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Medical Oncology
Erschienen in: Medical Oncology 10/2018

01.10.2018 | Review Article

Primary leiomyosarcoma of the skin: a comprehensive review on diagnosis and treatment

verfasst von: Martina Zacher, Markus V. Heppt, Titus J. Brinker, Kinan M. Hayani, Michael J. Flaig, Carola Berking

Erschienen in: Medical Oncology | Ausgabe 10/2018

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Abstract

Sarcomas are a heterogeneous group of mesenchymal tumors which can affect bone and soft tissue. Leiomyosarcoma (LMS) is a rare subtype localized to the skin or subcutaneous tissue. Due to the heterogeneity of sarcomas, reviews and guidelines with an in-depth focus specifically on primary LMS of the skin are sparse. This article is intended to provide an up to date and systematic overview on diagnosis, treatment, and surveillance of this rare entity to provide a framework for decision making and management for dermato-oncologists. We discuss novel treatment options for advanced disease such as targeted therapy with kinase inhibitors and immune checkpoint blockade which may improve the prognosis even in advanced stages of LMS.
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Metadaten
Titel
Primary leiomyosarcoma of the skin: a comprehensive review on diagnosis and treatment
verfasst von
Martina Zacher
Markus V. Heppt
Titus J. Brinker
Kinan M. Hayani
Michael J. Flaig
Carola Berking
Publikationsdatum
01.10.2018
Verlag
Springer US
Erschienen in
Medical Oncology / Ausgabe 10/2018
Print ISSN: 1357-0560
Elektronische ISSN: 1559-131X
DOI
https://doi.org/10.1007/s12032-018-1196-2

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