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Erschienen in: Current Infectious Disease Reports 4/2019

01.04.2019 | Healthcare Associated Infections (G Bearman and D Morgan, Section Editors)

Advances and Challenges in the Diagnosis and Treatment of Urinary Tract Infections: the Need for Diagnostic Stewardship

verfasst von: Kimberly C. Claeys, Natalia Blanco, Daniel J. Morgan, Surbhi Leekha, Kaede V. Sullivan

Erschienen in: Current Infectious Disease Reports | Ausgabe 4/2019

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Abstract

Purpose of Review

Urinary tract infections (UTIs), including catheter-associated UTIs, are among the most common bacterial infections in both inpatient and outpatient settings. Diagnosis of true UTI remains a clinical challenge, and excessive antimicrobial treatment of asymptomatic bacteriuria (ASB) or contaminated urine cultures is common.

Recent Findings

Challenges with the appropriate diagnosis of UTIs include the lack of specific signs and symptoms, no definitive diagnostic criteria, high incidence of ASB, contamination of samples, and frequent lack of indications for ordering urine cultures. Promising interventions include education and feedback, indication requirements when ordering cultures, and use of reflex culture policies that limit urine cultures.

Summary

Antimicrobial and diagnostic stewardship interventions can work synergistically to decrease ordering of urine cultures without clear indication and prevent excessive antimicrobial administration in patients without clearly defined UTI.
Literatur
1.
Zurück zum Zitat Foxman B. Urinary tract infection syndromes: occurrence, recurrence, bacteriology, risk factors, and disease burden. Infect Dis Clin N Am. 2014;28(1):1–13.CrossRef Foxman B. Urinary tract infection syndromes: occurrence, recurrence, bacteriology, risk factors, and disease burden. Infect Dis Clin N Am. 2014;28(1):1–13.CrossRef
2.
Zurück zum Zitat Foxman B. The epidemiology of urinary tract infection. Nat Rev Urol. 2010;7(12):653–60.CrossRef Foxman B. The epidemiology of urinary tract infection. Nat Rev Urol. 2010;7(12):653–60.CrossRef
3.
Zurück zum Zitat Flores-Mireles AL, Walker JN, Caparon M, Hultgren SJ. Urinary tract infections: epidemiology, mechanisms of infection and treatment options. Nat Rev Microbiol. 2015;13(5):269–84.CrossRefPubMed Flores-Mireles AL, Walker JN, Caparon M, Hultgren SJ. Urinary tract infections: epidemiology, mechanisms of infection and treatment options. Nat Rev Microbiol. 2015;13(5):269–84.CrossRefPubMed
4.
Zurück zum Zitat Magill SS, Edwards JR, Bamberg W, Beldavs ZG, Dumyati G, Kainer MA, et al. Multistate point-prevalence survey of health care-associated infections. N Engl J Med. 2014;370(13):1198–208.CrossRefPubMed Magill SS, Edwards JR, Bamberg W, Beldavs ZG, Dumyati G, Kainer MA, et al. Multistate point-prevalence survey of health care-associated infections. N Engl J Med. 2014;370(13):1198–208.CrossRefPubMed
7.
Zurück zum Zitat Apisarnthanarak A, Rutjanawech S, Wichansawakun S, Ratanabunjerdkul H, Patthranitima P, Thongphubeth K, et al. Initial inappropriate urinary catheters use in a tertiary-care center: incidence, risk factors, and outcomes. Am J Infect Control. 2007;35(9):594–9.CrossRef Apisarnthanarak A, Rutjanawech S, Wichansawakun S, Ratanabunjerdkul H, Patthranitima P, Thongphubeth K, et al. Initial inappropriate urinary catheters use in a tertiary-care center: incidence, risk factors, and outcomes. Am J Infect Control. 2007;35(9):594–9.CrossRef
8.
Zurück zum Zitat Klausing BT, Tillman SD, Wright PW, Talbot TR. The influence of contaminated urine cultures in inpatient and emergency department settings. Am J Infect Control. 2016;44(10):1166–7.CrossRef Klausing BT, Tillman SD, Wright PW, Talbot TR. The influence of contaminated urine cultures in inpatient and emergency department settings. Am J Infect Control. 2016;44(10):1166–7.CrossRef
9.
