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Pathology & Oncology Research

Erschienen in:

01.12.2009 | Original Paper

Prognostic Value of Tumor-Related Molecular Expression in Gastric Carcinoma

verfasst von: Zhong-Sheng Zhao, Yuan-Yu Wang, Zai-Yuan Ye, Hou-Quan Tao

Erschienen in: Pathology & Oncology Research | Ausgabe 4/2009

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Abstract

In order to identify reliable molecular markers for prognostic prediction in gastric carcinoma, we evaluated the expression of six molecular markers, namely bFGF, IGF-2, HGF, MMP-9, integrin β3 and uPA in gastric cancer. There was a significant correlation between the expression of these markers and the depth of tumor invasion, vessel invasion, lymph node and distant metastasis, TNM stage and microvessel density. The average survival time and 5-year survival rate of patients with positive expression of molecular markers was higher than those with negative expression. Multivariate analysis showed that abnormal expression of bFGF, MMP-9 and uPA, as well as depth of invasion, lymph node and distant metastasis and TNM stage were independently related to poor prognosis of gastric cancer. MMP-9, bFGF and uPA are potential candidates for development as clinically applicable molecular prognostic markers for gastric carcinoma, and may be effective therapeutic targets for the disease in the future.

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Titel: Prognostic Value of Tumor-Related Molecular Expression in Gastric Carcinoma
verfasst von: Zhong-Sheng Zhao
Yuan-Yu Wang
Zai-Yuan Ye
Hou-Quan Tao
Publikationsdatum: 01.12.2009
Verlag: Springer Netherlands
Erschienen in: Pathology & Oncology Research / Ausgabe 4/2009
Print ISSN: 1219-4956
Elektronische ISSN: 1532-2807
DOI: https://doi.org/10.1007/s12253-009-9158-9

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Prognostic Value of Tumor-Related Molecular Expression in Gastric Carcinoma

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