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Erschienen in: ADHD Attention Deficit and Hyperactivity Disorders 4/2015

01.12.2015 | Original Article

The association of emotional lability and emotional and behavioral difficulties among children with and without ADHD

verfasst von: Paul J. Rosen, Danielle M. Walerius, Nicholas D. Fogleman, Perry I. Factor

Erschienen in: ADHD Attention Deficit and Hyperactivity Disorders | Ausgabe 4/2015

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Abstract

Children with ADHD often demonstrate a pattern of emotional lability characterized by sudden and intense shifts in affect. Emotional lability has been linked to emotional and behavioral problems in children with and without ADHD, but few studies have examined emotional lability over time. This study examined the effects of emotional lability over time on the behavioral and emotional difficulties of children with and without ADHD using an ecological momentary assessment (EMA) methodology. One hundred and two children aged 8–12 years (56 with ADHD and 46 without ADHD) and their parents completed baseline measures of the children’s behavioral and emotional difficulties. Parents then completed a 28-day 3-times daily EMA assessment protocol to rate their child’s emotional lability. Results suggested that emotional lability was associated with internalizing and/or externalizing diagnoses independent of ADHD diagnostic status, but was not directly associated with ADHD. Hierarchical regression analyses supported ADHD diagnostic status as a moderator of the association of greater EMA-derived emotional lability with children’s behavioral difficulties, such that greater emotional lability was associated with greater behavioral difficulties among children with ADHD but not among children without ADHD. Results indicated that greater emotional lability was directly linked with greater emotional difficulties and that this relation was not moderated by ADHD diagnostic status. Overall, this study suggested that emotional lability is related to emotional difficulties independent of ADHD, but is differentially related to behavioral difficulties among children with and without ADHD.
Literatur
Zurück zum Zitat Achenbach TM (2001) Manual for the child behavioral checklist 6–18 and 2001 profile. University of Vermont Department of Psychiatry, Burlington Achenbach TM (2001) Manual for the child behavioral checklist 6–18 and 2001 profile. University of Vermont Department of Psychiatry, Burlington
Zurück zum Zitat American Psychiatric Association (2013) Diagnostic and statistical manual of mental disorders, 5th edn. American Psychiatric Publishing, Arlington American Psychiatric Association (2013) Diagnostic and statistical manual of mental disorders, 5th edn. American Psychiatric Publishing, Arlington
Zurück zum Zitat Anastopolous AD, Smith TF, Garrett ME, Morrissey-Kane E, Schatz NK et al (2011) Self-regulation of emotion, functional impairment, and comorbidity among children with ADHD. J Atten Disord 15(7):583–592CrossRef Anastopolous AD, Smith TF, Garrett ME, Morrissey-Kane E, Schatz NK et al (2011) Self-regulation of emotion, functional impairment, and comorbidity among children with ADHD. J Atten Disord 15(7):583–592CrossRef
Zurück zum Zitat Barkley RA (2010) Deficient emotion regulation is a core component of ADHD. Journal of ADHD and Related Disorders 1:5–37 Barkley RA (2010) Deficient emotion regulation is a core component of ADHD. Journal of ADHD and Related Disorders 1:5–37
Zurück zum Zitat Barkley RA (2013) Distinguishing sluggish cognitive tempo from ADHD in children and adolescents: executive functioning, impairment, and comorbidity. J Clin Child Adolesc Psychol 42(2):161–173CrossRefPubMed Barkley RA (2013) Distinguishing sluggish cognitive tempo from ADHD in children and adolescents: executive functioning, impairment, and comorbidity. J Clin Child Adolesc Psychol 42(2):161–173CrossRefPubMed
