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Erschienen in: Endocrine 1/2015

01.02.2015 | Pros and Cons in Endocrine Practice

The treatment of hyperprolactinemia in postmenopausal women with prolactin-secreting microadenomas: Cons

verfasst von: Alexander T. Faje, Anne Klibanski

Erschienen in: Endocrine | Ausgabe 1/2015

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Excerpt

The lifetime prevalence of dopamine agonist-treated hyperprolactinemia in women is estimated to be approximately 0.1 %. The incidence peaks in women during early adulthood and declines sharply with advancing age [1]. Women with symptomatic hyperprolactinemia can experience infertility, oligo-amenorrhea, galactorrhea, acne, or hirsutism. These symptoms or the presence of a prolactin-secreting pituitary macroadenoma (>10 mm) or enlarging microprolactinoma are the generally accepted indications for treatment. …
Literatur
1.
Zurück zum Zitat M. Kars, P.C. Souverein, R.M. Herings, J.A. Romijn, J.P. Vandenbroucke, A. de Boer, O.M. Dekkers, Estimated age- and sex-specific incidence and prevalence of dopamine agonist-treated hyperprolactinemia. J. Clin. Endocrinol. Metab. 94(8), 2729–2734 (2009). doi:10.1210/jc.2009-0177 CrossRefPubMed M. Kars, P.C. Souverein, R.M. Herings, J.A. Romijn, J.P. Vandenbroucke, A. de Boer, O.M. Dekkers, Estimated age- and sex-specific incidence and prevalence of dopamine agonist-treated hyperprolactinemia. J. Clin. Endocrinol. Metab. 94(8), 2729–2734 (2009). doi:10.​1210/​jc.​2009-0177 CrossRefPubMed
2.
Zurück zum Zitat D. Seriwatanachai, N. Krishnamra, J.P. van Leeuwen, Evidence for direct effects of prolactin on human osteoblasts: inhibition of cell growth and mineralization. J. Cell. Biochem. 107(4), 677–685 (2009). doi:10.1002/jcb.22161 CrossRefPubMed D. Seriwatanachai, N. Krishnamra, J.P. van Leeuwen, Evidence for direct effects of prolactin on human osteoblasts: inhibition of cell growth and mineralization. J. Cell. Biochem. 107(4), 677–685 (2009). doi:10.​1002/​jcb.​22161 CrossRefPubMed
3.
Zurück zum Zitat A. Klibanski, B.M. Biller, D.I. Rosenthal, D.A. Schoenfeld, V. Saxe, Effects of prolactin and estrogen deficiency in amenorrheic bone loss. J. Clin. Endocrinol. Metab. 67(1), 124–130 (1988). doi:10.1210/jcem-67-1-124 CrossRefPubMed A. Klibanski, B.M. Biller, D.I. Rosenthal, D.A. Schoenfeld, V. Saxe, Effects of prolactin and estrogen deficiency in amenorrheic bone loss. J. Clin. Endocrinol. Metab. 67(1), 124–130 (1988). doi:10.​1210/​jcem-67-1-124 CrossRefPubMed
4.
Zurück zum Zitat B. Couzinet, G. Meduri, M.G. Lecce, J. Young, S. Brailly, H. Loosfelt, E. Milgrom, G. Schaison, The postmenopausal ovary is not a major androgen-producing gland. J. Clin. Endocrinol. Metab. 86(10), 5060–5066 (2001). doi:10.1210/jcem.86.10.7900 CrossRefPubMed B. Couzinet, G. Meduri, M.G. Lecce, J. Young, S. Brailly, H. Loosfelt, E. Milgrom, G. Schaison, The postmenopausal ovary is not a major androgen-producing gland. J. Clin. Endocrinol. Metab. 86(10), 5060–5066 (2001). doi:10.​1210/​jcem.​86.​10.​7900 CrossRefPubMed
5.
