31:76–84.CrossRef
3.
Zurück zum Zitat Pinhas-Hamiel O, Livne M, Harari G, Achiron A. Prevalence of overweight, obesity and metabolic syndrome components in multiple sclerosis patients with significant disability. Eur J Neurol. 2015;22:1275–9.CrossRef Pinhas-Hamiel O, Livne M, Harari G, Achiron A. Prevalence of overweight, obesity and metabolic syndrome components in multiple sclerosis patients with significant disability. Eur J Neurol. 2015;22:1275–9.CrossRef
4.
Zurück zum Zitat Abou Kassm S, Hoertel N, Naja W, McMahon K, Barrière S, Blumenstock Y, et al. Metabolic syndrome among older adults with schizophrenia spectrum disorder: prevalence and associated factors in a multicenter study. Psychiatry Res. 2019;275:238–46.CrossRef Abou Kassm S, Hoertel N, Naja W, McMahon K, Barrière S, Blumenstock Y, et al. Metabolic syndrome among older adults with schizophrenia spectrum disorder: prevalence and associated factors in a multicenter study. Psychiatry Res. 2019;275:238–46.CrossRef
5.
Zurück zum Zitat Feldman HM, Reiff MI. Attention deficit–hyperactivity disorder in children and adolescents. N Engl J Med. 2014;370:838–46.CrossRef Feldman HM, Reiff MI. Attention deficit–hyperactivity disorder in children and adolescents. N Engl J Med. 2014;370:838–46.CrossRef
6.
Zurück zum Zitat Cortese S, Tessari L. Attention-deficit/hyperactivity disorder (ADHD) and obesity: update 2016. Curr Psychiatry Rep. 2017;19:4.CrossRef Cortese S, Tessari L. Attention-deficit/hyperactivity disorder (ADHD) and obesity: update 2016. Curr Psychiatry Rep. 2017;19:4.CrossRef
7.
Zurück zum Zitat • Thapar A, Cooper M. Attention deficit hyperactivity disorder. Lancet. 2016;387:1240–50. This is an updated review of ADHD with a clinical approach and wide coverage of various aspects of this disorder. CrossRef • Thapar A, Cooper M. Attention deficit hyperactivity disorder. Lancet. 2016;387:1240–50. This is an updated review of ADHD with a clinical approach and wide coverage of various aspects of this disorder. CrossRef
8.
Zurück zum Zitat Polanczyk G, de Lima MS, Horta BL, Biederman J, Rohde LA. The worldwide prevalence of ADHD: a systematic review and metaregression analysis. Am J Psychiatry. 2007;164:942–8.CrossRef Polanczyk G, de Lima MS, Horta BL, Biederman J, Rohde LA. The worldwide prevalence of ADHD: a systematic review and metaregression analysis. Am J Psychiatry. 2007;164:942–8.CrossRef
9.
Zurück zum Zitat Moreno-Alcázar A, Ramos-Quiroga JA, Radua J, Salavert J, Palomar G, Bosch R, et al. Brain abnormalities in adults with attention deficit hyperactivity disorder revealed by voxel-based morphometry. Psychiatry Res Neuroimaging. 2016;254:41–7.CrossRef Moreno-Alcázar A, Ramos-Quiroga JA, Radua J, Salavert J, Palomar G, Bosch R, et al. Brain abnormalities in adults with attention deficit hyperactivity disorder revealed by voxel-based morphometry. Psychiatry Res Neuroimaging. 2016;254:41–7.CrossRef
10.
Zurück zum Zitat Davidovitch M, Koren G, Fund N, Shrem M, Porath A. Challenges in defining the rates of ADHD diagnosis and treatment: trends over the last decade. BMC Pediatr. 2017;17:218.CrossRef Davidovitch M, Koren G, Fund N, Shrem M, Porath A. Challenges in defining the rates of ADHD diagnosis and treatment: trends over the last decade. BMC Pediatr. 2017;17:218.CrossRef
11.
Zurück zum Zitat Xu G, Strathearn L, Liu B, Yang B, Bao W. Twenty-year trends in diagnosed attention-deficit/hyperactivity disorder among US children and adolescents, 1997-2016. JAMA Netw Open. 2018;1:e181471.CrossRef Xu G, Strathearn L, Liu B, Yang B, Bao W. Twenty-year trends in diagnosed attention-deficit/hyperactivity disorder among US children and adolescents, 1997-2016. JAMA Netw Open. 2018;1:e181471.CrossRef
12.
Zurück zum Zitat Matthews M, Nigg JT, Fair DA. Attention deficit hyperactivity disorder. Curr Top Behav Neurosci. 2014;16:235–66.CrossRef Matthews M, Nigg JT, Fair DA. Attention deficit hyperactivity disorder. Curr Top Behav Neurosci. 2014;16:235–66.CrossRef
