nach oben

Current Neurology and Neuroscience Reports

Erschienen in:

01.12.2019 | Neuro-Ophthalmology (R. Mallery, Section Editor)

Clinical Characteristics and Treatment of MOG-IgG–Associated Optic Neuritis

verfasst von: Deena A. Tajfirouz, M. Tariq Bhatti, John J. Chen

Erschienen in: Current Neurology and Neuroscience Reports | Ausgabe 12/2019

Einloggen, um Zugang zu erhalten

Abstract

Purpose of Review

Antibodies against myelin oligodendrocyte glycoprotein (MOG) are associated with a unique acquired central nervous system demyelinating disease—termed MOG-IgG-associated disorder (MOGAD)—which has a variety of clinical manifestations, including optic neuritis, transverse myelitis, acute disseminating encephalomyelitis, and brainstem encephalitis. In this review, we summarize the current knowledge of the clinical characteristics, neuroimaging, treatments, and outcomes of MOGAD, with a focus on optic neuritis.

Recent Findings

The recent development of a reproducible, live cell–based assay for MOG-IgG, has improved our ability to identify and study this disease. Based on contemporary studies, it has become increasingly evident that MOGAD is distinct from multiple sclerosis and aquaporin-4-positive neuromyelitis optica spectrum disorder with different clinical features and treatment outcomes.

Summary

There is now sufficient evidence to separate MOGAD from other inflammatory central nervous system demyelinating disorders, which will allow focused research on understanding the pathophysiology of the disease. Prospective treatment trials are needed to determine the best course of treatment, and until then, treatment plans must be individualized to the clinical manifestations and severity of disease.

Schluesener HJ, Sobel RA, Linington C, Weiner HL. A monoclonal antibody against a myelin oligodendrocyte glycoprotein induces relapses and demyelination in central nervous system autoimmune disease. J Immunol. 1987;139(12):4016–21.PubMed

Steinman L, Zamvil SS. How to successfully apply animal studies in experimental allergic encephalomyelitis to research on multiple sclerosis. Ann Neurol. 2006;60(1):12–21. https://doi.org/10.1002/ana.20913.CrossRefPubMed

Berger T, Rubner P, Schautzer F, Egg R, Ulmer H, Mayringer I, et al. Antimyelin antibodies as a predictor of clinically definite multiple sclerosis after a first demyelinating event. N Engl J Med. 2003;349(2):139–45. https://doi.org/10.1056/NEJMoa022328.CrossRefPubMed

• Jarius S, Paul F, Aktas O, Asgari N, Dale RC, de Seze J, et al. MOG encephalomyelitis: international recommendations on diagnosis and antibody testing. J Neuroinflamm. 2018;15(1):134. https://doi.org/10.1186/s12974-018-1144-2 This article provides recommendations regarding diagnosis and antibody testing based on the literature available as of 2018. CrossRef

Weber MS, Derfuss T, Metz I, Bruck W. Defining distinct features of anti-MOG antibody associated central nervous system demyelination. Ther Adv Neurol Disord. 2018;11:1756286418762083. https://doi.org/10.1177/1756286418762083.CrossRefPubMedPubMedCentral

•• Jurynczyk M, Messina S, Woodhall MR, Raza N, Everett R, Roca-Fernandez A, et al. Clinical presentation and prognosis in MOG-antibody disease: a UK study. Brain. 2017;140(12):3128–38. https://doi.org/10.1093/brain/awx276 This study discusses the clinical characteristics of MOGAD in a large cohort of patients from the UK, which includes an incidence cohort. CrossRefPubMed

• Chen JJ, Flanagan EP, Jitprapaikulsan J, Lopez-Chiriboga ASS, Fryer JP, Leavitt JA, et al. Myelin oligodendrocyte glycoprotein antibody-positive optic neuritis: clinical characteristics, radiologic clues, and outcome. Am J Ophthalmol. 2018;195:8–15. https://doi.org/10.1016/j.ajo.2018.07.020 This study describes the clinical characteristics, radiological findings and outcomes of patients with optic neuritis from MOGAD in a large sample of patients. CrossRefPubMedPubMedCentral

Chen JJ, Fraser CL. Do myelin oligodendrocyte glycoprotein antibodies represent a distinct syndrome? J Neuroophthalmol. 2019. https://doi.org/10.1097/WNO.0000000000000779.CrossRefPubMed

Sepulveda M, Armangue T, Martinez-Hernandez E, Arrambide G, Sola-Valls N, Sabater L, et al. Clinical spectrum associated with MOG autoimmunity in adults: significance of sharing rodent MOG epitopes. J Neurol. 2016;263(7):1349–60. https://doi.org/10.1007/s00415-016-8147-7.CrossRefPubMedPubMedCentral

10.

