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Annals of Nuclear Medicine
Erschienen in: Annals of Nuclear Medicine 9/2016

02.08.2016 | Original Article

Carbidopa-assisted 18F-fluorodihydroxyphenylalanine PET/CT for the localization and staging of non-functioning neuroendocrine pancreatic tumors

verfasst von: Mehdi Helali, Pietro Addeo, Céline Heimburger, Julien Detour, Bernard Goichot, Philippe Bachellier, Izzie Jacques Namer, David Taïeb, Alessio Imperiale

Erschienen in: Annals of Nuclear Medicine | Ausgabe 9/2016

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Abstract

Objective

CD premedication was found to increase the value of 18F-fluorodihydroxyphenylalanine (18F-FDOPA) PET/CT imaging in the detection of adult insulinoma. The aim of this study was to evaluate the performance of CD-assisted 18F-FDOPA PET/CT in the diagnosis and staging of non-functioning pNETs.

Methods

Twenty consecutive patients with low-grade pNETs who underwent CD-assisted 18F-FDOPA PET/CT imaging and 111In-somatostatin receptor scintigraphy (SRS) were evaluated. Histology was considered as the gold standard. In case where no surgical resection was performed, the diagnosis of pNET was made by the confrontation of the different available imaging modalities.

Results

CD-assisted 18F-FDOPA PET/CT was positive in 18/20 cases (90 %), whereas SRS was positive in 13/19 cases (68 %). When considered the 19 patients underwent both nuclear medicine examinations, 18F-FDOPA PET/CT was significantly more sensitive then SRS for primary tumor detection (p = 0.049). False-negative results of both 18F-FDOPA PET/CT and SRS were observed in 2 cystic pNETs. SRS failed to detect one additional cystic tumor and 3 pNETs of 10, 12 and 17 mm, respectively. 18F-FDOPA PET/CT correctly identified all patients with lymphatic, visceral and bone metastases. SRS failed to detect lymphatic spread and was falsely negative in one patient with splenic metastasis.

Conclusions

Contrary to widely held assumptions, our study further expands the application of CD-assisted 18F-FDOPA PET/CT for non-functioning pNETs when 68Ga-radiolabeled somatostatin analogs are not available.
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Metadaten
Titel
Carbidopa-assisted 18F-fluorodihydroxyphenylalanine PET/CT for the localization and staging of non-functioning neuroendocrine pancreatic tumors
verfasst von
Mehdi Helali
Pietro Addeo
Céline Heimburger
Julien Detour
Bernard Goichot
Philippe Bachellier
Izzie Jacques Namer
David Taïeb
Alessio Imperiale
Publikationsdatum
02.08.2016
Verlag
Springer Japan
Erschienen in
Annals of Nuclear Medicine / Ausgabe 9/2016
Print ISSN: 0914-7187
Elektronische ISSN: 1864-6433
DOI
https://doi.org/10.1007/s12149-016-1110-y

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