13.
Zurück zum Zitat Hanć T, Cortese S. Attention deficit/hyperactivity-disorder and obesity: a review and model of current hypotheses explaining their comorbidity. Neurosci Biobehav Rev. 2018;92:16–28.CrossRef Hanć T, Cortese S. Attention deficit/hyperactivity-disorder and obesity: a review and model of current hypotheses explaining their comorbidity. Neurosci Biobehav Rev. 2018;92:16–28.CrossRef
14.
Zurück zum Zitat Samson SL, Garber AJ. Metabolic syndrome. Endocrinol Metab Clin N Am. 2014;43:1–23.CrossRef Samson SL, Garber AJ. Metabolic syndrome. Endocrinol Metab Clin N Am. 2014;43:1–23.CrossRef
15.
Zurück zum Zitat Grundy SM. Metabolic syndrome pandemic. Arterioscler Thromb Vasc Biol. 2008;28:629–36.CrossRef Grundy SM. Metabolic syndrome pandemic. Arterioscler Thromb Vasc Biol. 2008;28:629–36.CrossRef
16.
Zurück zum Zitat Friend A, Craig L, Turner S. The prevalence of metabolic syndrome in children: a systematic review of the literature. Metab Syndr Relat Disord. 2013;11:71–80.CrossRef Friend A, Craig L, Turner S. The prevalence of metabolic syndrome in children: a systematic review of the literature. Metab Syndr Relat Disord. 2013;11:71–80.CrossRef
17.
Zurück zum Zitat •• Chen Q, Hartman CA, Haavik J, Harro J, Klungsøyr K, Hegvik TA, et al. Common psychiatric and metabolic comorbidity of adult attention-deficit/hyperactivity disorder: a population-based cross-sectional study. PLoS One. 2018;13:e0204516. This epidemiologic study from Sweden deals with associations between ADHD and metabolic parameters. The study analyzed data from more than 5.5 million subjects. CrossRef •• Chen Q, Hartman CA, Haavik J, Harro J, Klungsøyr K, Hegvik TA, et al. Common psychiatric and metabolic comorbidity of adult attention-deficit/hyperactivity disorder: a population-based cross-sectional study. PLoS One. 2018;13:e0204516. This epidemiologic study from Sweden deals with associations between ADHD and metabolic parameters. The study analyzed data from more than 5.5 million subjects. CrossRef
18.
Zurück zum Zitat Mick E, McManus DD, Goldberg RJ. Meta-analysis of increased heart rate and blood pressure associated with CNS stimulant treatment of ADHD in adults. Eur Neuropsychopharmacol. 2013;23:534–41.CrossRef Mick E, McManus DD, Goldberg RJ. Meta-analysis of increased heart rate and blood pressure associated with CNS stimulant treatment of ADHD in adults. Eur Neuropsychopharmacol. 2013;23:534–41.CrossRef
19.
Zurück zum Zitat •• Chen M-H, Pan T-L, Hsu J-W, Huang KL, Su TP, Li CT, et al. Risk of type 2 diabetes in adolescents and young adults with attention-deficit/hyperactivity disorder. J Clin Psychiatry. 2018. https://doi.org/10.4088/JCP.17m11607. This paper deals with the association af ADHD and type 2 diabetes. It is one of the few studies that provide comprehensive insight of this issue. •• Chen M-H, Pan T-L, Hsu J-W, Huang KL, Su TP, Li CT, et al. Risk of type 2 diabetes in adolescents and young adults with attention-deficit/hyperactivity disorder. J Clin Psychiatry. 2018. https://​doi.​org/​10.​4088/​JCP.​17m11607. This paper deals with the association af ADHD and type 2 diabetes. It is one of the few studies that provide comprehensive insight of this issue.
20.
Zurück zum Zitat Chen H-J, Lee Y-J, Yeh GC, Lin H-C. Association of attention-deficit/hyperactivity disorder with diabetes: a population-based study. Pediatr Res. 2013;73:492–6.CrossRef Chen H-J, Lee Y-J, Yeh GC, Lin H-C. Association of attention-deficit/hyperactivity disorder with diabetes: a population-based study. Pediatr Res. 2013;73:492–6.CrossRef
21.
Zurück zum Zitat Fuemmeler BF, Østbye T, Yang C, McClernon FJ, Kollins SH. Association between attention-deficit/hyperactivity disorder symptoms and obesity and hypertension in early adulthood: a population-based study. Int J Obes. 2011;35:852–62.CrossRef Fuemmeler BF, Østbye T, Yang C, McClernon FJ, Kollins SH. Association between attention-deficit/hyperactivity disorder symptoms and obesity and hypertension in early adulthood: a population-based study. Int J Obes. 2011;35:852–62.CrossRef