•• Jarius S, Ruprecht K, Kleiter I, Borisow N, Asgari N, Pitarokoili K, et al. MOG-IgG in NMO and related disorders: a multicenter study of 50 patients. Part 2: epidemiology, clinical presentation, radiological and laboratory features, treatment responses, and long-term outcome. J Neuroinflammation. 2016;13(1):280. https://doi.org/10.1186/s12974-016-0718-0 This was one of the first large multicenter retrospective studies which reported the clinical presentation, radiological findings and long term outcomes of patients with MOGAD. CrossRefPubMedPubMedCentral

11.

• Ramanathan S, Mohammad S, Tantsis E, Nguyen TK, Merheb V, Fung VSC, et al. Clinical course, therapeutic responses and outcomes in relapsing MOG antibody-associated demyelination. J Neurol Neurosurg Psychiatry. 2018;89(2):127–37. https://doi.org/10.1136/jnnp-2017-316880 This study reports the clinical course and response to immunotherapy in patients with relapsing MOGAD. CrossRefPubMed

12.

Lucchinetti CF, Guo Y, Popescu BF, Fujihara K, Itoyama Y, Misu T. The pathology of an autoimmune astrocytopathy: lessons learned from neuromyelitis optica. Brain Pathol. 2014;24(1):83–97. https://doi.org/10.1111/bpa.12099.CrossRefPubMed

13.

Di Pauli F, Hoftberger R, Reindl M, Beer R, Rhomberg P, Schanda K, et al. Fulminant demyelinating encephalomyelitis: insights from antibody studies and neuropathology. Neurol Neuroimmunol Neuroinflamm. 2015;2(6):e175. https://doi.org/10.1212/NXI.0000000000000175.CrossRefPubMedPubMedCentral

14.

Spadaro M, Gerdes LA, Mayer MC, Ertl-Wagner B, Laurent S, Krumbholz M, et al. Histopathology and clinical course of MOG-antibody-associated encephalomyelitis. Ann Clin Transl Neurol. 2015;2(3):295–301. https://doi.org/10.1002/acn3.164.CrossRefPubMedPubMedCentral

15.

Jarius S, Metz I, Konig FB, Ruprecht K, Reindl M, Paul F, et al. Screening for MOG-IgG and 27 other anti-glial and anti-neuronal autoantibodies in ‘pattern II multiple sclerosis’ and brain biopsy findings in a MOG-IgG-positive case. Mult Scler. 2016;22(12):1541–9. https://doi.org/10.1177/1352458515622986.CrossRefPubMed

16.

de Mol CL, Wong Y, van Pelt ED, Wokke B, Siepman T, Neuteboom RF, et al. The clinical spectrum and incidence of anti-MOG-associated acquired demyelinating syndromes in children and adults. Mult Scler. 2019;1352458519845112. https://doi.org/10.1177/1352458519845112.

17.

Boesen MS, Jensen PEH, Born AP, Magyari M, Nilsson AC, Hoei-Hansen C, et al. Incidence of pediatric neuromyelitis optica spectrum disorder and myelin oligodendrocyte glycoprotein antibody-associated disease in Denmark 20082018: a nationwide, population-based cohort study. Mult Scler Relat Disord. 2019;33:162–7. https://doi.org/10.1016/j.msard.2019.06.002.CrossRefPubMed

18.

Etemadifar M, Abbasi M, Salari M, Etemadifar F, Tavakoli H. Comparing myelin oligodendrocyte glycoprotein antibody (MOG-Ab) and non MOG-Ab associated optic neuritis: Clinical course and treatment outcome. Mult Scler Relat Disord. 2019;27:127–30. https://doi.org/10.1016/j.msard.2018.10.013.CrossRefPubMed

19.

Ishikawa H, Kezuka T, Shikishima K, Yamagami A, Hiraoka M, Chuman H, et al. Epidemiologic and clinical characteristics of optic neuritis in Japan. Ophthalmology. 2019. https://doi.org/10.1016/j.ophtha.2019.04.042.CrossRefPubMed

20.

