Skip to main content
Hauptrubriken
CME Facharzt-Training Webinare Zeitschriften Bücher e.Medpedia Podcast
Service
Jobbörse Info & Hilfe
Fachgebiete
Anästhesiologie Allgemeinmedizin Arbeitsmedizin Augenheilkunde Chirurgie Dermatologie Gynäkologie und Geburtshilfe HNO Innere Medizin Kardiologie Neurologie Onkologie und Hämatologie Orthopädie und Unfallchirurgie Pädiatrie Pathologie Psychiatrie Radiologie Rechtsmedizin Urologie Zahnmedizin
Themen
Klimawandel und Gesundheit Neues aus dem Markt COVID-19 Praxis und Beruf Seltene Erkrankungen GOÄ & EBM Panorama
Sammlungen
Kasuistiken Algorithmen & Infografiken Blickdiagnosen Arthropedia FlapFinder (für Dermatochirurgen) Videos Kongressberichterstattung Medizin für Apothekerinnen und Apotheker Für Ärztinnen und Ärzte in Weiterbildung Für Medizinstudierende

Live-Webinar "Chronische Unterbauch- und Viszeralschmerzen in der Praxis managen"

Das Thema chronische Unterbauch- und Viszeralschmerzen wird im Live-Webinar am 7. Mai von 17.30 bis 19 Uhr aus internistischer, gynäkologischer und psychologisch-neurowissenschaftlicher Perspektive beleuchtet. Besprochen werden krankheitsbedingte Ursachen, Mechanismen der kognitiven Schmerzmodulation sowie mögliche Therapieoptionen. Die Fortbildung ist mit 2 CME-Punkten zertifiziert. Melden Sie sich jetzt an!
Erweiterte Suche
Anmelden
nach oben
Immunologic Research
Erschienen in: Immunologic Research 3/2008

01.07.2008

TCR-MHC docking orientation: natural selection, or thymic selection?