22.
24.
Zurück zum Zitat Spencer TJ, Faraone SV, Tarko L, McDermott K, Biederman J. Attention-deficit/hyperactivity disorder and adverse health outcomes in adults. J Nerv Ment Dis. 2014;202:725–31.CrossRef Spencer TJ, Faraone SV, Tarko L, McDermott K, Biederman J. Attention-deficit/hyperactivity disorder and adverse health outcomes in adults. J Nerv Ment Dis. 2014;202:725–31.CrossRef
25.
Zurück zum Zitat Pinho R, Wang B, Becker A, Rothenberger A, Outeiro TF, Herrmann-Lingen C, et al. Attention-deficit/hyperactivity disorder is associated with reduced levels of serum low-density lipoprotein cholesterol in adolescents. Data from the population-based German KiGGS study. World J Biol Psychiatry. 2018:1–9. Pinho R, Wang B, Becker A, Rothenberger A, Outeiro TF, Herrmann-Lingen C, et al. Attention-deficit/hyperactivity disorder is associated with reduced levels of serum low-density lipoprotein cholesterol in adolescents. Data from the population-based German KiGGS study. World J Biol Psychiatry. 2018:1–9.
26.
Zurück zum Zitat Ugur C, Uneri OS, Goker Z, Sekmen E, Aydemir H, Solmaz E. The assessment of serum lipid profiles of children with attention deficit hyperactivity disorder. Psychiatry Res. 2018;264:231–5.CrossRef Ugur C, Uneri OS, Goker Z, Sekmen E, Aydemir H, Solmaz E. The assessment of serum lipid profiles of children with attention deficit hyperactivity disorder. Psychiatry Res. 2018;264:231–5.CrossRef
27.
Zurück zum Zitat Nigg JT, Johnstone JM, Musser ED, Long HG, Willoughby MT, Shannon J. Attention-deficit/hyperactivity disorder (ADHD) and being overweight/obesity: new data and meta-analysis. Clin Psychol Rev. 2016;43:67–79.CrossRef Nigg JT, Johnstone JM, Musser ED, Long HG, Willoughby MT, Shannon J. Attention-deficit/hyperactivity disorder (ADHD) and being overweight/obesity: new data and meta-analysis. Clin Psychol Rev. 2016;43:67–79.CrossRef
28.
Zurück zum Zitat Agranat-Meged AN, Deitcher C, Goldzweig G, Leibenson L, Stein M, Galili-Weisstub E. Childhood obesity and attention deficit/hyperactivity disorder: a newly described comorbidity in obese hospitalized children. Int J Eat Disord. 2005;37:357–9.CrossRef Agranat-Meged AN, Deitcher C, Goldzweig G, Leibenson L, Stein M, Galili-Weisstub E. Childhood obesity and attention deficit/hyperactivity disorder: a newly described comorbidity in obese hospitalized children. Int J Eat Disord. 2005;37:357–9.CrossRef
29.
Zurück zum Zitat Altfas JR. Prevalence of attention deficit/hyperactivity disorder among adults in obesity treatment. BMC Psychiatry. 2002;2:9.CrossRef Altfas JR. Prevalence of attention deficit/hyperactivity disorder among adults in obesity treatment. BMC Psychiatry. 2002;2:9.CrossRef
30.
Zurück zum Zitat Alfonsson S, Parling T, Ghaderi A. Screening of adult ADHD among patients presenting for bariatric surgery. Obes Surg. 2012;22:918–26.CrossRef Alfonsson S, Parling T, Ghaderi A. Screening of adult ADHD among patients presenting for bariatric surgery. Obes Surg. 2012;22:918–26.CrossRef
31.
Zurück zum Zitat Cortese S, Castellanos FX. The relationship between ADHD and obesity: implications for therapy. Expert Rev Neurother. 2014;14:473–9.CrossRef Cortese S, Castellanos FX. The relationship between ADHD and obesity: implications for therapy. Expert Rev Neurother. 2014;14:473–9.CrossRef
32.
Zurück zum Zitat Simon V, Czobor P, Bálint S, Mészáros Á, Bitter I. Prevalence and correlates of adult attention-deficit hyperactivity disorder: meta-analysis. Br J Psychiatry. 2009;194:204–11.CrossRef Simon V, Czobor P, Bálint S, Mészáros Á, Bitter I. Prevalence and correlates of adult attention-deficit hyperactivity disorder: meta-analysis. Br J Psychiatry. 2009;194:204–11.CrossRef
33.
