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Current Osteoporosis Reports
Erschienen in: Current Osteoporosis Reports 5/2016

29.07.2016 | Craniofacial Skeleton (WE Roberts, Section Editor)

Osteonecrosis of the Jaw—a Bone Site-Specific Effect of Bisphosphonates

verfasst von: Jenny A. F. Vermeer, Greetje A. P. Renders, Vincent Everts

Erschienen in: Current Osteoporosis Reports | Ausgabe 5/2016

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Abstract

A known complication that can occur in patients using bisphosphonates (BPs) is osteonecrosis of the jaw (ONJ). ONJ features bone exposure that may be associated with severe pain, swelling, local infection, and pathological fracture of the jaw. Current literature indicates that a complex combination of factors is necessary to induce ONJ. Several hypotheses about the pathophysiology of ONJ were previously reported. Here, we review these hypotheses and introduce new ideas and suggestions on this topic, focusing on bone site-specific cells, and the effect that BPs and other anti-resorptive drugs have on those cells. Gaining more insight into bone site-specific effects may help to better understand the pathogenesis ONJ, and contribute to the development of new bone site-specific anti-resorptive drugs.
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Metadaten
Titel
Osteonecrosis of the Jaw—a Bone Site-Specific Effect of Bisphosphonates
verfasst von
Jenny A. F. Vermeer
Greetje A. P. Renders
Vincent Everts
Publikationsdatum
29.07.2016
Verlag
Springer US
Erschienen in
Current Osteoporosis Reports / Ausgabe 5/2016
Print ISSN: 1544-1873
Elektronische ISSN: 1544-2241
DOI
https://doi.org/10.1007/s11914-016-0318-z

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Patienten, die von Ärztinnen behandelt werden, dürfen offenbar auf bessere Therapieergebnisse hoffen als Patienten von Ärzten. Besonders scheint das auf weibliche Kranke zuzutreffen, wie eine Studie zeigt.

Update Orthopädie und Unfallchirurgie

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