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ADHD Attention Deficit and Hyperactivity Disorders

Erschienen in:

01.03.2010 | Original Article

A pilot study of combined working memory and inhibition training for children with AD/HD

verfasst von: Stuart J. Johnstone, Steven Roodenrys, Elise Phillips, Annele J. Watt, Sharlene Mantz

Erschienen in: ADHD Attention Deficit and Hyperactivity Disorders | Ausgabe 1/2010

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Abstract

Building on recent favourable outcomes using working memory (WM) training, this study examined the behavioural and physiological effect of concurrent computer-based WM and inhibition training for children with attention-deficit hyperactivity disorder (AD/HD). Using a double-blind active-control design, 29 children with AD/HD completed a 5-week at-home training programme and pre- and post-training sessions which included the assessment of overt behaviour, resting EEG, as well as task performance, skin conductance level and event-related potentials (ERPs) during a Go/Nogo task. Results indicated that after training, children from the high-intensity training condition showed reduced frequency of inattention and hyperactivity symptoms. Although there were trends for improved Go/Nogo performance, increased arousal and specific training effects for the inhibition-related N2 ERP component, they failed to reach standard levels of statistical significance. Both the low- and high-intensity conditions showed resting EEG changes (increased delta, reduced alpha and theta activity) and improved early attention alerting to Go and Nogo stimuli, as indicated by the N1 ERP component, post-training. Despite limitations, this preliminary work indicates the potential for cognitive training that concurrently targets the interrelated processes of WM and inhibition to be used as a treatment for AD/HD.

Given the exploratory nature of this study and the small number of participants involved, we felt that it was also appropriate to report post-hoc tests on the other variables that relate to the primary hypotheses, even though the trends for an interaction did not reach the standard levels of significance. Accordingly, these results need to be interpreted with some caution.

Achenbach TM, Conners CK, Quay HC, Verhulst FC, Howell CT (1989) Replication of empirically derived syndromes as a basis for taxonomy of child/adolescent psychopathology. J Abnorm Child Psychol 17:299–323CrossRefPubMed

APA (1994) Diagnostic and statistical manual of mental disorders. American Psychiatric Association, Washington, DC

Barkley RA (1997) Behavioral inhibition, sustained attention, and executive functions: constructing a unifying theory of ADHD. Psychol Bull 121:65–94CrossRefPubMed

Barkley RA (1999) Response inhibition in Attention-Deficit Hyperactivity Disorder. Ment Retard Dev Disabil Res Rev 5:177–184CrossRef

Barry RJ, Sokolov EN (1993) Habituation of phasic and tonic components of the orienting reflex. Int J Psychophysiol 15:39–42CrossRefPubMed

Barry RJ, Clarke AR, Johnstone SJ (2003a) A review of electrophysiology in attention-deficit/hyperactivity disorder: I. Qualitative and quantitative electroencephalography. Clin Neurophysiol 114:171–183CrossRefPubMed

Barry RJ, Johnstone SJ, Clarke AR (2003b) A review of electrophysiology in attention-deficit/hyperactivity disorder: II. Event-related potentials. Clin Neurophysiol 114:184–198CrossRefPubMed

Brandeis D, Van Leeuwen TH, Rubia K et al (1998) Neuroelectric mapping reveals precursor of stop failures in children with attention deficits. Behav Brain Res 94:111–125CrossRefPubMed

Broyd SJ, Johnstone SJ, Barry RJ et al (2005) The effect of methylphenidate on response inhibition and the event-related potential of children with attention deficit/hyperactivity disorder. Int J Psychophysiol 58:47–58CrossRefPubMed

Clark JM (1996) Contributions of inhibitory mechanisms to unified theory in neuroscience and psychology. Brain Cogn 30:127–152CrossRefPubMed

Clarke AR, Barry RJ, Bond D, McCarthy R, Selikowitz M (2002) Effects of stimulant medications on the EEG of children with attention-deficit/hyperactivity disorder. Psychopharmacology 164:277–284CrossRefPubMed

Clarke AR, Barry RJ, McCarthy R, Selikowitz M, Johnstone SJ (2007) Effects of stimulant medications on the EEG of girls with attention-deficit/hyperactivity disorder. Clin Neurophysiol 118:2700–2708CrossRefPubMed

Conners CK (1997) Conners parent rating scale revised. Abbott Laboratories, Chicago

