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Journal of Ocular Biology, Diseases, and Informatics

Erschienen in:

01.06.2011

Glial and neuronal dysfunction in streptozotocin-induced diabetic rats

verfasst von: Vickie H. Y. Wong, Algis J. Vingrys, Bang V. Bui

Erschienen in: Journal of Ocular Biology, Diseases, and Informatics | Ausgabe 1-2/2011

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Abstract

Neuronal dysfunction has been noted very soon after the induction of diabetes by streptozotocin injection in rats. It is not clear from anatomical evidence whether glial cell dysfunction accompanies the well-documented neuronal deficit. Here, we isolate the Müller cell driven slow-P3 component of the full-field electroretinogram and show that it is attenuated at 4 weeks following the onset of streptozotocin-hyperglycaemia. We also found a concurrent reduction in the sensitivity of the phototransduction cascade, as well as in the components of the electroretinogram known to indicate retinal ganglion cell and amacrine cell integrity. Our data support the idea that neuronal and Müller cell dysfunction occurs at the same time in streptozotocin-induced hyperglycaemia.

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Titel: Glial and neuronal dysfunction in streptozotocin-induced diabetic rats
verfasst von: Vickie H. Y. Wong
Algis J. Vingrys
Bang V. Bui
Publikationsdatum: 01.06.2011
Verlag: Springer-Verlag
Erschienen in: Journal of Ocular Biology, Diseases, and Informatics / Ausgabe 1-2/2011
Elektronische ISSN: 1936-8445
DOI: https://doi.org/10.1007/s12177-011-9069-3

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