Skip to main content
Erschienen in: Translational Behavioral Medicine 3/2015

01.09.2015 | Systematic Reviews

Computer-based HIV adherence promotion interventions: a systematic review

Translation Behavioral Medicine

verfasst von: Kasey R. Claborn, Anne Fernandez, Tyler Wray, Susan Ramsey

Erschienen in: Translational Behavioral Medicine | Ausgabe 3/2015

Einloggen, um Zugang zu erhalten

Abstract

Researchers have instituted a range of methodologies to increase access to HIV adherence interventions. This article reviews studies published through January 2014 utilizing computer-based delivery of such interventions to persons living with HIV. A systematic review of five databases identified ten studies (three RCTs, three pilot studies, three feasibility studies, and one single-group trial) that met the inclusion criteria. Descriptions of the interventions’ content and characteristics are included. Interventions varied widely in terms of program structure, theoretical framework, and content. Only six studies reported medication adherence outcomes. Of these, four (five RCTS and one single group pre-post test) reported significant improvement in adherence using various measures, and two approached significance. Results suggest that computer-delivered adherence interventions are feasible and acceptable among both HIV-positive adolescents and adults. Definitive conclusions regarding clinical impact cannot be drawn due to the small number of adequately powered randomized trials in this review. Additional randomized controlled research is needed to draw inferences regarding intervention efficacy.
Anhänge
Nur mit Berechtigung zugänglich
Literatur
1.
Zurück zum Zitat CDC. Monitoring selected national HIV prevention and care objectives by using HIV surveillance data-United States and 6 U.S. dependent areas-2010. HIV Surveillance Supplemental Report 2012. CDC. Monitoring selected national HIV prevention and care objectives by using HIV surveillance data-United States and 6 U.S. dependent areas-2010. HIV Surveillance Supplemental Report 2012.
2.
Zurück zum Zitat Hall H, Frazier E, Skarbinski J, et al. Differences in human immunodeficiency virus care and treatment among subpopulations in the United States. JAMA Internal Medicine. 2013; 173(14): 1337-1344.CrossRefPubMed Hall H, Frazier E, Skarbinski J, et al. Differences in human immunodeficiency virus care and treatment among subpopulations in the United States. JAMA Internal Medicine. 2013; 173(14): 1337-1344.CrossRefPubMed
3.
Zurück zum Zitat Ortego C, Huedo-Medina T, Vejo J, et al. Adherence to highly active antiretroviral therapy (HAART): a meta-analysis. AIDS and Behavior. 2011; 15(7): 1381-1396.CrossRefPubMed Ortego C, Huedo-Medina T, Vejo J, et al. Adherence to highly active antiretroviral therapy (HAART): a meta-analysis. AIDS and Behavior. 2011; 15(7): 1381-1396.CrossRefPubMed
4.
Zurück zum Zitat Paterson D, Swindells S, Singh N, et al. Adherence to protease inhibitor therapy and outcomes in patients with HIV infection. Annals of Internal Medicine. 2000; 133(1): 21-30.CrossRefPubMed Paterson D, Swindells S, Singh N, et al. Adherence to protease inhibitor therapy and outcomes in patients with HIV infection. Annals of Internal Medicine. 2000; 133(1): 21-30.CrossRefPubMed
5.
Zurück zum Zitat Bangsberg D, Perry S, Moss A, et al. Non-adherence to highly active antiretroviral therapy predicts progression to AIDS. AIDS (London, England). 2001; 15(9): 1181-1183.CrossRef Bangsberg D, Perry S, Moss A, et al. Non-adherence to highly active antiretroviral therapy predicts progression to AIDS. AIDS (London, England). 2001; 15(9): 1181-1183.CrossRef
6.
Zurück zum Zitat Lima V, Harrigan R, Montaner J, et al. The combined effect of modern highly active antiretroviral therapy regimens and adherence on mortality over time. Journal of Acquired Immune Deficiency Syndromes. 2009; 50(5): 529-536.PubMedCentralCrossRefPubMed Lima V, Harrigan R, Montaner J, et al. The combined effect of modern highly active antiretroviral therapy regimens and adherence on mortality over time. Journal of Acquired Immune Deficiency Syndromes. 2009; 50(5): 529-536.PubMedCentralCrossRefPubMed
7.