verfasst von: Edward J. Collins, David S. Riddle

Erschienen in: Immunologic Research | Ausgabe 3/2008

Einloggen, um Zugang zu erhalten

Abstract

T cell receptors (TCR) dock on their peptide-major histocompatibility complex (pMHC) targets in a conserved orientation. Since amino acid sidechains are the foundation of specific protein–protein interactions, a simple explanation for the conserved docking orientation is that key amino acids encoded by the TCR and MHC genes have been selected and maintained through evolution in order to preserve TCR/pMHC binding. Expectations that follow from the hypothesis that TCR and MHC evolved to interact are discussed in light of the data that both support and refute them. Finally, an alternative and equally simple explanation for the driving force behind the conserved docking orientation is described.
Literatur
1.
Garboczi DN, Ghosh P, Utz U, Fan QR, Biddison WE, Wiley DC. Structure of the complex between human T-cell receptor, viralpeptide and HLA-A2. Nature. 1996;384(6605):34–41.
2.
Garcia KC, Scott CA, Brunmark A, Carbone FR, Peterson PA, Wilson LA, et al. CD8 enhances formation of stable T-cell receptor/MHC class I molecule complexes. Nature. 1996;384(6609):577–81.PubMed
3.
Daniel C, Horvath S, Allen PM. A basis for alloreactivity: MHC helical residues broaden peptide recognition by the TCR. Immunity. 1998;8(5):543–52.PubMed
4.
Garcia KC, Degano M, Pease LR, Huang M, Peterson PA, Teyton L, et al. Structural basis of plasticity in T cell receptor recognition of a self peptide-MHC antigen. Science. 1998;279(5354):1166–72.PubMed
5.
Ding YH, Baker BM, Garboczi DN, Biddison WE, Wiley DC. Four A6-TCR/peptide/HLA-A2 structures that generate very different T cell signals are nearly identical. Immunity. 1999;11(1):45–56.PubMed
6.
Reiser JB, Darnault C, Guimezanes A, Gregoire C, Mosser T, Schmitt-Verhulst AM, et al. Crystal structure of a T cell receptor bound to an allogeneic MHC molecule. Nat Immunol. 2000;1(4):291–7.PubMed
7.
Buslepp J, Wang H, Biddison W, Appella E, Collins EJ. A correlation between TCR Valpha docking on MHC and CD8 dependence: implications for T cell selection. Immunity. 2003;19(4):595–606.PubMed
8.
Stewart-Jones GB, McMichael AJ, Bell JI, Stuart DI, Jones EY. A structural basis for immunodominant human T cell receptor recognition. Nat Immunol. 2003;4(7):657–63.PubMed
9.
Jerne NK. The somatic generation of immune recognition. Eur J Immunol. 1971;1(1):1–9.PubMed
10.
Cohn M. Tritope model of restrictive recognition by the TCR. Trends Immunol. 2003;24(3):127–31.PubMed
11.
Cohn M. Distinguishing the tritope from the interaction antigen models. Trends Immunol. 2004;25(1):8–9; author reply 9–10.PubMed
12.
Eddy SR. Non-coding RNA genes and the modern RNA world. Nat Rev Genet. 2001;2(12):919–29.PubMed
13.
Gutell RR, Noller HF, Woese CR. Higher order structure in ribosomal RNA. EMBO J. 1986;5(5):1111–3.PubMed
14.
Noller HF, Woese CR. Secondary structure of 16S ribosomal RNA. Science. 1981;212(4493):403–11.PubMed
15.
Pedersen JS, Bejerano G, Siepel A, Rosenbloom K, Lindblad-Toh K, Lander ES, et al. Identification and classification of conserved RNA secondary structures in the human genome. PLoS Comput Biol. 2006;2(4):e33.PubMed
16.
Rzhetsky A. Estimating substitution rates in ribosomal RNA genes. Genetics. 1995;141(2):771–83.PubMed
17.
Moyle WR, Campbell RK, Myers RV, Bernard MP, Han Y, Wang X. Co-evolution of ligand-receptor pairs. Nature. 1994;368(6468):251–5.PubMed
18.
van Kesteren RE, Tensen CP, Smit AB, van Minnen J, Kolakowski LF, Meyerhof W, et al. Co-evolution of ligand-receptor pairs in the vasopressin/oxytocin superfamily of bioactive peptides. J Biol Chem. 1996;271(7):3619–26.PubMed
19.
Li A, Sadasivam M, Ding JL. Receptor-ligand interaction between vitellogenin receptor (VtgR) and vitellogenin (Vtg), implications on low density lipoprotein receptor and apolipoprotein B/E. The first three ligand-binding repeats of VtgR interact with the amino-terminal region of Vtg. J Biol Chem. 2003;278(5):2799–806.PubMed
20.
Robinson J, Waller MJ, Parham P, de Groot N, Bontrop R, Kennedy LJ, et al. IMGT/HLA and IMGT/MHC: sequence databases for the study of the major histocompatibility complex. Nucleic Acids Res. 2003;31(1):311–4.PubMed
21.
Ohta T. Gene conversion vs point mutation in generating variability at the antigen recognition site of major histocompatibility complex loci. J Mol Evol. 1995;41(2):115–9.PubMed
22.
Hill AV, Allsopp CE, Kwiatkowski D, Anstey NM, Twumasi P, Rowe PA, et al. Common west African HLA antigens are associated with protection from severe malaria. Nature. 1991;352(6336):595–600.PubMed