Zurück zum Zitat Cole PM, Martin SE, Dennis TA (2004) Emotion regulation as a scientific construct: methodological challenges and directions for child development research. Child Dev 75(2):317–333CrossRefPubMed Cole PM, Martin SE, Dennis TA (2004) Emotion regulation as a scientific construct: methodological challenges and directions for child development research. Child Dev 75(2):317–333CrossRefPubMed
Zurück zum Zitat Ebesutani C, Regan J, Smith A, Reise S, Higa-McMillan C, Chorpita BF (2012) The 10-item positive and negative affect schedule for children, child and parent shortened versions: application of item response theory for more efficient assessment. J Psychopathol Behav Assess 34:191–203CrossRef Ebesutani C, Regan J, Smith A, Reise S, Higa-McMillan C, Chorpita BF (2012) The 10-item positive and negative affect schedule for children, child and parent shortened versions: application of item response theory for more efficient assessment. J Psychopathol Behav Assess 34:191–203CrossRef
Zurück zum Zitat Ebner-Priemer UW, Trull TJ (2009) Ecological momentary assessment of mood disorders and mood dysregulation. Psychol Assess 21(4):463–475CrossRefPubMed Ebner-Priemer UW, Trull TJ (2009) Ecological momentary assessment of mood disorders and mood dysregulation. Psychol Assess 21(4):463–475CrossRefPubMed
Zurück zum Zitat Factor PI, Reyes RA, Rosen PJ (2014) Emotional impulsivity in children with ADHD associated with comorbid—not ADHD—symptomatology. J Psychopathol Behav Assess 36:530–541CrossRef Factor PI, Reyes RA, Rosen PJ (2014) Emotional impulsivity in children with ADHD associated with comorbid—not ADHD—symptomatology. J Psychopathol Behav Assess 36:530–541CrossRef
Zurück zum Zitat Gartstein MA, Bridgett DJ, Dishion TJ, Kaufman NK (2009) Depressed mood and parental report of child behavior problems: another look at the depression–distortion hypothesis. J Appl Dev Psychol 30:149–160PubMedCentralCrossRefPubMed Gartstein MA, Bridgett DJ, Dishion TJ, Kaufman NK (2009) Depressed mood and parental report of child behavior problems: another look at the depression–distortion hypothesis. J Appl Dev Psychol 30:149–160PubMedCentralCrossRefPubMed
Zurück zum Zitat Graziano PA, McNamara JP, Geffken GR, Reid AM (2013) Differentiation co-occurring behavior problems in children with ADHD: patterns of emotional reactivity and executive functioning. J Atten Disord 17(3):249–260CrossRefPubMed Graziano PA, McNamara JP, Geffken GR, Reid AM (2013) Differentiation co-occurring behavior problems in children with ADHD: patterns of emotional reactivity and executive functioning. J Atten Disord 17(3):249–260CrossRefPubMed
Zurück zum Zitat Gross JJ (2002) Emotion regulation: affective, cognitive, and social consequences. Psychophysiology 39(3):281–291CrossRefPubMed Gross JJ (2002) Emotion regulation: affective, cognitive, and social consequences. Psychophysiology 39(3):281–291CrossRefPubMed
Zurück zum Zitat Gross JJ (ed) (2007) Handbook of emotion regulation. Guilford, New York Gross JJ (ed) (2007) Handbook of emotion regulation. Guilford, New York
Zurück zum Zitat Jahng S, Wood PK, Trull TJ (2008) Analysis of affective instability in ecological momentary assessment: indices using successive difference and group comparison via multilevel modeling. Psychol Methods 13(4):354–375CrossRefPubMed Jahng S, Wood PK, Trull TJ (2008) Analysis of affective instability in ecological momentary assessment: indices using successive difference and group comparison via multilevel modeling. Psychol Methods 13(4):354–375CrossRefPubMed
