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Current Neurology and Neuroscience Reports

Erschienen in:

01.03.2015 | Sleep (M Thorpy, M Billiard, Section Editors)

Parkinson’s Disease and Sleep/Wake Disturbances

verfasst von: Keisuke Suzuki, Masayuki Miyamoto, Tomoyuki Miyamoto, Koichi Hirata

Erschienen in: Current Neurology and Neuroscience Reports | Ausgabe 3/2015

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Abstract

Sleep disturbances are a common non-motor feature in patients with Parkinson’s disease (PD). Early diagnosis and appropriate management are imperative for enhancing patient quality of life. Sleep disturbances can be caused by multiple factors in addition to age-related changes in sleep, such as nocturnal motor symptoms (rigidity, resting tremor, akinesia, tardive dyskinesia, and the “wearing off” phenomenon), non-motor symptoms (pain, hallucination, and psychosis), nocturia, and medication. Disease-related pathology involving the brainstem and changes in the neurotransmitter systems (norepinephrine, serotonin, and acetylcholine) responsible for regulating sleep structure and the sleep/wake cycle play a role in emerging excessive daytime sleepiness and sleep disturbances. Additionally, screening for sleep apnea syndrome, rapid eye movement sleep behavior disorder, and restless legs syndrome is clinically important. Questionnaire-based assessment utilizing the PD Sleep Scale-2 is useful for screening PD-related nocturnal symptoms. In this review, we focus on the current understanding and management of sleep disturbances in PD.

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Titel: Parkinson’s Disease and Sleep/Wake Disturbances
verfasst von: Keisuke Suzuki
Masayuki Miyamoto
Tomoyuki Miyamoto
Koichi Hirata
Publikationsdatum: 01.03.2015
Verlag: Springer US
Erschienen in: Current Neurology and Neuroscience Reports / Ausgabe 3/2015
Print ISSN: 1528-4042
Elektronische ISSN: 1534-6293
DOI: https://doi.org/10.1007/s11910-015-0525-5

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