23.
Thursz MR, Kwiatkowski D, Allsopp CE, Greenwood BM, Thomas HC, Hill AV. Association between an MHC class II allele and clearance of hepatitis B virus in the Gambia. N Engl J Med. 1995;332(16):1065–9.PubMed
24.
Rast JP, Anderson MK, Strong SJ, Luer C, Litman RT, Litman GW. Alpha, beta, gamma, and delta T cell antigen receptor genes arose early in vertebrate phylogeny. Immunity. 1997;6(1):1–11.PubMed
25.
Li WH, Gouy M, Sharp PM, O’HUigin C, Yang YW. Molecular phylogeny of Rodentia, Lagomorpha, Primates, Artiodactyla, and Carnivora and molecular clocks. Proc Natl Acad Sci USA. 1990;87(17):6703–7.PubMed
26.
Mikkelsen TS, Wakefield MJ, Aken B, Amemiya CT, Chang JL, Duke S, et al. Genome of the marsupial Monodelphis domestica reveals innovation in non-coding sequences. Nature. 2007;447(7141):167–77.PubMed
27.
Parra ZE, Baker ML, Hathaway J, Lopez AM, Trujillo J, Sharp A, et al. Comparative genomic analysis and evolution of the T cell receptor loci in the opossum Monodelphis domestica. BMC Genomics. 2008;9:111.PubMed
28.
Criscitiello MF, Saltis M, Flajnik MF. An evolutionarily mobile antigen receptor variable region gene: doubly rearranging NAR-TcR genes in sharks. Proc Natl Acad Sci USA. 2006;103(13):5036–41.PubMed
29.
Reiser JB, Gregoire C, Darnault C, Mosser T, Guimezanes A, Schmitt-Verhulst AM, et al. A T cell receptor CDR3beta loop undergoes conformational changes of unprecedented magnitude upon binding to a peptide/MHC class I complex. Immunity. 2002;16(3):345–54.PubMed
30.
Mazza C, Malissen B. What guides MHC-restricted TCR recognition? Semin Immunol. 2007;19(4):225–35.PubMed
31.
Hahn M, Nicholson MJ, Pyrdol J, Wucherpfennig KW. Unconventional topology of self peptide-major histocompatibility complex binding by a human autoimmune T cell receptor. Nat Immunol. 2005;6(5):490–6.PubMed
32.
Li Y, Huang Y, Lue J, Quandt JA, Martin R, Mariuzza RA. Structure of a human autoimmune TCR bound to a myelin basic protein self-peptide and a multiple sclerosis-associated MHC class II molecule. Embo J. 2005;24(17):2968–79.PubMed
33.
Ely LK, Beddoe T, Clements CS, Matthews JM, Purcell AW, Kjer-Nielsen L, et al. Disparate thermodynamics governing T cell receptor-MHC-I interactions implicate extrinsic factors in guiding MHC restriction. Proc Natl Acad Sci USA. 2006;103(17):6641–6.PubMed
34.
Feng D, Bond CJ, Ely LK, Maynard J, Garcia KC. Structural evidence for a germline-encoded T cell receptor-major histocompatibility complex interaction ‘codon’. Nat Immunol. 2007;8(9):975–83.PubMed
35.
Dai S, Huseby ES, Rubtsova K, Scott-Browne J, Crawford F, Macdonald WA, et al. Crossreactive T Cells spotlight the germline rules for alphabeta T cell-receptor interactions with MHC molecules. Immunity. 2008;28(3):324–34.PubMed
36.
Wang C, Bradley P, Baker D. Protein-protein docking with backbone flexibility. J Mol Biol. 2007;373(2):503–19.PubMed
37.
McBeth C, Seamons A, Pizarro JC, Fleishman SJ, Baker D, Kortemme T, et al. A new twist in TCR diversity revealed by a forbidden alphabeta TCR. J Mol Biol. 2008;375(5):1306–19.PubMed
38.
Sim BC, Wung JL, Gascoigne NR. Polymorphism within a TCRAV family influences the repertoire through class I/II restriction. J Immunol. 1998;160(3):1204–11.PubMed
39.
Jameson SC, Kaye J, Gascoigne NR. A T cell receptor V alpha region selectively expressed in CD4+ cells. J Immunol. 1990;145(5):1324–31.PubMed
40.
Jameson SC, Nakajima PB, Brooks JL, Heath W, Kanagawa O, Gascoigne NR. The T cell receptor V alpha 11 gene family. Analysis of allelic sequence polymorphism and demonstration of J alpha region-dependent recognition by allele-specific antibodies. J Immunol. 1991;147(9):3185–93.PubMed
41.
Sim BC, Gascoigne NR. Reciprocal expression in CD4 or CD8 subsets of different members of the V alpha 11 gene family correlates with sequence polymorphism. J Immunol. 1999;162(6):3153–9.PubMed
42.
Sim BC, Zerva L, Greene MI, Gascoigne NR. Control of MHC restriction by TCR Valpha CDR1 and CDR2. Science. 1996;273(5277):963–6.PubMed
43.
Sim BC, Lo D, Gascoigne NR. Preferential expression of TCR V alpha regions in CD4/CD8 subsets: class discrimination or co-receptor recognition? Immunol Today. 1998;19(6):276–82.PubMed
44.
Manning TC, Parke EA, Teyton L, Kranz DM. Effects of complementarity determining region mutations on the affinity of an alpha/beta T cell receptor: measuring the energy associated with CD4/CD8 repertoire skewing. J Exp Med. 1999;189(3):461–70.PubMed
45.
Correia-Neves M, Waltzinger C, Wurtz JM, Benoist C, Mathis D. Amino acids specifying MHC class preference in TCR V alpha 2 regions. J Immunol. 1999;163(10):5471–7.PubMed
