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Erschienen in: Annals of Behavioral Medicine 2/2013

01.04.2013 | Original Article

The SHED-IT Community Trial: A Randomized Controlled Trial of Internet- and Paper-Based Weight Loss Programs Tailored for Overweight and Obese Men

verfasst von: Philip J. Morgan, Ph.D., Robin Callister, Ph.D., Clare E. Collins, Ph.D, Ronald C. Plotnikoff, Ph.D, Myles D. Young, B.Psych, Nina Berry, Ph.D., Patrick McElduff, Ph.D., Tracy Burrows, Ph.D., Elroy Aguiar, B.Biomed.Sc., Kristen L. Saunders, B.App.Sci.

Erschienen in: Annals of Behavioral Medicine | Ausgabe 2/2013

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Abstract

Background

There is limited evidence for effective obesity treatment programs that engage men.

Purpose

This study evaluated the efficacy of two gender-tailored weight loss interventions for men, which required no face-to-face contact.

Methods

This was a three-arm, randomized controlled trial: (1) Resources (n = 54), gender-tailored weight loss materials (DVD, handbooks, pedometer, tape measure); (2) Online (n = 53), Resources materials plus study website and e-feedback; and (3) Wait-list control (n = 52). The interventions lasted 3 months and were grounded in Social Cognitive Theory.

Results

At 6 months, significantly greater weight loss was observed for the Online (−4.7 kg; 95 % CI −6.1, −3.2) and Resources (−3.7 kg; 95 % CI −4.9, −2.5) groups compared to the control (−0.5 kg; 95 % CI −1.4, 0.4). Additionally, both intervention groups significantly improved body mass index, percent body fat, waist circumference, blood pressure, physical activity, quality of life, alcohol risk, and portion size, compared to controls.

