Skip to main content
Erschienen in: Current Urology Reports 6/2015

01.06.2015 | Prostate Cancer (A Kibel, Section Editor)

Current Trends and New Frontiers in Focal Therapy for Localized Prostate Cancer

verfasst von: Melissa H. Mendez, Daniel Y. Joh, Rajan Gupta, Thomas J. Polascik

Erschienen in: Current Urology Reports | Ausgabe 6/2015

Einloggen, um Zugang zu erhalten

Abstract

Prostate cancer (PCa) care is an ever-evolving field. Research and technological developments continue to refine our definitions and management of this disease. Now, with a greater understanding of the natural history of PCa, the prevention of overtreatment has shaped a new era with the adoption of active surveillance (AS) and advancement of focal therapy (FT). Multiparametric magnetic resonance imaging (mpMRI) allows us to define, locate, and monitor cancers in a way never before possible. These capabilities combined with promising results from current prospective studies have changed the face of FT. This review presents the latest developments, current trends, and next steps in FT.
Literatur
2.
Zurück zum Zitat Sanda MG, Dunn RL, Michalski J, Sandler HM, Northouse L, Hembroff L, et al. Quality of life and satisfaction with outcome among prostate-cancer survivors. N Engl J Med. 2008;358(12):1250–61. doi:10.1056/NEJMoa074311.CrossRefPubMed Sanda MG, Dunn RL, Michalski J, Sandler HM, Northouse L, Hembroff L, et al. Quality of life and satisfaction with outcome among prostate-cancer survivors. N Engl J Med. 2008;358(12):1250–61. doi:10.​1056/​NEJMoa074311.CrossRefPubMed
4.
Zurück zum Zitat Epstein JI, Walsh PC, Carmichael M, Brendler CB. Pathologic and clinical findings to predict tumor extent of nonpalpable (stage T1c) prostate cancer. JAMA. 1994;271(5):368–74.CrossRefPubMed Epstein JI, Walsh PC, Carmichael M, Brendler CB. Pathologic and clinical findings to predict tumor extent of nonpalpable (stage T1c) prostate cancer. JAMA. 1994;271(5):368–74.CrossRefPubMed
5.•
Zurück zum Zitat Van der Kwast TH, Roobol MJ. Defining the threshold for significant versus insignificant prostate cancer. Nat Rev Urol. 2013;10(8):473–82. doi:10.1038/nrurol.2013.112. Represents a growing body of evidence supporting the indolent nature of most GS6 disease and argues to expand the definition for insignificant disease.CrossRefPubMed Van der Kwast TH, Roobol MJ. Defining the threshold for significant versus insignificant prostate cancer. Nat Rev Urol. 2013;10(8):473–82. doi:10.​1038/​nrurol.​2013.​112. Represents a growing body of evidence supporting the indolent nature of most GS6 disease and argues to expand the definition for insignificant disease.CrossRefPubMed
6.
Zurück zum Zitat Sundi D, Ross AE, Humphreys EB, Han M, Partin AW, Carter HB, et al. African American men with very low-risk prostate cancer exhibit adverse oncologic outcomes after radical prostatectomy: should active surveillance still be an option for them? J Clin Oncol. 2013;31(24):2991–7. doi:10.1200/JCO.2012.47.0302.CrossRefPubMedCentralPubMed Sundi D, Ross AE, Humphreys EB, Han M, Partin AW, Carter HB, et al. African American men with very low-risk prostate cancer exhibit adverse oncologic outcomes after radical prostatectomy: should active surveillance still be an option for them? J Clin Oncol. 2013;31(24):2991–7. doi:10.​1200/​JCO.​2012.​47.​0302.CrossRefPubMedCentralPubMed
7.
Zurück zum Zitat Bhindi B, Kulkarni GS, Finelli A, Alibhai SM, Hamilton RJ, Toi A, et al. Obesity is associated with risk of progression for low-risk prostate cancers managed expectantly. Eur Urol. 2014. doi:10.1016/j.eururo.2014.06.005. Bhindi B, Kulkarni GS, Finelli A, Alibhai SM, Hamilton RJ, Toi A, et al. Obesity is associated with risk of progression for low-risk prostate cancers managed expectantly. Eur Urol. 2014. doi:10.​1016/​j.​eururo.​2014.​06.​005.
8.
Zurück zum Zitat Muller BG, van den Bos W, Brausi M, Cornud F, Gontero P, Kirkham A, et al. Role of multiparametric magnetic resonance imaging (MRI) in focal therapy for prostate cancer: a Delphi consensus project. BJU Int. 2014;114(5):698–707. doi:10.1111/bju.12548.CrossRefPubMed Muller BG, van den Bos W, Brausi M, Cornud F, Gontero P, Kirkham A, et al. Role of multiparametric magnetic resonance imaging (MRI) in focal therapy for prostate cancer: a Delphi consensus project. BJU Int. 2014;114(5):698–707. doi:10.​1111/​bju.​12548.CrossRefPubMed
9.••
Zurück zum Zitat Donaldson IA, Alonzi R, Barratt D, Barret E, Berge V, Bott S, et al. Focal therapy: patients, interventions, and outcomes—a report from a consensus meeting. Eur Urol. 2014. doi:10.1016/j.eururo.2014.09.018. Statements from the most recent expert consensus panel on recommendations for patient selection, appropriate work-up for FT treatments, and meaningful outcomes.PubMedCentral Donaldson IA, Alonzi R, Barratt D, Barret E, Berge V, Bott S, et al. Focal therapy: patients, interventions, and outcomes—a report from a consensus meeting. Eur Urol. 2014. doi:10.​1016/​j.​eururo.​2014.​09.​018. Statements from the most recent expert consensus panel on recommendations for patient selection, appropriate work-up for FT treatments, and meaningful outcomes.PubMedCentral