Zurück zum Zitat Jensen SA, Rosen LA (2004) Emotional reactivity in children with attention-deficit/hyperactivity disorder. J Atten Disord 8:53–61CrossRefPubMed Jensen SA, Rosen LA (2004) Emotional reactivity in children with attention-deficit/hyperactivity disorder. J Atten Disord 8:53–61CrossRefPubMed
Zurück zum Zitat Kovacs M (1992) The Children’s Depression Inventory (CDI). Multi-Health Systems Inc., Toronto Kovacs M (1992) The Children’s Depression Inventory (CDI). Multi-Health Systems Inc., Toronto
Zurück zum Zitat Larsen RJ (2000) Toward a science of mood regulation. Psychol Inq 11(3):129–141CrossRef Larsen RJ (2000) Toward a science of mood regulation. Psychol Inq 11(3):129–141CrossRef
Zurück zum Zitat Lewis MD, Granic I, Lamm C, Zelazo PD, Stieben J et al (2008) Changes in the neural bases of emotion regulation associated with clinical improvement in children with behavior problems. Dev Psychopathol 20:913–939CrossRefPubMed Lewis MD, Granic I, Lamm C, Zelazo PD, Stieben J et al (2008) Changes in the neural bases of emotion regulation associated with clinical improvement in children with behavior problems. Dev Psychopathol 20:913–939CrossRefPubMed
Zurück zum Zitat Marmorstein NR (2013) Associations between dispositions to rash action and internalizing and externalizing symptoms in children. J Clin Child Adolesc Psychol 42(1):131–138PubMedCentralCrossRefPubMed Marmorstein NR (2013) Associations between dispositions to rash action and internalizing and externalizing symptoms in children. J Clin Child Adolesc Psychol 42(1):131–138PubMedCentralCrossRefPubMed
Zurück zum Zitat Martel MM (2009) Research review: a new perspective on attention-deficit/hyperactivity disorder: emotion dysregulation and trait models. J Child Psychol Psychiatry 50(9):1042–1051CrossRefPubMed Martel MM (2009) Research review: a new perspective on attention-deficit/hyperactivity disorder: emotion dysregulation and trait models. J Child Psychol Psychiatry 50(9):1042–1051CrossRefPubMed
Zurück zum Zitat Martel MM, Nigg JT (2006) Child ADHD and personality/temperament traits of reactive and effortful control, resiliency, and emotionality. J Child Psychol Psychiatry 47(11):1175–1183CrossRefPubMed Martel MM, Nigg JT (2006) Child ADHD and personality/temperament traits of reactive and effortful control, resiliency, and emotionality. J Child Psychol Psychiatry 47(11):1175–1183CrossRefPubMed
Zurück zum Zitat Melnick SM, Hinshaw SP (2000) Emotion regulation and parenting in AD/HD and comparison boys: linkages with social behaviors and peer preference. J Abnorm Child Psychol 28(1):73–86CrossRefPubMed Melnick SM, Hinshaw SP (2000) Emotion regulation and parenting in AD/HD and comparison boys: linkages with social behaviors and peer preference. J Abnorm Child Psychol 28(1):73–86CrossRefPubMed
Zurück zum Zitat Miller DJ, Vachon DD, Lynam DR (2009) Neuroticism, negative affect, and negative affect instability. Establishing convergent and discriminant validity using ecological momentary assessment. Personal Individ Differ 47:873–877CrossRef Miller DJ, Vachon DD, Lynam DR (2009) Neuroticism, negative affect, and negative affect instability. Establishing convergent and discriminant validity using ecological momentary assessment. Personal Individ Differ 47:873–877CrossRef
Zurück zum Zitat Musser ED, Backs RW, Schmitt CF, Ablow JC, Measelle JR, Nigg JT (2011) Emotion regulation via the autonomic nervous system in children with attention-deficit/hyperactivity disorder (ADHD). J Abnorm Child Psychol 39:841–852PubMedCentralCrossRefPubMed Musser ED, Backs RW, Schmitt CF, Ablow JC, Measelle JR, Nigg JT (2011) Emotion regulation via the autonomic nervous system in children with attention-deficit/hyperactivity disorder (ADHD). J Abnorm Child Psychol 39:841–852PubMedCentralCrossRefPubMed
