nach oben

Translational Stroke Research

Erschienen in:

01.10.2014 | Commentary

Full Steam Ahead with Remote Ischemic Conditioning for Stroke

verfasst von: Richard F. Keep, Michael M. Wang, Jianming Xiang, Ya Hua, Guohua Xi

Erschienen in: Translational Stroke Research | Ausgabe 5/2014

Einloggen, um Zugang zu erhalten

Excerpt

The finding that brief periods of ischemia can protect tissues from later ischemic damage (ischemic preconditioning, IPC; [1, 2]) has not only engendered much research into underlying mechanisms [3‐5] but also debate as to how to translate these findings to the clinic [6‐11]. This was a focus of the 2nd Translational Preconditioning meeting held in Miami in 2012 [12] and likely to be a major focus of the 3rd meeting to be hosted by Dr. John Zhang in Los Angeles in 2014. …

Kitagawa K, Matsumoto M, Matsushita K, Mandai K, Mabuchi T, Yanagihara T, etal. Ischemic tolerance in moderately symptomatic gerbils after unilateral carotid occlusion. Brain Res. 1996;716:39–46.

Murry CE, Jennings RB, Reimer KA. Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium. Circulation. 1986;74:1124–36.PubMedCrossRef

Brand D, Ratan RR. Epigenetics and the environment: in search of the “toleroasome” vital to execution of ischemic preconditioning. Transl Stroke Res. 2013;4:56–62.PubMedCentralPubMedCrossRef

Meller R, Simon RP. Tolerance to ischemia—an increasingly complex biology. Transl Stroke Res. 2013;4:40–50.PubMedCentralPubMedCrossRef

Zhao X, Aronowski J. Nrf2 to pre-condition the brain against injury caused by products of hemolysis after ICH. Transl Stroke Res. 2013;4:71–5.

Bahjat FR, Gesuete R, Stenzel-Poore MP. Steps to translate preconditioning from basic research to the clinic. Transl Stroke Res. 2013;4:89–103.

Dezfulian C, Garrett M, Gonzalez NR. Clinical application of preconditioning and postconditioning to achieve neuroprotection. Transl Stroke Res. 2013;4:19–24.PubMedCrossRef

Koch S. Moving towards preconditioning for neurological disorders: are we ready for clinical trials? Transl Stroke Res. 2013;4:15–8.PubMedCrossRef

McLaughlin B, Gidday JM. Poised for success: implementation of sound conditioning strategies to promote endogenous protective responses to stroke in patients. Transl Stroke Res. 2013;4:104–13.PubMedCrossRef

10.

Keep RF, Wang MM, Xiang J, Hua Y, Xi G. Is there a place for cerebral preconditioning in the clinic? Transl Stroke Res. 2010;1:4–18.PubMedCentralPubMedCrossRef

11.

Narayanan SV, Dave KR, Perez-Pinzon MA. Ischemic preconditioning and clinical scenarios. Curr Opin Neurol. 2013;26:1–7.

12.

Koch S, Perez-Pinzon MA. Proceedings of the 2nd Translational Preconditioning Meeting Miami. Transl Stroke Res. 2013;4:1–2.

13.

Gidday JM. Cerebral preconditioning and ischaemic tolerance. Nat Rev Neurosci. 2006;7:437–48.PubMedCrossRef

14.

Gidday JM. Pharmacologic preconditioning: translating the promise. Transl Stroke Res. 2010;1:19–30.PubMedCentralPubMedCrossRef

15.

Dave KR, Saul I, Prado R, Busto R, Perez-Pinzon MA. Remote organ ischemic preconditioning protect brain from ischemic damage following asphyxial cardiac arrest. Neurosci Lett. 2006;404:170–5.

16.

Gho BC, Schoemaker RG, van den Doel MA, Duncker DJ, Verdouw PD. Myocardial protection by brief ischemia in noncardiac tissue. Circulation. 1996;94:2193–200.PubMedCrossRef

17.

Przyklenk K, Bauer B, Ovize M, Kloner RA, Whittaker P. Regional ischemic ‘preconditioning’ protects remote virgin myocardium from subsequent sustained coronary occlusion. Circulation. 1993;87:893–9.PubMedCrossRef

18.

Ren C, Gao X, Steinberg GK, Zhao H. Limb remote-preconditioning protects against focal ischemia in rats and contradicts the dogma of therapeutic time windows for preconditioning. Neuroscience. 2008;151:1099–103.

19.

Hoda MN, Siddiqui S, Herberg S, Periyasamy-Thandavan S, Bhatia K, Hafez SS, etal. Remote ischemic perconditioning is effective alone and in combination with intravenous tissue-type plasminogen activator in murine model of embolic stroke. Stroke. 2012;43:2794–9.

20.

Hougaard KD, Hjort N, Zeidler D, Sorensen L, Norgaard A, Hansen TM, etal. Remote ischemic perconditioning as an adjunct therapy to thrombolysis in patients with acute ischemic stroke: a randomized trial. Stroke. 2014;45:159–67.

21.

Zhao H. Hurdles to clear before clinical translation of ischemic postconditioning against stroke. Transl Stroke Res. 2013;4:63–70.PubMedCentralPubMedCrossRef

22.