Cobo-Calvo A, Ruiz A, Maillart E, Audoin B, Zephir H, Bourre B, et al. OFSEP and NOMADMUS Study Group. Clinical spectrum and prognostic value of CNS MOG autoimmunity in adults: The MOGADOR study. Neurology. 2018;90(21):e1858–e69. https://doi.org/10.1212/WNL.0000000000005560.CrossRefPubMed

21.

Sepulveda M, Armangue T, Sola-Valls N, Arrambide G, Meca-Lallana JE, Oreja-Guevara C, et al. Neuromyelitis optica spectrum disorders: comparison according to the phenotype and serostatus. Neurol Neuroimmunol Neuroinflamm. 2016;3(3):e225. https://doi.org/10.1212/NXI.0000000000000225.CrossRefPubMedPubMedCentral

22.

Zhao G, Chen Q, Huang Y, Li Z, Sun X, Lu P, et al. Clinical characteristics of myelin oligodendrocyte glycoprotein seropositive optic neuritis: a cohort study in Shanghai, China. J Neurol. 2018;265(1):33–40. https://doi.org/10.1007/s00415-017-8651-4.CrossRefPubMed

23.

Zhao Y, Tan S, Chan TCY, Xu Q, Zhao J, Teng D, et al. Clinical features of demyelinating optic neuritis with seropositive myelin oligodendrocyte glycoprotein antibody in Chinese patients. Br J Ophthalmol. 2018;102(10):1372–7. https://doi.org/10.1136/bjophthalmol-2017-311177.CrossRefPubMed

24.

Zhou H, Zhao S, Yin D, Chen X, Xu Q, Chen T, et al. Optic neuritis: a 5-year follow-up study of Chinese patients based on aquaporin-4 antibody status and ages. J Neurol. 2016;263(7):1382–9. https://doi.org/10.1007/s00415-016-8155-7.CrossRefPubMed

25.

Zhou L, Huang Y, Li H, Fan J, Zhangbao J, Yu H, et al. MOG-antibody associated demyelinating disease of the CNS: a clinical and pathological study in Chinese Han patients. J Neuroimmunol. 2017;305:19–28. https://doi.org/10.1016/j.jneuroim.2017.01.007.CrossRefPubMed

26.

Bouzar M, Daoudi S, Hattab S, Bouzar AA, Deiva K, Wildemann B, et al. Neuromyelitis optica spectrum disorders with antibodies to myelin oligodendrocyte glycoprotein or aquaporin-4: Clinical and paraclinical characteristics in Algerian patients. J Neurol Sci. 2017;381:240–4. https://doi.org/10.1016/j.jns.2017.08.3254.CrossRefPubMed

27.

Soelberg K, Jarius S, Skejoe H, Engberg H, Mehlsen JJ, Nilsson AC, et al. A population-based prospective study of optic neuritis. Mult Scler. 2017;23(14):1893–901. https://doi.org/10.1177/1352458517734070.CrossRefPubMed

28.

Reindl M, Waters P. Myelin oligodendrocyte glycoprotein antibodies in neurological disease. Nat Rev Neurol. 2019;15(2):89–102. https://doi.org/10.1038/s41582-018-0112-x.CrossRefPubMed

29.

Liu H, Zhou H, Wang J, Xu Q, Wei S. Antibodies to myelin oligodendrocyte glycoprotein in chronic relapsing inflammatory optic neuropathy. Br J Ophthalmol. 2018. https://doi.org/10.1136/bjophthalmol-2018-313142.CrossRefPubMed

30.

Lee HJ, Kim B, Waters P, Woodhall M, Irani S, Ahn S, et al. Chronic relapsing inflammatory optic neuropathy (CRION): a manifestation of myelin oligodendrocyte glycoprotein antibodies. J Neuroinflammation. 2018;15(1):302. https://doi.org/10.1186/s12974-018-1335-x.CrossRefPubMedPubMedCentral

31.

Ramanathan S, Prelog K, Barnes EH, Tantsis EM, Reddel SW, Henderson AP, et al. Radiological differentiation of optic neuritis with myelin oligodendrocyte glycoprotein antibodies, aquaporin-4 antibodies, and multiple sclerosis. Mult Scler. 2016;22(4):470–82. https://doi.org/10.1177/1352458515593406.CrossRefPubMed

32.

