nach oben

Hepatology International

Erschienen in:

01.06.2008 | HBV (Clinical & Basic)

Hepatitis B reactivation after chemotherapy: two decades of clinical research

verfasst von: George K. K. Lau

Erschienen in: Hepatology International | Ausgabe 2/2008

Einloggen, um Zugang zu erhalten

Abstract

Hepatitis due to hepatitis B virus reactivation after cytotoxic or immunosuppressive therapy is a serious cause of liver-related morbidity and mortality. With the characterization of the underlying pathogenesis, much progress in the management of this important clinical problem has been made in the past 2 decades. By year 2008, it is mandatory to screen for hepatitis B surface antigen status before initiating intensive chemotherapy or immunosuppressive therapy. All those who are hepatitis B surface antigen positive should be started on preemptive nucleos(t)ide analogues. However, there remains important issues, such as the type and duration of nucleos(t)ide analogue therapy, which need to be understood. As not all hepatitis B surface antigen-positive patients will suffer from HBV reactivation, it is therefore useful to identify risk factors related to HBV reactivation so that patients will not be treated unnecessarily with nucleos(t)ide analogues. To date, a high baseline level of viral replication, as reflected by high serum HBV DNA level, positive serum hepatitis B e antigen, and a high intrahepatic covalently closed circular DNA level, is the most important predictor for HBV reactivation. Recently, there has been an increased awareness of reactivation of occult hepatitis B virus, especially in hepatitis B virus endemic area, such as the Asia-Pacific region. Careful epidemiological study will be needed to clarify the impact of occult hepatitis B infection in patients treated with cytotoxic or immunosuppressive therapy.

Liang R, Lau GKK, Kwong YL. Chemotherapy and bone marrow transplantation for cancer patient who are also chronic hepatitis B carriers: a review of the problem. J Clin Oncol. 1999;17:394–98.PubMed

Luo XR, Yan AW, Liang R, Lau GKK. Hepatitis B virus (HBV) reactivation after cytotoxic or immunosuppressive therapy-pathogenesis and management. Rev Med Virol. 2001;11(5):287–9.

Lau GKK, Lee CK, Liang R. Hepatitis B and bone marrow transplantation. Crit Rev Oncol Hematol. 1999;31:71–6.PubMed

Yeo W, Johnson PJ. Diagnosis, prevention and management of hepatitis B virus reactivation during anticancer therapy. Hepatology. 2006;43(2):209–20.PubMed

Lalazar G, Rund D, Shouval D. Screening, prevention and treatment of viral hepatitis B reactivation in patients with haematological malignancies. Br J Haematol. 2007;136(5):699–712.PubMed

Lok ASF, Liang RHS, Chiu EKW, Wong KL, Chan TK, Todd D. Reactivation of hepatitis B virus replication in patients receiving cytotoxic therapy. Report of a prospective study. Gastroenterology. 1991;100:182–8.PubMed

Liang RHS, Lok ASF, Lai CL, Chan TK, Todd O, Chiu EKW. Hepatitis B infection in patients with lymphomas. Hematol Oncol. 1990;8:261–70.PubMed

Lau JY, Lai CL, Lin HJ, Lok ASF, Liang RHS, Wu PC, et al. Fatal reactivation of chronic hepatitis B virus infection following withdrawal of chemotherapy in lymphoma patients. Q J Med. 1989;73:911–7.PubMed

Soh LT, Ang PT, Sng I, Chua EJ, Ong YW. Fulminant hepatic failure in non- Hodgkin’s lymphoma patients treated with chemotherapy. Eur J Cancer. 1992;28A:1338–9.PubMed

10.

Yeo W, Chan PKS, Hui P, HoWM, Lam KC, Kwan WH, et al. Hepatitis B virus reactivation in breast cancer patients undergoing cytotoxic chemotherapy: a prospective study. J Med Virol. 2003;70:553–61.PubMed

11.

Bonadonna G, Valagussa P, Moliterni A, Zambetti M, Brambilla C. Adjuvant cyclophosphamide, and fluorouracil in node-positive breast cancer. The results of 20 years follow-up. N Engl J Med. 1995;332:901–6.PubMed

12.

Citron ML, Berry DA, Cirrincione C, Hudis C, Winer EP, Gradishar WJ, et al. Randomized trial of dose-dense versus conventionally scheduled and sequential versus concurrent combination chemotherapy as postoperative adjuvant treatment of node-positive primary breast cancer: first report of Intergroup Trial C9741/Cancer and Leukemia Group B Trial 9741. J Clin Oncol. 2003;21:1431–9.PubMed

13.