Zurück zum Zitat H.L. Judd, G.E. Judd, W.E. Lucas, S.S. Yen, Endocrine function of the postmenopausal ovary: concentration of androgens and estrogens in ovarian and peripheral vein blood. J. Clin. Endocrinol. Metab. 39(6), 1020–1024 (1974). doi:10.1210/jcem-39-6-1020 CrossRefPubMed H.L. Judd, G.E. Judd, W.E. Lucas, S.S. Yen, Endocrine function of the postmenopausal ovary: concentration of androgens and estrogens in ovarian and peripheral vein blood. J. Clin. Endocrinol. Metab. 39(6), 1020–1024 (1974). doi:10.​1210/​jcem-39-6-1020 CrossRefPubMed
6.
Zurück zum Zitat D.R. Meldrum, B.J. Davidson, I.V. Tataryn, H.L. Judd, Changes in circulating steroids with aging in postmenopausal women. Obstet. Gynecol. 57(5), 624–628 (1981)PubMed D.R. Meldrum, B.J. Davidson, I.V. Tataryn, H.L. Judd, Changes in circulating steroids with aging in postmenopausal women. Obstet. Gynecol. 57(5), 624–628 (1981)PubMed
9.
10.
Zurück zum Zitat N. Kalleinen, P. Polo-Kantola, K. Irjala, T. Porkka-Heiskanen, T. Vahlberg, A. Virkki, O. Polo, 24-hour serum levels of growth hormone, prolactin, and cortisol in pre- and postmenopausal women: the effect of combined estrogen and progestin treatment. J. Clin. Endocrinol. Metab. 93(5), 1655–1661 (2008). doi:10.1210/jc.2007-2677 CrossRefPubMed N. Kalleinen, P. Polo-Kantola, K. Irjala, T. Porkka-Heiskanen, T. Vahlberg, A. Virkki, O. Polo, 24-hour serum levels of growth hormone, prolactin, and cortisol in pre- and postmenopausal women: the effect of combined estrogen and progestin treatment. J. Clin. Endocrinol. Metab. 93(5), 1655–1661 (2008). doi:10.​1210/​jc.​2007-2677 CrossRefPubMed
11.
Zurück zum Zitat S. Karunakaran, R.C. Page, J.A. Wass, The effect of the menopause on prolactin levels in patients with hyperprolactinaemia. Clin. Endocrinol. 54(3), 295–300 (2001)CrossRef S. Karunakaran, R.C. Page, J.A. Wass, The effect of the menopause on prolactin levels in patients with hyperprolactinaemia. Clin. Endocrinol. 54(3), 295–300 (2001)CrossRef
12.
Zurück zum Zitat P. Touraine, J.F. Martini, B. Zafrani, J.C. Durand, F. Labaille, C. Malet, A. Nicolas, C. Trivin, M.C. Postel-Vinay, F. Kuttenn, P.A. Kelly, Increased expression of prolactin receptor gene assessed by quantitative polymerase chain reaction in human breast tumors versus normal breast tissues. J. Clin. Endocrinol. Metab. 83(2), 667–674 (1998). doi:10.1210/jcem.83.2.4564 CrossRefPubMed P. Touraine, J.F. Martini, B. Zafrani, J.C. Durand, F. Labaille, C. Malet, A. Nicolas, C. Trivin, M.C. Postel-Vinay, F. Kuttenn, P.A. Kelly, Increased expression of prolactin receptor gene assessed by quantitative polymerase chain reaction in human breast tumors versus normal breast tissues. J. Clin. Endocrinol. Metab. 83(2), 667–674 (1998). doi:10.​1210/​jcem.​83.​2.​4564 CrossRefPubMed
13.
Zurück zum Zitat B. Corenblum, L. Donovan, The safety of physiological estrogen plus progestin replacement therapy and with oral contraceptive therapy in women with pathological hyperprolactinemia. Fertil. Steril. 59(3), 671–673 (1993)PubMed B. Corenblum, L. Donovan, The safety of physiological estrogen plus progestin replacement therapy and with oral contraceptive therapy in women with pathological hyperprolactinemia. Fertil. Steril. 59(3), 671–673 (1993)PubMed
14.
