Skip to main content
Erschienen in: Annals of Behavioral Medicine 1/2011

01.08.2011 | Rapid Communication

Clinician-Assessed Depression and HAART Adherence in HIV-Infected Individuals in Methadone Maintenance Treatment

verfasst von: Jeffrey S. Gonzalez, Ph.D., Christina Psaros, Ph.D., Abigail Batchelder, M.P.H., Allison Applebaum, Ph.D., Howard Newville, M.A., Steven A. Safren, Ph.D.

Erschienen in: Annals of Behavioral Medicine | Ausgabe 1/2011

Einloggen, um Zugang zu erhalten

Abstract

Background

The impact of measurement methods on the relationship between depression and HIV treatment adherence has not been adequately examined.

Purpose

The purpose of this paper is to examine the relationship between clinician- and patient-rated depression and HIV medication adherence.

Methods

The participants were 91 HIV-infected individuals in methadone maintenance. Depression was assessed via clinician ratings (Clinical Global Impression Scale and Montgomery Asberg Depression Rating Scale) and self-report (Beck Depression Inventory-Short Form). Clinicians rated substance abuse using the Clinical Global Impression Scale and a structured interview. HIV medication adherence was measured over the following 2 weeks using electronic caps.

Results

Each unit increase in the Clinical Global Impression Scale was associated with 75% increased odds of nonadherence (OR = 1.75, p = 0.002, 95% CI = 1.23–2.48). Similarly, for each standard deviation Montgomery Asberg Depression Rating Scale increase, there was a 2.6-fold increased odds of nonadherence (OR = 2.60, p = 0.001, 95% CI = 1.45–4.67). Substance abuse and self-reported depression severity were not significantly related to adherence.