Wands JR, Chura CM, Roll FJ, Maddrey WC. Serial studies of hepatitis associated antigen and antibody in patients receiving antitumor chemotherapy for myeloproliferative and lymphoproliferative disorders. Gastroenterology. 1975;68:105–12.PubMed

14.

GN Vyas, Rao KR, Ibrahim AB. Australia antigen (hepatitis B antigen): a conformational antigen dependent on disulfide bonds. Science. 1972;178:1300–1.PubMed

15.

Galbraith RM, Eddleston ALWF, Wiiliams R, Zuckerman AJ, Bagshawe KD. Fulminant hepatic failure in leukemia and choriocarcinoma related to withdrawal of cytotoxic drug therapy. Lancet. 1975;2:528–30.PubMed

16.

Hoofnagle JH, Dusheiko GM, Schafer DF, Jones EA, Micetich KC, Young RC, et al. Reactivation of chronic hepatitis B virus infection by cancer chemotherapy. Ann Int Med. 1982;96:447–9.PubMed

17.

Kumagai K, Takagi T, Nakamura S, Sawada U, Kura U, Kodama F, et al. Hepatitis B virus carriers in the treatment of malignant lymphoma: an epidemiological study in Japan. Ann Oncol. 1997;8(Suppl 1):107–9.

18.

Yeo W, Lam KC, Zee B, Chan PSK, Mo FKF, Ho WM, et al. Hepatitis B reactivation in patients with hepatocellular carcinoma undergoing systemic chemotherapy. Ann Oncol. 2004;15:1661–6.PubMed

19.

Lau GKK, Liang RHS, Chiu EKW, Lee CK, Lam SK. Hepatic events after bone marrow transplantation in patients with hepatitis B infection: a case-controlled study. Bone Marrow Transplant. 1997;19:795–9.PubMed

20.

Lau GKK, Leung YH, Fong DYT, Au WY, Kwong YL, Lie A, et al. High HBV DNA viral load is the most significant risk factor for hepatitis B reactivation in hepatitis B surface antigen positive patients treated with autologous hematopoietic cell transplantation. Blood. 2002;99:2324–30.PubMed

21.

Cheng VCC, Lo CM, Lau GKK. Current issues and treatment of fulminant hepatic failure including transplantation in Hong Kong and Far East. Sem Liver Dis. 2003;23(3):239–50.

22.

Waite J, Gilson RJ, Weller IV, Lacey CJ, Hambling MH, Hawkins A, et al. Hepatitis B virus reactivation or reinfection associated with HIV-1 infection. AIDS. 1988;2(6):443–8.PubMedCrossRef

23.

Manegold C, Hannoun C, Wywiol A, Dietrich M, Polywka S, Chiwakata CB, et al. Reactivation of hepatitis B virus replication accompanied by acute hepatitis in patients receiving highly active antiretroviral therapy. Clin Infect Dis. 2001;32(1):144–8.PubMed

24.

Bani-Sadr F, Maillard A, Ponscarme D, Scieux C, Molina JM. Reactivation of HBV replication in HIV-HBV infected patients. Am J Med. 2003;114(9):768–9.PubMed

25.

Jain MK, Parekh NK, Hester J, Lee WM. Aminotransferase elevation in HIV/hepatitis B virus co-infected patients treated with two active hepatitis B virus drugs. AIDS Patient Care STDS. 2006;20(12):817–22.PubMed

26.

Barros MF, Piedade J, Nunes G, Canas-Ferreira W, Silva AP, Champalimaud JL, et al. Active replication of hepatitis B virus (HBV) in HIV type 1 and in HIV type 2 infected patients. Rev Inst Med Trop Sao Paulo. 1996;38(4):253–8.PubMed

27.

Clark SJ, Creighton S, Horner M, Smith HM, Portmann B, Taylor C, et al. Reactivation of latent hepatitis B virus infection with HIV-related immunosuppression. Int J STD AIDS. 2006;17(1):67–9.PubMed

28.

Ustun C, Koc H, Karayalcin S, Akyol G, Gurman G, Ilhan O, et al. Hepatitis B virus infection in allogeneic bone marrow transplantation. Bone Marrow Transplant. 1997;20:289–96.PubMed

29.

Yeo W, Steinberg JL, Tam JS, Chan PK, Leung NW, Lam KC, et al. Lamivudine in the treatment of hepatitis B virus reactivation during cytotoxic chemotherapy. J Med Virol. 1999;59:263–9.PubMed

30.

Markovic S, Drozina G, Vovk M, Fidler-Jenko M. Reactivation of hepatitis B but not hepatitis C in patients with malignant lymphoma and immunosuppressive therapy. A prospective study in 305 patients. Hepatogastroenterology. 1999;46:2925–30.PubMed

31.