Zurück zum Zitat Merzon E, Merhasin I, Vinker-Shuster M et al. The association between ADHD symptoms and cognitive decline in adult patients with diabetes. Proceeding of the 5th Conference of the Israeli Society for Quality in Healthcare - Tel Aviv, Israel; 2018. pp. 85. Merzon E, Merhasin I, Vinker-Shuster M et al. The association between ADHD symptoms and cognitive decline in adult patients with diabetes. Proceeding of the 5th Conference of the Israeli Society for Quality in Healthcare - Tel Aviv, Israel; 2018. pp. 85.
34.
Zurück zum Zitat Grisaru S, Yue M, Samuel SM, Chaput KH, Hamiwka LA. Blood pressure in children with attention deficit/hyperactivity disorder. Paediatr Child Health. 2018;23:e102–8.CrossRef Grisaru S, Yue M, Samuel SM, Chaput KH, Hamiwka LA. Blood pressure in children with attention deficit/hyperactivity disorder. Paediatr Child Health. 2018;23:e102–8.CrossRef
35.
Zurück zum Zitat Vitiello B, Elliott GR, Swanson JM, Arnold LE, Hechtman L, Abikoff H, et al. Blood pressure and heart rate over 10 years in the multimodal treatment study of children with ADHD. Am J Psychiatry. 2012;169:167–77.CrossRef Vitiello B, Elliott GR, Swanson JM, Arnold LE, Hechtman L, Abikoff H, et al. Blood pressure and heart rate over 10 years in the multimodal treatment study of children with ADHD. Am J Psychiatry. 2012;169:167–77.CrossRef
36.
Zurück zum Zitat Martinez-Raga J, Ferreros A, Knecht C, de Alvaro R, Carabal E. Attention-deficit hyperactivity disorder medication use: factors involved in prescribing, safety aspects and outcomes. Ther Adv Drug Saf. 2017;8:87–99.CrossRef Martinez-Raga J, Ferreros A, Knecht C, de Alvaro R, Carabal E. Attention-deficit hyperactivity disorder medication use: factors involved in prescribing, safety aspects and outcomes. Ther Adv Drug Saf. 2017;8:87–99.CrossRef
37.
Zurück zum Zitat Avcil S. Association between altered lipid profiles and attention deficit hyperactivity disorder in boys. Nord J Psychiatry. 2018;72:361–6.CrossRef Avcil S. Association between altered lipid profiles and attention deficit hyperactivity disorder in boys. Nord J Psychiatry. 2018;72:361–6.CrossRef
38.
Zurück zum Zitat • Tong L, Xiong X, Tan H. Attention-deficit/hyperactivity disorder and lifestyle-related behaviors in children. PLoS One. 2016;11:e0163434. The authors present a unique approch to examining lifestyle behaviors in children with ADHD. It is important to be aware of these behaviors and to discuss them with parents of children with ADHD. CrossRef • Tong L, Xiong X, Tan H. Attention-deficit/hyperactivity disorder and lifestyle-related behaviors in children. PLoS One. 2016;11:e0163434. The authors present a unique approch to examining lifestyle behaviors in children with ADHD. It is important to be aware of these behaviors and to discuss them with parents of children with ADHD. CrossRef
39.
Zurück zum Zitat Docet MF, Larrañaga A, Pérez Méndez LF, García-Mayor RV. Attention deficit hyperactivity disorder increases the risk of having abnormal eating behaviours in obese adults. Eat Weight Disord. 2012;17:e132–6.CrossRef Docet MF, Larrañaga A, Pérez Méndez LF, García-Mayor RV. Attention deficit hyperactivity disorder increases the risk of having abnormal eating behaviours in obese adults. Eat Weight Disord. 2012;17:e132–6.CrossRef
40.
Zurück zum Zitat Reinblatt SP, Mahone EM, Tanofsky-Kraff M, Lee-Winn AE, Yenokyan G, Leoutsakos J-MS, et al. Pediatric loss of control eating syndrome: association with attention-deficit/hyperactivity disorder and impulsivity. Int J Eat Disord. 2015;48:580–8.CrossRef Reinblatt SP, Mahone EM, Tanofsky-Kraff M, Lee-Winn AE, Yenokyan G, Leoutsakos J-MS, et al. Pediatric loss of control eating syndrome: association with attention-deficit/hyperactivity disorder and impulsivity. Int J Eat Disord. 2015;48:580–8.CrossRef
41.
Zurück zum Zitat Hvolby A. Associations of sleep disturbance with ADHD: implications for treatment. Atten Defic Hyperact Disord. 2015;7:1–18.CrossRef Hvolby A. Associations of sleep disturbance with ADHD: implications for treatment. Atten Defic Hyperact Disord. 2015;7:1–18.CrossRef