10.•
Zurück zum Zitat Valerio M, Ahmed HU, Emberton M, Lawrentschuk N, Lazzeri M, Montironi R, et al. The role of focal therapy in the management of localised prostate cancer: a systematic review. Eur Urol. 2014;66(4):732–51. doi:10.1016/j.eururo.2013.05.048. Systematic review of the short-to-medium term outcomes of FT treatments across multiple modalities.CrossRefPubMedCentralPubMed Valerio M, Ahmed HU, Emberton M, Lawrentschuk N, Lazzeri M, Montironi R, et al. The role of focal therapy in the management of localised prostate cancer: a systematic review. Eur Urol. 2014;66(4):732–51. doi:10.​1016/​j.​eururo.​2013.​05.​048. Systematic review of the short-to-medium term outcomes of FT treatments across multiple modalities.CrossRefPubMedCentralPubMed
11.
Zurück zum Zitat Klotz L, Polascik T. Low risk and very low risk prostate cancer: is there a role for focal therapy in the era of active surveillance. Oncology. 2014;28(11):950.PubMed Klotz L, Polascik T. Low risk and very low risk prostate cancer: is there a role for focal therapy in the era of active surveillance. Oncology. 2014;28(11):950.PubMed
19.
Zurück zum Zitat Iremashvili V, Pelaez L, Manoharan M, Acosta K, Rosenberg DL, Soloway MS. Tumor focality is not associated with biochemical outcome after radical prostatectomy. Prostate. 2012;72(7):762–8. doi:10.1002/pros.21481.CrossRefPubMed Iremashvili V, Pelaez L, Manoharan M, Acosta K, Rosenberg DL, Soloway MS. Tumor focality is not associated with biochemical outcome after radical prostatectomy. Prostate. 2012;72(7):762–8. doi:10.​1002/​pros.​21481.CrossRefPubMed
20.
Zurück zum Zitat Wise AM, Stamey TA, McNeal JE, Clayton JL. Morphologic and clinical significance of multifocal prostate cancers in radical prostatectomy specimens. Urology. 2002;60(2):264–9.CrossRefPubMed Wise AM, Stamey TA, McNeal JE, Clayton JL. Morphologic and clinical significance of multifocal prostate cancers in radical prostatectomy specimens. Urology. 2002;60(2):264–9.CrossRefPubMed
21.•
Zurück zum Zitat Le JD, Tan N, Shkolyar E, Lu DY, Kwan L, Marks LS, et al. Multifocality and prostate cancer detection by multiparametric magnetic resonance imaging: correlation with whole-mount histopathology. Eur Urol. 2014. doi:10.1016/j.eururo.2014.08.079. Demonstrates the histopathological findings of multifocal prostate cancer, the predominant prevalence of GS6 in SL, and mpMRI’s potential to miss small volume lesions.PubMed Le JD, Tan N, Shkolyar E, Lu DY, Kwan L, Marks LS, et al. Multifocality and prostate cancer detection by multiparametric magnetic resonance imaging: correlation with whole-mount histopathology. Eur Urol. 2014. doi:10.​1016/​j.​eururo.​2014.​08.​079. Demonstrates the histopathological findings of multifocal prostate cancer, the predominant prevalence of GS6 in SL, and mpMRI’s potential to miss small volume lesions.PubMed
22.••
Zurück zum Zitat de Rooij M, Hamoen EHJ, Fütterer JJ, Barentsz JO, Rovers MM. Accuracy of multiparametric MRI for prostate cancer detection: a meta-analysis. Am J Roentgenol. 2014;202(2):343–51. doi:10.2214/AJR.13.11046. Meta-analysis examining the accuracy of mpMRI found a pooled specificity of 88%, sensitivity of 74%, and NPV ranging from 64 to 94%.CrossRef de Rooij M, Hamoen EHJ, Fütterer JJ, Barentsz JO, Rovers MM. Accuracy of multiparametric MRI for prostate cancer detection: a meta-analysis. Am J Roentgenol. 2014;202(2):343–51. doi:10.​2214/​AJR.​13.​11046. Meta-analysis examining the accuracy of mpMRI found a pooled specificity of 88%, sensitivity of 74%, and NPV ranging from 64 to 94%.CrossRef
24.
Zurück zum Zitat Futterer JJ, Heijmink SW, Scheenen TW, Veltman J, Huisman HJ, Vos P, et al. Prostate cancer localization with dynamic contrast-enhanced MR imaging and proton MR spectroscopic imaging. Radiology. 2006;241(2):449–58. doi:10.1148/radiol.2412051866.CrossRefPubMed Futterer JJ, Heijmink SW, Scheenen TW, Veltman J, Huisman HJ, Vos P, et al. Prostate cancer localization with dynamic contrast-enhanced MR imaging and proton MR spectroscopic imaging. Radiology. 2006;241(2):449–58. doi:10.​1148/​radiol.​2412051866.CrossRefPubMed
25.
Zurück zum Zitat Gupta RT, Kauffman CR, Polascik TJ, Taneja SS, Rosenkrantz AB. The state of prostate MRI in 2013. Oncology (Williston Park). 2013;27(4):262–70. Gupta RT, Kauffman CR, Polascik TJ, Taneja SS, Rosenkrantz AB. The state of prostate MRI in 2013. Oncology (Williston Park). 2013;27(4):262–70.
26.
Zurück zum Zitat Hambrock T, Somford DM, Huisman HJ, van Oort IM, Witjes JA, Hulsbergen-van de Kaa CA, et al. Relationship between apparent diffusion coefficients at 3.0-T MR imaging and Gleason grade in peripheral zone prostate cancer. Radiology. 2011. doi:10.1148/radiol.091409. Hambrock T, Somford DM, Huisman HJ, van Oort IM, Witjes JA, Hulsbergen-van de Kaa CA, et al. Relationship between apparent diffusion coefficients at 3.0-T MR imaging and Gleason grade in peripheral zone prostate cancer. Radiology. 2011. doi:10.​1148/​radiol.​091409.
28.