Yagci M, Sucak GT, Haznedar R. Fludarabine and risk of hepatitis B virus reactivation in chronic lymphocytic leukemia. Am J Hematol. 2000;64:233–4.PubMed

32.

Silvestri F, Sperotto A, Ermacora A, Fanin R, Damiani D, Baccarani M. Lamivudine for the prevention of hepatitis B virus reactivation during autologous stem cell transplantation. A case report. Haematologica. 2000;85:327–9.PubMed

33.

Maguire CM, Crawford DH, Hourigan LF, Clouston AD, Walpole ET, Powell EE. Case report: lamivudine therapy for submassive hepatic necrosis due to reactivation of hepatitis B following chemotherapy. J Gastroenterol Hepatol. 1999;14:801–3.PubMed

34.

Alexopoulos CG, Vaslamatzis M, Hatzidimitriou G. Prevalence of hepatitis B virus marker positivity and evolution of hepatitis B virus profile, during chemotherapy, in patients with solid tumours. Br J Cancer. 1999;81:69–74.PubMed

35.

Clark FL, Drummond MW, Chambers S, Chapman BA, Patton WN. Successful treatment with lamivudine for fulminant reactivated hepatitis B infection following intensive therapy for high-grade non-Hodgkin’s lymphoma. Ann Oncol. 1998;9:385–7.PubMed

36.

Mertens T, Kock J, Hampl W, Schlicht HJ, Tillmann HL, Oldhafer KJ, et al. Reactivated fulminant hepatitis B virus replication after bone marrow transplantation: clinical course and possible treatment with ganciclovir. J Hepatol. 1996;25:968–71.PubMed

37.

Lau JY, Bird GL, Gimson AE, Alexander GJ, Williams R. Treatment of HBV reactivation after withdrawal of immunosuppression. Lancet. 1991;337:80249.

38.

Reed EC, Myerson D, Corey HT, Meyers JD. Allogeneic marrow transplantation in patients positive for hepatitis B surface antigen. Blood. 1991;77:195–200.PubMed

39.

Flowers MA, Heathcote J, Wanless IR, Sherman M, Reynolds WJ, Cameron RG, et al. Fulminant hepatitis as a consequence of reactivation of hepatitis B virus infection after discontinuation of low-dose methotrexate therapy. Ann Intern Med. 1990;12:381–2.

40.

Rostoker G, Rosenbaum J, Ben Maadi A, Nedelec G, Deforge L, Vidaud M, et al. Reactivation of hepatitis B virus by corticosteroids in a case of idiopathic nephrotic syndrome. Nephron. 1990;16:224.

41.

Pariente EA, Goudeau A, Dubois F, Degott C, Gluckman E, Devergie A, et al. Fulminant hepatitis due to reactivation of chronic hepatitis B virus infection after allogeneic bone marrow transplantation. Dig Dis Sci. 1988;33:1185–91.PubMed

42.

Nagington J, Cossart YE, Cohen BJ. Reactivation of hepatitis B after transplantation operations. Lancet. 1977;68:105–12.

43.

Grotz W, Rasenack J, Benzing T, Berthold H, Peters T, Walter E, et al. Occurrence and management of hepatitis B virus reactivation following kidney transplantation. Clin Nephrol. 1998;49:385–8.PubMed

44.

Blanpain C, Knoop C, Delforge ML, Antoine M, Peny MO, Liesnard C, et al. Reactivation of hepatitis B after transplantation in patients with pre-existing anti-hepatitis B surface antigen antibodies: report on three cases and review of the literature. Transplantation. 1998;66:883.PubMed

45.

Ahmed A, Keeffe EB. Lamivudine therapy for chemotherapy-induced reactivation of hepatitis B virus infection. Am J Gastroenterol. 1999;94:249–51.PubMed

46.

Romand F, Michallet M, Pichoud C, Trepo C, Zoulim F. Hepatitis B virus reactivation after allogeneic bone marrow transplantation in a patient previously cured of hepatitis B. Gastroenterol Clin Biol. 1999;23:770–4.PubMed

47.

Dhedin N, Douvin C, Kuentz M, Saint Marc MF, Reman O, Rieux C, et al. Reverse seroconversion of hepatitis B after allogeneic bone marrow transplantation: a retrospective study of 37 patients with pretransplant anti-HBs and anti-HBc. Transplantation. 1998;66:616.PubMed

48.

Schnepf N, Sellier P, Bendenoun M, Zini JM, Sanson-le Pors MJ, Mazeron MC. Reactivation of lamivudine-resistant occult hepatitis B in an HIV-infected patient undergoing cytotoxic chemotherapy. J Clin Virol. 2007;39(1):48–50.PubMed

49.