Zurück zum Zitat Schulz L, Hoffman RJ, Pothof J, Fox B. Top ten myths regarding the diagnosis and treatment of urinary tract infections. J Emerg Med. 2016;51(1):25–30.CrossRef Schulz L, Hoffman RJ, Pothof J, Fox B. Top ten myths regarding the diagnosis and treatment of urinary tract infections. J Emerg Med. 2016;51(1):25–30.CrossRef
10.
Zurück zum Zitat Ge IY, Fevrier HB, Conell C, Kheraj MN, Flint AC, Smith DS, et al. Reducing risk of Clostridium difficile infection and overall use of antibiotic in the outpatient treatment of urinary tract infection. Ther Adv Urol. 2018;10(10):283–93.CrossRefPubMed Ge IY, Fevrier HB, Conell C, Kheraj MN, Flint AC, Smith DS, et al. Reducing risk of Clostridium difficile infection and overall use of antibiotic in the outpatient treatment of urinary tract infection. Ther Adv Urol. 2018;10(10):283–93.CrossRefPubMed
11.
Zurück zum Zitat Köves B, Cai T, Veeratterapillay R, Pickard R, Seisen T, Lam TB, et al. Benefits and harms of treatment of asymptomatic bacteriuria: a systematic review and meta-analysis by the European Association of Urology Urological Infection Guidelines Panel. Eur Urol. 2017;72(6):865–8.CrossRef Köves B, Cai T, Veeratterapillay R, Pickard R, Seisen T, Lam TB, et al. Benefits and harms of treatment of asymptomatic bacteriuria: a systematic review and meta-analysis by the European Association of Urology Urological Infection Guidelines Panel. Eur Urol. 2017;72(6):865–8.CrossRef
12.
Zurück zum Zitat Trautner BW. Asymptomatic bacteriuria: when the treatment is worse than the disease. Nat Rev Urol. 2011;9(2):85–93.CrossRef Trautner BW. Asymptomatic bacteriuria: when the treatment is worse than the disease. Nat Rev Urol. 2011;9(2):85–93.CrossRef
13.
Zurück zum Zitat Abbo LM, Hooton TM. Antimicrobial stewardship and urinary tract infections. Antibiotics (Basel). 2014;3(2):174–92.CrossRef Abbo LM, Hooton TM. Antimicrobial stewardship and urinary tract infections. Antibiotics (Basel). 2014;3(2):174–92.CrossRef
14.
Zurück zum Zitat Barlam TF, Cosgrove SE, Abbo LM, MacDougall C, Schuetz AN, Septimus EJ, et al. Implementing an Antibiotic Stewardship Program: Guidelines by the Infectious Diseases Society of America and the Society for Healthcare Epidemiology of America. Clin Infect Dis. 2016;62(10):e51–77.CrossRefPubMed Barlam TF, Cosgrove SE, Abbo LM, MacDougall C, Schuetz AN, Septimus EJ, et al. Implementing an Antibiotic Stewardship Program: Guidelines by the Infectious Diseases Society of America and the Society for Healthcare Epidemiology of America. Clin Infect Dis. 2016;62(10):e51–77.CrossRefPubMed
15.
Zurück zum Zitat •• Morgan DJ, Malani P, Diekema DJ. Diagnostic stewardship—leveraging the laboratory to improve antimicrobial use. JAMA. 2017;318(7):607–8. Provides a concrete conceptual approach for Diagnostic Stewardship. CrossRef •• Morgan DJ, Malani P, Diekema DJ. Diagnostic stewardship—leveraging the laboratory to improve antimicrobial use. JAMA. 2017;318(7):607–8. Provides a concrete conceptual approach for Diagnostic Stewardship. CrossRef
16.
Zurück zum Zitat Hooton TM, Bradley SF, Cardenas DD, Colgan R, Geerlings SE, Rice JC, et al. Diagnosis, prevention, and treatment of catheter-associated urinary tract infection in adults: 2009 International Clinical Practice Guidelines from the Infectious Diseases Society of America. Clin Infect Dis. 2010;50(5):625–63.CrossRef Hooton TM, Bradley SF, Cardenas DD, Colgan R, Geerlings SE, Rice JC, et al. Diagnosis, prevention, and treatment of catheter-associated urinary tract infection in adults: 2009 International Clinical Practice Guidelines from the Infectious Diseases Society of America. Clin Infect Dis. 2010;50(5):625–63.CrossRef
17.
Zurück zum Zitat Hooton TM. Clinical practice. Uncomplicated urinary tract infection. N Engl J Med. 2012;366(11):1028–37.CrossRef Hooton TM. Clinical practice. Uncomplicated urinary tract infection. N Engl J Med. 2012;366(11):1028–37.CrossRef
18.