Meng R, Asmaro K, Meng L, Liu Y, Ma C, Xi C, etal. Upper limb ischemic preconditioning prevents recurrent stroke in intracranial arterial stenosis. Neurology. 2012;79:1853–61.

23.

Gonzalez NR, Hamilton R, Bilgin-Freiert A, Dusick J, Vespa P, Hu X, etal. Cerebral hemodynamic and metabolic effects of remote ischemic preconditioning in patients with subarachnoid hemorrhage. Acta Neurochir Suppl. 2013;115:193–8.

24.

Koch S, Katsnelson M, Dong C, Perez-Pinzon M. Remote ischemic limb preconditioning after subarachnoid hemorrhage: a phase Ib study of safety and feasibility. Stroke. 2011;42:1387–91.

25.

Sabbagh S, Henry Salzman MM, Kloner RA, Simkhovich BZ, Rezkalla SH. Remote ischemic preconditioning for coronary artery bypass graft operations. Ann Thorac Surg. 2013;96:727–36.PubMedCrossRef

26.

Zhou C, Liu Y, Yao Y, Zhou S, Fang N, Wang W, etal. Beta-blockers and volatile anesthetics may attenuate cardioprotection by remote preconditioning in adult cardiac surgery: a meta-analysis of 15 randomized trials. J Cardiothorac Vasc Anesth. 2013;27:305–11.

27.

Kottenberg E, Thielmann M, Bergmann L, Heine T, Jakob H, Heusch G, etal. Protection by remote ischemic preconditioning during coronary artery bypass graft surgery with isoflurane but not propofol—a clinical trial. Acta Anaesthesiol Scand. 2012;56:30–8.

28.

Kottenberg E, Musiolik J, Thielmann M, Jakob H, Peters J, Heusch G. Interference of propofol with signal transducer and activator of transcription 5 activation and cardioprotection by remote ischemic preconditioning during coronary artery bypass grafting. J Thorac Cardiovasc Surg. 2014;147:376–82.PubMedCrossRef

29.

Connolly M, Bilgin-Freiert A, Ellingson B, Dusick JR, Liebeskind D, Saver J, etal. Peripheral vascular disease as remote ischemic preconditioning, for acute stroke. Clin Neurol Neurosurg. 2013;115:2124–9.

30.

Della-Morte D, Cacciatore F, Salsano E, Pirozzi G, Del Genio MT, D’Antonio I, etal. Age-related reduction of cerebral ischemic preconditioning: myth or reality? Clin Interv Aging. 2013;8:1055–61.

31.

Koch S, Gonzalez N. Preconditioning the human brain: proving the principle in subarachnoid hemorrhage. Stroke. 2013;44:1748–53.PubMedCrossRef

32.

Schmidt MR, Stottrup NB, Michelsen MM, Contractor H, Sorensen KE, Kharbanda RK, etal. Remote ischemic preconditioning impairs ventricular function and increases infarct size after prolonged ischemia in the isolated neonatal rabbit heart. J Thorac Cardiovasc Surg. 2014;147:1049–55.

Titel: Full Steam Ahead with Remote Ischemic Conditioning for Stroke
verfasst von: Richard F. Keep
Michael M. Wang
Jianming Xiang
Ya Hua
Guohua Xi
Publikationsdatum: 01.10.2014
Verlag: Springer US
Erschienen in: Translational Stroke Research / Ausgabe 5/2014
Print ISSN: 1868-4483
Elektronische ISSN: 1868-601X
DOI: https://doi.org/10.1007/s12975-014-0363-9

Leitlinien kompakt für die Neurologie

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Neurologie

25.04.2024 | Hypotonie | Nachrichten

Update Neurologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Full Steam Ahead with Remote Ischemic Conditioning for Stroke

Excerpt

Leitlinien kompakt für die Neurologie

Neu im Fachgebiet Neurologie

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

Frühe Alzheimertherapie lohnt sich

Viel Bewegung in der Parkinsonforschung

Demenzkranke durch Antipsychotika vielfach gefährdet

Update Neurologie

Springer Medizin

Excerpt

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 5/2014

Recombinant T Cell Receptor Ligand Treatment Improves Neurological Outcome in the Presence of Tissue Plasminogen Activator in Experimental Ischemic Stroke

Deferoxamine Attenuates Acute Hydrocephalus After Traumatic Brain Injury in Rats

Polymorphonuclear Neutrophil in Brain Parenchyma After Experimental Intracerebral Hemorrhage

Strain Differences in Fatigue and Depression after Experimental Stroke

Novel Humanized Recombinant T Cell Receptor Ligands Protect the Female Brain After Experimental Stroke

Evaluation of the Protective Potential of Brain Microvascular Endothelial Cell Autophagy on Blood–Brain Barrier Integrity During Experimental Cerebral Ischemia–Reperfusion Injury

Leitlinien kompakt für die Neurologie

Neu im Fachgebiet Neurologie

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

Frühe Alzheimertherapie lohnt sich

Viel Bewegung in der Parkinsonforschung

Demenzkranke durch Antipsychotika vielfach gefährdet

Update Neurologie