Zurück zum Zitat Sethi A, Celentano D, Gange S, Moore R, Gallant J. Association between adherence to antiretroviral therapy and human immunodeficiency virus drug resistance. Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America. 2003; 37(8): 1112-1118.CrossRef Sethi A, Celentano D, Gange S, Moore R, Gallant J. Association between adherence to antiretroviral therapy and human immunodeficiency virus drug resistance. Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America. 2003; 37(8): 1112-1118.CrossRef
8.
Zurück zum Zitat Cohen M, Chen Y, Fleming T, et al. Prevention of HIV-1 infection with early antiretroviral therapy. The New England Journal of Medicine. 2011; 365(6): 493-505.PubMedCentralCrossRefPubMed Cohen M, Chen Y, Fleming T, et al. Prevention of HIV-1 infection with early antiretroviral therapy. The New England Journal of Medicine. 2011; 365(6): 493-505.PubMedCentralCrossRefPubMed
9.
Zurück zum Zitat Simoni J, Pearson C, Pantalone D, Marks G, Crepaz N. Efficacy of interventions in improving highly active antiretroviral therapy adherence and HIV-1 RNA viral load: a meta-analytic review of randomized controlled trials. Journal of Acquired Immune Deficiency Syndromes. 2006; 43(Suppl1): S23-S35.PubMedCentralCrossRefPubMed Simoni J, Pearson C, Pantalone D, Marks G, Crepaz N. Efficacy of interventions in improving highly active antiretroviral therapy adherence and HIV-1 RNA viral load: a meta-analytic review of randomized controlled trials. Journal of Acquired Immune Deficiency Syndromes. 2006; 43(Suppl1): S23-S35.PubMedCentralCrossRefPubMed
10.
Zurück zum Zitat Simoni J, Amico K, Smith L, Nelson K. Antiretroviral adherence interventions: translating research findings to the real world clinic. Current HIV/AIDS Reports. 2010; 7(1): 44-51.PubMedCentralCrossRefPubMed Simoni J, Amico K, Smith L, Nelson K. Antiretroviral adherence interventions: translating research findings to the real world clinic. Current HIV/AIDS Reports. 2010; 7(1): 44-51.PubMedCentralCrossRefPubMed
11.
Zurück zum Zitat Chen H, Grimley D, Waithaka Y, Aban I, Hu J, Bachmann L. A process evaluation of the implementation of a computer-based, health provider-delivered HIV-prevention intervention for HIV-positive men who have sex with men in the primary care setting. AIDS Care. 2008; 20(1): 51-60.CrossRefPubMed Chen H, Grimley D, Waithaka Y, Aban I, Hu J, Bachmann L. A process evaluation of the implementation of a computer-based, health provider-delivered HIV-prevention intervention for HIV-positive men who have sex with men in the primary care setting. AIDS Care. 2008; 20(1): 51-60.CrossRefPubMed
12.
Zurück zum Zitat Goldstein M, Guise B, Ruggiero L, Raciti M, Abrams D. Behavioral medicine strategies for medical patients. In: Clinical psychiatry for medical students [e-book]. Philadelphia: J B Lippincott Company; 1990: 609-629. Goldstein M, Guise B, Ruggiero L, Raciti M, Abrams D. Behavioral medicine strategies for medical patients. In: Clinical psychiatry for medical students [e-book]. Philadelphia: J B Lippincott Company; 1990: 609-629.
13.
Zurück zum Zitat Whitlock E, Orleans C, Pender N, Allan J. Evaluating primary care behavioral counseling interventions: an evidence-based approach. American Journal of Preventive Medicine. 2002; 22(4): 267-284.CrossRefPubMed Whitlock E, Orleans C, Pender N, Allan J. Evaluating primary care behavioral counseling interventions: an evidence-based approach. American Journal of Preventive Medicine. 2002; 22(4): 267-284.CrossRefPubMed
14.
Zurück zum Zitat Dewing S, Mathews C, Schaay N, Cloete A, Louw J, Simbayi L. Behaviour change counselling for ARV adherence support within primary health care facilities in the Western Cape, South Africa. AIDS and Behavior. 2012; 16(5): 1286-1294.CrossRefPubMed Dewing S, Mathews C, Schaay N, Cloete A, Louw J, Simbayi L. Behaviour change counselling for ARV adherence support within primary health care facilities in the Western Cape, South Africa. AIDS and Behavior. 2012; 16(5): 1286-1294.CrossRefPubMed
15.