Zurück zum Zitat Stone ND, Ashraf MS, Calder J, Crnich CJ, Crossley K, Drinka PJ, et al. Surveillance definitions of infections in long-term care facilities: revisiting the McGeer Criteria. Infect Control Hosp Epidemiol. 2012;33(10):965–77.CrossRefPubMed Stone ND, Ashraf MS, Calder J, Crnich CJ, Crossley K, Drinka PJ, et al. Surveillance definitions of infections in long-term care facilities: revisiting the McGeer Criteria. Infect Control Hosp Epidemiol. 2012;33(10):965–77.CrossRefPubMed
19.
Zurück zum Zitat McGeer A, Campbell B, Emori TG, Hierholzer WJ, Jackson MM, Nicolle LE, et al. Definitions of infection for surveillance in long-term care facilities. Am J Infect Control. 1991;19(1):1–7.CrossRef McGeer A, Campbell B, Emori TG, Hierholzer WJ, Jackson MM, Nicolle LE, et al. Definitions of infection for surveillance in long-term care facilities. Am J Infect Control. 1991;19(1):1–7.CrossRef
20.
Zurück zum Zitat Loeb M, Bentley DW, Bradley S, Crossley K, Garibaldi R, Gantz N, et al. Development of minimum criteria for the initiation of antibiotics in residents of long-term-care facilities: results of a consensus conference. Infect Control Hosp Epidemiol. 2001;22(2):120–4.CrossRef Loeb M, Bentley DW, Bradley S, Crossley K, Garibaldi R, Gantz N, et al. Development of minimum criteria for the initiation of antibiotics in residents of long-term-care facilities: results of a consensus conference. Infect Control Hosp Epidemiol. 2001;22(2):120–4.CrossRef
21.
Zurück zum Zitat Ryan S, Gillespie E, Stuart RL. Urinary tract infection surveillance in residential aged care. Am J Infect Control. 2018;46(1):67–72.CrossRef Ryan S, Gillespie E, Stuart RL. Urinary tract infection surveillance in residential aged care. Am J Infect Control. 2018;46(1):67–72.CrossRef
22.
Zurück zum Zitat Juthani-Mehta M, Tinetti M, Perrelli E, Towle V, Van Ness PH, Quagliarello V. Diagnostic accuracy of criteria for urinary tract infection in a cohort of nursing home residents. J Am Geriatr Soc. 2007;55(7):1072–7.CrossRef Juthani-Mehta M, Tinetti M, Perrelli E, Towle V, Van Ness PH, Quagliarello V. Diagnostic accuracy of criteria for urinary tract infection in a cohort of nursing home residents. J Am Geriatr Soc. 2007;55(7):1072–7.CrossRef
23.
Zurück zum Zitat Nicolle LE, Bradley S, Colgan R, Rice JC, Schaeffer A, Hooton TM. Infectious Diseases Society of America Guidelines for the Diagnosis and Treatment of Asymptomatic Bacteriuria in Adults. Clin Infect Dis. 2005;40(5):643–54.CrossRef Nicolle LE, Bradley S, Colgan R, Rice JC, Schaeffer A, Hooton TM. Infectious Diseases Society of America Guidelines for the Diagnosis and Treatment of Asymptomatic Bacteriuria in Adults. Clin Infect Dis. 2005;40(5):643–54.CrossRef
24.
Zurück zum Zitat Cortes-Penfield NW, Trautner BW, Jump RLP. Urinary tract infection and asymptomatic bacteriuria in older adults. Infect Dis Clin N Am. 2017;31(4):673–88.CrossRef Cortes-Penfield NW, Trautner BW, Jump RLP. Urinary tract infection and asymptomatic bacteriuria in older adults. Infect Dis Clin N Am. 2017;31(4):673–88.CrossRef
25.
Zurück zum Zitat Nicolle LE, Bentley DW, Garibaldi R, Neuhaus EG, Smith PW. Antimicrobial use in long-term-care facilities. SHEA Long-Term-Care Committee. Infect Control Hosp Epidemiol. 2000;21(8):537–45.CrossRef Nicolle LE, Bentley DW, Garibaldi R, Neuhaus EG, Smith PW. Antimicrobial use in long-term-care facilities. SHEA Long-Term-Care Committee. Infect Control Hosp Epidemiol. 2000;21(8):537–45.CrossRef
26.