Zurück zum Zitat Woodfield CA, Tung GA, Grand DJ, Pezzullo JA, Machan JT, Renzulli 2nd JF. Diffusion-weighted MRI of peripheral zone prostate cancer: comparison of tumor apparent diffusion coefficient with Gleason score and percentage of tumor on core biopsy. AJR Am J Roentgenol. 2010;194(4):W316–22. doi:10.2214/AJR.09.2651.CrossRefPubMed Woodfield CA, Tung GA, Grand DJ, Pezzullo JA, Machan JT, Renzulli 2nd JF. Diffusion-weighted MRI of peripheral zone prostate cancer: comparison of tumor apparent diffusion coefficient with Gleason score and percentage of tumor on core biopsy. AJR Am J Roentgenol. 2010;194(4):W316–22. doi:10.​2214/​AJR.​09.​2651.CrossRefPubMed
29.
Zurück zum Zitat Verma S, Rajesh A, Morales H, Lemen L, Bills G, Delworth M, et al. Assessment of aggressiveness of prostate cancer: correlation of apparent diffusion coefficient with histologic grade after radical prostatectomy. AJR Am J Roentgenol. 2011;196(2):374–81. doi:10.2214/AJR.10.4441.CrossRefPubMed Verma S, Rajesh A, Morales H, Lemen L, Bills G, Delworth M, et al. Assessment of aggressiveness of prostate cancer: correlation of apparent diffusion coefficient with histologic grade after radical prostatectomy. AJR Am J Roentgenol. 2011;196(2):374–81. doi:10.​2214/​AJR.​10.​4441.CrossRefPubMed
30.
Zurück zum Zitat Verma S, Turkbey B, Muradyan N, Rajesh A, Cornud F, Haider MA, et al. Overview of dynamic contrast-enhanced MRI in prostate cancer diagnosis and management. AJR Am J Roentgenol. 2012;198(6):1277–88. doi:10.2214/AJR.12.8510.CrossRefPubMed Verma S, Turkbey B, Muradyan N, Rajesh A, Cornud F, Haider MA, et al. Overview of dynamic contrast-enhanced MRI in prostate cancer diagnosis and management. AJR Am J Roentgenol. 2012;198(6):1277–88. doi:10.​2214/​AJR.​12.​8510.CrossRefPubMed
32.
Zurück zum Zitat Turkbey B, Mani H, Shah V, Rastinehad AR, Bernardo M, Pohida T, et al. Multiparametric 3 T prostate magnetic resonance imaging to detect cancer: histopathological correlation using prostatectomy specimens processed in customized magnetic resonance imaging based molds. J Urol. 2011;186(5):1818–24. doi:10.1016/j.juro.2011.07.013.CrossRefPubMed Turkbey B, Mani H, Shah V, Rastinehad AR, Bernardo M, Pohida T, et al. Multiparametric 3 T prostate magnetic resonance imaging to detect cancer: histopathological correlation using prostatectomy specimens processed in customized magnetic resonance imaging based molds. J Urol. 2011;186(5):1818–24. doi:10.​1016/​j.​juro.​2011.​07.​013.CrossRefPubMed
34.
Zurück zum Zitat Rosenkrantz AB, Neil J, Kong X, Melamed J, Babb JS, Taneja SS, et al. Prostate cancer: comparison of 3D T2-weighted with conventional 2D T2-weighted imaging for image quality and tumor detection. AJR Am J Roentgenol. 2010;194(2):446–52. doi:10.2214/ajr.09.3217.CrossRefPubMed Rosenkrantz AB, Neil J, Kong X, Melamed J, Babb JS, Taneja SS, et al. Prostate cancer: comparison of 3D T2-weighted with conventional 2D T2-weighted imaging for image quality and tumor detection. AJR Am J Roentgenol. 2010;194(2):446–52. doi:10.​2214/​ajr.​09.​3217.CrossRefPubMed
35.
Zurück zum Zitat Kitajima K, Kaji Y, Fukabori Y, Yoshida K, Suganuma N, Sugimura K. Prostate cancer detection with 3 T MRI: comparison of diffusion-weighted imaging and dynamic contrast-enhanced MRI in combination with T2-weighted imaging. J Magn Reson Imaging. 2010;31(3):625–31. doi:10.1002/jmri.22075.CrossRefPubMed Kitajima K, Kaji Y, Fukabori Y, Yoshida K, Suganuma N, Sugimura K. Prostate cancer detection with 3 T MRI: comparison of diffusion-weighted imaging and dynamic contrast-enhanced MRI in combination with T2-weighted imaging. J Magn Reson Imaging. 2010;31(3):625–31. doi:10.​1002/​jmri.​22075.CrossRefPubMed
36.
Zurück zum Zitat Vilanova JC, Barcelo-Vidal C, Comet J, Boada M, Barcelo J, Ferrer J, et al. Usefulness of prebiopsy multifunctional and morphologic MRI combined with free-to-total prostate-specific antigen ratio in the detection of prostate cancer. AJR Am J Roentgenol. 2011;196(6):W715–22. doi:10.2214/ajr.10.5700.CrossRefPubMed Vilanova JC, Barcelo-Vidal C, Comet J, Boada M, Barcelo J, Ferrer J, et al. Usefulness of prebiopsy multifunctional and morphologic MRI combined with free-to-total prostate-specific antigen ratio in the detection of prostate cancer. AJR Am J Roentgenol. 2011;196(6):W715–22. doi:10.​2214/​ajr.​10.​5700.CrossRefPubMed
37.
Zurück zum Zitat Portalez D, Mozer P, Cornud F, Renard-Penna R, Misrai V, Thoulouzan M, et al. Validation of the European Society of Urogenital Radiology scoring system for prostate cancer diagnosis on multiparametric magnetic resonance imaging in a cohort of repeat biopsy patients. Eur Urol. 2012;62(6):986–96. doi:10.1016/j.eururo.2012.06.044.CrossRefPubMed Portalez D, Mozer P, Cornud F, Renard-Penna R, Misrai V, Thoulouzan M, et al. Validation of the European Society of Urogenital Radiology scoring system for prostate cancer diagnosis on multiparametric magnetic resonance imaging in a cohort of repeat biopsy patients. Eur Urol. 2012;62(6):986–96. doi:10.​1016/​j.​eururo.​2012.​06.​044.CrossRefPubMed
38.