Chamorro AJ, Casado JL, Bellido D, Moreno S. Reactivation of hepatitis B in an HIV-infected patient with antibodies against hepatitis B core antigen as the only serological marker. Eur J Clin Microbiol Infect Dis. 2005;24(7):492–4.PubMed

50.

Tsutsumi Y, Tanaka J, Kawamura T, Miura T, Kanamori H, Asaka M, et al. Possible efficacy of lamivudine treatment to prevent hepatitis B virus reactivation due to rituximab therapy in a patient with non-Hodgkin’s lymphoma. Ann Hematol. 2003;83:58–60.PubMed

51.

Dervite I, Hober D, Morel P. Acute hepatitis B in a patient with antibodies to hepatitis B surface antigen who was receiving rituximab. N Engl J Med. 2001;344:68–9.PubMed

52.

Westhoff TH, Jochimsen F, Schmittel A, Stoffler-Meilicke M, Schafer JH, Zidek W, et al. Fatal hepatitis B virus reactivation by an escape mutant following rituximab therapy. Blood. 2003;102:1930.PubMed

53.

Perceau G, Diris N, Estines O, Derancourt C, Lévy S, Bernard P. Late lethal hepatitis B virus reactivation after rituximab treatment of low-grade cutaneous B-cell lymphoma. Br J Dermatol. 2006;155(5):1053–6.PubMed

54.

Hui CK, Cheung WWW, Au WY, Zhang HY, Yueng YH, Leung N, et al. Rituximab increases the risk of de novo hepatitis B infection in hepatitis B surface antigen negative patients undergoing cytotoxic chemotherapy. Gastroenterology. 2006;131(1):59–68.PubMed

55.

Iannitto E, Minardi V, Calvaruso G, Mule A, Ammatuna E, Trapani RD, et al. Hepatitis B virus reactivation and alemtuzumab therapy. Eur J Haematol. 2005;74:254–8.PubMed

56.

Lau GK, Yiu HHY, Fong DYT, Cheng HC, Au WY, Lai LSY, et al. “Early” is superior to “deferred” pre-emptive lamivudine therapy for hepatitis B patients undergoing chemotherapy. Gastroenterology. 2003;125:1742–9.PubMed

57.

Nagamatsu H, Itano S, Nagaoka S, Akiyoshi J, Matsugaki S, Kurogi J, et al. Prophylactic lamivudine administration prevents exacerbation of liver damage in HBe antigen positive patients with hepatocellular carcinoma undergoing transhepatic arterial infusion chemotherapy. Am J Gastroenterol. 2004;99:2369–75.PubMed

58.

Nagamatsu H, Kumashiro R, Itano S, Matsugaki S, Sata M. Investigation of associating factors in exacerbation of liver damage after chemotherapy in patients with HBV-related HCC. Hepatol Res. 2003;26:293–301.PubMed

59.

Steinberg JL, Yeo W, Zhong S, Chan JY, Tam JS, Chan PK, et al. Hepatitis B virus reactivation in patients undergoing cytotoxic chemotherapy for solid tumours: precore/core mutations may play an important role. J Med Virol. 2000;60:249–55.PubMed

60.

Yeo W, Hui EP, Chan AT, Ho WM, Lam KC, Chan PK, et al. Prevention of hepatitis B virus reactivation in patients with nasopharyngeal carcinoma with lamivudine. Am J Clin Oncol. 2005;28(4):379–84.PubMed

61.

Locasciulli A, Bacigalupo A, Van Lint MT, Chemello L, Pontisso P, Occhini D, et al. Hepatitis B virus (HBV) infection and liver disease after allogeneic bone marrow transplantation: a report of 30 cases. Bone Marrow Transplant. 1990;6(1):25–9.PubMed

62.

Zampino R, Marrone A, Ragone E, Costagliola L, Cirillo G, Karayiannis P, et al. Heart transplantation in patients with chronic hepatitis B: clinical evolution, molecular analysis, and effect of treatment. Transplantation. 2005;80(9):1340–3.PubMed

63.

Berger A, Preiser W, Kachel HG, Stürmer M, Doerr HW. HBV reactivation after kidney transplantation. J Clin Virol. 2005;32(2):162–5.PubMed

64.

Degos F, Lugassy C, Degott C, Debure A, Carnot F, Theirs V, et al. Hepatitis B virus and hepatitis B-related viral infection in renal transplant recipients. A prospective study of 90 patients. Gastroenterology. 1988;94(1):151–6.PubMed

65.

Esteve M, Saro C, González-Huix F, Suarez F, Forné M, Viver JM. Chronic hepatitis B reactivation following infliximab therapy in Crohn’s disease patients: need for primary prophylaxis. Gut. 2004;53(9):1363–5.PubMed

66.

Chisari FV, Ferrari C. Hepatitis B virus immunopathogenesis. Annu Rev Immunol. 1995;13:29–60.PubMed

67.