46.
Eshima K, Suzuki H, Shinohara N. Cross-positive selection of thymocytes expressing a single TCR by multiple major histocompatibility complex molecules of both classes: implications for CD4+ versus CD8+ lineage commitment. J Immunol. 2006;176(3):1628–36.PubMed
47.
Merkenschlager M, Benoist C, Mathis D. MHC control of the naive TCR alpha-chain repertoire. J Immunol. 1994;153(7):3005–13.PubMed
48.
Turner SJ, Doherty PC, McCluskey J, Rossjohn J. Structural determinants of T-cell receptor bias in immunity. Nat Rev Immunol. 2006;6(12):883–94.PubMed
49.
Lim A, Trautmann L, Peyrat MA, Couedel C, Davodeau F, Romagne F, et al. Frequent contribution of T cell clonotypes with public TCR features to the chronic response against a dominant EBV-derived epitope: application to direct detection of their molecular imprint on the human peripheral T cell repertoire. J Immunol. 2000;165(4):2001–11.PubMed
50.
Casrouge A, Beaudoing E, Dalle S, Pannetier C, Kanellopoulos J, Kourilsky P. Size estimate of the alpha beta TCR repertoire of naive mouse splenocytes. J Immunol. 2000;164(11):5782–7.PubMed
51.
Penit C, Lucas B, Vasseur F. Cell expansion and growth arrest phases during the transition from precursor (CD4−8−) to immature (CD4+8+) thymocytes in normal and genetically modified mice. J Immunol. 1995;154(10):5103–13.PubMed
52.
Hamrouni A, Aublin A, Guillaume P, Maryanski JL. T cell receptor gene rearrangement lineage analysis reveals clues for the origin of highly restricted antigen-specific repertoires. J Exp Med. 2003;197(5):601–14.PubMed
53.
Hughes MM, Yassai M, Sedy JR, Wehrly TD, Huang CY, Kanagawa O, et al. T cell receptor CDR3 loop length repertoire is determined primarily by features of the V(D)J recombination reaction. Eur J Immunol. 2003;33(6):1568–75.PubMed
54.
Kortemme T, Baker D. A simple physical model for binding energy hot spots in protein-protein complexes. Proc Natl Acad Sci USA. 2002;99(22):14116–21.PubMed
55.
Adams EJ, Strop P, Shin S, Chien YH, Garcia KC. An autonomous CDR3delta is sufficient for recognition of the nonclassical MHC class I molecules T10 and T22 by gammadelta T cells. Nat Immunol. 2008;9(7):777–84.PubMed
56.
Blackman M, Yague J, Kubo R, Gay D, Coleclough C, Palmer E, et al. The T cell repertoire may be biased in favor of MHC recognition. Cell. 1986;47(3):349–57.PubMed
57.
Ignatowicz L, Kappler J, Marrack P. The repertoire of T cells shaped by a single MHC/peptide ligand. Cell. 1996;84(4):521–9.PubMed
58.
Marrack P, Bender J, Jordan M, Rees W, Robertson J, Schaefer BC, et al. Major histocompatibility complex proteins and TCRs: do they really go together like a horse and carriage? J Immunol. 2001;167(2):617–21.PubMed
59.
Liu CP, Parker D, Kappler J, Marrack P. Selection of antigen-specific T cells by a single IEk peptide combination. J Exp Med. 1997;186(9):1441–50.PubMed
60.
Huseby ES, White J, Crawford F, Vass T, Becker D, Pinilla C, et al. How the T cell repertoire becomes peptide and MHC specific. Cell. 2005;122(2):247–60.PubMed
61.
Woolnough JA, Misko IS, Lafferty KJ. Cytotoxic and proliferative lymphocyte responses to allogeneic and xenogeneic antigens in vitro. Aust J Exp Biol Med Sci. 1979;57(5):467–77.PubMed
62.
Engelhard VH, Le AX, Holterman MJ. Species-specific structural differences in the alpha 1 + alpha 2 domains determine the frequency of murine cytotoxic T cell precursors stimulated by human and murine class I molecules. J Immunol. 1988;141(6):1835–9.PubMed
63.
Irwin MJ, Heath WR, Sherman LA. Species-restricted interactions between CD8 and the alpha 3 domain of class I influence the magnitude of the xenogeneic response. J Exp Med. 1989;170(4):1091–101.PubMed
64.
Zerrahn J, Held W, Raulet DH. The MHC reactivity of the T cell repertoire prior to positive and negative selection. Cell. 1997;88(5):627–36.PubMed
65.
Laouini D, Casrouge A, Dalle S, Lemonnier F, Kourilsky P, Kanellopoulos J. V beta T cell repertoire of CD8+ splenocytes selected on nonpolymorphic MHC class I molecules. J Immunol. 2000;165(11):6381–6.PubMed
66.
Berg RE, Princiotta MF, Irion S, Moticka JA, Dahl KR, Staerz UD. Positive selection of an H2-M3 restricted T cell receptor. Immunity. 1999;11(1):33–43.PubMed
67.
Kurepa Z, Su J, Forman J. Memory phenotype of CD8+ T cells in MHC class la-deficient mice. J Immunol. 2003;170(11):5414–20.PubMed
68.
Seaman MS, Perarnau B, Lindahl KF, Lemonnier FA, Forman J. Response to Listeria monocytogenes in mice lacking MHC class Ia molecules. J Immunol. 1999;162(9):5429–36.PubMed
69.
