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Neuroscience Bulletin
Erschienen in: Neuroscience Bulletin 1/2018

01.02.2018 | Review

Infection, Pain, and Itch

verfasst von: Isaac M. Chiu

Erschienen in: Neuroscience Bulletin | Ausgabe 1/2018

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Abstract

Pain and itch are unpleasant sensations that often accompany infections caused by viral, bacterial, parasitic, and fungal pathogens. Recent studies show that sensory neurons are able to directly detect pathogens to mediate pain and itch. Nociceptor and pruriceptor neurons respond to pathogen-associated molecular patterns, including Toll-like receptor ligands, N-formyl peptides, and bacterial toxins. Other pathogens are able to silence neuronal activity to produce analgesia during infection. Pain and itch could lead to neuronal modulation of the immune system or behavioral avoidance of future pathogen exposure. Conversely, pathogens could modulate neuronal signaling to potentiate their pathogenesis and facilitate their spread to other hosts. Defining how pathogens modulate pain and itch has critical implications for sensory neurobiology and our understanding of host-microbe interactions.
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Metadaten
Titel
Infection, Pain, and Itch
verfasst von
Isaac M. Chiu
Publikationsdatum
01.02.2018
Verlag
Springer Singapore
Erschienen in
Neuroscience Bulletin / Ausgabe 1/2018
Print ISSN: 1673-7067
Elektronische ISSN: 1995-8218
DOI
https://doi.org/10.1007/s12264-017-0098-1

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