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Pathology & Oncology Research

Erschienen in:

21.02.2019 | Review

MEG3: an Oncogenic Long Non-coding RNA in Different Cancers

verfasst von: Arwa Al-Rugeebah, Mohammed Alanazi, Narasimha Reddy Parine

Erschienen in: Pathology & Oncology Research | Ausgabe 3/2019

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Abstract

Long noncoding RNAs (lncRNAs) have recently considered as central regulators in diverse biological processes and emerged as vital players controlling tumorigenesis. Several lncRNAs can be classified into oncogenes and tumor suppressor genes depending on their function in cancer. A maternally expressed gene 3 (MEG3) gene transcripts a 1.6 kb lncRNA whose act as an antitumor component in different cancer cells, such as breast, liver, glioma, colorectal, cervical, gastric, lung, ovarian and osteosarcoma cancer cells. The present review highlights biological function of MEG3 to repress tumor through regulating the major tumor suppressor genes p53 and Rb, inhibiting angiogenesis-related factor, or controlling miRNAs. On the other hand, previous studies have also suggested that MEG3 mediates epithelial-mesenchymal transition (EMT). However, deregulation of MEG3 is associated with the development and progression of cancer, suggesting that MEG3 may function as a potential biomarker and therapeutic target for human cancers.

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Titel: MEG3: an Oncogenic Long Non-coding RNA in Different Cancers
verfasst von: Arwa Al-Rugeebah
Mohammed Alanazi
Narasimha Reddy Parine
Publikationsdatum: 21.02.2019
Verlag: Springer Netherlands
Erschienen in: Pathology & Oncology Research / Ausgabe 3/2019
Print ISSN: 1219-4956
Elektronische ISSN: 1532-2807
DOI: https://doi.org/10.1007/s12253-019-00614-3

Springer Medizin

MEG3: an Oncogenic Long Non-coding RNA in Different Cancers

Abstract

Neu im Fachgebiet Onkologie

Adjuvante Immuntherapie verlängert Leben bei RCC

Alectinib verbessert krankheitsfreies Überleben bei ALK-positivem NSCLC

Bei Senioren mit Prostatakarzinom auf Anämie achten!

ICI-Therapie in der Schwangerschaft wird gut toleriert

Update Onkologie

Springer Medizin

Abstract

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