Zurück zum Zitat Sedor J, Mulholland SG. Hospital-acquired urinary tract infections associated with the indwelling catheter. Urol Clin North Am. 1999;26(4):821–8.CrossRef Sedor J, Mulholland SG. Hospital-acquired urinary tract infections associated with the indwelling catheter. Urol Clin North Am. 1999;26(4):821–8.CrossRef
27.
Zurück zum Zitat Ipe DS, Sundac L, Benjamin WH, Moore KH, Ulett GC. Asymptomatic bacteriuria: prevalence rates of causal microorganisms, etiology of infection in different patient populations, and recent advances in molecular detection. FEMS Microbiol Lett. 2013;346(1):1–10.CrossRef Ipe DS, Sundac L, Benjamin WH, Moore KH, Ulett GC. Asymptomatic bacteriuria: prevalence rates of causal microorganisms, etiology of infection in different patient populations, and recent advances in molecular detection. FEMS Microbiol Lett. 2013;346(1):1–10.CrossRef
28.
Zurück zum Zitat Saint S, Chenoweth CE. Biofilms and catheter-associated urinary tract infections. Infect Dis Clin North Am. 2003;17(2):411–32.CrossRef Saint S, Chenoweth CE. Biofilms and catheter-associated urinary tract infections. Infect Dis Clin North Am. 2003;17(2):411–32.CrossRef
29.
Zurück zum Zitat Centers for Disease Control and Prevention (CDC). Urinary Tract Infection (Catheter-Associated Urinary Tract Infection [CAUTI] and Non-Catheter-Associated Urinary Tract Infection [UTI]) and Other Urinary System Infection [USI]) Events. In: Device-associated Module. 2019. Centers for Disease Control and Prevention (CDC). Urinary Tract Infection (Catheter-Associated Urinary Tract Infection [CAUTI] and Non-Catheter-Associated Urinary Tract Infection [UTI]) and Other Urinary System Infection [USI]) Events. In: Device-associated Module. 2019.
30.
Zurück zum Zitat Garcia R, Spitzer ED. Promoting appropriate urine culture management to improve health care outcomes and the accuracy of catheter-associated urinary tract infections. Am J Infect Control. 2017;45(10):1143–53.CrossRef Garcia R, Spitzer ED. Promoting appropriate urine culture management to improve health care outcomes and the accuracy of catheter-associated urinary tract infections. Am J Infect Control. 2017;45(10):1143–53.CrossRef
31.
Zurück zum Zitat Bekeris LG, Jones BA, Walsh MK, Wagar EA. Urine culture contamination: a College of American Pathologists Q-Probes study of 127 laboratories. Arch Pathol Lab Med. 2008;132(6):913–7. Bekeris LG, Jones BA, Walsh MK, Wagar EA. Urine culture contamination: a College of American Pathologists Q-Probes study of 127 laboratories. Arch Pathol Lab Med. 2008;132(6):913–7.
32.
Zurück zum Zitat Hartley S, Valley S, Kuhn L, Washer LL, Gandhi T, Meddings J, et al. Inappropriate testing for urinary tract infection in hospitalized patients: an opportunity for improvement. Infect Control Hosp Epidemiol. 2013;34(11):1204–7.CrossRefPubMed Hartley S, Valley S, Kuhn L, Washer LL, Gandhi T, Meddings J, et al. Inappropriate testing for urinary tract infection in hospitalized patients: an opportunity for improvement. Infect Control Hosp Epidemiol. 2013;34(11):1204–7.CrossRefPubMed
33.
Zurück zum Zitat Llor C, Moragas A, Hernández S, Crispi S, Cots JM. Misconceptions of Spanish general practitioners’ attitudes toward the management of urinary tract infections and asymptomatic bacteriuria: an internet-based questionnaire study. Rev Esp Quimioter. 2017;30(5):372–8. Llor C, Moragas A, Hernández S, Crispi S, Cots JM. Misconceptions of Spanish general practitioners’ attitudes toward the management of urinary tract infections and asymptomatic bacteriuria: an internet-based questionnaire study. Rev Esp Quimioter. 2017;30(5):372–8.
34.
Zurück zum Zitat Leis JA, Gold WL, Daneman N, Shojania K, McGeer A. Downstream impact of urine cultures ordered without indication at two acute care teaching hospitals. Infect Control Hosp Epidemiol. 2013;34(10):1113–4.CrossRef Leis JA, Gold WL, Daneman N, Shojania K, McGeer A. Downstream impact of urine cultures ordered without indication at two acute care teaching hospitals. Infect Control Hosp Epidemiol. 2013;34(10):1113–4.CrossRef
35.