Zurück zum Zitat Mepham S, Zondi Z, Mbuyazi A, Mkhwanazi N, Newell M. Challenges in PMTCT antiretroviral adherence in northern KwaZulu-Natal, South Africa. AIDS Care. 2011; 23(6): 741-747.CrossRefPubMed Mepham S, Zondi Z, Mbuyazi A, Mkhwanazi N, Newell M. Challenges in PMTCT antiretroviral adherence in northern KwaZulu-Natal, South Africa. AIDS Care. 2011; 23(6): 741-747.CrossRefPubMed
16.
Zurück zum Zitat Grant E, Logie D, Masura M, Gorman D, Murray S. Factors facilitating and challenging access and adherence to antiretroviral therapy in a township in the Zambian Copperbelt: a qualitative study. AIDS Care. 2008; 20(10): 1155-1160.CrossRefPubMed Grant E, Logie D, Masura M, Gorman D, Murray S. Factors facilitating and challenging access and adherence to antiretroviral therapy in a township in the Zambian Copperbelt: a qualitative study. AIDS Care. 2008; 20(10): 1155-1160.CrossRefPubMed
17.
Zurück zum Zitat Murray L, Semrau K, Bolton P, et al. Barriers to acceptance and adherence of antiretroviral therapy in urban Zambian women: a qualitative study. AIDS Care. 2009; 21(1): 78-86.PubMedCentralCrossRefPubMed Murray L, Semrau K, Bolton P, et al. Barriers to acceptance and adherence of antiretroviral therapy in urban Zambian women: a qualitative study. AIDS Care. 2009; 21(1): 78-86.PubMedCentralCrossRefPubMed
18.
Zurück zum Zitat Rotheram-Borus M, Swendeman D, Chovnick G. The past, present, and future of HIV prevention: integrating behavioral, biomedical, and structural intervention strategies for the next generation of HIV prevention. Annual Review of Clinical Psychology [serial online]. 2009; 5: 143-167.CrossRef Rotheram-Borus M, Swendeman D, Chovnick G. The past, present, and future of HIV prevention: integrating behavioral, biomedical, and structural intervention strategies for the next generation of HIV prevention. Annual Review of Clinical Psychology [serial online]. 2009; 5: 143-167.CrossRef
19.
Zurück zum Zitat Swendeman D, Rotheram-Borus M. Innovation in sexually transmitted disease and HIV prevention: internet and mobile phone delivery vehicles for global diffusion. Current Opinion in Psychiatry. 2010; 23(2): 139-144.PubMedCentralCrossRefPubMed Swendeman D, Rotheram-Borus M. Innovation in sexually transmitted disease and HIV prevention: internet and mobile phone delivery vehicles for global diffusion. Current Opinion in Psychiatry. 2010; 23(2): 139-144.PubMedCentralCrossRefPubMed
20.
Zurück zum Zitat Pellowski J, Kalichman S. Recent advances (2011–2012) in technology-delivered interventions for people living with HIV. Current HIV/AIDS Reports. 2012; 9(4): 326-334.PubMedCentralCrossRefPubMed Pellowski J, Kalichman S. Recent advances (2011–2012) in technology-delivered interventions for people living with HIV. Current HIV/AIDS Reports. 2012; 9(4): 326-334.PubMedCentralCrossRefPubMed
21.
Zurück zum Zitat Mohr DC, Burns M, Schueller SM, Clarke G, Klinkman M. Behavioral intervention technologies: evidence review and recommendations for future research in mental health. General Hospital Psychiatry. 2013; 35(4): 332-338.PubMedCentralCrossRefPubMed Mohr DC, Burns M, Schueller SM, Clarke G, Klinkman M. Behavioral intervention technologies: evidence review and recommendations for future research in mental health. General Hospital Psychiatry. 2013; 35(4): 332-338.PubMedCentralCrossRefPubMed
23.
Zurück zum Zitat Chiasson M, Hirshfield S, Rietmeijer C. HIV prevention and care in the digital age. Journal of Acquired Immune Deficiency Syndromes. 2010; 55(Suppl 2): S94-S97.CrossRefPubMed Chiasson M, Hirshfield S, Rietmeijer C. HIV prevention and care in the digital age. Journal of Acquired Immune Deficiency Syndromes. 2010; 55(Suppl 2): S94-S97.CrossRefPubMed
24.
Zurück zum Zitat Catalani C, Philbrick W, Fraser H, Mechael P, Israelski D. mHealth for HIV treatment & prevention: a systematic review of the literature. The Open AIDS Journal. 2013; 7: 17-41.PubMedCentralCrossRefPubMed Catalani C, Philbrick W, Fraser H, Mechael P, Israelski D. mHealth for HIV treatment & prevention: a systematic review of the literature. The Open AIDS Journal. 2013; 7: 17-41.PubMedCentralCrossRefPubMed
25.