Zurück zum Zitat Norvilitis JM, Casey RJ, Brooklier KM, Bonello PJ (2000) Emotion appraisal in children with attention-deficit/hyperactivity disorder and their parents. J Atten Disord 4:15–26CrossRef Norvilitis JM, Casey RJ, Brooklier KM, Bonello PJ (2000) Emotion appraisal in children with attention-deficit/hyperactivity disorder and their parents. J Atten Disord 4:15–26CrossRef
Zurück zum Zitat Pelham WE, Fabiano GA (2008) Evidence-based psychosocial treatments for attention-deficit/hyperactivity disorder. J Clin Child Adolesc Psychol 37(1):184–214CrossRefPubMed Pelham WE, Fabiano GA (2008) Evidence-based psychosocial treatments for attention-deficit/hyperactivity disorder. J Clin Child Adolesc Psychol 37(1):184–214CrossRefPubMed
Zurück zum Zitat Raine A, Dodge K, Loeber R, Gatzke-Kopp L, Lynam D et al (2006) The reactive-proactive aggression questionnaire: differential correlates of reactive and proactive aggression in adolescent boys. Aggress Behav 32(2):159–171PubMedCentralCrossRefPubMed Raine A, Dodge K, Loeber R, Gatzke-Kopp L, Lynam D et al (2006) The reactive-proactive aggression questionnaire: differential correlates of reactive and proactive aggression in adolescent boys. Aggress Behav 32(2):159–171PubMedCentralCrossRefPubMed
Zurück zum Zitat Rosen PJ, Loren REA, Epstein JN (2010) Managing Frustration for Children: a group treatment for emotion dysregulation in children. Presented at the 2010 annual meeting of the Association for Behavioral and Cognitive Therapies in San Francisco, CA Rosen PJ, Loren REA, Epstein JN (2010) Managing Frustration for Children: a group treatment for emotion dysregulation in children. Presented at the 2010 annual meeting of the Association for Behavioral and Cognitive Therapies in San Francisco, CA
Zurück zum Zitat Rosen PJ, Milich R, Harris MJ (2012) Dysregulated negative emotional reactivity as a predictor of chronic peer victimization in childhood. Aggress Behav 38(5):414–427CrossRefPubMed Rosen PJ, Milich R, Harris MJ (2012) Dysregulated negative emotional reactivity as a predictor of chronic peer victimization in childhood. Aggress Behav 38(5):414–427CrossRefPubMed
Zurück zum Zitat Rosen PJ, Epstein JN, Van Orden G (2013) I know it when I quantify it: ecological momentary assessment and recurrence quantification analysis of emotion dysregulation in children with ADHD. Atten Deficit Hyperact Disord 5(3):283–294CrossRef Rosen PJ, Epstein JN, Van Orden G (2013) I know it when I quantify it: ecological momentary assessment and recurrence quantification analysis of emotion dysregulation in children with ADHD. Atten Deficit Hyperact Disord 5(3):283–294CrossRef
Zurück zum Zitat Shaffer D, Fisher P, Lucas CP, Dulcan MK, Schwab-Stone ME (2000) NIMH Diagnostic Interview Schedule for Children Version IV (NIMH DISC-IV): description, differences from previous versions, and reliability of some common diagnoses. JAACAP 39(1):28–38 Shaffer D, Fisher P, Lucas CP, Dulcan MK, Schwab-Stone ME (2000) NIMH Diagnostic Interview Schedule for Children Version IV (NIMH DISC-IV): description, differences from previous versions, and reliability of some common diagnoses. JAACAP 39(1):28–38
Zurück zum Zitat Shaw P, Stringaris A, Nigg J, Leibenluft E (2014) Emotion dysregulation in attention deficit hyperactivity disorder. Am J Psychiatry 171(3):276–293PubMedCentralCrossRefPubMed Shaw P, Stringaris A, Nigg J, Leibenluft E (2014) Emotion dysregulation in attention deficit hyperactivity disorder. Am J Psychiatry 171(3):276–293PubMedCentralCrossRefPubMed
Zurück zum Zitat Sheppes G, Gross JJ (2011) Is timing everything? Temporal considerations in emotion regulation. Pers Soc Psychol Rev 15(4):319–331CrossRefPubMed Sheppes G, Gross JJ (2011) Is timing everything? Temporal considerations in emotion regulation. Pers Soc Psychol Rev 15(4):319–331CrossRefPubMed