Zurück zum Zitat Grey AD, Chana MS, Popert R, Wolfe K, Liyanage SH, Acher PL. Diagnostic accuracy of magnetic resonance imaging (MRI) prostate imaging reporting and data system (PI-RADS) scoring in a transperineal prostate biopsy setting. BJU Int. 2014. doi:10.1111/bju.12862.PubMed Grey AD, Chana MS, Popert R, Wolfe K, Liyanage SH, Acher PL. Diagnostic accuracy of magnetic resonance imaging (MRI) prostate imaging reporting and data system (PI-RADS) scoring in a transperineal prostate biopsy setting. BJU Int. 2014. doi:10.​1111/​bju.​12862.PubMed
39.
Zurück zum Zitat Pokorny MR, de Rooij M, Duncan E, Schroder FH, Parkinson R, Barentsz JO, et al. Prospective study of diagnostic accuracy comparing prostate cancer detection by transrectal ultrasound-guided biopsy versus magnetic resonance (MR) imaging with subsequent MR-guided biopsy in men without previous prostate biopsies. Eur Urol. 2014;66(1):22–9. doi:10.1016/j.eururo.2014.03.002.CrossRefPubMed Pokorny MR, de Rooij M, Duncan E, Schroder FH, Parkinson R, Barentsz JO, et al. Prospective study of diagnostic accuracy comparing prostate cancer detection by transrectal ultrasound-guided biopsy versus magnetic resonance (MR) imaging with subsequent MR-guided biopsy in men without previous prostate biopsies. Eur Urol. 2014;66(1):22–9. doi:10.​1016/​j.​eururo.​2014.​03.​002.CrossRefPubMed
40.
Zurück zum Zitat Pepe P, Garufi A, Priolo G, Pennisi M. Can 3-Tesla pelvic phased-array multiparametric MRI avoid unnecessary repeat prostate biopsy in patients with PSA < 10 ng/mL? Clin Genitourin Cancer. 2014. doi:10.1016/j.clgc.2014.06.013. Pepe P, Garufi A, Priolo G, Pennisi M. Can 3-Tesla pelvic phased-array multiparametric MRI avoid unnecessary repeat prostate biopsy in patients with PSA < 10 ng/mL? Clin Genitourin Cancer. 2014. doi:10.​1016/​j.​clgc.​2014.​06.​013.
41.
Zurück zum Zitat Jambor I, Kahkonen E, Taimen P, Merisaari H, Saunavaara J, Alanen K, et al. Prebiopsy multiparametric 3 T prostate MRI in patients with elevated PSA, normal digital rectal examination, and no previous biopsy. J Magn Reson Imaging. 2014. doi:10.1002/jmri.24682. Jambor I, Kahkonen E, Taimen P, Merisaari H, Saunavaara J, Alanen K, et al. Prebiopsy multiparametric 3 T prostate MRI in patients with elevated PSA, normal digital rectal examination, and no previous biopsy. J Magn Reson Imaging. 2014. doi:10.​1002/​jmri.​24682.
42.
43.•
Zurück zum Zitat Panebianco V, Barchetti F, Sciarra A, Ciardi A, Indino EL, Papalia R, et al. Multiparametric magnetic resonance imaging vs. standard care in men being evaluated for prostate cancer: a randomized study. Urol Oncol. 2015;33(1):17–e1-7. doi:10.1016/j.urolonc.2014.09.013. Largest randomized study to date assessing the mpMRI/MRGB pathway vs standard of care found a higher detection of clinically significant cancer utilizing the mpMRI/MRGB pathway supported by a 97% accuracy of mpMRI for detecting PCa. Panebianco V, Barchetti F, Sciarra A, Ciardi A, Indino EL, Papalia R, et al. Multiparametric magnetic resonance imaging vs. standard care in men being evaluated for prostate cancer: a randomized study. Urol Oncol. 2015;33(1):17–e1-7. doi:10.​1016/​j.​urolonc.​2014.​09.​013. Largest randomized study to date assessing the mpMRI/MRGB pathway vs standard of care found a higher detection of clinically significant cancer utilizing the mpMRI/MRGB pathway supported by a 97% accuracy of mpMRI for detecting PCa.
44.••
Zurück zum Zitat Muller BG, Futterer JJ, Gupta RT, Katz A, Kirkham A, Kurhanewicz J, et al. The role of magnetic resonance imaging (MRI) in focal therapy for prostate cancer: recommendations from a consensus panel. BJU Int. 2014;113(2):218–27. doi:10.1111/bju.12243. Expert consensus panel recommendations on the utilization of mpMRI in FT for patient selection, planning and follow-up. Muller BG, Futterer JJ, Gupta RT, Katz A, Kirkham A, Kurhanewicz J, et al. The role of magnetic resonance imaging (MRI) in focal therapy for prostate cancer: recommendations from a consensus panel. BJU Int. 2014;113(2):218–27. doi:10.​1111/​bju.​12243. Expert consensus panel recommendations on the utilization of mpMRI in FT for patient selection, planning and follow-up.
45.
Zurück zum Zitat Borkowetz A, Platzek I, Toma M, Laniado M, Baretton G, Froehner M, et al. Comparison of systematic transrectal biopsy to transperineal MRI/ultrasound-fusion biopsy for the diagnosis of prostate cancer. BJU Int. 2014. doi:10.1111/bju.13023.PubMed Borkowetz A, Platzek I, Toma M, Laniado M, Baretton G, Froehner M, et al. Comparison of systematic transrectal biopsy to transperineal MRI/ultrasound-fusion biopsy for the diagnosis of prostate cancer. BJU Int. 2014. doi:10.​1111/​bju.​13023.PubMed
47.
Zurück zum Zitat Noguchi M, Stamey TA, McNeal JE, Yemoto CM. Relationship between systematic biopsies and histological features of 222 radical prostatectomy specimens: lack of prediction of tumor significance for men with nonpalpable prostate cancer. J Urol. 2001;166(1):104–9. discussion 9–10.CrossRefPubMed Noguchi M, Stamey TA, McNeal JE, Yemoto CM. Relationship between systematic biopsies and histological features of 222 radical prostatectomy specimens: lack of prediction of tumor significance for men with nonpalpable prostate cancer. J Urol. 2001;166(1):104–9. discussion 9–10.CrossRefPubMed