Conclusions

Men achieved significant weight loss after receiving novel, minimal-contact, gender-tailored programs, which were designed for widespread dissemination.
Literatur
1.
Zurück zum Zitat Finucane MM, Stevens GA, Cowan MJ, et al. National, regional, and global trends in body-mass index since 1980: Systematic analysis of health examination surveys and epidemiological studies with 960 country-years and 9.1 million participants. Lancet. 2011;377:557-567. Finucane MM, Stevens GA, Cowan MJ, et al. National, regional, and global trends in body-mass index since 1980: Systematic analysis of health examination surveys and epidemiological studies with 960 country-years and 9.1 million participants. Lancet. 2011;377:557-567.
2.
Zurück zum Zitat Wirth A, Steinmetz B. Gender differences in changes in subcutaneous and intra-abdominal fat during weight reduction: An ultrasound study. Obes Res. 1998;6:393-399. Wirth A, Steinmetz B. Gender differences in changes in subcutaneous and intra-abdominal fat during weight reduction: An ultrasound study. Obes Res. 1998;6:393-399.
3.
Zurück zum Zitat Australian Bureau of Statistics: Overweight and obesity in adults in Australia: A snapshot, 2007–2008. Canberra, 2011. Australian Bureau of Statistics: Overweight and obesity in adults in Australia: A snapshot, 20072008. Canberra, 2011.
4.
Zurück zum Zitat Pagoto SL, Schneider KL, Oleski JL, et al. Male Inclusion in Randomized Controlled Trials of Lifestyle Weight Loss Interventions. Obesity. 2012;20:1234-1239.PubMedCrossRef Pagoto SL, Schneider KL, Oleski JL, et al. Male Inclusion in Randomized Controlled Trials of Lifestyle Weight Loss Interventions. Obesity. 2012;20:1234-1239.PubMedCrossRef
5.
Zurück zum Zitat Gray CM, Anderson AS, Clarke AM, et al. Addressing male obesity: An evaluation of a group-based weight management intervention for Scottish men. J Mens Health. 2009;6:70-81. Gray CM, Anderson AS, Clarke AM, et al. Addressing male obesity: An evaluation of a group-based weight management intervention for Scottish men. J Mens Health. 2009;6:70-81.
6.
Zurück zum Zitat Sabinsky MS, Toft U, Raben A, Holm L. Overweight men’s motivations and perceived barriers towards weight loss. Eur J Clin Nutr. 2007;61:526-531.PubMed Sabinsky MS, Toft U, Raben A, Holm L. Overweight men’s motivations and perceived barriers towards weight loss. Eur J Clin Nutr. 2007;61:526-531.PubMed
7.
Zurück zum Zitat Egger G. Intervening in men's nutrition: Lessons from the GutBuster men's 'waist loss' program. Aust J Nutr Diet. 2000;57:46-49. Egger G. Intervening in men's nutrition: Lessons from the GutBuster men's 'waist loss' program. Aust J Nutr Diet. 2000;57:46-49.
8.
Zurück zum Zitat Morgan PJ, Warren JM, Lubans DR, Collins CE, Callister R. Engaging men in weight loss: Experiences of men who participated in the male only SHED-IT pilot study. Obes Res Clin Prac. 2011;5:e239-e248.CrossRef Morgan PJ, Warren JM, Lubans DR, Collins CE, Callister R. Engaging men in weight loss: Experiences of men who participated in the male only SHED-IT pilot study. Obes Res Clin Prac. 2011;5:e239-e248.CrossRef
9.
Zurück zum Zitat Young MD, Morgan PJ, Plotnikoff RC, Callister R, Collins CE. Effectiveness of male-only weight loss and weight loss maintenance interventions: A systematic review with meta-analysis. Obes Rev. 2012;13:393-408. Young MD, Morgan PJ, Plotnikoff RC, Callister R, Collins CE. Effectiveness of male-only weight loss and weight loss maintenance interventions: A systematic review with meta-analysis. Obes Rev. 2012;13:393-408.
10.
Zurück zum Zitat Egger G, Bolton A, O'Neill M, Freeman D. Effectiveness of an abdominal obesity reduction programme in men: The GutBuster 'waist loss' programme. Int J Obes Relat Metab Disord. 1996;20:227-231. Egger G, Bolton A, O'Neill M, Freeman D. Effectiveness of an abdominal obesity reduction programme in men: The GutBuster 'waist loss' programme. Int J Obes Relat Metab Disord. 1996;20:227-231.
11.