Zurück zum Zitat Lee MJ, Kim M, Kim N-H, Kim C-J, Song K-H, Choe PG, et al. Why is asymptomatic bacteriuria overtreated?: a tertiary care institutional survey of resident physicians. BMC Infect Dis. 2015;15:289.CrossRefPubMed Lee MJ, Kim M, Kim N-H, Kim C-J, Song K-H, Choe PG, et al. Why is asymptomatic bacteriuria overtreated?: a tertiary care institutional survey of resident physicians. BMC Infect Dis. 2015;15:289.CrossRefPubMed
36.
Zurück zum Zitat Drekonja DM, Gnadt C, Kuskowski MA, Johnson JR. Urine cultures among hospitalized veterans: casting too broad a net? Infect Control Hosp Epidemiol. 2014;35(5):574–6.CrossRef Drekonja DM, Gnadt C, Kuskowski MA, Johnson JR. Urine cultures among hospitalized veterans: casting too broad a net? Infect Control Hosp Epidemiol. 2014;35(5):574–6.CrossRef
37.
Zurück zum Zitat Drekonja DM, Abbo LM, Kuskowski MA, Gnadt C, Shukla B, Johnson JR. A survey of resident physicians’ knowledge regarding urine testing and subsequent antimicrobial treatment. Am J Infect Control. 2013;41(10):892–6.CrossRef Drekonja DM, Abbo LM, Kuskowski MA, Gnadt C, Shukla B, Johnson JR. A survey of resident physicians’ knowledge regarding urine testing and subsequent antimicrobial treatment. Am J Infect Control. 2013;41(10):892–6.CrossRef
39.
Zurück zum Zitat Morgan DJ, Croft LD, Deloney V, Popovich KJ, Crnich C, Srinivasan A, et al. Choosing wisely in healthcare epidemiology and antimicrobial stewardship. Infect Control Hosp Epidemiol. 2016;37(7):755–60.CrossRefPubMed Morgan DJ, Croft LD, Deloney V, Popovich KJ, Crnich C, Srinivasan A, et al. Choosing wisely in healthcare epidemiology and antimicrobial stewardship. Infect Control Hosp Epidemiol. 2016;37(7):755–60.CrossRefPubMed
40.
Zurück zum Zitat Trautner BW, Grigoryan L, Petersen NJ, Hysong S, Cadena J, Patterson JE, et al. Effectiveness of an antimicrobial stewardship approach for urinary catheter-associated asymptomatic bacteriuria. JAMA Intern Med. 2015;175(7):1120–7.CrossRef Trautner BW, Grigoryan L, Petersen NJ, Hysong S, Cadena J, Patterson JE, et al. Effectiveness of an antimicrobial stewardship approach for urinary catheter-associated asymptomatic bacteriuria. JAMA Intern Med. 2015;175(7):1120–7.CrossRef
41.
Zurück zum Zitat Egger M, Balmer F, Friedli-Wüthrich H, Mühlemann K. Reduction of urinary catheter use and prescription of antibiotics for asymptomatic bacteriuria in hospitalised patients in internal medicine: before-and-after intervention study. Swiss Med Wkly. 2013;143:w13796. Egger M, Balmer F, Friedli-Wüthrich H, Mühlemann K. Reduction of urinary catheter use and prescription of antibiotics for asymptomatic bacteriuria in hospitalised patients in internal medicine: before-and-after intervention study. Swiss Med Wkly. 2013;143:w13796.
42.
Zurück zum Zitat Irfan N, Brooks A, Mithoowani S, Celetti SJ, Main C, Mertz D. A controlled quasi-experimental study of an educational intervention to reduce the unnecessary use of antimicrobials for asymptomatic bacteriuria. PLoS One. 2015;10(7):e0132071.CrossRefPubMed Irfan N, Brooks A, Mithoowani S, Celetti SJ, Main C, Mertz D. A controlled quasi-experimental study of an educational intervention to reduce the unnecessary use of antimicrobials for asymptomatic bacteriuria. PLoS One. 2015;10(7):e0132071.CrossRefPubMed
43.