48.
Zurück zum Zitat Hambrock T, Hoeks C, Hulsbergen-van de Kaa C, Scheenen T, Futterer J, Bouwense S, et al. Prospective assessment of prostate cancer aggressiveness using 3-T diffusion-weighted magnetic resonance imaging-guided biopsies versus a systematic 10-core transrectal ultrasound prostate biopsy cohort. European urology. 2012;61(1):177–84. doi:10.1016/j.eururo.2011.08.042.CrossRefPubMed Hambrock T, Hoeks C, Hulsbergen-van de Kaa C, Scheenen T, Futterer J, Bouwense S, et al. Prospective assessment of prostate cancer aggressiveness using 3-T diffusion-weighted magnetic resonance imaging-guided biopsies versus a systematic 10-core transrectal ultrasound prostate biopsy cohort. European urology. 2012;61(1):177–84. doi:10.​1016/​j.​eururo.​2011.​08.​042.CrossRefPubMed
49.
Zurück zum Zitat Baco E, Rud E, Ukimura O, Vlatkovic L, Svindland A, Matsugasumi T, et al. Effect of targeted biopsy guided by elastic image fusion of MRI with 3D-TRUS on diagnosis of anterior prostate cancer. Urol Oncol. 2014. doi:10.1016/j.urolonc.2014.07.014.PubMed Baco E, Rud E, Ukimura O, Vlatkovic L, Svindland A, Matsugasumi T, et al. Effect of targeted biopsy guided by elastic image fusion of MRI with 3D-TRUS on diagnosis of anterior prostate cancer. Urol Oncol. 2014. doi:10.​1016/​j.​urolonc.​2014.​07.​014.PubMed
51.
Zurück zum Zitat Hoeks CM, Schouten MG, Bomers JG, Hoogendoorn SP, Hulsbergen-van de Kaa CA, Hambrock T, et al. Three-Tesla magnetic resonance-guided prostate biopsy in men with increased prostate-specific antigen and repeated, negative, random, systematic, transrectal ultrasound biopsies: detection of clinically significant prostate cancers. European urology. 2012;62(5):902–9. doi:10.1016/j.eururo.2012.01.047.CrossRefPubMed Hoeks CM, Schouten MG, Bomers JG, Hoogendoorn SP, Hulsbergen-van de Kaa CA, Hambrock T, et al. Three-Tesla magnetic resonance-guided prostate biopsy in men with increased prostate-specific antigen and repeated, negative, random, systematic, transrectal ultrasound biopsies: detection of clinically significant prostate cancers. European urology. 2012;62(5):902–9. doi:10.​1016/​j.​eururo.​2012.​01.​047.CrossRefPubMed
52.
Zurück zum Zitat Franiel T, Stephan C, Erbersdobler A, Dietz E, Maxeiner A, Hell N, et al. Areas suspicious for prostate cancer: MR-guided biopsy in patients with at least one transrectal US-guided biopsy with a negative finding–multiparametric MR imaging for detection and biopsy planning. Radiology. 2011;259(1):162–72. doi:10.1148/radiol.10101251.CrossRefPubMed Franiel T, Stephan C, Erbersdobler A, Dietz E, Maxeiner A, Hell N, et al. Areas suspicious for prostate cancer: MR-guided biopsy in patients with at least one transrectal US-guided biopsy with a negative finding–multiparametric MR imaging for detection and biopsy planning. Radiology. 2011;259(1):162–72. doi:10.​1148/​radiol.​10101251.CrossRefPubMed
53.
Zurück zum Zitat Anastasiadis AG, Lichy MP, Nagele U, Kuczyk MA, Merseburger AS, Hennenlotter J, et al. MRI-guided biopsy of the prostate increases diagnostic performance in men with elevated or increasing PSA levels after previous negative TRUS biopsies. Eur Urol. 2006;50(4):738–48. doi:10.1016/j.eururo.2006.03.007. discussion 48–9.CrossRefPubMed Anastasiadis AG, Lichy MP, Nagele U, Kuczyk MA, Merseburger AS, Hennenlotter J, et al. MRI-guided biopsy of the prostate increases diagnostic performance in men with elevated or increasing PSA levels after previous negative TRUS biopsies. Eur Urol. 2006;50(4):738–48. doi:10.​1016/​j.​eururo.​2006.​03.​007. discussion 48–9.CrossRefPubMed
54.
Zurück zum Zitat Taira AV, Merrick GS, Galbreath RW, Andreini H, Taubenslag W, Curtis R, et al. Performance of transperineal template-guided mapping biopsy in detecting prostate cancer in the initial and repeat biopsy setting. Prostate Cancer Prostatic Dis. 2010;13(1):71–7. doi:10.1038/pcan.2009.42.CrossRefPubMedCentralPubMed Taira AV, Merrick GS, Galbreath RW, Andreini H, Taubenslag W, Curtis R, et al. Performance of transperineal template-guided mapping biopsy in detecting prostate cancer in the initial and repeat biopsy setting. Prostate Cancer Prostatic Dis. 2010;13(1):71–7. doi:10.​1038/​pcan.​2009.​42.CrossRefPubMedCentralPubMed
56.••
Zurück zum Zitat Bomers JG, Barentsz JO. Standardization of multiparametric prostate MR imaging using PI-RADS. BioMed Res Int. 2014;2014:431680. doi:10.1155/2014/431680. This paper introduces and describes PI-RADS and reviews every single parameter of the scoring system. Two patient cases are provided to explain the overall interpretation score in multiparametric imaging.CrossRefPubMedCentralPubMed Bomers JG, Barentsz JO. Standardization of multiparametric prostate MR imaging using PI-RADS. BioMed Res Int. 2014;2014:431680. doi:10.​1155/​2014/​431680. This paper introduces and describes PI-RADS and reviews every single parameter of the scoring system. Two patient cases are provided to explain the overall interpretation score in multiparametric imaging.CrossRefPubMedCentralPubMed