Hui CK, Lau GK. The present and future therapy for chronic hepatitis B infection. Semin Liver Dis. 2006;26(2):192–7.PubMed

68.

Wu J, Xie HY, Jiang GP, Xu X, Zheng SS. The effect of mycophenolate acid on hepatitis B virus replication in vitro. Hepatobiliary Pancreat Dis Int. 2003;2(3):410–3.PubMed

69.

Gong ZJ, De Meyer S, Clarysse C, Verslype C, Neyts J, De Clercq E, et al. Mycophenolic acid, an immunosuppressive agent, inhibits HBV replication in vitro. J Viral Hepat. 1999;6(3):229–36.PubMed

70.

Tur-Kaspa R, Burk RD, Shaul Y, Shafritz DA. Hepatitis B virus DNA contains a glucocorticoid-responsive element. Proc Natl Acad Sci USA. 1986;83:1627–31.PubMed

71.

Liaw YF. Hepatitis viruses under immunosuppressive agents. J Gastroenterol Hepatol. 1998;13:14–20.PubMed

72.

McIvor C, Morton J, Bryant A, Cooksley WG, Durrant S, Walker N. Fatal reactivation of precore mutant hepatitis B virus associated with fibrosing cholestatic hepatitis after bone marrow transplantation. Ann Intern Med. 1994;121:274–5.PubMed

73.

Yoshiba M, Sekiyama K, Sugata F, Okamoto H, Yamamoto K, Yotsumoto S. Reactivation of precore mutant hepatitis B virus leading to fulminant hepatic failure following cytotoxic treatment. Dig Dis Sci. 1992;37:1253–9.PubMed

74.

Talbodec N, Loriot MA, Gigou M, Guigonis V, Boyer N, Bezeaud A, et al. Hepatitis B virus precore mutations and HBeAg negative reactivation of chronic hepatitis B after interferon therapy. Liver. 1995;15:93–8.PubMed

75.

Allice T, Cerutti F, Pittaluga F, Varetto S, Gabella S, Marzano A, et al. COBAS AmpliPrep-COBAS TaqMan hepatitis B virus (HBV) test: a novel automated real-time PCR assay for quantification of HBV DNA in plasma. J Clin Microbiol. 2007;45(3):828–34.PubMed

76.

Carman WF, Korula J, Wallace L, MacPhee R, Mimms L, Decker R. Fulminant reactivation of hepatitis B due to envelope protein mutant that escaped detection by monoclonal HBsAg ELISA. Lancet. 1995;345:1406–7.PubMed

77.

Grellier L, Mutimer D, Ahmed M, et al. Lamivudine prophylaxis against reinfection in liver transplantation for hepatitis B cirrhosis. Lancet. 1996;348:1212–5.PubMed

78.

Kryger P. Significance of anti-HBc IgM in the differential diagnosis of viral hepatitis. J Virol Methods. 1985;10:283–9.PubMed

79.

Chau KH, Hargie MP, Decker RH, Mushahwar IK, Overby LR. Serodiagnosis of recent hepatitis B infection by IgM class anti-HBc. Hepatology. 1983;3:142–9.PubMed

80.

Colloredo Mels G, Bellati G, Leandro G, Brunetto MR, Vicari O, Piantino P, et al. Role of IgM antibody to hepatitis B core antigen in the diagnosis of hepatitis B exacerbations. Arch Virol Suppl. 1993;8:203–11.PubMed

81.

Jones RJ, Lee KS, Beschorner WE, Vogel VG, Grochow LB, Braine HG, et al. Venoocclusive disease of the liver following bone marrow transplantation. Transplantation. 1987;44:778–83.PubMed

82.

Glucksberg H, Storb R, Fefer A, Buckner CD, Neiman PE, Clift RA, et al. Clinical manifestations of graft-versus-host disease in human recipients of marrow from HL-A-matched sibling donors. Transplantation. 1974;18:295–304.PubMed

83.

Hui CK, Bowden S, Jackson K, Au WY, Fong DY, Lie AK, et al. Clinical significance of intrahepatic hepatitis B virus covalently closed circular DNA in chronic hepatitis B patients who received cytotoxic chemotherapy. Blood. 2005;105:2616–7.PubMed

84.

Lau GKK, Liang RHS, Wu PC, Lee CK, Lim WL, Au WY. Use of famciclovir to prevent HBV reactivation in HBsAg-positive recipients after allogeneic bone marrow transplantation. J Hepatol. 1998;28:359–68.PubMed

85.

Lau GK, He ML, Fong DY, Bartholomeusz A, Au WY, Lie AK, et al. Preemptive use of lamivudine reduces hepatitis B exacerbation after allogeneic hematopoietic cell transplantation. Hepatology. 2002;36:702–9.PubMed

86.