Zurück zum Zitat Keller SC, Feldman L, Smith J, Pahwa A, Cosgrove SE, Chida N. The use of clinical decision support in reducing diagnosis of and treatment of asymptomatic bacteriuria. J Hosp Med. 2018;13(6):392–5. Keller SC, Feldman L, Smith J, Pahwa A, Cosgrove SE, Chida N. The use of clinical decision support in reducing diagnosis of and treatment of asymptomatic bacteriuria. J Hosp Med. 2018;13(6):392–5.
44.
Zurück zum Zitat Shirley D, Scholtz H, Osterby K, Musuuza J, Fox B, Safdar N. Optimizing inpatient urine culture ordering practices using the electronic medical record: a pilot study. Infect Control Hosp Epidemiol. 2017;38(4):486–8.CrossRef Shirley D, Scholtz H, Osterby K, Musuuza J, Fox B, Safdar N. Optimizing inpatient urine culture ordering practices using the electronic medical record: a pilot study. Infect Control Hosp Epidemiol. 2017;38(4):486–8.CrossRef
45.
Zurück zum Zitat Redwood R, Knobloch MJ, Pellegrini DC, Ziegler MJ, Pulia M, Safdar N. Reducing unnecessary culturing: a systems approach to evaluating urine culture ordering and collection practices among nurses in two acute care settings. Antimicrob Resist Infect Control. 2018;7:4.CrossRefPubMed Redwood R, Knobloch MJ, Pellegrini DC, Ziegler MJ, Pulia M, Safdar N. Reducing unnecessary culturing: a systems approach to evaluating urine culture ordering and collection practices among nurses in two acute care settings. Antimicrob Resist Infect Control. 2018;7:4.CrossRefPubMed
46.
Zurück zum Zitat •• LaRocco MT, Franek J, Leibach EK, Weissfeld AS, Kraft CS, Sautter RL, et al. Effectiveness of preanalytic practices on contamination and diagnostic accuracy of urine cultures: a laboratory medicine best practices systematic review and meta-analysis. Clin Microbiol Rev. 2016;29(1):105–47. Excellent synthesis of preanalytic practices for urine cultures and their effectiveness. CrossRef •• LaRocco MT, Franek J, Leibach EK, Weissfeld AS, Kraft CS, Sautter RL, et al. Effectiveness of preanalytic practices on contamination and diagnostic accuracy of urine cultures: a laboratory medicine best practices systematic review and meta-analysis. Clin Microbiol Rev. 2016;29(1):105–47. Excellent synthesis of preanalytic practices for urine cultures and their effectiveness. CrossRef
47.
Zurück zum Zitat Jacob MS, Kulie P, Benedict C, Ordoobadi AJ, Sikka N, Steinmetz E, et al. Use of a midstream clean catch mobile application did not lower urine contamination rates in an ED. Am J Emerg Med. 2018;36(1):61–5.CrossRef Jacob MS, Kulie P, Benedict C, Ordoobadi AJ, Sikka N, Steinmetz E, et al. Use of a midstream clean catch mobile application did not lower urine contamination rates in an ED. Am J Emerg Med. 2018;36(1):61–5.CrossRef
48.
Zurück zum Zitat Maher PJ, Brown AEC, Gatewood MO. The effect of written posted instructions on collection of clean-catch urine specimens in the Emergency Department. J Emerg Med. 2017;52(5):639–44.CrossRef Maher PJ, Brown AEC, Gatewood MO. The effect of written posted instructions on collection of clean-catch urine specimens in the Emergency Department. J Emerg Med. 2017;52(5):639–44.CrossRef
49.
Zurück zum Zitat Eley R, Judge C, Knight L, Dimeski G, Sinnott M. Illustrations reduce contamination of midstream urine samples in the emergency department. J Clin Pathol. 2016;69(10):921–5.CrossRef Eley R, Judge C, Knight L, Dimeski G, Sinnott M. Illustrations reduce contamination of midstream urine samples in the emergency department. J Clin Pathol. 2016;69(10):921–5.CrossRef
50.
Zurück zum Zitat Mullin KM, Kovacs CS, Fatica C, Einloth C, Neuner EA, Guzman JA, et al. A multifaceted approach to reduction of catheter-associated urinary tract infections in the intensive care unit with an emphasis on “stewardship of culturing.”. Infect Control Hosp Epidemiol. 2017;38(2):186–8.CrossRef Mullin KM, Kovacs CS, Fatica C, Einloth C, Neuner EA, Guzman JA, et al. A multifaceted approach to reduction of catheter-associated urinary tract infections in the intensive care unit with an emphasis on “stewardship of culturing.”. Infect Control Hosp Epidemiol. 2017;38(2):186–8.CrossRef
51.