57.
Zurück zum Zitat Schimmoller L, Quentin M, Arsov C, Hiester A, Kropil P, Rabenalt R, et al. Predictive power of the ESUR scoring system for prostate cancer diagnosis verified with targeted MR-guided in-bore biopsy. Eur J Radiol. 2014;83(12):2103–8. doi:10.1016/j.ejrad.2014.08.006.CrossRefPubMed Schimmoller L, Quentin M, Arsov C, Hiester A, Kropil P, Rabenalt R, et al. Predictive power of the ESUR scoring system for prostate cancer diagnosis verified with targeted MR-guided in-bore biopsy. Eur J Radiol. 2014;83(12):2103–8. doi:10.​1016/​j.​ejrad.​2014.​08.​006.CrossRefPubMed
58.
Zurück zum Zitat Lee T, Mendhiratta N, Sperling D, Lepor H. Focal laser ablation for localized prostate cancer: principles, clinical trials, and our initial experience. Rev Urol. 2014;16(2):55–66.PubMedCentralPubMed Lee T, Mendhiratta N, Sperling D, Lepor H. Focal laser ablation for localized prostate cancer: principles, clinical trials, and our initial experience. Rev Urol. 2014;16(2):55–66.PubMedCentralPubMed
59.
Zurück zum Zitat Valerio M, Stricker PD, Ahmed HU, Dickinson L, Ponsky L, Shnier R, et al. Initial assessment of safety and clinical feasibility of irreversible electroporation in the focal treatment of prostate cancer. Prostate Cancer Prostatic Dis. 2014. doi:10.1038/pcan.2014.33.PubMed Valerio M, Stricker PD, Ahmed HU, Dickinson L, Ponsky L, Shnier R, et al. Initial assessment of safety and clinical feasibility of irreversible electroporation in the focal treatment of prostate cancer. Prostate Cancer Prostatic Dis. 2014. doi:10.​1038/​pcan.​2014.​33.PubMed
60.
Zurück zum Zitat Valerio M, Dickinson L, Ali A, Ramachandran N, Donaldson I, Freeman A, et al. A prospective development study investigating focal irreversible electroporation in men with localised prostate cancer: Nanoknife Electroporation Ablation Trial (NEAT). Contemp Clin Trials. 2014;39(1):57–65. doi:10.1016/j.cct.2014.07.006.CrossRefPubMedCentralPubMed Valerio M, Dickinson L, Ali A, Ramachandran N, Donaldson I, Freeman A, et al. A prospective development study investigating focal irreversible electroporation in men with localised prostate cancer: Nanoknife Electroporation Ablation Trial (NEAT). Contemp Clin Trials. 2014;39(1):57–65. doi:10.​1016/​j.​cct.​2014.​07.​006.CrossRefPubMedCentralPubMed
61.
Zurück zum Zitat van den Bos W, de Bruin DM, Muller BG, Varkarakis IM, Karagiannis AA, Zondervan PJ, et al. The safety and efficacy of irreversible electroporation for the ablation of prostate cancer: a multicentre prospective human in vivo pilot study protocol. BMJ Open. 2014;4(10), e006382. doi:10.1136/bmjopen-2014-006382.CrossRefPubMedCentralPubMed van den Bos W, de Bruin DM, Muller BG, Varkarakis IM, Karagiannis AA, Zondervan PJ, et al. The safety and efficacy of irreversible electroporation for the ablation of prostate cancer: a multicentre prospective human in vivo pilot study protocol. BMJ Open. 2014;4(10), e006382. doi:10.​1136/​bmjopen-2014-006382.CrossRefPubMedCentralPubMed
62.
Zurück zum Zitat van den Bos W, Muller BG, de la Rosette JJ. A randomized controlled trial on focal therapy for localized prostate carcinoma: hemiablation versus complete ablation with irreversible electroporation. J Endourol Endourol Soc. 2013;27(3):262–4. doi:10.1089/end.2013.1568. van den Bos W, Muller BG, de la Rosette JJ. A randomized controlled trial on focal therapy for localized prostate carcinoma: hemiablation versus complete ablation with irreversible electroporation. J Endourol Endourol Soc. 2013;27(3):262–4. doi:10.​1089/​end.​2013.​1568.
66.
Zurück zum Zitat Riches SF, Payne GS, Desouza NM, Dearnaley D, Morgan VA, Morgan SC, et al. Effect on therapeutic ratio of planning a boosted radiotherapy dose to the dominant intraprostatic tumour lesion within the prostate based on multifunctional MR parameters. Br J Radiol. 2014;87(1037):20130813. doi:10.1259/bjr.20130813.CrossRefPubMedCentralPubMed Riches SF, Payne GS, Desouza NM, Dearnaley D, Morgan VA, Morgan SC, et al. Effect on therapeutic ratio of planning a boosted radiotherapy dose to the dominant intraprostatic tumour lesion within the prostate based on multifunctional MR parameters. Br J Radiol. 2014;87(1037):20130813. doi:10.​1259/​bjr.​20130813.CrossRefPubMedCentralPubMed
68.
Zurück zum Zitat Moore CM, Azzouzi AR, Barret E, Villers A, Muir G, Barber N, et al. Determination of optimal drug dose and light dose index to achieve minimally invasive focal ablation of localized prostate cancer using WST11-Vascular Targeted Photodynamic (VTP) therapy. BJU Int. 2014. doi:10.1111/bju.12816. Moore CM, Azzouzi AR, Barret E, Villers A, Muir G, Barber N, et al. Determination of optimal drug dose and light dose index to achieve minimally invasive focal ablation of localized prostate cancer using WST11-Vascular Targeted Photodynamic (VTP) therapy. BJU Int. 2014. doi:10.​1111/​bju.​12816.
70.
71.