Conclusions

Clinician-rated depression severity was a strong predictor of nonadherence. Assessment methods may influence the relationship between depression and HIV nonadherence.
Literatur
1.
Zurück zum Zitat Crum NF, Riffenburgh RH, Wegner S, et al. Comparisons of causes of death and mortality rates among HIV infected persons: Analysis of the pre-, early, and late HAART (highly active antiretroviral therapy) eras. J Acq Immun Def Synd. 2006; 41(2): 194–200.CrossRef Crum NF, Riffenburgh RH, Wegner S, et al. Comparisons of causes of death and mortality rates among HIV infected persons: Analysis of the pre-, early, and late HAART (highly active antiretroviral therapy) eras. J Acq Immun Def Synd. 2006; 41(2): 194–200.CrossRef
2.
Zurück zum Zitat Glass TR, De Geest S, Hirschel B, et al. Self-reported non-adherence to antiretroviral therapy repeatedly assessed by two questions predicts treatment failure in virologically suppressed patients. Antivir Ther. 2008; (13): 77–85. Glass TR, De Geest S, Hirschel B, et al. Self-reported non-adherence to antiretroviral therapy repeatedly assessed by two questions predicts treatment failure in virologically suppressed patients. Antivir Ther. 2008; (13): 77–85.
3.
Zurück zum Zitat DiMatteo MR, Lepper HS, Croghan TW. Depression is a risk factor for noncompliance with medical treatment - Meta-analysis of the effects of anxiety and depression on patient adherence. Arch Intern Med. 2000; 160(14): 2101–2107.PubMedCrossRef DiMatteo MR, Lepper HS, Croghan TW. Depression is a risk factor for noncompliance with medical treatment - Meta-analysis of the effects of anxiety and depression on patient adherence. Arch Intern Med. 2000; 160(14): 2101–2107.PubMedCrossRef
4.
Zurück zum Zitat Bing EG, Burnam A, Longshore D, et al. Psychiatric disorders and drug use among human immunodeficiency virus-infected adults in the United States. Arch Gen Psychiat. 2001; 58(8): 721–728.PubMedCrossRef Bing EG, Burnam A, Longshore D, et al. Psychiatric disorders and drug use among human immunodeficiency virus-infected adults in the United States. Arch Gen Psychiat. 2001; 58(8): 721–728.PubMedCrossRef
5.
Zurück zum Zitat Tucker JS, Burnam MA, Sherbourne CD, Kuong F, Gifford AL. Substance use and mental health correlates of nonadherence to antiretroviral medications in a sample of patients with human immunodeficiency virus infection. Am J Med. 2003; 114(7): 573–580.PubMedCrossRef Tucker JS, Burnam MA, Sherbourne CD, Kuong F, Gifford AL. Substance use and mental health correlates of nonadherence to antiretroviral medications in a sample of patients with human immunodeficiency virus infection. Am J Med. 2003; 114(7): 573–580.PubMedCrossRef
6.
Zurück zum Zitat Wagner GJ. Predictors of antiretroviral adherence as measured by self-report, electronic monitoring, and medication diaries. AIDS Patient Care ST. 2002; 16(12): 599–608.CrossRef Wagner GJ. Predictors of antiretroviral adherence as measured by self-report, electronic monitoring, and medication diaries. AIDS Patient Care ST. 2002; 16(12): 599–608.CrossRef
7.
Zurück zum Zitat Gibbie T, Hay M, Hutchison CW, Mijch A. Depression, social support and adherence to highly active antiretroviral therapy in people living with HIV/AIDS. Sexual Health. 2007; 4(4): 227–232.PubMedCrossRef Gibbie T, Hay M, Hutchison CW, Mijch A. Depression, social support and adherence to highly active antiretroviral therapy in people living with HIV/AIDS. Sexual Health. 2007; 4(4): 227–232.PubMedCrossRef
8.
Zurück zum Zitat Gonzalez JS, Penedo FJ, Antoni MH et al. Social support, positive states of mind, and HIV treatment adherence in men and women living with HIV/AIDS. Health Psychol. 2004; 23(4): 413–418.PubMedCrossRef Gonzalez JS, Penedo FJ, Antoni MH et al. Social support, positive states of mind, and HIV treatment adherence in men and women living with HIV/AIDS. Health Psychol. 2004; 23(4): 413–418.PubMedCrossRef
9.
Zurück zum Zitat O’Cleirigh C, Ironson G, Weiss A, Costa PT. Conscientiousness predicts disease progression (CD4 Number and Viral Load) in people living with HIV. Health Psychol. 2007; 26(4): 473–480.PubMedCrossRef O’Cleirigh C, Ironson G, Weiss A, Costa PT. Conscientiousness predicts disease progression (CD4 Number and Viral Load) in people living with HIV. Health Psychol. 2007; 26(4): 473–480.PubMedCrossRef
10.
Zurück zum Zitat Ammassari A, Antinori A, Aloisi MS, et al. Depressive symptoms, neurocognitive impairment, and adherence to highly active antiretroviral therapy among HIV-infected persons. Psychosomatics. 2004; 45(5): 394–402.PubMedCrossRef Ammassari A, Antinori A, Aloisi MS, et al. Depressive symptoms, neurocognitive impairment, and adherence to highly active antiretroviral therapy among HIV-infected persons. Psychosomatics. 2004; 45(5): 394–402.PubMedCrossRef
11.
Zurück zum Zitat Arnsten JH, Li X, Mizuno Y, et al. Factors associated with antiretroviral therapy adherence and medication errors among HIV-infected injection drug users. J Acq Immun Def Synd. 2007; 46: S64–S71.CrossRef Arnsten JH, Li X, Mizuno Y, et al. Factors associated with antiretroviral therapy adherence and medication errors among HIV-infected injection drug users. J Acq Immun Def Synd. 2007; 46: S64–S71.CrossRef
12.
Zurück zum Zitat Avants SK, Margolin A, Warburton LA, Hawkins KA. Predictors of nonadherence to HIV-related medication regimes during methadone stabilization. Am J Addiction. 2001; 10:69–78.CrossRef Avants SK, Margolin A, Warburton LA, Hawkins KA. Predictors of nonadherence to HIV-related medication regimes during methadone stabilization. Am J Addiction. 2001; 10:69–78.CrossRef
13.
Zurück zum Zitat Arnsten JH, Demas PA, Grant RW, et al. Impact of active drug use on antiretroviral therapy adherence and viral suppression in HIV+ drug users. J Gen Intern Med. 2002; 17(5): 377–381.PubMed Arnsten JH, Demas PA, Grant RW, et al. Impact of active drug use on antiretroviral therapy adherence and viral suppression in HIV+ drug users. J Gen Intern Med. 2002; 17(5): 377–381.PubMed
14.
Zurück zum Zitat Berg K, Demas P, Howard A, Schoenbaum E, Gourevitch M, Arnsten J. Gender differences in factors associated with adherence to antiretroviral therapy. J Gen Intern Med. 2004; 19(11): 1111–1117.PubMedCrossRef Berg K, Demas P, Howard A, Schoenbaum E, Gourevitch M, Arnsten J. Gender differences in factors associated with adherence to antiretroviral therapy. J Gen Intern Med. 2004; 19(11): 1111–1117.PubMedCrossRef
15.
Zurück zum Zitat Beck AT. Cognitive therapy of depression. 1979; The Guilford Press: New York, NY. Beck AT. Cognitive therapy of depression. 1979; The Guilford Press: New York, NY.
16.
Zurück zum Zitat Matt GE, Vázquez C, Campbell KW. Mood-congruent recall of affectively toned stimuli: A meta-analytic review. Clin Psychol Rev. 1992; 12(2): 227–255. Matt GE, Vázquez C, Campbell KW. Mood-congruent recall of affectively toned stimuli: A meta-analytic review. Clin Psychol Rev. 1992; 12(2): 227–255.
17.
Zurück zum Zitat Hansen RA, Dusetzina SB, Song L, Gaynes BN, Tu W, Murray MD. Depression affects adherence measurement but not the effectiveness of an adherence intervention in heart failure patients. J Am Pharm Assoc. 2009, 49(6): 760–768.CrossRef Hansen RA, Dusetzina SB, Song L, Gaynes BN, Tu W, Murray MD. Depression affects adherence measurement but not the effectiveness of an adherence intervention in heart failure patients. J Am Pharm Assoc. 2009, 49(6): 760–768.CrossRef
18.
Zurück zum Zitat Sheehan DV, Lecrubier Y, Sheehan KH, et al. The Mini-International Neuropsychiatric Interview (MINI): The development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiat. 1998; 59(Suppl 20): 22–33. Sheehan DV, Lecrubier Y, Sheehan KH, et al. The Mini-International Neuropsychiatric Interview (MINI): The development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiat. 1998; 59(Suppl 20): 22–33.
19.
Zurück zum Zitat Montgomery SA, Asberg M. A new depression scale designed to be sensitive to change. Br J Psychiat. 1979; 13(4): 382–389.CrossRef Montgomery SA, Asberg M. A new depression scale designed to be sensitive to change. Br J Psychiat. 1979; 13(4): 382–389.CrossRef
20.
Zurück zum Zitat Guy W. Clinical Global Impression. ECDEU Assessment Manual for Psychopharmacology. U.S. Department of Health, Education, and Welfare, Public Health Service, Alcohol, Drug Abuse, and Mental Health Administration, NIMH. 1976; 218–222. Guy W. Clinical Global Impression. ECDEU Assessment Manual for Psychopharmacology. U.S. Department of Health, Education, and Welfare, Public Health Service, Alcohol, Drug Abuse, and Mental Health Administration, NIMH. 1976; 218–222.
21.
Zurück zum Zitat Beck AT, Rial WY, Rickels K. Short form of depression inventory: Cross-validation. Psychol Rep. 1974; 34(3):1184–1186.PubMed Beck AT, Rial WY, Rickels K. Short form of depression inventory: Cross-validation. Psychol Rep. 1974; 34(3):1184–1186.PubMed
22.
Zurück zum Zitat Reynolds WM, Gould JW. A psychometric investigation of the standard and short form Beck Depression Inventory. J Consult Clin Psych. 1981; 49(2): 306–307.CrossRef Reynolds WM, Gould JW. A psychometric investigation of the standard and short form Beck Depression Inventory. J Consult Clin Psych. 1981; 49(2): 306–307.CrossRef
23.
Zurück zum Zitat McLellan AT, Luborsky L, Woody GE, O’Brien CP. An improved diagnostic evaluation instrument for substance abuse patients: The Addiction Severity Index. J Nerv Ment Dis. 1980; 168(1): 26–33.PubMedCrossRef McLellan AT, Luborsky L, Woody GE, O’Brien CP. An improved diagnostic evaluation instrument for substance abuse patients: The Addiction Severity Index. J Nerv Ment Dis. 1980; 168(1): 26–33.PubMedCrossRef
Metadaten
Titel
Clinician-Assessed Depression and HAART Adherence in HIV-Infected Individuals in Methadone Maintenance Treatment
verfasst von
Jeffrey S. Gonzalez, Ph.D.
Christina Psaros, Ph.D.
Abigail Batchelder, M.P.H.
Allison Applebaum, Ph.D.
Howard Newville, M.A.
Steven A. Safren, Ph.D.
Publikationsdatum
01.08.2011
Verlag
Springer-Verlag
Erschienen in
Annals of Behavioral Medicine / Ausgabe 1/2011
Print ISSN: 0883-6612
Elektronische ISSN: 1532-4796
DOI
https://doi.org/10.1007/s12160-011-9268-y

