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Current Hepatology Reports
Erschienen in: Current Hepatology Reports 4/2018

15.10.2018 | Hepatitis B (J Lim, Section Editor)

Non-invasive Fibrosis Testing in Patients with Chronic Hepatitis B

verfasst von: Clément Lejealle, Laurent Castera

Erschienen in: Current Hepatology Reports | Ausgabe 4/2018

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Abstract

Purpose of Review

Summarizing the available evidence and advantages and disadvantages of the use of non-invasive tests for the management of patients with chronic hepatitis B virus (HBV) infection, including before and during antiviral therapy.

Recent Findings

Staging of liver fibrosis and early detection of compensated cirrhosis are critical in the treatment decisions and surveillance of HBV patients. Non-invasive assessment of liver fibrosis has been one of the major advances in hepatology over the past decade, relying either on the dosage of serum biomarkers or on the measurement of liver stiffness, using either ultrasound- or magnetic resonance-based elastography techniques. The most widely used and validated tests in HBV patients are APRI, FIB-4 (non-patented), and FibroTest-Fibrosure® (patented) for serum biomarkers and transient elastography. Liver stiffness also has prognostic value in the context of cirrhosis.

Summary

Non-invasive tests are now recommended by national and international guidelines as first-line tools for fibrosis assessment.
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Metadaten
Titel
Non-invasive Fibrosis Testing in Patients with Chronic Hepatitis B
verfasst von
Clément Lejealle
Laurent Castera
Publikationsdatum
15.10.2018
Verlag
Springer US
Erschienen in
Current Hepatology Reports / Ausgabe 4/2018
Elektronische ISSN: 2195-9595
DOI
https://doi.org/10.1007/s11901-018-0439-1

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