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Translational Stroke Research

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01.06.2013 | Original Article

Recommendations for Preclinical Research in Hemorrhagic Transformation

verfasst von: Susan C. Fagan, Paul A. Lapchak, David S. Liebeskind, Tauheed Ishrat, Adviye Ergul

Erschienen in: Translational Stroke Research | Ausgabe 3/2013

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Abstract

Hemorrhagic transformation (HT) is an important complication of ischemic stroke and is responsible for most of the mortality associated with acute reperfusion therapy. Although many important publications address the preclinical models of ischemic stroke, there are no current recommendations on the conduct of research aimed at understanding the mechanisms and consequences of HT. The purpose of this review is to present the various models used in HT research, the clinical correlates, and the experimental variables known to influence the quantitation of HT in preclinical investigation. Lastly, recommendations for the conduct of preclinical research in HT are provided.

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Titel: Recommendations for Preclinical Research in Hemorrhagic Transformation
verfasst von: Susan C. Fagan
Paul A. Lapchak
David S. Liebeskind
Tauheed Ishrat
Adviye Ergul
Publikationsdatum: 01.06.2013
Verlag: Springer-Verlag
Erschienen in: Translational Stroke Research / Ausgabe 3/2013
Print ISSN: 1868-4483
Elektronische ISSN: 1868-601X
DOI: https://doi.org/10.1007/s12975-012-0222-5

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