Akaishi T, Sato DK, Nakashima I, Takeshita T, Takahashi T, Doi H, et al. MRI and retinal abnormalities in isolated optic neuritis with myelin oligodendrocyte glycoprotein and aquaporin-4 antibodies: a comparative study. J Neurol Neurosurg Psychiatry. 2016;87(4):446–8. https://doi.org/10.1136/jnnp-2014-310206.CrossRefPubMed

33.

Ramanathan S, Reddel SW, Henderson A, Parratt JD, Barnett M, Gatt PN, et al. Antibodies to myelin oligodendrocyte glycoprotein in bilateral and recurrent optic neuritis. Neurol Neuroimmunol Neuroinflamm. 2014;1(4):e40. https://doi.org/10.1212/NXI.0000000000000040.CrossRefPubMedPubMedCentral

34.

Liu H, Zhou H, Wang J, Sun M, Teng D, Song H, et al. The prevalence and prognostic value of myelin oligodendrocyte glycoprotein antibody in adult optic neuritis. J Neurol Sci. 2019;396:225–31. https://doi.org/10.1016/j.jns.2018.11.029.CrossRefPubMed

35.

Jarius S, Franciotta D, Paul F, Ruprecht K, Bergamaschi R, Rommer PS, et al. Cerebrospinal fluid antibodies to aquaporin-4 in neuromyelitis optica and related disorders: frequency, origin, and diagnostic relevance. J Neuroinflammation. 2010;7:52. https://doi.org/10.1186/1742-2094-7-52.CrossRefPubMedPubMedCentral

36.

Sato DK, Callegaro D, Lana-Peixoto MA, Waters PJ, de Haidar Jorge FM, Takahashi T, et al. Distinction between MOG antibody-positive and AQP4 antibody-positive NMO spectrum disorders. Neurology. 2014;82(6):474–81. https://doi.org/10.1212/WNL.0000000000000101.CrossRefPubMedPubMedCentral

37.

Kitley J, Waters P, Woodhall M, Leite MI, Murchison A, George J, et al. Neuromyelitis optica spectrum disorders with aquaporin-4 and myelin-oligodendrocyte glycoprotein antibodies: a comparative study. JAMA Neurol. 2014;71(3):276–83. https://doi.org/10.1001/jamaneurol.2013.5857.CrossRefPubMed

38.

Jurynczyk M, Geraldes R, Probert F, Woodhall MR, Waters P, Tackley G, et al. Distinct brain imaging characteristics of autoantibody-mediated CNS conditions and multiple sclerosis. Brain. 2017;140(3):617–27. https://doi.org/10.1093/brain/aww350.CrossRefPubMed

39.

• Dubey D, Pittock SJ, Krecke KN, Morris PP, Sechi E, Zalewski NL, et al. Clinical, radiologic, and prognostic features of myelitis associated with myelin oligodendrocyte glycoprotein autoantibody. JAMA Neurol. 2019;76(3):301–9. https://doi.org/10.1001/jamaneurol.2018.4053 This study reports the clinical, radiological and prognostic features of MOGAD compared with myelitis with aquaporin-4 IgG and multiple sclerosis in a large retrospective study of patients. CrossRefPubMed

40.

Jarius S, Eichhorn P, Franciotta D, Petereit HF, Akman-Demir G, Wick M, et al. The MRZ reaction as a highly specific marker of multiple sclerosis: re-evaluation and structured review of the literature. J Neurol. 2017;264(3):453–66. https://doi.org/10.1007/s00415-016-8360-4.CrossRefPubMed

41.

Kim SM, Woodhall MR, Kim JS, Kim SJ, Park KS, Vincent A, et al. Antibodies to MOG in adults with inflammatory demyelinating disease of the CNS. Neurol Neuroimmunol Neuroinflamm. 2015;2(6):e163. https://doi.org/10.1212/NXI.0000000000000163.CrossRefPubMedPubMedCentral

42.

Jarius S, Ruprecht K, Stellmann JP, Huss A, Ayzenberg I, Willing A, et al. MOG-IgG in primary and secondary chronic progressive multiple sclerosis: a multicenter study of 200 patients and review of the literature. J Neuroinflammation. 2018;15(1):88. https://doi.org/10.1186/s12974-018-1108-6.CrossRefPubMedPubMedCentral

43.

O'Connor KC, McLaughlin KA, De Jager PL, Chitnis T, Bettelli E, Xu C, et al. Self-antigen tetramers discriminate between myelin autoantibodies to native or denatured protein. Nat Med. 2007;13(2):211–7. https://doi.org/10.1038/nm1488.CrossRefPubMedPubMedCentral

44.