Zurück zum Zitat Uchida T, Tomonaga T, Kim H, Nakano M, Shoji S, Nagata Y, et al. Improved outcomes owing to high-intensity focused ultrasound devices version-up for the treatment of patients with localized prostate cancer. J Urol. 2014. doi:10.1016/j.juro.2014.07.096.PubMed Uchida T, Tomonaga T, Kim H, Nakano M, Shoji S, Nagata Y, et al. Improved outcomes owing to high-intensity focused ultrasound devices version-up for the treatment of patients with localized prostate cancer. J Urol. 2014. doi:10.​1016/​j.​juro.​2014.​07.​096.PubMed
72.
Zurück zum Zitat Crouzet S, Chapelon JY, Rouviere O, Mege-Lechevallier F, Colombel M, Tonoli-Catez H, et al. Whole-gland ablation of localized prostate cancer with high-intensity focused ultrasound: oncologic outcomes and morbidity in 1002 patients. Eur Urol. 2014;65(5):907–14. doi:10.1016/j.eururo.2013.04.039.CrossRefPubMed Crouzet S, Chapelon JY, Rouviere O, Mege-Lechevallier F, Colombel M, Tonoli-Catez H, et al. Whole-gland ablation of localized prostate cancer with high-intensity focused ultrasound: oncologic outcomes and morbidity in 1002 patients. Eur Urol. 2014;65(5):907–14. doi:10.​1016/​j.​eururo.​2013.​04.​039.CrossRefPubMed
74.
Zurück zum Zitat Berge V, Dickinson L, McCartan N, Hindley RG, Diep LM, Emberton M, et al. Morbidity associated with primary high intensity focused ultrasound and redo high intensity focused ultrasound for localized prostate cancer. J Urol. 2014;191(6):1764–9. doi:10.1016/j.juro.2013.12.036.CrossRefPubMed Berge V, Dickinson L, McCartan N, Hindley RG, Diep LM, Emberton M, et al. Morbidity associated with primary high intensity focused ultrasound and redo high intensity focused ultrasound for localized prostate cancer. J Urol. 2014;191(6):1764–9. doi:10.​1016/​j.​juro.​2013.​12.​036.CrossRefPubMed
75.
Zurück zum Zitat Baco E, Gelet A, Crouzet S, Rud E, Rouviere O, Tonoli-Catez H, et al. Hemi salvage high-intensity focused ultrasound (HIFU) in unilateral radiorecurrent prostate cancer: a prospective two-centre study. BJU Int. 2014;114(4):532–40. doi:10.1111/bju.12545. Baco E, Gelet A, Crouzet S, Rud E, Rouviere O, Tonoli-Catez H, et al. Hemi salvage high-intensity focused ultrasound (HIFU) in unilateral radiorecurrent prostate cancer: a prospective two-centre study. BJU Int. 2014;114(4):532–40. doi:10.​1111/​bju.​12545.
79.
Zurück zum Zitat Bahn D, de Castro Abreu AL, Gill IS, Hung AJ, Silverman P, Gross ME, et al. Focal cryotherapy for clinically unilateral, low-intermediate risk prostate cancer in 73 men with a median follow-up of 3.7 years. Eur Urol. 2012;62(1):55–63. doi:10.1016/j.eururo.2012.03.006.CrossRefPubMed Bahn D, de Castro Abreu AL, Gill IS, Hung AJ, Silverman P, Gross ME, et al. Focal cryotherapy for clinically unilateral, low-intermediate risk prostate cancer in 73 men with a median follow-up of 3.7 years. Eur Urol. 2012;62(1):55–63. doi:10.​1016/​j.​eururo.​2012.​03.​006.CrossRefPubMed
80.
Zurück zum Zitat Li YH, Elshafei A, Agarwal G, Ruckle H, Pow-Sang J, Jones JS. Salvage focal prostate cryoablation for locally recurrent prostate cancer after radiotherapy: Initial results from the cryo on-line data registry. Prostate. 2014. doi:10.1002/pros.22881. Li YH, Elshafei A, Agarwal G, Ruckle H, Pow-Sang J, Jones JS. Salvage focal prostate cryoablation for locally recurrent prostate cancer after radiotherapy: Initial results from the cryo on-line data registry. Prostate. 2014. doi:10.​1002/​pros.​22881.
84.•
Zurück zum Zitat Ahmed HU, Berge V, Bottomley D, Cross W, Heer R, Kaplan R, et al. Can we deliver randomized trials of focal therapy in prostate cancer? Nat Rev Clin Oncol. 2014;11(8):482–91. doi:10.1038/nrclinonc.2014.44. This article by the Prostate Cancer RCT Consensus Group is the first to advocate the use of cohort embedded randomized controlled trial design for future focal therapy trials. Ahmed HU, Berge V, Bottomley D, Cross W, Heer R, Kaplan R, et al. Can we deliver randomized trials of focal therapy in prostate cancer? Nat Rev Clin Oncol. 2014;11(8):482–91. doi:10.​1038/​nrclinonc.​2014.​44. This article by the Prostate Cancer RCT Consensus Group is the first to advocate the use of cohort embedded randomized controlled trial design for future focal therapy trials.
85.
Zurück zum Zitat Relton C, Torgerson D, O'Cathain A, Nicholl J. Rethinking pragmatic randomised controlled trials: introducing the “cohort multiple randomised controlled trial” design. BMJ (Clinical Research ed). 2010;340:c1066. doi:10.1136/bmj.c1066.CrossRef Relton C, Torgerson D, O'Cathain A, Nicholl J. Rethinking pragmatic randomised controlled trials: introducing the “cohort multiple randomised controlled trial” design. BMJ (Clinical Research ed). 2010;340:c1066. doi:10.​1136/​bmj.​c1066.CrossRef
Metadaten
Titel
Current Trends and New Frontiers in Focal Therapy for Localized Prostate Cancer
verfasst von
Melissa H. Mendez
Daniel Y. Joh
Rajan Gupta
Thomas J. Polascik
Publikationsdatum
01.06.2015
Verlag
Springer US
Erschienen in
Current Urology Reports / Ausgabe 6/2015
Print ISSN: 1527-2737
Elektronische ISSN: 1534-6285
DOI
https://doi.org/10.1007/s11934-015-0513-y

