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Current Osteoporosis Reports

Erschienen in:

26.01.2019 | Therapeutics and Medical Management (S Jan de Beur and B Clarke, Section Editors)

Glucocorticoid-Induced Osteoporosis: New Insights into the Pathophysiology and Treatments

verfasst von: Nancy E. Lane

Erschienen in: Current Osteoporosis Reports | Ausgabe 1/2019

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Abstract

Purpose of this Review

The goal of the review is to provide an updated understanding of the pathophysiology of glucocorticoid-induced osteoporosis and treatment recommendations.

Recent Findings

Glucocorticoids reduce osteoblast and osteocyte lifespan and activity and reduce the vascularity of the bone that together may explain the greater reductions in bone strength than those of bone mass. Treatments with parathyroid hormone fragments appear to reverse glucocorticoid-induced bone loss and fracture risk partially through maintaining bone vascularity and bone strength.

Summary

This review identifies how glucocorticoid anti-osteogenic and vascular effects together may reduce bone strength. It also provides guidance to clinicians on rationale treatment for glucocorticoid-induced osteoporosis.

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Titel: Glucocorticoid-Induced Osteoporosis: New Insights into the Pathophysiology and Treatments
verfasst von: Nancy E. Lane
Publikationsdatum: 26.01.2019
Verlag: Springer US
Erschienen in: Current Osteoporosis Reports / Ausgabe 1/2019
Print ISSN: 1544-1873
Elektronische ISSN: 1544-2241
DOI: https://doi.org/10.1007/s11914-019-00498-x

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Abstract

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Recent Findings

Summary

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