Rohrlich PS, Fazilleau N, Ginhoux F, Firat H, Michel F, Cochet M, et al. Direct recognition by alphabeta cytolytic T cells of Hfe, a MHC class Ib molecule without antigen-presenting function. Proc Natl Acad Sci USA. 2005;102(36):12855–60.PubMed
70.
Grusby MJ, Auchincloss H Jr, Lee R, Johnson RS, Spencer JP, Zijlstra M, et al. Mice lacking major histocompatibility complex class I and class II molecules. Proc Natl Acad Sci USA. 1993;90(9):3913–7.PubMed
71.
Lee RS, Grusby MJ, Laufer TM, Colvin R, Glimcher LH, Auchincloss H Jr. CD8+ effector cells responding to residual class I antigens, with help from CD4+ cells stimulated indirectly, cause rejection of “major histocompatibility complex-deficient” skin grafts. Transplantation. 1997;63(8):1123–33.PubMed
72.
Merkenschlager M, Graf D, Lovatt M, Bommhardt U, Zamoyska R, Fisher AG. How many thymocytes audition for selection? J Exp Med. 1997;186(7):1149–58.PubMed
73.
Henderson SC, Berezovskaya A, English A, Palliser D, Rock KL, Bamezai A. CD4+ T cells mature in the absence of MHC class I and class II expression in Ly-6A.2 transgenic mice. J Immunol. 1998;161(1):175–82.PubMed
74.
Robey E, Itano A, Fanslow WC, Fowlkes BJ. Constitutive CD8 expression allows inefficient maturation of CD4+ helper T cells in class II major histocompatibility complex mutant mice. J Exp Med. 1994;179(6):1997–2004.PubMed
75.
Swanson PA 2nd, Pack CD, Hadley A, Wang CR, Stroynowski I, Jensen PE, et al. An MHC class Ib-restricted CD8 T cell response confers antiviral immunity. J Exp Med. 2008;205(7):1647–57.PubMed
76.
Lefranc MP. IMGT, the international ImMunoGeneTics information system(R): a standardized approach for immunogenetics and immunoinformatics. Immunome Res. 2005;1(1):3.PubMed
77.
Bangham R, Michaud GA, Schweitzer B, Predki PF. Protein microarray-based screening of antibody specificity. Methods Mol Med. 2005;114:173–82.PubMed
78.
Van Laethem F, Sarafova SD, Park JH, Tai X, Pobezinsky L, Guinter TI, et al. Deletion of CD4 and CD8 coreceptors permits generation of alphabeta T cells that recognize antigens independently of the MHC. Immunity. 2007;27(5):735–50.PubMedCrossRef
79.
Huseby ES, Kappler JW, Marrack P. Thymic selection stifles TCR reactivity with the main chain structure of MHC and forces interactions with the peptide side chains. Mol Immunol. 2008;45(3):599–606.PubMed
80.
Marrack P, Scott-Browne JP, Dai S, Gapin L, Kappler JW. Evolutionary conserved amino acids that control TCR-MHC interaction. Annu Rev Immunol. 2008;26:171–203.PubMed
81.
Coif LA, Bankovich AJ, Hanick NA, Bowerman NA, Jones LL, Kranz DM, et al. How a single T cell receptor recognizes both self and foreign MHC. Cell. 2007;129(1):135–46.
82.
Batalia MA, Collins EJ. Peptide binding by class I and class II MHC molecules. Biopolymers. 1997;43(4):281–302.PubMed
83.
Garcia KC, Adams EJ. How the T cell receptor sees antigen—a structural view. Cell. 2005;122(3):333–6.PubMed
84.
Miller PJ, Pazy Y, Conti B, Riddle D, Appella E, Collins EJ. Single MHC mutation eliminates enthalpy associated with T cell receptor binding. J Mol Biol. 2007;373(2):315–27.PubMed
85.
Hutchinson SL, Wooldridge L, Tafuro S, Laugel B, Glick M, Boulter JM, et al. The CD8 T cell coreceptor exhibits disproportionate biological activity at extremely low binding affinities. J Biol Chem. 2003;278(27):24285–93.PubMed
86.
Pecht I, Gakamsky DM. Spatial coordination of CD8 and TCR molecules controls antigen recognition by CD8+ T-cells. FEBS Lett. 2005;579(15):3336–41.PubMed
87.
Mallaun M, Naeher D, Daniels MA, Yachi PP, Hausmann B, Luescher IF, et al. The T cell receptor’s alpha-chain connecting peptide motif promotes close approximation of the CD8 coreceptor allowing efficient signal initiation. J Immunol. 2008;180(12):8211–21.PubMed
88.
Purbhoo MA, Boulter JM, Price DA, Vuidepot AL, Hourigan CS, Dunbar PR, et al. The human CD8 coreceptor effects cytotoxic T cell activation and antigen sensitivity primarily by mediating complete phosphorylation of the T cell receptor zeta chain. J Biol Chem. 2001;276(35):32786–92.PubMed
89.
Wooldridge L, van den Berg HA, Glick M, Gostick E, Laugel B, Hutchinson SL, et al. Interaction between the CD8 coreceptor and major histocompatibility complex class I stabilizes T cell receptor-antigen complexes at the cell surface. J Biol Chem. 2005;280(30):27491–501.PubMed
90.
Wyer JR, Willcox BE, Gao GF, Gerth UC, Davis SJ, Bell JI, et al. T cell receptor and coreceptor CD8 alphaalpha bind peptide-MHC independently and with distinct kinetics. Immunity. 1999;10(2):219–25.PubMed
91.
Norment AM, Salter RD, Parham P, Engelhard VH, Littman DR. Cell-cell adhesion mediated by CD8 and MHC class I molecules. Nature. 1988;336(6194):79–81.PubMed
92.