Zurück zum Zitat Chan WW. Section 3.12: Urine Cultures. In: Amy Leber, ed. Clinical Microbiology Procedures Handbook. 4th ed. Washington, DC: ASM Press, 2016. Chan WW. Section 3.12: Urine Cultures. In: Amy Leber, ed. Clinical Microbiology Procedures Handbook. 4th ed. Washington, DC: ASM Press, 2016.
52.
Zurück zum Zitat Jones CW, Culbreath KD, Mehrotra A, Gilligan PH. Reflect urine culture cancelation in the emergency department. J Emerg Med. 2014;46(1):71–6.CrossRef Jones CW, Culbreath KD, Mehrotra A, Gilligan PH. Reflect urine culture cancelation in the emergency department. J Emerg Med. 2014;46(1):71–6.CrossRef
53.
Zurück zum Zitat Hertz JT, Lescallette RD, Barrett TW, Ward MJ, Self WH. External validation of an ED protocol for reflex urine culture cancelation. Am J Emerg Med. 2015;33(12):1838-1839.CrossRefPubMed Hertz JT, Lescallette RD, Barrett TW, Ward MJ, Self WH. External validation of an ED protocol for reflex urine culture cancelation. Am J Emerg Med. 2015;33(12):1838-1839.CrossRefPubMed
54.
Zurück zum Zitat Stagg A, Lutz H, Kirpalaney S, Matelski JJ, Kaufman A, Leis J, et al. Impact of two-step urine culture ordering in the emergency department: a time series analysis. BMJ Qual Saf 2017 Stagg A, Lutz H, Kirpalaney S, Matelski JJ, Kaufman A, Leis J, et al. Impact of two-step urine culture ordering in the emergency department: a time series analysis. BMJ Qual Saf 2017
55.
Zurück zum Zitat • Epstein L, Edwards JR, Halpin AL, Preas MA, Blythe D, Harris AD, et al. Evaluation of a novel intervention to reduce unnecessary urine cultures in intensive care units at a tertiary care hospital in Maryland, 2011–2014. Infect Control Hosp Epidemiol. 2016;37(5):606–9. Demonstrated effect of implementing reflex urine culturing. CrossRef • Epstein L, Edwards JR, Halpin AL, Preas MA, Blythe D, Harris AD, et al. Evaluation of a novel intervention to reduce unnecessary urine cultures in intensive care units at a tertiary care hospital in Maryland, 2011–2014. Infect Control Hosp Epidemiol. 2016;37(5):606–9. Demonstrated effect of implementing reflex urine culturing. CrossRef
56.
Zurück zum Zitat Sarg M, Waldrop GE, Beier MA, Heil EL, Thom KA, Preas MA, et al. Impact of changes in urine culture ordering practice on antimicrobial utilization in intensive care units at an academic medical center. Infect Control Hosp Epidemiol. 2016;37(4):448–54.CrossRefPubMed Sarg M, Waldrop GE, Beier MA, Heil EL, Thom KA, Preas MA, et al. Impact of changes in urine culture ordering practice on antimicrobial utilization in intensive care units at an academic medical center. Infect Control Hosp Epidemiol. 2016;37(4):448–54.CrossRefPubMed
57.
Zurück zum Zitat Munigala S, Jackups RR, Poirier RF, Liang SY, Wood H, Jafarzadeh SR, et al. Impact of order set design on urine culturing practices at an academic medical centre emergency department. BMJ Qual Saf. 2018;27(8):587–92.CrossRef Munigala S, Jackups RR, Poirier RF, Liang SY, Wood H, Jafarzadeh SR, et al. Impact of order set design on urine culturing practices at an academic medical centre emergency department. BMJ Qual Saf. 2018;27(8):587–92.CrossRef
58.
Zurück zum Zitat Dietz J, Lo TS, Hammer K, Zegarra M. Impact of eliminating reflex urine cultures on performed urine cultures and antibiotic use. Am J Infect Control. 2016;44(12):1750–1.CrossRef Dietz J, Lo TS, Hammer K, Zegarra M. Impact of eliminating reflex urine cultures on performed urine cultures and antibiotic use. Am J Infect Control. 2016;44(12):1750–1.CrossRef
59.
