Erschienen in:
01.12.2011 | Original Article
Fatigue, Depression, Sleep, and Activity During Chemotherapy: Daily and Intraday Variation and Relationships Among Symptom Changes
verfasst von:
Heather S. L. Jim, Ph.D., Brent Small, Ph.D., Leigh Anne Faul, Ph.D., Jamie Franzen, B.A, Sachin Apte, M.D., Paul B. Jacobsen, Ph.D.
Erschienen in:
Annals of Behavioral Medicine
|
Ausgabe 3/2011
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Abstract
Background
Previous research suggests that cancer patients frequently experience multiple symptoms during chemotherapy; however, relationships among symptom changes are largely unknown.
Purpose
The aim of the current study was to examine daily and intraday changes and interrelationships among fatigue, depression, and objectively measured disruptions in sleep and activity during chemotherapy.
Methods
Participants were 78 women with gynecologic cancer. Fatigue, depression, sleep, and activity were assessed the week before and the week after the participants’ first three infusions.
Results
Significant changes in fatigue, depression, sleep, and activity were observed over time. Before infusions, increases in fatigue were associated with increases in depression. After infusions, increases in fatigue were associated with increases in depression and minutes awake at night, as well as decreases in daytime activity and regularity of sleep/activity patterns (ps < .05).
Conclusions
This study is among the first to track daily and intraday changes in symptoms and interrelationships during chemotherapy. Results indicate that symptoms are interrelated and return to baseline levels after infusions.