Jelonek MT, Classon BJ, Hudson PJ, Margulies DH. Direct binding of the MHC class I molecule H-2Ld to CD8: interaction with the amino terminus of a mature cell surface protein. J Immunol. 1998;160(6):2809–14.PubMed
93.
Daniels MA, Jameson SC. Critical role for CD8 in T cell receptor binding and activation by peptide/major histocompatibility complex multimers. J Exp Med. 2000;191(2):335–46.PubMed
94.
Holler PD, Kranz DM. Quantitative analysis of the contribution of TCR/pepMHC affinity and CD8 to T cell activation. Immunity. 2003;18(2):255–64.PubMed
95.
Norment AM, Littman DR. A second subunit of CD8 is expressed in human T cells. Embo J. 1988;7(11):3433–9.PubMed
96.
Bachmann MF, Oxenius A, Mak TW, Zinkernagel RM. T cell development in CD8−/− mice. Thymic positive selection is biased toward the helper phenotype. J Immunol. 1995;155(8):3727–33.PubMed
97.
Arcaro A, Gregoire C, Boucheron N, Stotz S, Palmer E, Malissen B, et al. Essential role of CD8 palmitoylation in CD8 coreceptor function. J Immunol. 2000;165(4):2068–76.PubMed
98.
Bosselut R, Kubo S, Guinter T, Kopacz JL, Altman JD, Feigenbaum L, et al. Role of CD8beta domains in CD8 coreceptor function: importance for MHC I binding, signaling, and positive selection of CD8+ T cells in the thymus. Immunity. 2000;12(4):409–18.PubMed
99.
McNicol AM, Bendle G, Holler A, Matjeka T, Dalton E, Rettig L, et al. CD8alpha/alpha homodimers fail to function as co-receptor for a CD8-dependent TCR. Eur J Immunol. 2007;37(6):1634–41.PubMed
100.
Turner JM, Brodsky MH, Irving BA, Levin SD, Perlmutter RM, Littman DR. Interaction of the unique N-terminal region of tyrosine kinase p56lck with cytoplasmic domains of CD4 and CD8 is mediated by cysteine motifs. Cell. 1990;60(5):755–65.PubMed
101.
Shaw AS, Chalupny J, Whitney JA, Hammond C, Amrein KE, Kavathas P, et al. Short related sequences in the cytoplasmic domains of CD4 and CD8 mediate binding to the amino-terminal domain of the p56lck tyrosine protein kinase. Mol Cell Biol. 1990;10(5):1853–62.PubMed
102.
Zamoyska R, Derham P, Gorman SD, von Hoegen P, Bolen JB, Veillette A, et al. Inability of CD8 alpha′ polypeptides to associate with p56lck correlates with impaired function in vitro and lack of expression in vivo. Nature. 1989;342(6247):278–81.PubMed
103.
Love PE, Lee J, Shores EW. Critical relationship between TCR signaling potential and TCR affinity during thymocyte selection. J Immunol. 2000;165(6):3080–7.PubMed
104.
Gao GF, Tormo J, Gerth UC, Wyer JR, McMichael AJ, Stuart DI, et al. Crystal structure of the complex between human CD8alpha(alpha) and HLA-A2. Nature. 1997;387(6633):630–4.PubMed
105.
Kern PS, Teng MK, Smolyar A, Liu JH, Liu J, Hussey RE, et al. Structural basis of CD8 coreceptor function revealed by crystallographic analysis of a murine CD8alphaalpha ectodomain fragment in complex with H-2Kb. Immunity. 1998;9(4):519–30.PubMed
106.
Chang HC, Tan K, Ouyang J, Parisini E, Liu JH, Le Y, et al. Structural and mutational analyses of a CD8alphabeta heterodimer and comparison with the CD8alphaalpha homodimer. Immunity. 2005;23(6):661–71.PubMed
107.
Kwan Lim GE, McNeill L, Whitley K, Becker DL, Zamoyska R. Co-capping studies reveal CD8/TCR interactions after capping CD8β polypeptides and intracellular associations of CD8 with p56lck. Eur J Immunol. 1998;28(2):745–54.PubMed
108.
Boursier JP, Alcover A, Herve F, Laisney I, Acuto O. Evidence for an extended structure of the T-cell co-receptor CD8 alpha as deduced from the hydrodynamic properties of soluble forms of the extracellular region. J Biol Chem. 1993;268(3):2013–20.PubMed
109.
Manolios N, Bonifacino JS, Klausner RD. Transmembrane helical interactions and the assembly of the T cell receptor complex. Science. 1990;249(4966):274–7.PubMed
110.
Backstrom BT, Milia E, Peter A, Jaureguiberry B, Baldari CT, Palmer E. A motif within the T cell receptor alpha chain constant region connecting peptide domain controls antigen responsiveness. Immunity. 1996;5(5):437–47.PubMed
111.
Naeher D, Luescher IF, Palmer E. A role for the alpha-chain connecting peptide motif in mediating TCR-CD8 cooperation. J Immunol. 2002;169(6):2964–70.PubMed
112.
Ulivieri C, Peter A, Orsini E, Palmer E, Baldari CT. Defective signaling to Fyn by a T cell antigen receptor lacking the alpha-chain connecting peptide motif. J Biol Chem. 2001;276(5):3574–80.PubMed
113.
Werlen G, Hausmann B, Palmer E. A motif in the alphabeta T-cell receptor controls positive selection by modulating ERK activity. Nature. 2000;406(6794):422–6.PubMed
114.
Gagnon SJ, Borbulevych OY, Davis-Harrison RL, Turner RV, Damirjian M, Wojnarowicz A, et al. T cell receptor recognition via cooperative conformational plasticity. J Mol Biol. 2006;363(1):228–43.PubMed
