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International Journal of Hematology

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01.02.2011 | Progress in Hematology

Transcriptional regulation by GATA1 and GATA2 during erythropoiesis

verfasst von: Mikiko Suzuki, Ritsuko Shimizu, Masayuki Yamamoto

Erschienen in: International Journal of Hematology | Ausgabe 2/2011

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Abstract

The transcription factor GATA1 regulates multiple genes in erythroid lineage cells. However, the means by which GATA1 regulates the expression of target genes during erythropoiesis remains to be elucidated. Three mechanisms have been postulated for the regulation of genes by GATA1. First, individual target genes may have multiple discrete thresholds for cellular GATA1. GATA1 has a dynamic expression profile during erythropoiesis, thus the expression of a set of GATA1 target genes may be triggered at a given stage of differentiation by cellular GATA1. Second, the expression of GATA1 target genes may be modified, at least in part, by GATA2 occupying the GATA-binding motifs. GATA2 is expressed earlier in erythropoiesis than GATA1, and prior GATA2 binding may afford GATA1 access to GATA motifs through epigenetic remodeling and thus facilitate target gene expression. Third, other regulatory molecules specific to each target gene may function cooperatively with GATA1. If GATA1 is required for the expression of such cofactors, a regulatory network will be formed and relevant gene expression will be delayed. We propose that the stage-specific regulation of erythroid genes by GATA1 is tightly controlled through a combination of these mechanisms in vivo.

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Titel: Transcriptional regulation by GATA1 and GATA2 during erythropoiesis
verfasst von: Mikiko Suzuki
Ritsuko Shimizu
Masayuki Yamamoto
Publikationsdatum: 01.02.2011
Verlag: Springer Japan
Erschienen in: International Journal of Hematology / Ausgabe 2/2011
Print ISSN: 0925-5710
Elektronische ISSN: 1865-3774
DOI: https://doi.org/10.1007/s12185-011-0770-6

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