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The Cerebellum
Erschienen in: The Cerebellum 2/2017

01.04.2017 | Original Paper

Constrained Spherical Deconvolution Tractography Reveals Cerebello-Mammillary Connections in Humans

verfasst von: Alberto Cacciola, Demetrio Milardi, Alessandro Calamuneri, Lilla Bonanno, Silvia Marino, Pietro Ciolli, Margherita Russo, Daniele Bruschetta, Antonio Duca, Fabio Trimarchi, Angelo Quartarone, Giuseppe Anastasi

Erschienen in: The Cerebellum | Ausgabe 2/2017

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Abstract

According to the classical view, the cerebellum has long been confined to motor control physiology; however, it has now become evident that it exerts several non-somatic features other than the coordination of movement and is engaged also in the regulation of cognition and emotion. In a previous diffusion-weighted imaging-constrained spherical deconvolution (CSD) tractography study, we demonstrated the existence of a direct cerebellum-hippocampal pathway, thus reinforcing the hypothesis of the cerebellar role in non-motor domains. However, our understanding of limbic-cerebellar interconnectivity in humans is rather sparse, primarily due to the intrinsic limitation in the acquisition of in vivo tracing. Here, we provided tractographic evidences of connectivity patterns between the cerebellum and mammillary bodies by using whole-brain CSD tractography in 13 healthy subjects. We found both ipsilateral and contralateral connections between the mammillary bodies, cerebellar cortex, and dentate nucleus, in line with previous studies performed in rodents and primates. These pathways could improve our understanding of cerebellar role in several autonomic functions, visuospatial orientation, and memory and may shed new light on neurodegenerative diseases in which clinically relevant impairments in navigational skills or memory may become manifest at early stages.
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Metadaten
Titel
Constrained Spherical Deconvolution Tractography Reveals Cerebello-Mammillary Connections in Humans
verfasst von
Alberto Cacciola
Demetrio Milardi
Alessandro Calamuneri
Lilla Bonanno
Silvia Marino
Pietro Ciolli
Margherita Russo
Daniele Bruschetta
Antonio Duca
Fabio Trimarchi
Angelo Quartarone
Giuseppe Anastasi
Publikationsdatum
01.04.2017
Verlag
Springer US
Erschienen in
The Cerebellum / Ausgabe 2/2017
Print ISSN: 1473-4222
Elektronische ISSN: 1473-4230
DOI
https://doi.org/10.1007/s12311-016-0830-9

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