42.
Zurück zum Zitat Bijlenga D, Vollebregt MA, Kooij JJS, Arns M. The role of the circadian system in the etiology and pathophysiology of ADHD: time to redefine ADHD? ADHD Atten Deficit Hyperact Disord. 2019;11:5–19.CrossRef Bijlenga D, Vollebregt MA, Kooij JJS, Arns M. The role of the circadian system in the etiology and pathophysiology of ADHD: time to redefine ADHD? ADHD Atten Deficit Hyperact Disord. 2019;11:5–19.CrossRef
43.
Zurück zum Zitat Baird AL, Coogan AN, Siddiqui A, Donev RM, Thome J. Adult attention-deficit hyperactivity disorder is associated with alterations in circadian rhythms at the behavioural, endocrine and molecular levels. Mol Psychiatry. 2012;17:988–95.CrossRef Baird AL, Coogan AN, Siddiqui A, Donev RM, Thome J. Adult attention-deficit hyperactivity disorder is associated with alterations in circadian rhythms at the behavioural, endocrine and molecular levels. Mol Psychiatry. 2012;17:988–95.CrossRef
44.
Zurück zum Zitat Koren D, Taveras EM. Association of sleep disturbances with obesity, insulin resistance and the metabolic syndrome. Metabolism. 2018;84:67–75.CrossRef Koren D, Taveras EM. Association of sleep disturbances with obesity, insulin resistance and the metabolic syndrome. Metabolism. 2018;84:67–75.CrossRef
45.
Zurück zum Zitat Mellström E, Forsman C, Engh L, Hallerbäck MU, Wikström S. Methylphenidate and reduced overweight in children with ADHD. J Atten Disord. 2018;22:1095–1108. Mellström E, Forsman C, Engh L, Hallerbäck MU, Wikström S. Methylphenidate and reduced overweight in children with ADHD. J Atten Disord. 2018;22:1095–1108.
46.
Zurück zum Zitat Charach G, Kaysar N, Grosskopf I, Rabinovich A, Weintraub M. Methylphenidate has positive hypocholesterolemic and hypotriglyceridemic effects: new data. J Clin Pharmacol. 2009;49:848–51.CrossRef Charach G, Kaysar N, Grosskopf I, Rabinovich A, Weintraub M. Methylphenidate has positive hypocholesterolemic and hypotriglyceridemic effects: new data. J Clin Pharmacol. 2009;49:848–51.CrossRef
47.
Zurück zum Zitat Lachaine J, De G, Sikirica V, van Stralen J, Hodgkins P, Yang H, et al. Treatment patterns, resource use, and economic outcomes associated with atypical antipsychotic prescriptions in children and adolescents with attention-deficit hyperactivity disorder in Quebec. Can J Psychiatr. 2014;59:597–608.CrossRef Lachaine J, De G, Sikirica V, van Stralen J, Hodgkins P, Yang H, et al. Treatment patterns, resource use, and economic outcomes associated with atypical antipsychotic prescriptions in children and adolescents with attention-deficit hyperactivity disorder in Quebec. Can J Psychiatr. 2014;59:597–608.CrossRef
48.
Zurück zum Zitat Sikirica V, Pliszka SR, Betts KA, Hodgkins P, Samuelson T, Xie J, et al. Comparative treatment patterns, resource utilization, and costs in stimulant-treated children with ADHD who require subsequent pharmacotherapy with atypical antipsychotics versus non-antipsychotics. J Manag Care Pharm. 2012;18:676–89.PubMed Sikirica V, Pliszka SR, Betts KA, Hodgkins P, Samuelson T, Xie J, et al. Comparative treatment patterns, resource utilization, and costs in stimulant-treated children with ADHD who require subsequent pharmacotherapy with atypical antipsychotics versus non-antipsychotics. J Manag Care Pharm. 2012;18:676–89.PubMed
49.
Zurück zum Zitat Sohn M, Moga DC, Blumenschein K, Talbert J. National trends in off-label use of atypical antipsychotics in children and adolescents in the United States. Medicine (Baltimore). 2016;95:e3784.CrossRef Sohn M, Moga DC, Blumenschein K, Talbert J. National trends in off-label use of atypical antipsychotics in children and adolescents in the United States. Medicine (Baltimore). 2016;95:e3784.CrossRef
50.
