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Clinical Orthopaedics and Related Research®

Erschienen in:

01.02.2011 | Symposium: Papers Presented at the Hip Society Meetings 2010

Perivascular Lymphocytic Infiltration Is Not Limited to Metal-on-Metal Bearings

verfasst von: Vincent Y. Ng, MD, Adolph V. Lombardi Jr, MD, Keith R. Berend, MD, Michael D. Skeels, DO, Joanne B. Adams, BFA

Erschienen in: Clinical Orthopaedics and Related Research® | Ausgabe 2/2011

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Abstract

Background

Perivascular lymphocytic infiltration (PVLI) suggests an adaptive immune response. Metal hypersensitivity after THA is presumed associated with idiopathic pain and aseptic loosening, but its incidence and relationship to metallic wear leading to revision are unclear as are its presence and relevance in non-metal-on-metal arthroplasty.

Questions/purposes

We compared (1) incidence and severity of PVLI in failed hip metal-on-metal (MoM) to non-MoM implants and TKA; (2) PVLI in MoM and non-MoM hip arthroplasty based on reason for revision; and (3) PVLI grade to diffuse lymphocytic infiltration (DLI) and tissue reaction to metal particles.

Patients and Methods

We retrospectively examined incidence and severity of PVLI, DLI, and tissue reaction in periprosthetic tissue from 215 THA and 242 TKA revisions including 32 MoM hips.

Results

Perivascular lymphocytic infiltration was present in more TKAs (40%) than overall hip arthroplasties (24%) without difference in severity. Compared to non-MoM hips, MoM bearings were more commonly associated with PVLI (59% versus 18%) and demonstrated increased severity (41% versus 3% greater than mild). Histologically, PVLI correlated (r = 0.51) with DLI, but not tissue reaction. In THA, PVLI was most commonly associated with idiopathic pain (70%) and aseptic loosening (54%) in MoM, and infection in all hip revisions (53%).

Conclusions

Perivascular lymphocytic infiltration is more extensive in revisions of MoM and in aseptic loosening, idiopathic pain, or infection but is also present in TKA, non-MoM, and different reasons for revision. It correlates with other signs of metal hypersensitivity, but not with histologic measures of metal particulate load.

Level of Evidence

Level III, diagnostic study. See the Guidelines for Authors for a complete description of levels of evidence.

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Titel: Perivascular Lymphocytic Infiltration Is Not Limited to Metal-on-Metal Bearings
verfasst von: Vincent Y. Ng, MD
Adolph V. Lombardi Jr, MD
Keith R. Berend, MD
Michael D. Skeels, DO
Joanne B. Adams, BFA
Publikationsdatum: 01.02.2011
Verlag: Springer-Verlag
Erschienen in: Clinical Orthopaedics and Related Research® / Ausgabe 2/2011
Print ISSN: 0009-921X
Elektronische ISSN: 1528-1132
DOI: https://doi.org/10.1007/s11999-010-1570-7

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Abstract

Background

Questions/purposes

Patients and Methods

Results

Conclusions

Level of Evidence

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