Kohrt HE, Ouyang DL, Keeffe EB. Antiviral prophylaxis for chemotherapy-induced reactivation of chronic hepatitis B virus infection. Clin Liver Dis. 2007;11(4):965–91.PubMed

87.

Hui CK, Cheung WWW, Au WY, Lie AWK, Zhang HY, Yueng YH, et al. Hepatitis B reactivation after withdrawal of preemptive lamivudine in patients with hematological malignancy upon completion of cytotoxic chemotherapy. Gut. 2005;54(11):1597–603.PubMed

88.

Jang JW, Choi JY, Bae SH, Yoon SK, Chang UI, Kim CW, et al. A randomized controlled study of preemptive lamivudine in patients receiving transarterial chemo-lipiodolization. Hepatology. 2006;43(2):233–40.PubMed

89.

Jang JW, Choi JY, Bae SH, Kim CW, Yoon SK, Cho SH, et al. Transarterial chemo-lipiodolization can reactivate hepatitis B virus replication in patients with hepatocellular carcinoma. J Hepatol. 2004;41:427–35.PubMed

90.

Zhong S, Yeo W, Schroder C, Chan P, Wong W, Ho WM, et al. High hepatitis B virus (HBV) DNA viral load is an important risk factor for HBV reactivation in breast cancer patients undergoing cytotoxic chemotherapy. J Viral Hepat. 2004;11:55–9.PubMed

91.

Yeo W, Mo FK, Chan SL, Leung NW, Hui P, Lam WY, et al. Hepatitis B viral load predicts survival of HCC patients undergoing systemic chemotherapy. Hepatology. 2007;45(6):1382–9.PubMed

92.

Werle-Lapostolle B, Bowden S, Locarnini S, Wursthorn K, Petersen J, Lau G, et al. Persistence of cccDNA during the natural history of chronic hepatitis B and decline during adefovir dipivoxil therapy. Gastroenterology. 2004;126:1750–8.PubMed

93.

Yeo W, Zhong S, Chan PKS, Ho WM, Wong HTM, Chan ASK, et al. Sequence variations of precore/core and precore promoter regions of hepatitis B virus in patients with or without viral reactivation during cytotoxic chemotherapy. J Viral Hepat. 2000;7:448–58.PubMed

94.

Picardi M, Pane F, Quintarelli C, De Renzo A, Del Giudice A, De Divitiis B, et al. Hepatitis B virus reactivation after fludarabine-based regimens for indolent non-Hodgkin’s lymphomas: high prevalence of acquired viral genomic mutations. Haematologica. 2003;88:1296–303.PubMed

95.

Liao CA, Lee CM, Wu HC, Wang MC, Lu SN, Eng HL. Lamivudine for the treatment of hepatitis B virus reactivation following chemotherapy for non-Hodgkin’s lymphoma. Br J Haematol. 2002;116:166–9.PubMed

96.

Carman WF, Fagan EA, Hadziyannis S, Karayiannis P, Tassopoulos NC, Williams R, et al. Association of a precore genomic variant of HBV with fulminant hepatitis. Hepatology. 1991;14:219–22.PubMed

97.

Yu MW, Yeh SH, Chen PJ, Liaw YF, Lin CL, Liu CJ, et al. Hepatitis B virus genotype and DNA level and hepatocellular carcinoma: a prospective study in men. J Natl Cancer Inst. 2005;97(4):265–72.PubMedCrossRef

98.

Chu CM, Liaw YF. Genotype C hepatitis B virus infection is associated with a higher risk of reactivation of hepatitis B, progression to cirrhosis than genotype B: a longitudinal study of hepatitis B e antigen-positive patients with normal aminotransferase levels at baseline. J Hepatol. 2005;43(3):411–7.PubMed

99.

Hsu CH, Hsu HC, Chen HL, Gao M, Yeh PY, Chen PJ, et al. Doxorubicin activates hepatitis B virus (HBV) replication in HBV-harboring hepatoblastoma cells. A possible novel mechanism of HBV reactivation in HBV carriers receiving systemic chemotherapy. Anticancer Res. 2004;24(5A):3035–40.PubMed

100.

Cheng AL, Hsiung CA, Su IJ, Chen PJ, Chang MC, Tsao CJ, et al. Steroid- free chemotherapy decreases risk of hepatitis B virus (HBV) reactivation in HBV-carriers with lymphoma. Hepatology. 2003;37:1320–8.

101.

Yeo W, Lam KC, Zee B, Chan PS, Mo FK, Ho WM, et al. Hepatitis B reactivation in patients with hepatocellular carcinoma undergoing systemic chemotherapy. Ann Oncol. 2004;15(11):1661–6.PubMed

102.