Zurück zum Zitat Shields A, Cicchetti D (1997) Emotion regulation among school-age children: the development and validation of a new criterion Q-sort scale. Dev Psychopathol 33(6):906–916CrossRef Shields A, Cicchetti D (1997) Emotion regulation among school-age children: the development and validation of a new criterion Q-sort scale. Dev Psychopathol 33(6):906–916CrossRef
Zurück zum Zitat Shrier LA, Shih M-C, Beardslee WR (2005) Affect and sexual behavior in adolescents: a review of the literature and comparison of momentary sampling with diary and retrospective self-report methods of measurement. Pediatrics 115(5):573–581CrossRef Shrier LA, Shih M-C, Beardslee WR (2005) Affect and sexual behavior in adolescents: a review of the literature and comparison of momentary sampling with diary and retrospective self-report methods of measurement. Pediatrics 115(5):573–581CrossRef
Zurück zum Zitat Silk JS, Steinberg L, Sheffield Morris A (2003) Adolescents’ emotion regulation in daily life: links to depressive symptoms and problem behavior. Child Dev 74(6):1869–1880CrossRefPubMed Silk JS, Steinberg L, Sheffield Morris A (2003) Adolescents’ emotion regulation in daily life: links to depressive symptoms and problem behavior. Child Dev 74(6):1869–1880CrossRefPubMed
Zurück zum Zitat Skirrow C, Asherson P (2013) Emotional lability, comorbidity and impairment in adults with attention-deficit hyperactivity disorder. J Affect Disord 147(1–3):80–86CrossRefPubMed Skirrow C, Asherson P (2013) Emotional lability, comorbidity and impairment in adults with attention-deficit hyperactivity disorder. J Affect Disord 147(1–3):80–86CrossRefPubMed
Zurück zum Zitat Skirrow C, McLoughlin G, Kuntsi J, Asherson P (2009) Behavioral, neurocognitive, and treatment overlap between attention-deficit/hyperactivity disorder and mood instability. Expert Rev Neurother 9(4):489–503CrossRefPubMed Skirrow C, McLoughlin G, Kuntsi J, Asherson P (2009) Behavioral, neurocognitive, and treatment overlap between attention-deficit/hyperactivity disorder and mood instability. Expert Rev Neurother 9(4):489–503CrossRefPubMed
Zurück zum Zitat Sobanski E, Banaschewski T, Asherson P, Buitelaar J, Franke B et al (2010) Emotional lability in children and adolescents with attention-deficit/hyperactivity disorder (ADHD): clinical correlates and familial prevalence. J Child Psychol Psychiatry 51(8):915–923CrossRefPubMed Sobanski E, Banaschewski T, Asherson P, Buitelaar J, Franke B et al (2010) Emotional lability in children and adolescents with attention-deficit/hyperactivity disorder (ADHD): clinical correlates and familial prevalence. J Child Psychol Psychiatry 51(8):915–923CrossRefPubMed
Zurück zum Zitat Solhan MB, Trull TJ, Jahng S, Wood PK (2009) Clinical assessment of affective instability: comparing EMA indices, questionnaire reports, and retrospective recall. Psychol Assess 21(3):425–436PubMedCentralCrossRefPubMed Solhan MB, Trull TJ, Jahng S, Wood PK (2009) Clinical assessment of affective instability: comparing EMA indices, questionnaire reports, and retrospective recall. Psychol Assess 21(3):425–436PubMedCentralCrossRefPubMed
Zurück zum Zitat Stone AA, Shiffman S (1994) Ecological momentary assessment (EMA) in behavioral medicine. Ann Behav Med 16:199–202 Stone AA, Shiffman S (1994) Ecological momentary assessment (EMA) in behavioral medicine. Ann Behav Med 16:199–202
Zurück zum Zitat Strine TW, Lesesne CA, Okoro CA, McGuire LC, Chaoman DP et al (2006) Emotion and behavioral difficulties and impairments in everyday functioning among children with a history of attention-deficit/hyperactivity disorder. Prev Chronic Dis 3(2):1–10 Strine TW, Lesesne CA, Okoro CA, McGuire LC, Chaoman DP et al (2006) Emotion and behavioral difficulties and impairments in everyday functioning among children with a history of attention-deficit/hyperactivity disorder. Prev Chronic Dis 3(2):1–10