Zurück zum Zitat Collins CE, Morgan PJ, Warren JM, Lubans DR, Callister R. Men participating in a weight-loss intervention are able to implement key dietary messages, but not those relating to vegetables or alcohol: The Self-Help, Exercise and Diet using Internet Technology (SHED-IT) study. Public Health Nutr. 2011;14:168-175. Collins CE, Morgan PJ, Warren JM, Lubans DR, Callister R. Men participating in a weight-loss intervention are able to implement key dietary messages, but not those relating to vegetables or alcohol: The Self-Help, Exercise and Diet using Internet Technology (SHED-IT) study. Public Health Nutr. 2011;14:168-175.
12.
Zurück zum Zitat Lubans D, Morgan P, Collins C, Warren J, Callister R. Exploring the mechanisms of weight loss in the SHED-IT intervention for overweight men: A mediation analysis. Int J Behav Nutr Phys Act. 2009;6:76. Lubans D, Morgan P, Collins C, Warren J, Callister R. Exploring the mechanisms of weight loss in the SHED-IT intervention for overweight men: A mediation analysis. Int J Behav Nutr Phys Act. 2009;6:76.
13.
Zurück zum Zitat Morgan PJ, Lubans DR, Collins CE, Warren JM, Callister R. The SHED-IT Randomized Controlled Trial: Evaluation of an Internet-based Weight Loss Program for Men. Obesity. 2009;17:2025-2032.PubMedCrossRef Morgan PJ, Lubans DR, Collins CE, Warren JM, Callister R. The SHED-IT Randomized Controlled Trial: Evaluation of an Internet-based Weight Loss Program for Men. Obesity. 2009;17:2025-2032.PubMedCrossRef
14.
Zurück zum Zitat Morgan PJ, Lubans DR, Collins CE, Warren JM, Callister R. 12-Month Outcomes and Process Evaluation of the SHED-IT RCT: An Internet-Based Weight Loss Program Targeting Men. Obesity. 2011;19:142-151.PubMedCrossRef Morgan PJ, Lubans DR, Collins CE, Warren JM, Callister R. 12-Month Outcomes and Process Evaluation of the SHED-IT RCT: An Internet-Based Weight Loss Program Targeting Men. Obesity. 2011;19:142-151.PubMedCrossRef
15.
Zurück zum Zitat Morgan PJ, Collins CE, Plotnikoff RC, et al. The SHED-IT community trial study protocol: A randomised controlled trial of weight loss programs for overweight and obese men. BMC Public Health. 2010;10:701. Morgan PJ, Collins CE, Plotnikoff RC, et al. The SHED-IT community trial study protocol: A randomised controlled trial of weight loss programs for overweight and obese men. BMC Public Health. 2010;10:701.
16.
Zurück zum Zitat Norton K. Sports Medicine Australia pre-exercise screening system. Sports Medicine Australia (SMA), 2005. Norton K. Sports Medicine Australia pre-exercise screening system. Sports Medicine Australia (SMA), 2005.
17.
Zurück zum Zitat Morgan PJ, Lubans DR, Callister R, et al. The 'Healthy Dads, Healthy Kids' randomized controlled trial: Efficacy of a healthy lifestyle program for overweight fathers and their children. Int J Obes. 2011;35:436-447. Morgan PJ, Lubans DR, Callister R, et al. The 'Healthy Dads, Healthy Kids' randomized controlled trial: Efficacy of a healthy lifestyle program for overweight fathers and their children. Int J Obes. 2011;35:436-447.
18.
Zurück zum Zitat Bandura A. Social foundations of thought and action: A Social Cognitive Theory. Englewood Cliffs, NJ: Prentice-Hall; 1986. Bandura A. Social foundations of thought and action: A Social Cognitive Theory. Englewood Cliffs, NJ: Prentice-Hall; 1986.
19.
Zurück zum Zitat Gough B, Conner MT. Barriers to healthy eating amongst men: A qualitative analysis. Soc Sci Med. 2006;62:387-395. Gough B, Conner MT. Barriers to healthy eating amongst men: A qualitative analysis. Soc Sci Med. 2006;62:387-395.
20.
Zurück zum Zitat Kiefer I, Rathemanner T, Kunze M. Eating and dieting differences in men and women. J Mens Health Gend. 2005;2:194-201.CrossRef Kiefer I, Rathemanner T, Kunze M. Eating and dieting differences in men and women. J Mens Health Gend. 2005;2:194-201.CrossRef
21.