Zurück zum Zitat • Sullivan KV, Morgan DJ, Leekha S. Use of diagnostic stewardship practices to improve urine culturing among SHEA Research Network hospitals. Infect Control Hosp Epidemiol. 2018;7:1–4. Provides a synthesis of reflex urine culture procedures in use. • Sullivan KV, Morgan DJ, Leekha S. Use of diagnostic stewardship practices to improve urine culturing among SHEA Research Network hospitals. Infect Control Hosp Epidemiol. 2018;7:1–4. Provides a synthesis of reflex urine culture procedures in use.
60.
Zurück zum Zitat Coupat C, Pradier C, Degand N, Hofliger P, Pulcini C. Selective reporting of antibiotic susceptibility data improves the appropriateness of intended antibiotic prescriptions in urinary tract infections: a case-vignette randomized study. Eur J Clin Microbiol Infect Dis. 2013;32(5):627–36.CrossRef Coupat C, Pradier C, Degand N, Hofliger P, Pulcini C. Selective reporting of antibiotic susceptibility data improves the appropriateness of intended antibiotic prescriptions in urinary tract infections: a case-vignette randomized study. Eur J Clin Microbiol Infect Dis. 2013;32(5):627–36.CrossRef
61.
Zurück zum Zitat Langford BJ, Seah J, Chan A, Downing M, Johnstone J, Matukas LM. Antimicrobial stewardship in the microbiology laboratory: impact of selective susceptibility reporting on ciprofloxacin utilization and susceptibility of gram-negative isolates to ciprofloxacin in a hospital setting. J Clin Microbiol. 2016;54(9):2343–7.CrossRefPubMed Langford BJ, Seah J, Chan A, Downing M, Johnstone J, Matukas LM. Antimicrobial stewardship in the microbiology laboratory: impact of selective susceptibility reporting on ciprofloxacin utilization and susceptibility of gram-negative isolates to ciprofloxacin in a hospital setting. J Clin Microbiol. 2016;54(9):2343–7.CrossRefPubMed
62.
Zurück zum Zitat McNulty CAM, Lasseter GM, Charlett A, Lovering A, Howell-Jones R, Macgowan A, et al. Does laboratory antibiotic susceptibility reporting influence primary care prescribing in urinary tract infection and other infections? J Antimicrob Chemother. 2011;66(6):1396–404.CrossRef McNulty CAM, Lasseter GM, Charlett A, Lovering A, Howell-Jones R, Macgowan A, et al. Does laboratory antibiotic susceptibility reporting influence primary care prescribing in urinary tract infection and other infections? J Antimicrob Chemother. 2011;66(6):1396–404.CrossRef
63.
Zurück zum Zitat Linares LA, Thornton DJ, Strymish J, Baker E, Gupta K. Electronic memorandum decreases unnecessary antimicrobial use for asymptomatic bacteriuria and culture-negative pyuria. Infect Control Hosp Epidemiol. 2011;32(7):644–8.CrossRef Linares LA, Thornton DJ, Strymish J, Baker E, Gupta K. Electronic memorandum decreases unnecessary antimicrobial use for asymptomatic bacteriuria and culture-negative pyuria. Infect Control Hosp Epidemiol. 2011;32(7):644–8.CrossRef
64.
Zurück zum Zitat Daley P, Garcia D, Inayatullah R, Penney C, Boyd S. Modified reporting of positive urine cultures to reduce inappropriate treatment of asymptomatic bacteriuria among nonpregnant, noncatheterized inpatients: a randomized controlled trial. Infect Control Hosp Epidemiol. 2018;39(7):814–9.CrossRef Daley P, Garcia D, Inayatullah R, Penney C, Boyd S. Modified reporting of positive urine cultures to reduce inappropriate treatment of asymptomatic bacteriuria among nonpregnant, noncatheterized inpatients: a randomized controlled trial. Infect Control Hosp Epidemiol. 2018;39(7):814–9.CrossRef
Metadaten
Titel
Advances and Challenges in the Diagnosis and Treatment of Urinary Tract Infections: the Need for Diagnostic Stewardship
verfasst von
Kimberly C. Claeys
Natalia Blanco
Daniel J. Morgan
Surbhi Leekha
Kaede V. Sullivan
Publikationsdatum
01.04.2019
Verlag
Springer US
Erschienen in
Current Infectious Disease Reports / Ausgabe 4/2019
Print ISSN: 1523-3847
Elektronische ISSN: 1534-3146
DOI
https://doi.org/10.1007/s11908-019-0668-7

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