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02.12.2019 | Review Article

The Role of Melatonin in Colorectal Cancer

verfasst von: Shahrokh Iravani, Pegah Eslami, Arash Dooghaie Moghadam, Bobak Moazzami, Azim Mehrvar, Mahmood Reza Hashemi, Fariborz Mansour-Ghanaei, Alireza Mansour-Ghanaei, Keivan Majidzadeh-A

Erschienen in: Journal of Gastrointestinal Cancer | Ausgabe 3/2020

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Abstract

The prevalence and mortality rate of colorectal cancer have been dramatically rising globally. Currently, colorectal cancer is emerging as the fourth leading cause of death and the third most common malignancy worldwide. The major drawback in colorectal cancer treatment is related to severe adverse events of both chemotherapy and radiation therapy that lead to toxicity and inflammation. Recently, melatonin as an antioxidant, immune-stimulant, and antimutagenic agent has been noticed. Different studies worked on the molecular role of melatonin on carcinogenesis progression. Overall, the anticancer activity of melatonin, combined with its actions via multiple signaling pathways, is considered hugely exciting to use this drug as a possible treatment strategy to cure cancer. Apart from its anticancer potential, this drug has shown to induce modulation of chemotherapy toxicity and improving its therapeutic efficacy. The present review aimed to discuss the possible role of melatonin usage in management of colorectal cancer.

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Titel: The Role of Melatonin in Colorectal Cancer
verfasst von: Shahrokh Iravani
Pegah Eslami
Arash Dooghaie Moghadam
Bobak Moazzami
Azim Mehrvar
Mahmood Reza Hashemi
Fariborz Mansour-Ghanaei
Alireza Mansour-Ghanaei
Keivan Majidzadeh-A
Publikationsdatum: 02.12.2019
Verlag: Springer US
Erschienen in: Journal of Gastrointestinal Cancer / Ausgabe 3/2020
Print ISSN: 1941-6628
Elektronische ISSN: 1941-6636
DOI: https://doi.org/10.1007/s12029-019-00336-4

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25.04.2024 | Nierenkarzinom | Nachrichten

Springer Medizin

The Role of Melatonin in Colorectal Cancer

Abstract

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