Zurück zum Zitat Van Volkom M, Stapley J, Amaturo V. Revisiting the digital divide: generational differences in technology use in everyday life. North American Journal of Psychology. 2014; 16(3): 557-574. Van Volkom M, Stapley J, Amaturo V. Revisiting the digital divide: generational differences in technology use in everyday life. North American Journal of Psychology. 2014; 16(3): 557-574.
26.
Zurück zum Zitat Moher D, Liberati A, Tetzlaff J, Altman D. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. International Journal of Surgery (London, England). 2010; 8(5): 336-341.CrossRef Moher D, Liberati A, Tetzlaff J, Altman D. Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. International Journal of Surgery (London, England). 2010; 8(5): 336-341.CrossRef
27.
Zurück zum Zitat Claborn K, Leffingwell T, Miller M, Meier E, Stephens J. Pilot study examining the efficacy of an electronic intervention to promote HIV medication adherence. AIDS Care. 2014; 26(3): 404-409.CrossRefPubMed Claborn K, Leffingwell T, Miller M, Meier E, Stephens J. Pilot study examining the efficacy of an electronic intervention to promote HIV medication adherence. AIDS Care. 2014; 26(3): 404-409.CrossRefPubMed
28.
Zurück zum Zitat Côté J, Godin G, Fadel G, et al. Evaluation of a real-time virtual intervention to empower persons living with HIV to use therapy self-management: study protocol for an online randomized controlled trial. Trials. 2012; 13: 187.PubMedCentralCrossRefPubMed Côté J, Godin G, Fadel G, et al. Evaluation of a real-time virtual intervention to empower persons living with HIV to use therapy self-management: study protocol for an online randomized controlled trial. Trials. 2012; 13: 187.PubMedCentralCrossRefPubMed
29.
Zurück zum Zitat Fisher J, Amico K, Friedland G, et al. Computer-based intervention in HIV clinical care setting improves antiretroviral adherence: the LifeWindows Project. AIDS and Behavior. 2011; 15(8): 1635-1646.CrossRefPubMed Fisher J, Amico K, Friedland G, et al. Computer-based intervention in HIV clinical care setting improves antiretroviral adherence: the LifeWindows Project. AIDS and Behavior. 2011; 15(8): 1635-1646.CrossRefPubMed
30.
Zurück zum Zitat Hersch R, Cook R, Spencer J, et al. Test of a web-based program to improve adherence to HIV medications. AIDS and Behavior. 2013; 17(9): 2963-2976.CrossRefPubMed Hersch R, Cook R, Spencer J, et al. Test of a web-based program to improve adherence to HIV medications. AIDS and Behavior. 2013; 17(9): 2963-2976.CrossRefPubMed
31.
Zurück zum Zitat Horvath K, Oakes J, Simoni J, et al. Feasibility, acceptability and preliminary efficacy of an online peer-to-peer social support ART adherence intervention. AIDS and Behavior. 2013; 17(6): 2031-2044.PubMedCentralCrossRefPubMed Horvath K, Oakes J, Simoni J, et al. Feasibility, acceptability and preliminary efficacy of an online peer-to-peer social support ART adherence intervention. AIDS and Behavior. 2013; 17(6): 2031-2044.PubMedCentralCrossRefPubMed
32.
Zurück zum Zitat Naar-King S, Outlaw A, Ondersma S, et al. Motivational Enhancement System for Adherence (MESA): pilot randomized trial of a brief computer-delivered prevention intervention for youth initiating antiretroviral treatment. Journal of Pediatric Psychology. 2013; 38(6): 638-648.PubMedCentralCrossRefPubMed Naar-King S, Outlaw A, Ondersma S, et al. Motivational Enhancement System for Adherence (MESA): pilot randomized trial of a brief computer-delivered prevention intervention for youth initiating antiretroviral treatment. Journal of Pediatric Psychology. 2013; 38(6): 638-648.PubMedCentralCrossRefPubMed
33.
Zurück zum Zitat Ownby R, Waldrop-Valverde D, Caballero J, Jacobs R. Baseline medication adherence and response to an electronically delivered health literacy intervention targeting adherence. Neurobehavioral HIV Medicine. 2012; 4: 113-121.PubMedCentralCrossRefPubMed Ownby R, Waldrop-Valverde D, Caballero J, Jacobs R. Baseline medication adherence and response to an electronically delivered health literacy intervention targeting adherence. Neurobehavioral HIV Medicine. 2012; 4: 113-121.PubMedCentralCrossRefPubMed
34.