Dimoska A, Johnstone SJ, Barry RJ, Clarke AR (2003) Inhibitory motor control in children with attention-deficit/hyperactivity disorder: Event-related potentials in the stop-signal paradigm. Biol Psychiatry 54:1345–1354CrossRefPubMed

Duffy E (1962) Activation and behavior. Wiley, New York

Geurts HM, Verte S, Oosterlaan J, Roeyers H, Sergeant JA (2005) ADHD subtypes: do they differ in their executive functioning profile? Arch Clin Neuropsychol 20:457–477CrossRefPubMed

Hasher L, Zacks RT (1988) Working memory, comprehension, and aging: a review and a new view. In: Bower GH (ed) The psychology of learning and motivation. Academic Press, San Diego

Jodo E, Kayama Y (1992) Relation of a negative ERP component to response inhibition in a Go/No-go task. Electroencephalogr Clin Neurophysiol 82:477–482CrossRefPubMed

Johnstone SJ, Barry RJ (1996) Auditory event-related potentials to a two-tone discrimination paradigm in attention deficit hyperactivity disorder. Psychiatry Res 64:179–192CrossRefPubMed

Johnstone SJ, Pleffer CB, Barry RJ, Clarke AR, Smith JL (2005) Development of inhibitory processing during the Go/NoGo task: a behavioral and event-related potential study of children and adults. J Psychophysiol 19:11–23CrossRef

Johnstone SJ, Barry RJ, Clarke AR (2007) Behavioural and ERP indices of response inhibition during a Stop-signal task in children with two subtypes of Attention-Deficit Hyperactivity Disorder. Int J Psychophysiol 66:37–47CrossRefPubMed

Kida N, Oda S, Matsumura M (2005) Intensive baseball practice improves the Go/No go reaction time, but not the simple reaction time. Cogn Brain Res 22:257–264CrossRef

Kimko HC, Cross JT, Abernethy DR (1999) Pharmacokinetics and clinical effectiveness of methylphenidate. Clin Pharmacokinet 37:457–470CrossRefPubMed

Klingberg T, Forssberg H, Westerberg H (2002) Training of working memory in children with ADHD. J Clin Exp Neuropsychol 24:781–791CrossRefPubMed

Klingberg T, Fernell E, Olesen PJ et al (2005) Computerized training of working memory in children with ADHD—a randomized, controlled trial. J Am Acad Child Adolesc Psychiatry 44:177–186CrossRefPubMed

Kotwal DB, Burns WJ, Montgomery DD (1996) Computer-assisted cognitive training for ADHD: a case study. Behav Modif 20:85–96CrossRef

Lawrence CA, Barry RJ, Clarke AR et al (2005) Methylphenidate effects in attention deficit/hyperactivity disorder: electrodermal and ERP measures during a continuous performance task. Psychopharmacology 183:81–91CrossRefPubMed

Lazzaro I, Gordon E, Li W et al (1999) Simultaneous EEG and EDA measures in adolescent attention deficit hyperactivity disorder. Int J Psychophysiol 34:123–134CrossRefPubMed

Magee CA, Clarke AR, Barry RJ, McCarthy R, Selikowitz M (2005) Examining the diagnostic utility of EEG power measures in children with attention deficit/hyperactivity disorder. Clin Neurophysiol 116:1033–1040CrossRefPubMed

Mannuzza S, Klein RG, Moulton Iii JL (2008) Lifetime criminality among boys with attention deficit hyperactivity disorder: a prospective follow-up study into adulthood using official arrest records. Psychiatry Res 160:237–246CrossRefPubMed

McNab F, Leroux G, Strand F et al (2008) Common and unique components of inhibition and working memory: an fMRI, within-subjects investigation. Neuropsychologia 46:2668–2682CrossRefPubMed

Mitchell P (2007) Attention deficit hyperactivity disorder in children and adolescents in New South Wales—2007. Final report of the Special Review. Sydney, Clinical Excellence Commission

Naatanen R, Picton T (1987) The N1 wave of the human electric and magnetic response to sound: a review and an analysis of the component structure. Psychophysiology 24:375–425CrossRefPubMed

Neale MD (1999) Neale analysis of reading ability. ACER, Melbourne

Nieuwenhuis S, Yeung N, Van Den Wildenberg W, Ridderinkhof KR (2003) Electrophysiological correlates of anterior cingulate function in a go/no-go task: effects of response conflict and trial type frequency. Cogn Affect Behav Neurosci 3:17–26CrossRefPubMed