Weitere Artikel der Ausgabe 1/2011

Annals of Behavioral Medicine 1/2011 Zur Ausgabe

Neu in den Fachgebieten Neurologie und Psychiatrie

Akuter Schwindel: Wann lohnt sich eine MRT?

28.04.2024 Schwindel Nachrichten

Akuter Schwindel stellt oft eine diagnostische Herausforderung dar. Wie nützlich dabei eine MRT ist, hat eine Studie aus Finnland untersucht. Immerhin einer von sechs Patienten wurde mit akutem ischämischem Schlaganfall diagnostiziert.

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

25.04.2024 Hypotonie Nachrichten

Wenn unter einer medikamentösen Hochdrucktherapie der diastolische Blutdruck in den Keller geht, steigt das Risiko für schwere kardiovaskuläre Ereignisse: Darauf deutet eine Sekundäranalyse der SPRINT-Studie hin.

Frühe Alzheimertherapie lohnt sich

25.04.2024 AAN-Jahrestagung 2024 Nachrichten

Ist die Tau-Last noch gering, scheint der Vorteil von Lecanemab besonders groß zu sein. Und beginnen Erkrankte verzögert mit der Behandlung, erreichen sie nicht mehr die kognitive Leistung wie bei einem früheren Start. Darauf deuten neue Analysen der Phase-3-Studie Clarity AD.

Viel Bewegung in der Parkinsonforschung

25.04.2024 Parkinson-Krankheit Nachrichten

Neue arznei- und zellbasierte Ansätze, Frühdiagnose mit Bewegungssensoren, Rückenmarkstimulation gegen Gehblockaden – in der Parkinsonforschung tut sich einiges. Auf dem Deutschen Parkinsonkongress ging es auch viel um technische Innovationen.