Zurück zum Zitat Lewis S, Thomas SL, Hyde J, Castle DJ, Komesaroff PA. A qualitative investigation of obese men's experiences with their weight. Am J Health Behav. 2011;35:458-469.PubMedCrossRef Lewis S, Thomas SL, Hyde J, Castle DJ, Komesaroff PA. A qualitative investigation of obese men's experiences with their weight. Am J Health Behav. 2011;35:458-469.PubMedCrossRef
22.
Zurück zum Zitat Smith JA, Braunack-Mayer AJ, Wittert GA, Warin MJ. Qualities men value when communicating with general practitioners: Implications for primary care settings. Med J Aust. 2008;189:618-621. Smith JA, Braunack-Mayer AJ, Wittert GA, Warin MJ. Qualities men value when communicating with general practitioners: Implications for primary care settings. Med J Aust. 2008;189:618-621.
24.
Zurück zum Zitat Australian Bureau of Statistics: Socio-economic Indexes for Areas (SEIFA) Australia- 2006: Postal Areas, Index of Relative Socio-economic Advantage and Disadvantage No. ABS catalogue 2033.0.55.001. Canberra: Commonwealth of Australia, 2008. Australian Bureau of Statistics: Socio-economic Indexes for Areas (SEIFA) Australia- 2006: Postal Areas, Index of Relative Socio-economic Advantage and Disadvantage No. ABS catalogue 2033.0.55.001. Canberra: Commonwealth of Australia, 2008.
25.
Zurück zum Zitat World Health Organization (WHO): Waist circumference and waist-hip ratio: Report of a WHO expert consultation. Geneva, Switzerland: WHO, 8–11 December 2008. World Health Organization (WHO): Waist circumference and waist-hip ratio: Report of a WHO expert consultation. Geneva, Switzerland: WHO, 8–11 December 2008.
26.
Zurück zum Zitat Gibson AL, Holmes JC, Desautels RL, Edmonds LB, Nuudi L. Ability of new octapolar bioimpedance spectroscopy analyzers to predict 4-component-model percentage body fat in Hispanic, black, and white adults. Am J Clin Nutr. 2008;87:332-338.PubMed Gibson AL, Holmes JC, Desautels RL, Edmonds LB, Nuudi L. Ability of new octapolar bioimpedance spectroscopy analyzers to predict 4-component-model percentage body fat in Hispanic, black, and white adults. Am J Clin Nutr. 2008;87:332-338.PubMed
27.
Zurück zum Zitat Le Masurier GC, Lee SM, Tudor-Locke C. Motion sensor accuracy under controlled and free-living conditions. Med Sci Sports Exerc. 2004;36:905-910.PubMed Le Masurier GC, Lee SM, Tudor-Locke C. Motion sensor accuracy under controlled and free-living conditions. Med Sci Sports Exerc. 2004;36:905-910.PubMed
28.
Zurück zum Zitat Steeves JA, Silcott NA, Bassett DR, Thompson DL, Fitzhugh EC. Evaluation of the Omron HJ-720ITC Pedometer under Free-Living Conditions. Med Sci Sports Exerc. 2011;43:1791-1797.PubMedCrossRef Steeves JA, Silcott NA, Bassett DR, Thompson DL, Fitzhugh EC. Evaluation of the Omron HJ-720ITC Pedometer under Free-Living Conditions. Med Sci Sports Exerc. 2011;43:1791-1797.PubMedCrossRef
29.
Zurück zum Zitat Marshall AL, Miller YD, Burton NW, Brown WJ. Measuring total and domain-specific sitting: A study of reliability and validity. Med Sci Sports Exerc. 2010;42:1094-1102. Marshall AL, Miller YD, Burton NW, Brown WJ. Measuring total and domain-specific sitting: A study of reliability and validity. Med Sci Sports Exerc. 2010;42:1094-1102.
30.
Zurück zum Zitat Watson J, Collins C, Sibbritt D, Dibley M, Garg M. Reproducibility and comparative validity of a food frequency questionnaire for Australian children and adolescents. Int J Behav Nutr Phys Act. 2009;6:62.PubMedCrossRef Watson J, Collins C, Sibbritt D, Dibley M, Garg M. Reproducibility and comparative validity of a food frequency questionnaire for Australian children and adolescents. Int J Behav Nutr Phys Act. 2009;6:62.PubMedCrossRef
31.
Zurück zum Zitat Giles GG, Ireland PD. Dietary Questionnaire for Epidemiological Studies (Version 2). Melbourne: The Cancer Council Victoria; 1996. Giles GG, Ireland PD. Dietary Questionnaire for Epidemiological Studies (Version 2). Melbourne: The Cancer Council Victoria; 1996.
32.