Zurück zum Zitat Wynchank D, Bijlenga D, Lamers F, Kooij JJS, Bron TI, Beekman ATF, et al. The association between metabolic syndrome, obesity-related outcomes, and ADHD in adults with comorbid affective disorders. J Atten Disord. 2018;22:460–71.CrossRef Wynchank D, Bijlenga D, Lamers F, Kooij JJS, Bron TI, Beekman ATF, et al. The association between metabolic syndrome, obesity-related outcomes, and ADHD in adults with comorbid affective disorders. J Atten Disord. 2018;22:460–71.CrossRef
51.
Zurück zum Zitat Chen M-H, Su T-P, Chen Y-S, Hsu J-W, Huang K-L, Chang W-H, et al. Higher risk of developing mood disorders among adolescents with comorbidity of attention deficit hyperactivity disorder and disruptive behavior disorder: a nationwide prospective study. J Psychiatr Res. 2013;47:1019–23.CrossRef Chen M-H, Su T-P, Chen Y-S, Hsu J-W, Huang K-L, Chang W-H, et al. Higher risk of developing mood disorders among adolescents with comorbidity of attention deficit hyperactivity disorder and disruptive behavior disorder: a nationwide prospective study. J Psychiatr Res. 2013;47:1019–23.CrossRef
52.
Zurück zum Zitat Singh R, Bansal Y, Medhi B, Kuhad A. Antipsychotics-induced metabolic alterations: recounting the mechanistic insights, therapeutic targets and pharmacological alternatives. Eur J Pharmacol. 2019;844:231–40.CrossRef Singh R, Bansal Y, Medhi B, Kuhad A. Antipsychotics-induced metabolic alterations: recounting the mechanistic insights, therapeutic targets and pharmacological alternatives. Eur J Pharmacol. 2019;844:231–40.CrossRef
53.
Zurück zum Zitat Hergüner S, Harmancı H, Toy H. Attention deficit-hyperactivity disorder symptoms in women with polycystic ovary syndrome. Int J Psychiatry Med. 2015;50:317–25.CrossRef Hergüner S, Harmancı H, Toy H. Attention deficit-hyperactivity disorder symptoms in women with polycystic ovary syndrome. Int J Psychiatry Med. 2015;50:317–25.CrossRef
54.
Zurück zum Zitat Kong L, Norstedt G, Schalling M, Gissler M, Lavebratt C. The risk of offspring psychiatric disorders in the setting of maternal obesity and diabetes. Pediatrics. 2018;142:e20180776.CrossRef Kong L, Norstedt G, Schalling M, Gissler M, Lavebratt C. The risk of offspring psychiatric disorders in the setting of maternal obesity and diabetes. Pediatrics. 2018;142:e20180776.CrossRef
55.
Zurück zum Zitat Xiang AH, Wang X, Martinez MP, Getahun D, Page KA, Buchanan TA, et al. Maternal gestational diabetes mellitus, type 1 diabetes, and type 2 diabetes during pregnancy and risk of ADHD in offspring. Diabetes Care. 2018;41:2502–8.CrossRef Xiang AH, Wang X, Martinez MP, Getahun D, Page KA, Buchanan TA, et al. Maternal gestational diabetes mellitus, type 1 diabetes, and type 2 diabetes during pregnancy and risk of ADHD in offspring. Diabetes Care. 2018;41:2502–8.CrossRef
56.
Zurück zum Zitat Kosidou K, Dalman C, Widman L, Arver S, Lee BK, Magnusson C, et al. Maternal polycystic ovary syndrome and risk for attention-deficit/hyperactivity disorder in the offspring. Biol Psychiatry. 2017;82:651–9.CrossRef Kosidou K, Dalman C, Widman L, Arver S, Lee BK, Magnusson C, et al. Maternal polycystic ovary syndrome and risk for attention-deficit/hyperactivity disorder in the offspring. Biol Psychiatry. 2017;82:651–9.CrossRef
57.
Zurück zum Zitat Rodriguez A, Miettunen J, Henriksen TB, Olsen J, Obel C, Taanila A, et al. Maternal adiposity prior to pregnancy is associated with ADHD symptoms in offspring: evidence from three prospective pregnancy cohorts. Int J Obes. 2008;32:550–7.CrossRef Rodriguez A, Miettunen J, Henriksen TB, Olsen J, Obel C, Taanila A, et al. Maternal adiposity prior to pregnancy is associated with ADHD symptoms in offspring: evidence from three prospective pregnancy cohorts. Int J Obes. 2008;32:550–7.CrossRef
Metadaten
Titel
Attention Deficit/Hyperactivity, the Metabolic Syndrome, and Type 2 Diabetes
verfasst von
Zohar Landau
Orit Pinhas-Hamiel
Publikationsdatum
01.08.2019
Verlag
Springer US
Erschienen in
Current Diabetes Reports / Ausgabe 8/2019
Print ISSN: 1534-4827
Elektronische ISSN: 1539-0829
DOI
https://doi.org/10.1007/s11892-019-1174-x