Oosterlaan J, Sergeant JA (1996) Inhibition in ADHD, aggressive, and anxious children: a biologically based model of child psychopathology. J Abnorm Child Psychol 24:19–36CrossRefPubMed

Pennington BF, Ozonoff S (1996) Executive functions and developmental psychopathology. J Child Psychol Psychiatry 37:51–87CrossRefPubMed

Pliszka SR, Liotti M, Woldorff MG (2000) Inhibitory control in children with attention-deficit/hyperactivity disorder: event-related potentials identify the processing component and timing of an impaired right-frontal response-inhibition mechanism. Biol Psychiatry 48:238–246CrossRefPubMed

Quay HC (1997) Inhibition and attention deficit hyperactivity disorder. J Abnorm Child Psychol 25:7–13CrossRefPubMed

Raven JC (1989) Standard progressive matrices Australian manual. Australian Council for Education Research, Victoria

Roberts RJ, Pennington BF (1996) An interactive framework for examining prefrontal cognitive processes. Dev Neuropsychol 12:105–126CrossRef

Roodenrys S (2006) Working memory function in attention deficit hyperactivity disorder. In: Packiam Alloway T, Gathercole SE (eds) Working memory and neurodevelopmental condition. Psychology Press, Hove

Rubia K, Overmeyer S, Taylor E et al (1999) Hypofrontality in attention deficit hyperactivity disorder during higher-order motor control: a study with functional MRI. Am J Psychiatry 156:891–896PubMed

Satterfield JH, Dawson ME (1971) Electrodermal correlates of hyperactivity in children. Psychophysiology 8:191–197CrossRefPubMed

Satterfield JH, Schell AM, Backs RW, Hidaka KC (1984) A cross-sectional and longitudinal study of age effects of electrophysiological measures in hyperactive and normal children. Biol Psychiatry 19:973–990PubMed

Semlitsch HV, Anderer P, Schuster P, Presslich OA (1986) A solution for reliable and valid reduction of ocular artifacts, applied to the P300 ERP. Psychophysiology 23:695–703CrossRefPubMed

Sergeant J (2000) The cognitive-energetic model: an empirical approach to Attention-Deficit Hyperactivity Disorder. Neurosci Biobehav Rev 24:7–12CrossRefPubMed

Smith JL, Johnstone SJ, Barry RJ (2003) Aiding diagnosis of attention-deficit/hyperactivity disorder and its subtypes: discriminant function analysis of event-related potential data. J Child Psychol Psychiatry 44:1067–1075CrossRefPubMed

Smith JL, Johnstone SJ, Barry RJ (2004) Inhibitory processing during the Go/NoGo task: an ERP analysis of children with attention-deficit/hyperactivity disorder. Clin Neurophysiol 115:1320–1331CrossRefPubMed

Smith JL, Johnstone SJ, Barry RJ (2007) Response priming in the Go/NoGo task: the N2 reflects neither inhibition nor conflict. Clin Neurophysiol 118:343–355CrossRefPubMed

Swanson JM, Elliott GR, Greenhill LL et al (2007) Effects of stimulant medication on growth rates across 3 years in the MTA follow-up. J Am Acad Child Adolesc Psychiatry 46:1015–1027CrossRefPubMed

Verbruggen F, Logan GD (2008) Automatic and controlled response inhibition: associative learning in the Go/No-Go and stop-signal paradigms. J Exp Psychol Gen 137:649–672CrossRefPubMed

Westwood PS (1979) South Australian spelling test. Education Department of South Australia Adelaide

Young SE, Friedman NP, Miyake A et al (2009) Behavioral disinhibition: liability for externalizing spectrum disorders and its genetic and environmental relation to response inhibition across adolescence. J Abnorm Psychol 118:117–130CrossRefPubMed

Titel: A pilot study of combined working memory and inhibition training for children with AD/HD
verfasst von: Stuart J. Johnstone
Steven Roodenrys
Elise Phillips
Annele J. Watt
Sharlene Mantz
Publikationsdatum: 01.03.2010
Verlag: Springer Vienna
Erschienen in: ADHD Attention Deficit and Hyperactivity Disorders / Ausgabe 1/2010
Print ISSN: 1866-6116
Elektronische ISSN: 1866-6647
DOI: https://doi.org/10.1007/s12402-009-0017-z

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