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Erschienen in: Journal of Cardiovascular Translational Research 5/2014

01.07.2014

Swine Model of Chronic Postcapillary Pulmonary Hypertension with Right Ventricular Remodeling: Long-Term Characterization by Cardiac Catheterization, Magnetic Resonance, and Pathology

verfasst von: Daniel Pereda, Ana García-Alvarez, Damián Sánchez-Quintana, Mario Nuño, Leticia Fernández-Friera, Rodrigo Fernández-Jiménez, José Manuel García-Ruíz, Elena Sandoval, Jaume Aguero, Manuel Castellá, Roger J. Hajjar, Valentín Fuster, Borja Ibáñez

Erschienen in: Journal of Cardiovascular Translational Research | Ausgabe 5/2014

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Abstract

Pulmonary hypertension (PH) is prevalent and carries high morbidity and mortality, mostly due to right ventricular (RV) dysfunction. Postcapillary PH is the most frequent form but there are no large-animal models available. We developed and characterized a porcine model of postcapillary PH by non-restrictive banding of the confluent of both inferior pulmonary veins (n = 10; sham controls n = 3). Right heart catheterization and magnetic resonance were performed before the procedure and monthly during 4 months. All banded animals developed PH. Compared to controls, banded animals presented higher mean pulmonary artery pressure [median (first to third quartile) 30 mmHg (25–37) vs. 20 mmHg (18–23); p = 0.018] and higher pulmonary vascular resistance [5.2 WU (3.8–7.1) vs. 2.3 WU (2.1–3.5); p = 0.028] after 2 months. Differences in indexed RV end-systolic volume [42 mL/m2 (36–53) vs. 24 mL/m2 (24–33); p = 0.028] and RV ejection fraction [59 % (54–63) vs. 66 % (64–68); p = 0.028] were also significant after 2 months. Differences remained significant throughout the study. Histopathology revealed increased lung weight and fibrosis but no increase in average water content. Also, remodeling on pulmonary arteries including increased medial and intimal thickness and fibrosis and RV myocardial disarray and fibrosis was demonstrated. Lung remodeling findings were similar in all pulmonary lobes.
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Metadaten
Titel
Swine Model of Chronic Postcapillary Pulmonary Hypertension with Right Ventricular Remodeling: Long-Term Characterization by Cardiac Catheterization, Magnetic Resonance, and Pathology
verfasst von
Daniel Pereda
Ana García-Alvarez
Damián Sánchez-Quintana
Mario Nuño
Leticia Fernández-Friera
Rodrigo Fernández-Jiménez
José Manuel García-Ruíz
Elena Sandoval
Jaume Aguero
Manuel Castellá
Roger J. Hajjar
Valentín Fuster
Borja Ibáñez
Publikationsdatum
01.07.2014
Verlag
Springer US
Erschienen in
Journal of Cardiovascular Translational Research / Ausgabe 5/2014
Print ISSN: 1937-5387
Elektronische ISSN: 1937-5395
DOI
https://doi.org/10.1007/s12265-014-9564-6

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