Clark FL, Drummond MW, Chambers S, et al. Successful treatment with lamivudine for fulminant reactivated hepatitis B infection following intensive therapy for high-grade non-Hodgkin’s lymphoma. Ann Oncol. 1998;9:385–87.PubMed

103.

104.

Ahmed A, Keeffe EB. Lamivudine therapy for chemotherapy-induced reactivation of hepatitis B virus infection. Am J Gastroenterol. 1999;94:249–51.PubMed

105.

106.

Matsuo K, Takenaka K, Shimomura H, Fujii N, Shinagawa K, Kiura K, et al. Lamivudine and glycyrrhizin for treatment of chemotherapy-induced hepatitis B virus (HBV) hepatitis in a chronic HBV carrier with non-Hodgkin lymphoma. Leuk Lymphoma. 2001;41:191–5.PubMed

107.

Jung YO, Lee YS, Yang WS, Han DJ, Park JS, Park SK. Treatment of chronic hepatitis B with lamivudine in renal transplant recipients. Transplantation. 1998;66:733–7.PubMed

108.

Henkes M, Martin S, Einsele H, Aulitzky WE. Successful antiviral treatment for fulminant reactivated hepatitis B after autologous stem cell transplantation and prophylaxis during subsequent allogeneic stem cell transplantation. Ann Hematol. 2002;81:343–6.PubMed

109.

Saif MW, Little RF, Hamilton JM, Allegra CJ, Wilson WH. Reactivation of chronic hepatitis B infection following intensive chemotherapy and successful treatment with lamivudine: a case report and review of the literature. Ann Oncol. 2001;12:123–9.PubMed

110.

Tang S, Ho SK, Moniri K, Lai KN, Chan TM. Efficacy of famciclovir in the treatment of lamivudine resistance related to an atypical hepatitis B virus mutant. Transplantation. 2002;73:148–51.PubMed

111.

Dai MS, Wu PF, Lu JJ, Shyu RY, Chao TY. Preemptive use of lamivudine in breast cancer patients carrying hepatitis B virus undergoing cytotoxic chemotherapy: a longitudinal study. Support Care Cancer. 2004;12:191–6.PubMed

112.

Shibolet O, Ilan Y, Gillis S, Hubert A, Shouval D, Safadi R. Lamivudine therapy for prevention of immunosuppressive-induced hepatitis B virus reactivation in hepatitis B surface antigen carriers. Blood. 2002;100:391–6.PubMed

113.

Persico M, De Marino F, Russo GD, Morante A, Rotoli B, Torella R, et al. Efficacy of lamivudine to prevent hepatitis reactivation in hepatitis B virus-infected patients treated for non-Hodgkin lymphoma. Blood. 2002;99:724–5.PubMed

114.

Ozguroglu M, Bilici A, Turna H, Serdengecti S. Reactivation of hepatitis B infection with cytotoxic therapy in non-Hodgkin’s lymphoma. Med Oncol. 2004;21:67–72.PubMed

115.

Leaw SJ, Yen CJ, Huang WT, Chen TY, Su WC, Tsao CJ. Preemptive use of interferon or lamivudine for hepatitis B reactivation in patients with aggressive lymphoma receiving chemotherapy. Ann Hematol. 2004;83:270–5.PubMed

116.

Yeo W, Chan PKS, Ho WM, Zee B, Lam KC, Lei KIK, et al. Lamivudine for the prevention of hepatitis B virus reactivation in HBsAg seropositive cancer patients undergoing cytotoxic chemotherapy. J Clin Oncol. 2004;15:1661–6.

117.

Idilman R, Arat M, Soydan E, Toruner M, Soykan I, Akbulut H, et al. Lamivudine prophylaxis for prevention of chemotherapy-induced hepatitis B virus reactivation in hepatitis B virus carriers with malignancies. J Viral Hepat. 2004;11:141–7.PubMed

118.

Lee GW, Ryu MH, Lee JL, Oh S, Kim E, Lee JH, et al. The prophylactic use of lamivudine can maintain dose-intensity of adriamycin in hepatitis-B surface antigen (HBsAg)-positive patients with non-Hodgkin’s lymphoma who receive cytotoxic chemotherapy. J Korean Med Sci. 2003;18:849–54.PubMed

119.

Yeo W, Ho WM, Hui P, Chan PK, Lam KC, Lee JJ, et al. Use of lamivudine to prevent hepatitis B virus reactivation during chemotherapy in breast cancer patients. Breast Cancer Res Treat. 2004;88(3):209–15.PubMed

120.

