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01.03.2011 | Letter to the Editor

A First Reported Case of Dedifferentiated Liposarcoma of the Esophagus with Molecular Diagnosis

verfasst von: Emmanuel Watkin, Mojgan Devouassoux-Shisheboran, Florence Pedeutour, Pauline Lagarde, Monique Salle, Dominique Ranchère-Vince, Jacques Baulieux, Raphaëlle Barnoud

Erschienen in: Journal of Gastrointestinal Cancer | Ausgabe 1/2011

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Excerpt

Liposarcoma is one of the most common soft tissue sarcomas in adults but is rarely seen in the gastrointestinal tract, especially in the esophagus. Since the first description of primary liposarcoma of the esophagus in 1983 by Mansour et al. [1], around 20 cases have been reported in the English literature. We describe herein, the first case of dedifferentiated liposarcoma (DDLPS) of the esophagus. This diagnosis was based on MDM2 and CDK4 immunoexpression and molecular analysis. …

Mansour KA, Fritz RC, Jacobs DM, Vellios F. Pedunculated liposarcoma of the esophagus: a first case report. J Thorac Cardiovasc Surg. 1983;86(3):447–50.PubMed

Chibon F, Mariani O, Derré J, Malinge S, Coindre JM, Guillou L, et al. A subgroup of malignant fibrous histiocytomas is associated with genetic changes similar to those of well-differentiated liposarcomas. Cancer Genet Cytogenet. 2002;139(1):24–9.CrossRefPubMed

Binh MB, Sastre-Garau X, Guillou L, de Pinieux G, Terrier P, Lagacé R, et al. MDM2 and CDK4 immunostainings are useful adjuncts in diagnosing well-differentiated and dedifferentiated liposarcoma subtypes: a comparative analysis of 559 soft tissue neoplasms with genetic data. Am J Surg Pathol. 2005;29(10):1340–7.CrossRefPubMed

Hostein I, Pelmus M, Aurias A, Pedeutour F, Mathoulin-Pélissier S, Coindre JM. Evaluation of MDM2 and CDK4 amplification by real-time PCR on paraffin wax-embedded material: a potential tool for the diagnosis of atypical lipomatous tumours/well-differentiated liposarcomas. J Pathol. 2004;202(1):95–102.CrossRefPubMed

Sirvent N, Coindre JM, Maire G, Hostein I, Keslair F, Guillou L, et al. Detection of MDM2-CDK4 amplification by fluorescence in situ hybridization in 200 paraffin-embedded tumor samples: utility in diagnosing adipocytic lesions and comparison with immunohistochemistry and real-time PCR. Am J Surg Pathol. 2007;31(10):1476–89.CrossRefPubMed

Jakowski JD, Wakely Jr PE. Rhabdomyomatous well-differentiated liposarcoma arising in giant fibrovascular polyp of the esophagus. Ann Diagn Pathol. 2009;13(4):263–8.CrossRefPubMed

Titel: A First Reported Case of Dedifferentiated Liposarcoma of the Esophagus with Molecular Diagnosis
verfasst von: Emmanuel Watkin
Mojgan Devouassoux-Shisheboran
Florence Pedeutour
Pauline Lagarde
Monique Salle
Dominique Ranchère-Vince
Jacques Baulieux
Raphaëlle Barnoud
Publikationsdatum: 01.03.2011
Verlag: Springer US
Erschienen in: Journal of Gastrointestinal Cancer / Ausgabe 1/2011
Print ISSN: 1941-6628
Elektronische ISSN: 1941-6636
DOI: https://doi.org/10.1007/s12029-010-9174-8

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A First Reported Case of Dedifferentiated Liposarcoma of the Esophagus with Molecular Diagnosis

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