Zurück zum Zitat Suveg C, Payne M, Thomassin K, Jacob ML (2010) Electronic diaries: a feasible method of assessing emotional experiences in youth? J Psychopathol Behav Assess 32(1):57–67CrossRef Suveg C, Payne M, Thomassin K, Jacob ML (2010) Electronic diaries: a feasible method of assessing emotional experiences in youth? J Psychopathol Behav Assess 32(1):57–67CrossRef
Zurück zum Zitat Teper R, Segal ZV, Inzlicht M (2013) Inside the mindful mind: how mindfulness enhances emotion regulation through improvements in executive control. Curr Dir Psychol Sci 22(6):449–454CrossRef Teper R, Segal ZV, Inzlicht M (2013) Inside the mindful mind: how mindfulness enhances emotion regulation through improvements in executive control. Curr Dir Psychol Sci 22(6):449–454CrossRef
Zurück zum Zitat Walcott CM, Landau S (2004) The relation between disinhibition and emotion regulation in boys with attention deficit hyperactivity disorder. J Clin Child Adolesc Psychol 33(4):772–782CrossRefPubMed Walcott CM, Landau S (2004) The relation between disinhibition and emotion regulation in boys with attention deficit hyperactivity disorder. J Clin Child Adolesc Psychol 33(4):772–782CrossRefPubMed
Zurück zum Zitat Watson D, Clark LA, Tellegen A (1988) Development and validation of brief measures of positive and negative affect: the PANAS scales. J Pers Soc Psychol 54(6):1063–1070CrossRefPubMed Watson D, Clark LA, Tellegen A (1988) Development and validation of brief measures of positive and negative affect: the PANAS scales. J Pers Soc Psychol 54(6):1063–1070CrossRefPubMed
Zurück zum Zitat Waxmonsky JG, Wymbs FA, Pariseau ME, Belin PJ, Waschbusch DA et al (2013) A novel group therapy for children with ADHD and severe mood dysregulation. J Atten Disord 17(6):527–541PubMedCentralCrossRefPubMed Waxmonsky JG, Wymbs FA, Pariseau ME, Belin PJ, Waschbusch DA et al (2013) A novel group therapy for children with ADHD and severe mood dysregulation. J Atten Disord 17(6):527–541PubMedCentralCrossRefPubMed
Zurück zum Zitat Weiss HM, Beal DJ, Lucy SL, MacDermid SM (2004) Conducting EMA studies with PMAT: the purdue momentary assessment tool user’s manual. Purdue University, West Lafayette Weiss HM, Beal DJ, Lucy SL, MacDermid SM (2004) Conducting EMA studies with PMAT: the purdue momentary assessment tool user’s manual. Purdue University, West Lafayette
Zurück zum Zitat Whalen CK, Henker B, Ishikawa SS, Floro JN, Emmerson NA et al (2009) ADHD and anger contexts: electronic diary mood reports from mothers and children. J Pediatr Psychol 34(9):940–953CrossRefPubMed Whalen CK, Henker B, Ishikawa SS, Floro JN, Emmerson NA et al (2009) ADHD and anger contexts: electronic diary mood reports from mothers and children. J Pediatr Psychol 34(9):940–953CrossRefPubMed
Zurück zum Zitat Zapolski TC, Stairs AM, Settles RF, Combs JL, Smith GT (2010) The measurement of dispositions to rash actions in children. Assessment 17(1):116–125PubMedCentralCrossRefPubMed Zapolski TC, Stairs AM, Settles RF, Combs JL, Smith GT (2010) The measurement of dispositions to rash actions in children. Assessment 17(1):116–125PubMedCentralCrossRefPubMed
Zurück zum Zitat Zeman J, Cassano M, Perry-Parish C, Stegall S (2006) Emotion regulation in children and adolescents. Dev Behav Pediatr 27(2):155–168CrossRef Zeman J, Cassano M, Perry-Parish C, Stegall S (2006) Emotion regulation in children and adolescents. Dev Behav Pediatr 27(2):155–168CrossRef
Metadaten
Titel
The association of emotional lability and emotional and behavioral difficulties among children with and without ADHD
verfasst von
Paul J. Rosen
Danielle M. Walerius
Nicholas D. Fogleman
Perry I. Factor
Publikationsdatum
01.12.2015
Verlag
Springer Vienna
Erschienen in
ADHD Attention Deficit and Hyperactivity Disorders / Ausgabe 4/2015
Print ISSN: 1866-6116
Elektronische ISSN: 1866-6647
DOI
https://doi.org/10.1007/s12402-015-0175-0

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