Zurück zum Zitat G. Testa, W. Vegetti, T. Motta, F. Alagna, D. Bianchedi, C. Carlucci, M. Bianchi, F. Parazzini, P.G. Crosignani, Two-year treatment with oral contraceptives in hyperprolactinemic patients. Contraception 58(2), 69–73 (1998)CrossRefPubMed G. Testa, W. Vegetti, T. Motta, F. Alagna, D. Bianchedi, C. Carlucci, M. Bianchi, F. Parazzini, P.G. Crosignani, Two-year treatment with oral contraceptives in hyperprolactinemic patients. Contraception 58(2), 69–73 (1998)CrossRefPubMed
15.
Zurück zum Zitat U.M. Fahy, P.A. Foster, H.W. Torode, M. Hartog, M.G. Hull, The effect of combined estrogen/progestogen treatment in women with hyperprolactinemic amenorrhea. Gynecol. Endocrinol. 6(3), 183–188 (1992)CrossRefPubMed U.M. Fahy, P.A. Foster, H.W. Torode, M. Hartog, M.G. Hull, The effect of combined estrogen/progestogen treatment in women with hyperprolactinemic amenorrhea. Gynecol. Endocrinol. 6(3), 183–188 (1992)CrossRefPubMed
16.
Zurück zum Zitat C.M. March, O.A. Kletzky, V. Davajan, J. Teal, M. Weiss, M.L. Apuzzo, R.P. Marrs, D.R. Mishell Jr, Longitudinal evaluation of patients with untreated prolactin-secreting pituitary adenomas. Am. J. Obstet. Gynecol. 139(7), 835–844 (1981)PubMed C.M. March, O.A. Kletzky, V. Davajan, J. Teal, M. Weiss, M.L. Apuzzo, R.P. Marrs, D.R. Mishell Jr, Longitudinal evaluation of patients with untreated prolactin-secreting pituitary adenomas. Am. J. Obstet. Gynecol. 139(7), 835–844 (1981)PubMed
17.
Zurück zum Zitat J. Schlechte, K. Dolan, B. Sherman, F. Chapler, A. Luciano, The natural history of untreated hyperprolactinemia: a prospective analysis. J. Clin. Endocrinol. Metab. 68(2), 412–418 (1989). doi:10.1210/jcem-68-2-412 CrossRefPubMed J. Schlechte, K. Dolan, B. Sherman, F. Chapler, A. Luciano, The natural history of untreated hyperprolactinemia: a prospective analysis. J. Clin. Endocrinol. Metab. 68(2), 412–418 (1989). doi:10.​1210/​jcem-68-2-412 CrossRefPubMed
18.
Zurück zum Zitat M.H. Weiss, J. Teal, P. Gott, R. Wycoff, R. Yadley, M.L. Apuzzo, S.L. Giannotta, O. Kletzky, C. March, Natural history of microprolactinomas: six-year follow-up. Neurosurgery 12(2), 180–183 (1983)CrossRefPubMed M.H. Weiss, J. Teal, P. Gott, R. Wycoff, R. Yadley, M.L. Apuzzo, S.L. Giannotta, O. Kletzky, C. March, Natural history of microprolactinomas: six-year follow-up. Neurosurgery 12(2), 180–183 (1983)CrossRefPubMed
19.
Zurück zum Zitat D.A. Sisam, J.P. Sheehan, L.R. Sheeler, The natural history of untreated microprolactinomas. Fertil. Steril. 48(1), 67–71 (1987)PubMed D.A. Sisam, J.P. Sheehan, L.R. Sheeler, The natural history of untreated microprolactinomas. Fertil. Steril. 48(1), 67–71 (1987)PubMed
20.
Zurück zum Zitat N. Karavitaki, R. Dobrescu, J.V. Byrne, A.B. Grossman, J.A. Wass, Does hypopituitarism recover when macroprolactinomas are treated with cabergoline? Clin. Endocrinol. 79(2), 217–223 (2013). doi:10.1111/cen.12124 CrossRef N. Karavitaki, R. Dobrescu, J.V. Byrne, A.B. Grossman, J.A. Wass, Does hypopituitarism recover when macroprolactinomas are treated with cabergoline? Clin. Endocrinol. 79(2), 217–223 (2013). doi:10.​1111/​cen.​12124 CrossRef
21.
