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Current HIV/AIDS Reports

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01.03.2015 | HIV Pathogenesis and Treatment (AL Landay, Section Editor)

Understanding Frailty, Aging, and Inflammation in HIV Infection

verfasst von: Sean X. Leng, Joseph B. Margolick

Erschienen in: Current HIV/AIDS Reports | Ausgabe 1/2015

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Abstract

Frailty is a clinical syndrome initially characterized in geriatric populations with a hallmark of age-related declines in physiologic reserve and function and increased vulnerability to adverse health outcomes. Recently, frailty has increasingly been recognized as a common and important HIV-associated non-AIDS (HANA) condition. This article provides an overview of our current understanding of frailty and its phenotypic characteristics and evidence that they are related to aging and to chronic inflammation that is associated with aging and also with long-term treated HIV infection. The etiology of this chronic inflammation is unknown but we discuss evidence linking it to persistent infection with cytomegalovirus in both geriatric populations and people living with HIV infection.

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Titel: Understanding Frailty, Aging, and Inflammation in HIV Infection
verfasst von: Sean X. Leng
Joseph B. Margolick
Publikationsdatum: 01.03.2015
Verlag: Springer US
Erschienen in: Current HIV/AIDS Reports / Ausgabe 1/2015
Print ISSN: 1548-3568
Elektronische ISSN: 1548-3576
DOI: https://doi.org/10.1007/s11904-014-0247-3

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25.04.2024 Hypertonie Nachrichten

Beginnen ältere Männer im Pflegeheim eine Antihypertensiva-Therapie, dann ist die Frakturrate in den folgenden 30 Tagen mehr als verdoppelt. Besonders häufig stürzen Demenzkranke und Männer, die erstmals Blutdrucksenker nehmen. Dafür spricht eine Analyse unter US-Veteranen.

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