Liaw YF, Leung N, Guan R, Lau GK, Merican I, McCaughan G, et al. For the Asian Pacific Consensus update working party on chronic hepatitis B. Asian-Pacific Consensus statement on the management of chronic hepatitis B: A 2005 update. Liver Int. 2005;25(3):472–89.

121.

de Franchis R, Hadengue A, Lau GK, Lavanchy D, Lok A, McIntyre N, et al. EASL JuryEASL International Consensus Conference on Hepatitis B. 13–14 September, 2002 Geneva, Switzerland. Consensus statement (long version). J Hepatol. 2003;39(Suppl 1):S3–25.

122.

Lok AS, McMahon BJ. Chronic hepatitis B. Hepatology. 2007;45(2):507–39.PubMed

123.

Hui CK, Bowden S, Lewin S, Locarnini S, Naoumov NV, Lau GK. The use of real-time PCR assays for monitoring hepatitis B virus DNA response to antiviral therapy. J Clin Microbiol. 2006;44(8):2983–7.PubMed

124.

Lee YC, Young KC, Su WC, Tsao CJ, Chen TY. Emergence of YMDD mutant hepatitis B virus after allogeneic stem cell transplantation from a HBsAg-positive donor during lamivudine prophylaxis. Haematologica. 2004;89(4):ECR09.PubMed

125.

Chan HL, Chui AK, Lau WY, Chan FK, Hui AY, Rao AR, et al. Outcome of lamivudine resistant hepatitis B virus mutant post-liver transplantation on lamivudine monoprophylaxis. Clin Transplant. 2004;18(3):295–300.PubMed

126.

Lau GK, Piratvisuth T, Luo KX, Marcellin P, Thongasawat S, Cooksley G, et al. Peginterferon alfa-2a (40KD) (PEGASYS^®) monotherapy and in combination with lamivudine is more effective than lamivudine monotherapy in HBeAg-positive chronic hepatitis B: results from a large, multinational study. N Engl J Med. 2005;352(26):2682–95.PubMed

127.

Lim LL, Wai CT, Lee YM, Kong HL, Lim R, Koay E, et al. Prophylactic lamivudine prevents hepatitis B reactivation in chemotherapy patients. Aliment Pharmacol Ther. 2002;16:1939–44.PubMed

Titel: Hepatitis B reactivation after chemotherapy: two decades of clinical research
verfasst von: George K. K. Lau
Publikationsdatum: 01.06.2008
Verlag: Springer-Verlag
Erschienen in: Hepatology International / Ausgabe 2/2008
Print ISSN: 1936-0533
Elektronische ISSN: 1936-0541
DOI: https://doi.org/10.1007/s12072-008-9056-3

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Innere Medizin

Notfall-TEP der Hüfte ist auch bei 90-Jährigen machbar

26.04.2024 Hüft-TEP Nachrichten

Ob bei einer Notfalloperation nach Schenkelhalsfraktur eine Hemiarthroplastik oder eine totale Endoprothese (TEP) eingebaut wird, sollte nicht allein vom Alter der Patientinnen und Patienten abhängen. Auch über 90-Jährige können von der TEP profitieren.

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

25.04.2024 Hypotonie Nachrichten

Wenn unter einer medikamentösen Hochdrucktherapie der diastolische Blutdruck in den Keller geht, steigt das Risiko für schwere kardiovaskuläre Ereignisse: Darauf deutet eine Sekundäranalyse der SPRINT-Studie hin.

Bei schweren Reaktionen auf Insektenstiche empfiehlt sich eine spezifische Immuntherapie

25.04.2024 Allergien und Intoleranzreaktionen Nachrichten

Insektenstiche sind bei Erwachsenen die häufigsten Auslöser einer Anaphylaxie. Einen wirksamen Schutz vor schweren anaphylaktischen Reaktionen bietet die allergenspezifische Immuntherapie. Jedoch kommt sie noch viel zu selten zum Einsatz.

Therapiestart mit Blutdrucksenkern erhöht Frakturrisiko

25.04.2024 Hypertonie Nachrichten

Beginnen ältere Männer im Pflegeheim eine Antihypertensiva-Therapie, dann ist die Frakturrate in den folgenden 30 Tagen mehr als verdoppelt. Besonders häufig stürzen Demenzkranke und Männer, die erstmals Blutdrucksenker nehmen. Dafür spricht eine Analyse unter US-Veteranen.

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 2/2008

Economic evaluation of a surveillance program of hepatocellular carcinoma (HCC) in India

Nonalcoholic fatty liver disease in a district general hospital: clinical presentation and risk factors

Clinical impact of serum transforming growth factor-alpha mRNA as a predictive biomarker for the prognosis of fulminant hepatitis

Prognostic analysis of pulmonary metastases from hepatocellular carcinoma

Pentoxifylline: not just for alcoholic hepatitis anymore?