Zurück zum Zitat A. Colao, A. Di Sarno, E. Guerra, R. Pivonello, P. Cappabianca, F. Caranci, A. Elefante, L.M. Cavallo, F. Briganti, S. Cirillo, G. Lombardi, Predictors of remission of hyperprolactinaemia after long-term withdrawal of cabergoline therapy. Clin. Endocrinol. 67(3), 426–433 (2007). doi:10.1111/j.1365-2265.2007.02905.x CrossRef A. Colao, A. Di Sarno, E. Guerra, R. Pivonello, P. Cappabianca, F. Caranci, A. Elefante, L.M. Cavallo, F. Briganti, S. Cirillo, G. Lombardi, Predictors of remission of hyperprolactinaemia after long-term withdrawal of cabergoline therapy. Clin. Endocrinol. 67(3), 426–433 (2007). doi:10.​1111/​j.​1365-2265.​2007.​02905.​x CrossRef
23.
Zurück zum Zitat O.M. Dekkers, J. Lagro, P. Burman, J.O. Jorgensen, J.A. Romijn, A.M. Pereira, Recurrence of hyperprolactinemia after withdrawal of dopamine agonists: systematic review and meta-analysis. J. Clin. Endocrinol. Metab. 95(1), 43–51 (2010). doi:10.1210/jc.2009-1238 CrossRefPubMed O.M. Dekkers, J. Lagro, P. Burman, J.O. Jorgensen, J.A. Romijn, A.M. Pereira, Recurrence of hyperprolactinemia after withdrawal of dopamine agonists: systematic review and meta-analysis. J. Clin. Endocrinol. Metab. 95(1), 43–51 (2010). doi:10.​1210/​jc.​2009-1238 CrossRefPubMed
24.
Zurück zum Zitat J. Webster, G. Piscitelli, A. Polli, C.I. Ferrari, I. Ismail, M.F. Scanlon, A comparison of cabergoline and bromocriptine in the treatment of hyperprolactinemic amenorrhea. Cabergoline Comparative Study Group. N. Engl. J. Med. 331(14), 904–909 (1994). doi:10.1056/NEJM199410063311403 CrossRefPubMed J. Webster, G. Piscitelli, A. Polli, C.I. Ferrari, I. Ismail, M.F. Scanlon, A comparison of cabergoline and bromocriptine in the treatment of hyperprolactinemic amenorrhea. Cabergoline Comparative Study Group. N. Engl. J. Med. 331(14), 904–909 (1994). doi:10.​1056/​NEJM199410063311​403 CrossRefPubMed
26.
Zurück zum Zitat E. Valassi, A. Klibanski, B.M. Biller, Clinical review#: potential cardiac valve effects of dopamine agonists in hyperprolactinemia. J. Clin. Endocrinol. Metab. 95(3), 1025–1033 (2010). doi:10.1210/jc.2009-2095 CrossRefPubMed E. Valassi, A. Klibanski, B.M. Biller, Clinical review#: potential cardiac valve effects of dopamine agonists in hyperprolactinemia. J. Clin. Endocrinol. Metab. 95(3), 1025–1033 (2010). doi:10.​1210/​jc.​2009-2095 CrossRefPubMed
27.
Zurück zum Zitat G. Trifiro, M.M. Mokhles, J.P. Dieleman, E.M. van Soest, K. Verhamme, G. Mazzaglia, R. Herings, C. de Luise, D. Ross, G. Brusselle, A. Colao, W. Haverkamp, R. Schade, G. van Camp, R. Zanettini, M.C. Sturkenboom, Risk of cardiac valve regurgitation with dopamine agonist use in Parkinson’s disease and hyperprolactinaemia: a multi-country, nested case–control study. Drug Saf. 35(2), 159–171 (2012). doi:10.2165/11594940-000000000-00000 CrossRefPubMed G. Trifiro, M.M. Mokhles, J.P. Dieleman, E.M. van Soest, K. Verhamme, G. Mazzaglia, R. Herings, C. de Luise, D. Ross, G. Brusselle, A. Colao, W. Haverkamp, R. Schade, G. van Camp, R. Zanettini, M.C. Sturkenboom, Risk of cardiac valve regurgitation with dopamine agonist use in Parkinson’s disease and hyperprolactinaemia: a multi-country, nested case–control study. Drug Saf. 35(2), 159–171 (2012). doi:10.​2165/​11594940-000000000-00000 CrossRefPubMed
28.