Zurück zum Zitat Saunders JB, Aasland OG, Babor TF, de la Fuente JR, Grant M. Development of the Alcohol Use Disorders Identification Test (AUDIT): WHO Collaborative Project on Early Detection of Persons with Harmful Alcohol Consumption–II. Addiction. 1993;88:791-804.PubMedCrossRef Saunders JB, Aasland OG, Babor TF, de la Fuente JR, Grant M. Development of the Alcohol Use Disorders Identification Test (AUDIT): WHO Collaborative Project on Early Detection of Persons with Harmful Alcohol Consumption–II. Addiction. 1993;88:791-804.PubMedCrossRef
33.
Zurück zum Zitat Allen JP, Litten RZ, Fertig JB, Babor T. A review of research on the Alcohol Use Disorders Identification Test (AUDIT). Alcohol Clin Exp Res. 1997;21:613-619.PubMedCrossRef Allen JP, Litten RZ, Fertig JB, Babor T. A review of research on the Alcohol Use Disorders Identification Test (AUDIT). Alcohol Clin Exp Res. 1997;21:613-619.PubMedCrossRef
34.
Zurück zum Zitat Ware J Jr. Kosinski M, Keller SD: A 12-Item Short-Form Health Survey: construction of scales and preliminary tests of reliability and validity. Med Care. 1996;34:220-233.PubMedCrossRef Ware J Jr. Kosinski M, Keller SD: A 12-Item Short-Form Health Survey: construction of scales and preliminary tests of reliability and validity. Med Care. 1996;34:220-233.PubMedCrossRef
35.
Zurück zum Zitat Johns MW. A new method for measuring daytime sleepiness: The Epworth sleepiness scale. Sleep. 1991;14:540-545. Johns MW. A new method for measuring daytime sleepiness: The Epworth sleepiness scale. Sleep. 1991;14:540-545.
36.
Zurück zum Zitat Fayers P, King M. The baseline characteristics did not differ significantly. Qual Life Res. 2008;17:1047-1048.PubMedCrossRef Fayers P, King M. The baseline characteristics did not differ significantly. Qual Life Res. 2008;17:1047-1048.PubMedCrossRef
37.
Zurück zum Zitat White IR, Horton NJ, Carpenter J, Pocock SJ. Strategy for intention to treat analysis in randomised trials with missing outcome data. Br Med J. 2011;342:d40.CrossRef White IR, Horton NJ, Carpenter J, Pocock SJ. Strategy for intention to treat analysis in randomised trials with missing outcome data. Br Med J. 2011;342:d40.CrossRef
38.
Zurück zum Zitat Moher D, Hopewell S, Schulz KF, et al. CONSORT 2010 Explanation and Elaboration: Updated guidelines for reporting parallel group randomised trials. Br Med J. 2010;340:c869. Moher D, Hopewell S, Schulz KF, et al. CONSORT 2010 Explanation and Elaboration: Updated guidelines for reporting parallel group randomised trials. Br Med J. 2010;340:c869.
39.
Zurück zum Zitat Neve M, Morgan P, Collins C. Weight change in a commercial web-based weight loss program and its association with website use: Cohort study. J Med Int Res. 2011;13:e83. Neve M, Morgan P, Collins C. Weight change in a commercial web-based weight loss program and its association with website use: Cohort study. J Med Int Res. 2011;13:e83.
40.
Zurück zum Zitat Diabetes Prevention Program Research Group. Reduction in the Incidence of Type 2 Diabetes with Lifestyle Intervention or Metformin. N Eng J Med. 2002;346:393-403.CrossRef Diabetes Prevention Program Research Group. Reduction in the Incidence of Type 2 Diabetes with Lifestyle Intervention or Metformin. N Eng J Med. 2002;346:393-403.CrossRef
41.
Zurück zum Zitat Patrick K, Calfas KJ, Norman GJ, et al. Outcomes of a 12-month web-based intervention for overweight and obese men. Ann Behav Med. 2011;42:391-401.PubMedCrossRef Patrick K, Calfas KJ, Norman GJ, et al. Outcomes of a 12-month web-based intervention for overweight and obese men. Ann Behav Med. 2011;42:391-401.PubMedCrossRef
42.
Zurück zum Zitat Tanaka M, Adachi Y, Adachi K, Sato C. Effects of a non-face-to-face behavioral weight-control program among Japanese overweight males: a randomized controlled trial. Int J Behav Med. 2010;17:17-24.PubMedCrossRef Tanaka M, Adachi Y, Adachi K, Sato C. Effects of a non-face-to-face behavioral weight-control program among Japanese overweight males: a randomized controlled trial. Int J Behav Med. 2010;17:17-24.PubMedCrossRef
43.
