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Journal of Cardiovascular Translational Research

Erschienen in:

01.12.2015

Panax Notoginseng Saponins Ameliorates Coxsackievirus B3-Induced Myocarditis by Activating the Cystathionine-γ-Lyase/Hydrogen Sulfide Pathway

verfasst von: Lulu Pan, Yuanhai Zhang, Jiacheng Lu, Zhimin Geng, Lianhong Jia, Xing Rong, Zhenquan Wang, Qifeng Zhao, Rongzhou Wu, Maoping Chu, Chunxiang Zhang

Erschienen in: Journal of Cardiovascular Translational Research | Ausgabe 9/2015

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Abstract

This study is to determine the therapeutic effects of Panax notoginseng saponins (PNSs) on coxsackievirus B3 (CVB3)-induced myocarditis, and whether cystathionine-γ-lyase (CSE)/hydrogen sulfide (H₂S) pathway is involved. Mouse model of myocarditis was induced by CVB3 infection, and the mice were subjected to vehicle (saline) or drug treatments (sodium bisulfide (NaHS), propargylglycine (PAG), or PNSs). The results showed that there were inflammatory cell infiltrations, interstitial edemas, and elevated inflammatory cytokines, in CVB3-induced myocarditis. PAG administration increased, whereas NaHS treatment decreased the severity of the myocarditis. PNS treatment dramatically alleviated these myocardial injuries and decreased the viral messenger RNA (mRNA) expression by the enhanced expression of CSE/H₂S pathway. Moreover, the therapeutic effects of PNSs on myocarditis were stronger than those of NaHS. Finally, the effect of PNSs on CSE/H₂S pathway and cardiac cell protection were verified in cultured cardiac cells. PNSs may be a promising medication for viral myocarditis therapy.

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Titel: Panax Notoginseng Saponins Ameliorates Coxsackievirus B3-Induced Myocarditis by Activating the Cystathionine-γ-Lyase/Hydrogen Sulfide Pathway
verfasst von: Lulu Pan
Yuanhai Zhang
Jiacheng Lu
Zhimin Geng
Lianhong Jia
Xing Rong
Zhenquan Wang
Qifeng Zhao
Rongzhou Wu
Maoping Chu
Chunxiang Zhang
Publikationsdatum: 01.12.2015
Verlag: Springer US
Erschienen in: Journal of Cardiovascular Translational Research / Ausgabe 9/2015
Print ISSN: 1937-5387
Elektronische ISSN: 1937-5395
DOI: https://doi.org/10.1007/s12265-015-9659-8

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Panax Notoginseng Saponins Ameliorates Coxsackievirus B3-Induced Myocarditis by Activating the Cystathionine-γ-Lyase/Hydrogen Sulfide Pathway

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