Zurück zum Zitat R.S. Auriemma, R. Pivonello, Y. Perone, L.F. Grasso, L. Ferreri, C. Simeoli, D. Iacuaniello, M. Gasperi, A. Colao, Safety of long-term treatment with cabergoline on cardiac valve disease in patients with prolactinomas. Eur. J. Endocrinol. 169(3), 359–366 (2013). doi:10.1530/EJE-13-0231 CrossRefPubMed R.S. Auriemma, R. Pivonello, Y. Perone, L.F. Grasso, L. Ferreri, C. Simeoli, D. Iacuaniello, M. Gasperi, A. Colao, Safety of long-term treatment with cabergoline on cardiac valve disease in patients with prolactinomas. Eur. J. Endocrinol. 169(3), 359–366 (2013). doi:10.​1530/​EJE-13-0231 CrossRefPubMed
30.
Zurück zum Zitat S.S. Tworoger, A.H. Eliassen, P. Sluss, S.E. Hankinson, A prospective study of plasma prolactin concentrations and risk of premenopausal and postmenopausal breast cancer. J. Clin. Oncol. 25(12), 1482–1488 (2007). doi:10.1200/JCO.2006.07.6356 CrossRefPubMed S.S. Tworoger, A.H. Eliassen, P. Sluss, S.E. Hankinson, A prospective study of plasma prolactin concentrations and risk of premenopausal and postmenopausal breast cancer. J. Clin. Oncol. 25(12), 1482–1488 (2007). doi:10.​1200/​JCO.​2006.​07.​6356 CrossRefPubMed
34.
Zurück zum Zitat S.E. Hankinson, J.E. Manson, D. Spiegelman, W.C. Willett, C. Longcope, F.E. Speizer, Reproducibility of plasma hormone levels in postmenopausal women over a 2–3-year period. Cancer Epidemiol. Biomarkers Prev. 4(6), 649–654 (1995)PubMed S.E. Hankinson, J.E. Manson, D. Spiegelman, W.C. Willett, C. Longcope, F.E. Speizer, Reproducibility of plasma hormone levels in postmenopausal women over a 2–3-year period. Cancer Epidemiol. Biomarkers Prev. 4(6), 649–654 (1995)PubMed
35.
Zurück zum Zitat S.A. Missmer, D. Spiegelman, E.R. Bertone-Johnson, R.L. Barbieri, M.N. Pollak, S.E. Hankinson, Reproducibility of plasma steroid hormones, prolactin, and insulin-like growth factor levels among premenopausal women over a 2- to 3-year period. Cancer Epidemiol. Biomarkers Prev. 15(5), 972–978 (2006). doi:10.1158/1055-9965.EPI-05-0848 CrossRefPubMed S.A. Missmer, D. Spiegelman, E.R. Bertone-Johnson, R.L. Barbieri, M.N. Pollak, S.E. Hankinson, Reproducibility of plasma steroid hormones, prolactin, and insulin-like growth factor levels among premenopausal women over a 2- to 3-year period. Cancer Epidemiol. Biomarkers Prev. 15(5), 972–978 (2006). doi:10.​1158/​1055-9965.​EPI-05-0848 CrossRefPubMed
36.
38.
Zurück zum Zitat J.S. Damiano, K.G. Rendahl, C. Karim, M.G. Embry, M. Ghoddusi, J. Holash, A. Fanidi, T.J. Abrams, J.A. Abraham, Neutralization of prolactin receptor function by monoclonal antibody LFA102, a novel potential therapeutic for the treatment of breast cancer. Mol. Cancer Ther. 12(3), 295–305 (2013). doi:10.1158/1535-7163.MCT-12-0886 CrossRefPubMed J.S. Damiano, K.G. Rendahl, C. Karim, M.G. Embry, M. Ghoddusi, J. Holash, A. Fanidi, T.J. Abrams, J.A. Abraham, Neutralization of prolactin receptor function by monoclonal antibody LFA102, a novel potential therapeutic for the treatment of breast cancer. Mol. Cancer Ther. 12(3), 295–305 (2013). doi:10.​1158/​1535-7163.​MCT-12-0886 CrossRefPubMed
40.