115.
Ding YH, Smith KJ, Garboczi DN, Utz U, Biddison WE, Wiley DC. Two human T cell receptors bind in a similar diagonal mode to the HLA-A2/Tax peptide complex using different TCR amino acids. Immunity. 1998;8(4):403–11.PubMed
116.
Chen JL, Stewart-Jones G, Bossi G, Lissin NM, Wooldridge L, Choi EM, et al. Structural and kinetic basis for heightened immunogenicity of T cell vaccines. J Exp Med. 2005;201(8):1243–55.PubMed
117.
Sami M, Rizkallah P, Dunn S, Molloy P, Moysey R, Vuidepot A, et al. Crystal structures of high affinity human T-cell receptors bound to peptide major histocompatibility complex reveal native diagonal binding geometry. Protein Eng Des Sel. 2007;20:397–403.PubMed
118.
Tynan FE, Burrows SR, Buckle AM, Clements CS, Borg NA, Miles JJ, et al. T cell receptor recognition of a ‘super-bulged’ major histocompatibility complex class I-boundpeptide. Nat Immunol. 2005;6(11):1114–22.PubMed
119.
Kjer-Nielsen L, Clements CS, Brooks AG, Purcell AW, McCluskey J, Rossjohn J. The 1.5 A crystal structure of a highly selected antiviral T cell receptor provides evidence for a structural basis of immunodominance. Structure. 2002;10(11):1521–32.PubMed
120.
Tynan FE, Reid HH, Kjer-Nielsen L, Miles JJ, Wilce MC, Kostenko L, et al. A T cell receptor flattens a bulged antigenic peptide presented by a major histocompatibility complex class I molecule. Nat Immunol. 2007;8(3):268–76.PubMed
121.
Reiser JB, Darnault C, Gregoire C, Mosser T, Mazza G, Kearney A, et al. CDR3 loop flexibility contributes to the degeneracy of TCR recognition. Nat Immunol. 2003;4(3):241–7.PubMed
122.
Housset D, Mazza G, Gregoire C, Piras C, Malissen B, Fontecilla-Camps JC. The three-dimensional structure of a T-cell antigen receptor V alpha V beta heterodimer reveals a novel arrangement of the V beta domain. Embo J. 1997;16(14):4205–16.PubMed
123.
Teng MK, Smolyar A, Tse AG, Liu JH, Liu J, Hussey RE, et al. Identification of a common docking topology with substantial variation among different TCR-peptide-MHC complexes. Curr Biol. 1998;8(7):409–12.PubMed
124.
Wang J, Lim K, Smolyar A, Teng M, Liu J, Tse AG, et al. Atomic structure of an alphabeta T cell receptor (TCR) heterodimer in complex with an anti-TCR fab fragment derived from a mitogenic antibody. Embo J. 1998;17(1):10–26.PubMed
125.
Luz JG, Huang M, Garcia KC, Rudolph MG, Apostolopoulos V, Teyton L, et al. Structural comparison of allogeneic and syngeneic T cell receptor-peptide-major histocompatibility complex complexes: a buried alloreactive mutation subtly alters peptide presentation substantially increasing V(beta) Interactions. J Exp Med. 2002;195(9):1175–86.PubMed
126.
Degano M, Garcia KC, Apostolopoulos V, Rudolph MG, Teyton L, Wilson LA. A functional hot spot for antigen recognition in a superagonist TCR/MHC complex. Immunity. 2000;12(3):251–61.PubMed
127.
Hoare HL, Sullivan LC, Pietra G, Clements CS, Lee EJ, Ely LK, et al. Structural basis for a major histocompatibility complex class Ib-restricted T cell response. Nat Immunol. 2006;7(3):256–64.PubMed
128.
Hennecke J, Carfi A, Wiley DC. Structure of a covalently stabilized complex of a human alphabeta T-cell receptor, influenza HA peptide and MHC class II molecule, HLA-DR1. Embo J. 2000;19(21):5611–24.PubMed
129.
Hennecke J, Wiley DC. Structure of a complex of the human alpha/beta T cell receptor (TCR) HA 1.7, influenza hemagglutinin peptide, and major histocompatibility complex class II molecule, HLA-DR4 (DRA*0101 and DRB 1*0401): insight into TCR cross-restriction and alloreactivity. J Exp Med. 2002;195(5):571–81.PubMed
130.
Reinherz EL, Tan K, Tang L, Kern P, Liu J, Xiong Y, et al. The crystal structure of a T cell receptor in complex with peptide and MHC class II. Science. 1999;286(5446):1913–21.PubMed
131.
Hare BJ, Wyss DF, Osburne MS, Kern PS, Reinherz EL, Wagner G. Structure, specificity and CDR mobility of a class II restricted single-chain T-cell receptor. Nat Struct Biol. 1999;6(6):574–81.PubMed
132.
Maynard J, Petersson K, Wilson DH, Adams EJ, Blondelle SE, Boulanger MJ, et al. Structure of an autoimmune T cell receptor complexed with class II peptide-MHC: insights into MHC bias and antigen specificity. Immunity. 2005;22(1):81–92.PubMed
Metadaten
Titel
TCR-MHC docking orientation: natural selection, or thymic selection?
verfasst von
Edward J. Collins
David S. Riddle
Publikationsdatum
01.07.2008
Verlag
Humana Press Inc
Erschienen in
Immunologic Research / Ausgabe 3/2008
Print ISSN: 0257-277X
Elektronische ISSN: 1559-0755
DOI
https://doi.org/10.1007/s12026-008-8040-2