Zurück zum Zitat Leslie WS, Lean MEJ, Baillie HM, Hankey C. Weight management: A comparison of existing dietary approaches in a work-site setting. Int J Obes. 2002;26:1469-1475. Leslie WS, Lean MEJ, Baillie HM, Hankey C. Weight management: A comparison of existing dietary approaches in a work-site setting. Int J Obes. 2002;26:1469-1475.
44.
Zurück zum Zitat Janssen I, Katzmarzyk PT, Ross R. Body mass index, waist circumference, and health risk: Evidence in support of current National Institutes of Health guidelines. Arch Intern Med. 2002;162:2074-2079. Janssen I, Katzmarzyk PT, Ross R. Body mass index, waist circumference, and health risk: Evidence in support of current National Institutes of Health guidelines. Arch Intern Med. 2002;162:2074-2079.
45.
Zurück zum Zitat Neve M, Morgan PJ, Jones PR, Collins CE. Effectiveness of web-based interventions in achieving weight loss and weight loss maintenance in overweight and obese adults: A systematic review with meta-analysis. Obes Rev. 2010;11:306-321. Neve M, Morgan PJ, Jones PR, Collins CE. Effectiveness of web-based interventions in achieving weight loss and weight loss maintenance in overweight and obese adults: A systematic review with meta-analysis. Obes Rev. 2010;11:306-321.
46.
Zurück zum Zitat Norman GJ, Zabinski MF, Adams MA, et al. A Review of eHealth Interventions for Physical Activity and Dietary Behavior Change. Am J Prev Med. 2007;33:336-345.PubMedCrossRef Norman GJ, Zabinski MF, Adams MA, et al. A Review of eHealth Interventions for Physical Activity and Dietary Behavior Change. Am J Prev Med. 2007;33:336-345.PubMedCrossRef
47.
Zurück zum Zitat Donnelly JE, Blair SN, Jakicic JM, et al. American College of Sports Medicine Position Stand. Appropriate physical activity intervention strategies for weight loss and prevention of weight regain for adults. Med Sci Sports Exerc. 2009;41:459-471.PubMed Donnelly JE, Blair SN, Jakicic JM, et al. American College of Sports Medicine Position Stand. Appropriate physical activity intervention strategies for weight loss and prevention of weight regain for adults. Med Sci Sports Exerc. 2009;41:459-471.PubMed
48.
Zurück zum Zitat George ES, Kolt GS, Duncan MJ, et al. A Review of the Effectiveness of Physical Activity Interventions for Adult Males. Sports Med. 2012;42:281-300.PubMedCrossRef George ES, Kolt GS, Duncan MJ, et al. A Review of the Effectiveness of Physical Activity Interventions for Adult Males. Sports Med. 2012;42:281-300.PubMedCrossRef
49.
Zurück zum Zitat Barker R, Cooke B. Diet, obesity and being overweight: A qualitative research study. Health Educ J. 1992;51:117-121. Barker R, Cooke B. Diet, obesity and being overweight: A qualitative research study. Health Educ J. 1992;51:117-121.
50.
Zurück zum Zitat Jackson M, Ball K, Crawford D. Beliefs about the causes of weight change in the Australian population. Int J Obes. 2001;25:1512-1516.CrossRef Jackson M, Ball K, Crawford D. Beliefs about the causes of weight change in the Australian population. Int J Obes. 2001;25:1512-1516.CrossRef
51.
Zurück zum Zitat Australian Bureau of Statistics: Alcohol Consumption in Australia: A Snapshot, 2004–05 No. 4832.0.55.001. Canberra, 2006. Australian Bureau of Statistics: Alcohol Consumption in Australia: A Snapshot, 200405 No. 4832.0.55.001. Canberra, 2006.
Metadaten
Titel
The SHED-IT Community Trial: A Randomized Controlled Trial of Internet- and Paper-Based Weight Loss Programs Tailored for Overweight and Obese Men
verfasst von
Philip J. Morgan, Ph.D.
Robin Callister, Ph.D.
Clare E. Collins, Ph.D
Ronald C. Plotnikoff, Ph.D
Myles D. Young, B.Psych
Nina Berry, Ph.D.
Patrick McElduff, Ph.D.
Tracy Burrows, Ph.D.
Elroy Aguiar, B.Biomed.Sc.
Kristen L. Saunders, B.App.Sci.
Publikationsdatum
01.04.2013
Verlag
Springer-Verlag
Erschienen in
Annals of Behavioral Medicine / Ausgabe 2/2013
Print ISSN: 0883-6612
Elektronische ISSN: 1532-4796
DOI
https://doi.org/10.1007/s12160-012-9424-z

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