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Current Hypertension Reports

Erschienen in:

01.10.2010

Should All Hypertensive Dialysis Patients Receive a Blocker of the Renin-Angiotensin System?

verfasst von: Arjun D. Sinha, Rajiv Agarwal

Erschienen in: Current Hypertension Reports | Ausgabe 5/2010

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Abstract

Cardiovascular mortality and hypertension remain common in the dialysis population, and two recent meta-analyses have suggested that antihypertensive pharmacotherapy reduces cardiovascular events in dialysis patients. Based on their benefits in other populations, blockers of the renin-angiotensin-aldosterone system (RAAS) are an attractive treatment option. The evidence that RAAS blockers improve surrogate end points is mixed. However, a recent meta-analysis found significant improvement in left ventricular mass with RAAS-blocking drugs in hemodialysis patients. Only a few trials have examined RAAS-blocking drugs and cardiovascular events in dialysis patients, and a recent meta-analysis found no significant benefit in hemodialysis patients. The single trial of peritoneal dialysis patients that reported cardiovascular events found no benefit from RAAS blockers. Fortunately, the risk of hyperkalemia appears low. Based on the available evidence, we cannot categorically recommend that all hypertensive dialysis patients be treated with RAAS blockers. We await the results of adequately powered clinical trials.

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Titel: Should All Hypertensive Dialysis Patients Receive a Blocker of the Renin-Angiotensin System?
verfasst von: Arjun D. Sinha
Rajiv Agarwal
Publikationsdatum: 01.10.2010
Verlag: Current Science Inc.
Erschienen in: Current Hypertension Reports / Ausgabe 5/2010
Print ISSN: 1522-6417
Elektronische ISSN: 1534-3111
DOI: https://doi.org/10.1007/s11906-010-0137-z

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