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Current Osteoporosis Reports

Erschienen in:

01.08.2015 | Bone and Joint Pain (PW Mantyh and TJ Schnitzer, Section Editors)

Altered Central Sensitization and Pain Modulation in the CNS in Chronic Joint Pain

verfasst von: Lars Arendt-Nielsen, Søren T. Skou, Thomas A. Nielsen, Kristian K. Petersen

Erschienen in: Current Osteoporosis Reports | Ausgabe 4/2015

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Abstract

Musculoskeletal pain disorders are the second largest contributor to global disability underlining the significance of effective treatments. However, treating chronic musculoskeletal pain, and chronic joint pain (osteoarthritis (OA)) in particular, is challenging as the underlying peripheral and central pain mechanisms are not fully understood, and safe and efficient analgesic drugs are not available. The pain associated with joint pain is highly individual, and features from radiological imaging have not demonstrated robust associations with the pain manifestations. In recent years, a variety of human quantitative pain assessment tools (quantitative sensory testing (QST)) have been developed providing new opportunities for profiling patients and reaching a greater understanding of the mechanisms involved in chronic joint pain. As joint pain is a complex interaction between many different pain mechanisms, available tools are important for patent profiling and providing the basic knowledge for development of new drugs and for developing pain management regimes.

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Titel: Altered Central Sensitization and Pain Modulation in the CNS in Chronic Joint Pain
verfasst von: Lars Arendt-Nielsen
Søren T. Skou
Thomas A. Nielsen
Kristian K. Petersen
Publikationsdatum: 01.08.2015
Verlag: Springer US
Erschienen in: Current Osteoporosis Reports / Ausgabe 4/2015
Print ISSN: 1544-1873
Elektronische ISSN: 1544-2241
DOI: https://doi.org/10.1007/s11914-015-0276-x

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