Weitere Artikel der Ausgabe 6/2015

Current Urology Reports 6/2015 Zur Ausgabe

Urothelial Cancer (A Sagalowsky, Section Editor)

Practical Tips for Safe and Efficient Robotic Cystectomy

New Imaging Techniques (A Rastinehad and S Rais-Bahrami, Section Editors)

The Role of MRI in Active Surveillance for Prostate Cancer

Men’s Health (R Carrion and C Yang, Section Editors)

Evaluation and Management of Chronic Scrotal Content Pain

Men’s Health (R Carrion and C Yang, Section Editors)

The Evolution of Vasectomy Reversal

Prostate Cancer (A Kibel, Section Editor)

Immunotherapy in Prostate Cancer

Ambulantisierung: Erste Erfahrungen mit dem Hybrid-DRG

02.05.2024 DCK 2024 Kongressbericht

Die Hybrid-DRG-Verordnung soll dazu führen, dass mehr chirurgische Eingriffe ambulant durchgeführt werden, wie es in anderen Ländern schon länger üblich ist. Die gleiche Vergütung im ambulanten und stationären Sektor hatten Niedergelassene schon lange gefordert. Aber die Umsetzung bereitet ihnen doch Kopfzerbrechen.

Sind Frauen die fähigeren Ärzte?

30.04.2024 Gendermedizin Nachrichten

Patienten, die von Ärztinnen behandelt werden, dürfen offenbar auf bessere Therapieergebnisse hoffen als Patienten von Ärzten. Besonders gilt das offenbar für weibliche Kranke, wie eine Studie zeigt.

Harninkontinenz: Netz-Op. erfordert über lange Zeit intensive Nachsorge

30.04.2024 Harninkontinenz Nachrichten

Frauen mit Belastungsinkontinenz oder Organprolaps sind nach einer Netz-Operation keineswegs beschwerdefrei. Vielmehr scheint die Krankheitslast weiterhin hoch zu sein, sogar höher als von harninkontinenten Frauen, die sich nicht haben operieren lassen.

Adjuvante Immuntherapie verlängert Leben bei RCC

25.04.2024 Nierenkarzinom Nachrichten

Nun gibt es auch Resultate zum Gesamtüberleben: Eine adjuvante Pembrolizumab-Therapie konnte in einer Phase-3-Studie das Leben von Menschen mit Nierenzellkarzinom deutlich verlängern. Die Sterberate war im Vergleich zu Placebo um 38% geringer.

Update Urologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.