Zurück zum Zitat S.J. Nyante, J.M. Faupel-Badger, M.E. Sherman, R.M. Pfeiffer, M.M. Gaudet, R.T. Falk, A.A. Andaya, J. Lissowska, L.A. Brinton, B. Peplonska, B.K. Vonderhaar, S. Chanock, M. Garcia-Closas, J.D. Figueroa, Genetic variation in PRL and PRLR, and relationships with serum prolactin levels and breast cancer risk: results from a population-based case–control study in Poland. Breast Cancer Res. 13(2), R42 (2011). doi:10.1186/bcr2864 CrossRefPubMedCentralPubMed S.J. Nyante, J.M. Faupel-Badger, M.E. Sherman, R.M. Pfeiffer, M.M. Gaudet, R.T. Falk, A.A. Andaya, J. Lissowska, L.A. Brinton, B. Peplonska, B.K. Vonderhaar, S. Chanock, M. Garcia-Closas, J.D. Figueroa, Genetic variation in PRL and PRLR, and relationships with serum prolactin levels and breast cancer risk: results from a population-based case–control study in Poland. Breast Cancer Res. 13(2), R42 (2011). doi:10.​1186/​bcr2864 CrossRefPubMedCentralPubMed
41.
Zurück zum Zitat H. Wallaschofski, M. Donne, M. Eigenthaler, B. Hentschel, R. Faber, H. Stepan, M. Koksch, T. Lohmann, PRL as a novel potent cofactor for platelet aggregation. J. Clin. Endocrinol. Metab. 86(12), 5912–5919 (2001). doi:10.1210/jcem.86.12.8085 CrossRefPubMed H. Wallaschofski, M. Donne, M. Eigenthaler, B. Hentschel, R. Faber, H. Stepan, M. Koksch, T. Lohmann, PRL as a novel potent cofactor for platelet aggregation. J. Clin. Endocrinol. Metab. 86(12), 5912–5919 (2001). doi:10.​1210/​jcem.​86.​12.​8085 CrossRefPubMed
42.
Zurück zum Zitat A.Q. Reuwer, R. Nieuwland, I. Fernandez, V. Goffin, C.M. van Tiel, M.C. Schaap, R.J. Berckmans, J.J. Kastelein, M.T. Twickler, Prolactin does not affect human platelet aggregation or secretion. Thromb. Haemost. 101(6), 1119–1127 (2009)PubMed A.Q. Reuwer, R. Nieuwland, I. Fernandez, V. Goffin, C.M. van Tiel, M.C. Schaap, R.J. Berckmans, J.J. Kastelein, M.T. Twickler, Prolactin does not affect human platelet aggregation or secretion. Thromb. Haemost. 101(6), 1119–1127 (2009)PubMed
44.
Zurück zum Zitat S.Y. Mon, A. Alkabbani, A. Hamrahian, J.N. Thorton, L. Kennedy, R. Weil, L. Olansky, K. Doshi, V. Makin, B. Hatipoglu, Risk of thromboembolic events in patients with prolactinomas compared with patients with nonfunctional pituitary adenomas. Pituitary 16(4), 523–527 (2013). doi:10.1007/s11102-012-0450-4 CrossRefPubMed S.Y. Mon, A. Alkabbani, A. Hamrahian, J.N. Thorton, L. Kennedy, R. Weil, L. Olansky, K. Doshi, V. Makin, B. Hatipoglu, Risk of thromboembolic events in patients with prolactinomas compared with patients with nonfunctional pituitary adenomas. Pituitary 16(4), 523–527 (2013). doi:10.​1007/​s11102-012-0450-4 CrossRefPubMed
45.
Zurück zum Zitat B. van Zaane, A. Squizzato, A.Q. Reuwer, A.P. van Zanten, M.T. Twickler, O.M. Dekkers, S.C. Cannegieter, H.R. Buller, V.E. Gerdes, D.P. Brandjes, Prolactin and venous thrombosis: indications for a novel risk factor? Arterioscler. Thromb. Vasc. Biol. 31(3), 672–677 (2011). doi:10.1161/ATVBAHA.110.209569 CrossRefPubMed B. van Zaane, A. Squizzato, A.Q. Reuwer, A.P. van Zanten, M.T. Twickler, O.M. Dekkers, S.C. Cannegieter, H.R. Buller, V.E. Gerdes, D.P. Brandjes, Prolactin and venous thrombosis: indications for a novel risk factor? Arterioscler. Thromb. Vasc. Biol. 31(3), 672–677 (2011). doi:10.​1161/​ATVBAHA.​110.​209569 CrossRefPubMed
46.