Petzold A, Woodhall M, Khaleeli Z, Tobin WO, Pittock SJ, Weinshenker BG, et al. Aquaporin-4 and myelin oligodendrocyte glycoprotein antibodies in immune-mediated optic neuritis at long-term follow-up. J Neurol Neurosurg Psychiatry. 2019;90(9):1021–6. https://doi.org/10.1136/jnnp-2019-320493.CrossRefPubMed

45.

• Waters PJ, Komorowski L, Woodhall M, Lederer S, Majed M, Fryer J, et al. A multicenter comparison of MOG-IgG cell-based assays. Neurology. 2019;92(11):e1250–e5. https://doi.org/10.1212/WNL.0000000000007096 The authors compared MOG-IgG testing from 3different international centers, which showed good sensitivity and specificity for cell-based assays. CrossRefPubMedPubMedCentral

46.

Lopez-Chiriboga AS, Majed M, Fryer J, Dubey D, McKeon A, Flanagan EP, et al. Association of MOG-IgG serostatus with relapse after acute disseminated encephalomyelitis and proposed diagnostic criteria for MOG-IgG-associated disorders. JAMA Neurol. 2018;75(11):1355–63. https://doi.org/10.1001/jamaneurol.2018.1814.CrossRefPubMedPubMedCentral

47.

Hyun JW, Woodhall MR, Kim SH, Jeong IH, Kong B, Kim G, et al. Longitudinal analysis of myelin oligodendrocyte glycoprotein antibodies in CNS inflammatory diseases. J Neurol Neurosurg Psychiatry. 2017;88(10):811–7. https://doi.org/10.1136/jnnp-2017-315998.CrossRefPubMed

48.

• Cobo-Calvo A, Sepulveda M, d'Indy H, Armangue T, Ruiz A, Maillart E, et al. Usefulness of MOG-antibody titres at first episode to predict the future clinical course in adults. J Neurol. 2019;266(4):806–15. https://doi.org/10.1007/s00415-018-9160-9 This study analyzes MOG-IgG titer levels at onset of disease, in correlation with the clinical phenotype and assesses the risk of future relapses. CrossRefPubMed

49.

Stiebel-Kalish H, Hellmann MA, Mimouni M, Paul F, Bialer O, Bach M, et al. Does time equal vision in the acute treatment of a cohort of AQP4 and MOG optic neuritis? Neurol Neuroimmunol Neuroinflamm. 2019;6(4):e572. https://doi.org/10.1212/NXI.0000000000000572.CrossRefPubMedPubMedCentral

50.

Chen JJ, Tobin WO, Majed M, Jitprapaikulsan J, Fryer JP, Leavitt JA, et al. Prevalence of myelin oligodendrocyte glycoprotein and aquaporin-4-IgG in patients in the optic neuritis treatment trial. JAMA Ophthalmol. 2018;136(4):419–22. https://doi.org/10.1001/jamaophthalmol.2017.6757.CrossRefPubMedPubMedCentral

51.

Bonnan M, Valentino R, Debeugny S, Merle H, Ferge JL, Mehdaoui H, et al. Short delay to initiate plasma exchange is the strongest predictor of outcome in severe attacks of NMO spectrum disorders. J Neurol Neurosurg Psychiatry. 2018;89(4):346–51. https://doi.org/10.1136/jnnp-2017-316286.CrossRefPubMed

52.

Magana SM, Keegan BM, Weinshenker BG, Erickson BJ, Pittock SJ, Lennon VA, et al. Beneficial plasma exchange response in central nervous system inflammatory demyelination. Arch Neurol. 2011;68(7):870–8. https://doi.org/10.1001/archneurol.2011.34.CrossRefPubMedPubMedCentral

53.

Merle H, Olindo S, Jeannin S, Valentino R, Mehdaoui H, Cabot F, et al. Treatment of optic neuritis by plasma exchange (add-on) in neuromyelitis optica. Arch Ophthalmol. 2012;130(7):858–62. https://doi.org/10.1001/archophthalmol.2012.1126.CrossRefPubMed

54.

• Hacohen Y, Wong YY, Lechner C, Jurynczyk M, Wright S, Konuskan B, et al. Disease course and treatment responses in children with relapsing myelin oligodendrocyte glycoprotein antibody-associated disease. JAMA Neurol. 2018;75(4):478–87. https://doi.org/10.1001/jamaneurol.2017.4601 This study evaluates treatment response in a large cohort of children with MOGAD. CrossRefPubMedPubMedCentral

55.