Weitere Artikel der Ausgabe 8/2019

Current Diabetes Reports 8/2019 Zur Ausgabe

Pathogenesis of Type 2 Diabetes and Insulin Resistance (M-E Patti, Section Editor)

Type 2 Diabetes: Multiple Genes, Multiple Diseases

Immunology, Transplantation, and Regenerative Medicine (L Piemonti and V Sordi, Section Editors)

Machine Perfusion and the Pancreas: Will It Increase the Donor Pool?

Pathogenesis of Type 2 Diabetes and Insulin Resistance (M-E Patti, Section Editor)

Developmental Programming of Body Composition: Update on Evidence and Mechanisms

Pathogenesis of Type 2 Diabetes and Insulin Resistance (M-E Patti, Section Editor)

Epigenetics and Type 2 Diabetes Risk

Pathogenesis of Type 1 Diabetes (A Pugliese and SJ Richardson, Section Editors)

How, When, and Where Do Human β-Cells Regenerate?

Diabetes Epidemiology (E Selvin and K Foti, Section Editors)

Second-line Glucose-Lowering Therapy in Type 2 Diabetes Mellitus

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Notfall-TEP der Hüfte ist auch bei 90-Jährigen machbar

26.04.2024 Hüft-TEP Nachrichten

Ob bei einer Notfalloperation nach Schenkelhalsfraktur eine Hemiarthroplastik oder eine totale Endoprothese (TEP) eingebaut wird, sollte nicht allein vom Alter der Patientinnen und Patienten abhängen. Auch über 90-Jährige können von der TEP profitieren.

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

25.04.2024 Hypotonie Nachrichten

Wenn unter einer medikamentösen Hochdrucktherapie der diastolische Blutdruck in den Keller geht, steigt das Risiko für schwere kardiovaskuläre Ereignisse: Darauf deutet eine Sekundäranalyse der SPRINT-Studie hin.

Bei schweren Reaktionen auf Insektenstiche empfiehlt sich eine spezifische Immuntherapie

Insektenstiche sind bei Erwachsenen die häufigsten Auslöser einer Anaphylaxie. Einen wirksamen Schutz vor schweren anaphylaktischen Reaktionen bietet die allergenspezifische Immuntherapie. Jedoch kommt sie noch viel zu selten zum Einsatz.

Therapiestart mit Blutdrucksenkern erhöht Frakturrisiko

25.04.2024 Hypertonie Nachrichten

Beginnen ältere Männer im Pflegeheim eine Antihypertensiva-Therapie, dann ist die Frakturrate in den folgenden 30 Tagen mehr als verdoppelt. Besonders häufig stürzen Demenzkranke und Männer, die erstmals Blutdrucksenker nehmen. Dafür spricht eine Analyse unter US-Veteranen.

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.