Zurück zum Zitat A. Ciresi, M.C. Amato, V. Guarnotta, F. Lo Castro, C. Giordano, Higher doses of cabergoline further improve metabolic parameters in patients with prolactinoma regardless of the degree of reduction in prolactin levels. Clin. Endocrinol. (2013). doi:10.1111/cen.12204 A. Ciresi, M.C. Amato, V. Guarnotta, F. Lo Castro, C. Giordano, Higher doses of cabergoline further improve metabolic parameters in patients with prolactinoma regardless of the degree of reduction in prolactin levels. Clin. Endocrinol. (2013). doi:10.​1111/​cen.​12204
47.
Zurück zum Zitat A.Q. Reuwer, M.T. Twickler, B.A. Hutten, F.W. Molema, N.J. Wareham, G.M. Dallinga-Thie, R.L. Bogorad, V. Goffin, M. Smink-Bol, J.J. Kastelein, S.M. Boekholdt, K.T. Khaw, Prolactin levels and the risk of future coronary artery disease in apparently healthy men and women. Circ. Cardiovasc. Genet. 2(4), 389–395 (2009). doi:10.1161/CIRCGENETICS.109.853572 CrossRefPubMed A.Q. Reuwer, M.T. Twickler, B.A. Hutten, F.W. Molema, N.J. Wareham, G.M. Dallinga-Thie, R.L. Bogorad, V. Goffin, M. Smink-Bol, J.J. Kastelein, S.M. Boekholdt, K.T. Khaw, Prolactin levels and the risk of future coronary artery disease in apparently healthy men and women. Circ. Cardiovasc. Genet. 2(4), 389–395 (2009). doi:10.​1161/​CIRCGENETICS.​109.​853572 CrossRefPubMed
50.
Zurück zum Zitat S. Melmed, F.F. Casanueva, A.R. Hoffman, D.L. Kleinberg, V.M. Montori, J.A. Schlechte, J.A. Wass, S. Endocrine, Diagnosis and treatment of hyperprolactinemia: an Endocrine Society clinical practice guideline. J. Clin. Endocrinol. Metab. 96(2), 273–288 (2011). doi:10.1210/jc.2010-1692 CrossRefPubMed S. Melmed, F.F. Casanueva, A.R. Hoffman, D.L. Kleinberg, V.M. Montori, J.A. Schlechte, J.A. Wass, S. Endocrine, Diagnosis and treatment of hyperprolactinemia: an Endocrine Society clinical practice guideline. J. Clin. Endocrinol. Metab. 96(2), 273–288 (2011). doi:10.​1210/​jc.​2010-1692 CrossRefPubMed
Metadaten
Titel
The treatment of hyperprolactinemia in postmenopausal women with prolactin-secreting microadenomas: Cons
verfasst von
Alexander T. Faje
Anne Klibanski
Publikationsdatum
01.02.2015
Verlag
Springer US
Erschienen in
Endocrine / Ausgabe 1/2015
Print ISSN: 1355-008X
Elektronische ISSN: 1559-0100
DOI
https://doi.org/10.1007/s12020-014-0308-9

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Patienten mit Arteriosklerose-bedingten kardiovaskulären Erkrankungen, die trotz Statineinnahme zu hohe Triglyzeridspiegel haben, profitieren von einer Behandlung mit Icosapent-Ethyl, und zwar unabhängig vom individuellen Risikoprofil.

Gibt es eine Wende bei den bioresorbierbaren Gefäßstützen?

In den USA ist erstmals eine bioresorbierbare Gefäßstütze – auch Scaffold genannt – zur Rekanalisation infrapoplitealer Arterien bei schwerer PAVK zugelassen worden. Das markiert einen Wendepunkt in der Geschichte dieser speziellen Gefäßstützen.

Vorsicht, erhöhte Blutungsgefahr nach PCI!

10.05.2024 Koronare Herzerkrankung Nachrichten

Nach PCI besteht ein erhöhtes Blutungsrisiko, wenn die Behandelten eine verminderte linksventrikuläre Ejektionsfraktion aufweisen. Das Risiko ist umso höher, je stärker die Pumpfunktion eingeschränkt ist.

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