Cobo-Calvo A, Sepulveda M, Rollot F, Armangue T, Ruiz A, Maillart E, et al. Evaluation of treatment response in adults with relapsing MOG-Ab-associated disease. J Neuroinflammation. 2019;16(1):134. https://doi.org/10.1186/s12974-019-1525-1.CrossRefPubMedPubMedCentral

56.

Trebst C, Jarius S, Berthele A, Paul F, Schippling S, Wildemann B, et al. Neuromyelitis Optica Study Group (NEMOS). Update on the diagnosis and treatment of neuromyelitis optica: recommendations of the Neuromyelitis Optica Study Group (NEMOS). J Neurol. 2014;261(1):1–16. https://doi.org/10.1007/s00415-013-7169-7.CrossRefPubMed

57.

Whittam D C-CA, Lopez-Chiriboga AS, Pardo S DJ, Brandt A, Berek K, et al. Treatment of MOG-IgG-associated demyelination with rituximab: a multinational study of 98 patients. Neurology. 2018;90(15).

58.

Tsantes E, Curti E, Siena E, Granella F. Successful intravenous immunoglobulin treatment in relapsing MOG-antibody-associated disease. Mult Scler Relat Disord. 2019;32:27–9. https://doi.org/10.1016/j.msard.2019.04.021.CrossRefPubMed

59.

Pittock SJ, Berthele A, Fujihara K, Kim HJ, Levy M, Palace J, et al. Eculizumab in aquaporin-4-positive neuromyelitis optica spectrum disorder. N Engl J Med. 2019;381(7):614–25. https://doi.org/10.1056/NEJMoa1900866.CrossRefPubMed

Titel: Clinical Characteristics and Treatment of MOG-IgG–Associated Optic Neuritis
verfasst von: Deena A. Tajfirouz
M. Tariq Bhatti
John J. Chen
Publikationsdatum: 01.12.2019
Verlag: Springer US
Erschienen in: Current Neurology and Neuroscience Reports / Ausgabe 12/2019
Print ISSN: 1528-4042
Elektronische ISSN: 1534-6293
DOI: https://doi.org/10.1007/s11910-019-1014-z

Leitlinien kompakt für die Neurologie

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Neurologie

Sind Frauen die fähigeren Ärzte?

30.04.2024 Gendermedizin Nachrichten

Patienten, die von Ärztinnen behandelt werden, dürfen offenbar auf bessere Therapieergebnisse hoffen als Patienten von Ärzten. Besonders gilt das offenbar für weibliche Kranke, wie eine Studie zeigt.

Akuter Schwindel: Wann lohnt sich eine MRT?

28.04.2024 Schwindel Nachrichten

Akuter Schwindel stellt oft eine diagnostische Herausforderung dar. Wie nützlich dabei eine MRT ist, hat eine Studie aus Finnland untersucht. Immerhin einer von sechs Patienten wurde mit akutem ischämischem Schlaganfall diagnostiziert.

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

25.04.2024 Hypotonie Nachrichten

Wenn unter einer medikamentösen Hochdrucktherapie der diastolische Blutdruck in den Keller geht, steigt das Risiko für schwere kardiovaskuläre Ereignisse: Darauf deutet eine Sekundäranalyse der SPRINT-Studie hin.

Frühe Alzheimertherapie lohnt sich

25.04.2024 AAN-Jahrestagung 2024 Nachrichten

Ist die Tau-Last noch gering, scheint der Vorteil von Lecanemab besonders groß zu sein. Und beginnen Erkrankte verzögert mit der Behandlung, erreichen sie nicht mehr die kognitive Leistung wie bei einem früheren Start. Darauf deuten neue Analysen der Phase-3-Studie Clarity AD.

Update Neurologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Abstract

Purpose of Review

Recent Findings

Summary

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 12/2019

Atypical Pediatric Demyelinating Diseases of the Central Nervous System

Sherpas, Coca Leaves, and Planes: High Altitude and Airplane Headache Review with a Case of Post-LASIK Myopic Shift

Current Diagnosis and Treatment of Painful Small Fiber Neuropathy

Neuroimaging in Vascular Parkinsonism

Inflammatory Disorders of the Skull Base: a Review