Weitere Artikel der Ausgabe 3/2008

Immunologic Research 3/2008 Zur Ausgabe

OriginalPaper

Complement and cutaneous autoimmune blistering diseases

OriginalPaper

Microglial cells and Parkinson’s disease

OriginalPaper

Anti-Sm B cell tolerance and tolerance loss in systemic lupus erythematosus

OriginalPaper

NF-κB pathways in the immune system: control of the germinal center reaction

OriginalPaper

Foxp3 and Treg cells in HIV-1 infection and immuno-pathogenesis

OriginalPaper

The evolving role of semaphorins and plexins in the immune system: Plexin-A1 regulation of dendritic cell function

Neu im Fachgebiet HNO

Nur selten Nachblutungen nach Abszesstonsillektomie

03.05.2024 Tonsillektomie Nachrichten

In einer Metaanalyse von 18 Studien war die Rate von Nachblutungen nach einer Abszesstonsillektomie mit weniger als 7% recht niedrig. Nur rund 2% der Behandelten mussten nachoperiert werden. Die Therapie scheint damit recht sicher zu sein.

Rezidivierender Peritonsillarabszess nach Oralsex

02.05.2024 Peritonsillarabszess Kasuistik

Die erotischen Dimensionen von Peritonsillarabszessen scheinen eng begrenzt zu sein. Das heißt aber nicht, solche Abszesse und Erotik hätten nichts miteinander gemein, wie ein Fallbericht verdeutlicht.

Endlich: Zi zeigt, mit welchen PVS Praxen zufrieden sind

IT für Ärzte Nachrichten

Darauf haben viele Praxen gewartet: Das Zi hat eine Liste von Praxisverwaltungssystemen veröffentlicht, die von Nutzern positiv bewertet werden. Eine gute Grundlage für wechselwillige Ärzte und Psychotherapeuten.

Kinder mit anhaltender Sinusitis profitieren häufig von Antibiotika

30.04.2024 Rhinitis und Sinusitis Nachrichten

Persistieren Sinusitisbeschwerden bei Kindern länger als zehn Tage, ist eine Antibiotikatherapie häufig gut wirksam: Ein Therapieversagen ist damit zu über 40% seltener zu beobachten als unter Placebo.

Update HNO

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert – ganz bequem per eMail.

Newsletter bestellen
Bildnachweise