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Breast Cancer
Erschienen in: Breast Cancer 2/2015

01.03.2015 | Review Article

HER2-directed therapy: current treatment options for HER2-positive breast cancer

verfasst von: Shahid Ahmed, Amer Sami, Jim Xiang

Erschienen in: Breast Cancer | Ausgabe 2/2015

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Abstract

Over the past decade, the management of HER2-positive breast cancer has evolved dramatically. In addition to advances in screening, genetic testing, imaging, surgical and radiation techniques, innovations in medical therapy including widespread use of HER2-directed therapy in early and advanced breast cancer have revolutionized breast cancer care and changed the natural history of HER2-positive breast cancer. A substantial number of HER2-targeted agents are being developed including monoclonal antibodies, small molecule inhibitors, and antibody drug conjugates. Trastuzumab is the prototype HER2-directed therapy that was introduced in the late 1990s for the management of metastatic breast cancer and later showed efficacy in early stage disease. Despite the practice changing impact of trastuzumab and improvement in outcomes of women with HER2-positive breast cancer resistance to trrastuzumab is a major clinical issue, occurring in both early stage and advanced disease, and new treatment strategies are clearly required. Combining HER2-targeted agents and dual HER2 blockade has been successful in early and advanced breast cancer. Furthermore, selected delivery of potent chemotherapeutic agent coupled with HER2 inhibition promises new treatment options. This review is focused on current HER2-directed treatments for women with HER2-positive breast cancer including monoclonal antibodies, small molecule inhibitors, and antibody drug conjugates.
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Metadaten
Titel
HER2-directed therapy: current treatment options for HER2-positive breast cancer
verfasst von
Shahid Ahmed
Amer Sami
Jim Xiang
Publikationsdatum
01.03.2015
Verlag
Springer Japan
Erschienen in
Breast Cancer / Ausgabe 2/2015
Print ISSN: 1340-6868
Elektronische ISSN: 1880-4233
DOI
https://doi.org/10.1007/s12282-015-0587-x

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