Zurück zum Zitat Remien R, Mellins C, Stein D, et al. Masivukeni: development of a multimedia based antiretroviral therapy adherence intervention for counselors and patients in South Africa. AIDS and Behavior. 2013; 17(6): 1979-1991.PubMedCentralCrossRefPubMed Remien R, Mellins C, Stein D, et al. Masivukeni: development of a multimedia based antiretroviral therapy adherence intervention for counselors and patients in South Africa. AIDS and Behavior. 2013; 17(6): 1979-1991.PubMedCentralCrossRefPubMed
35.
Zurück zum Zitat Shegog R, Markham C, Leonard A, Bui T, Paul M. ' + CLICK': pilot of a web-based training program to enhance ART adherence among HIV-positive youth. AIDS Care. 2012; 24(3): 310-318.CrossRefPubMed Shegog R, Markham C, Leonard A, Bui T, Paul M. ' + CLICK': pilot of a web-based training program to enhance ART adherence among HIV-positive youth. AIDS Care. 2012; 24(3): 310-318.CrossRefPubMed
36.
Zurück zum Zitat Higgins J, Altman D, Sterne J, et al. The Cochrane Collaboration's tool for assessing risk of bias in randomised trials. BMJ (Clinical Research Ed). 2011; 343: d5928.CrossRef Higgins J, Altman D, Sterne J, et al. The Cochrane Collaboration's tool for assessing risk of bias in randomised trials. BMJ (Clinical Research Ed). 2011; 343: d5928.CrossRef
37.
Zurück zum Zitat Outlaw A, Naar-King S, Merlo L, et al. The initial feasibility of a computer-based motivational intervention for adherence for youth newly recommended to start antiretroviral treatment. AIDS Care. 2014; 26(1): 130-135.CrossRefPubMed Outlaw A, Naar-King S, Merlo L, et al. The initial feasibility of a computer-based motivational intervention for adherence for youth newly recommended to start antiretroviral treatment. AIDS Care. 2014; 26(1): 130-135.CrossRefPubMed
38.
Zurück zum Zitat Pop-Eleches C, Thirumurthy H, Bangsberg D, et al. Mobile phone technologies improve adherence to antiretroviral treatment in a resource-limited setting: a randomized controlled trial of text message reminders. Aids. 2011; 25(6): 825-834.PubMedCentralCrossRefPubMed Pop-Eleches C, Thirumurthy H, Bangsberg D, et al. Mobile phone technologies improve adherence to antiretroviral treatment in a resource-limited setting: a randomized controlled trial of text message reminders. Aids. 2011; 25(6): 825-834.PubMedCentralCrossRefPubMed
39.
Zurück zum Zitat Safren S, Otto M, Worth J. Life-steps: applying cognitive behavioral therapy to HIV medication adherence. Cognitive and Behavioral Practice [serial online]. Fal 1999 1999;6(4):332–341. Safren S, Otto M, Worth J. Life-steps: applying cognitive behavioral therapy to HIV medication adherence. Cognitive and Behavioral Practice [serial online]. Fal 1999 1999;6(4):332–341.
40.
Zurück zum Zitat Cole-Lewis H, Kershaw T. Text messaging as a tool for behavior change in disease prevention and management. Epidemiologic Reviews. 2010; 32(1): 56-69.PubMedCentralCrossRefPubMed Cole-Lewis H, Kershaw T. Text messaging as a tool for behavior change in disease prevention and management. Epidemiologic Reviews. 2010; 32(1): 56-69.PubMedCentralCrossRefPubMed
41.
Zurück zum Zitat Thirumurthy H, Lester RT. M-health for health behaviour change in resource-limited settings: applications to HIV care and beyond. Bulletin of the World Health Organization. 2012; 90(5): 390-392.PubMedCentralCrossRefPubMed Thirumurthy H, Lester RT. M-health for health behaviour change in resource-limited settings: applications to HIV care and beyond. Bulletin of the World Health Organization. 2012; 90(5): 390-392.PubMedCentralCrossRefPubMed
42.
Zurück zum Zitat Faulkner C, Fidler F, Cumming G. The value of RCT evidence depends on the quality of statistical analysis. Behaviour Research and Therapy. 2008; 46(2): 270-281.CrossRefPubMed Faulkner C, Fidler F, Cumming G. The value of RCT evidence depends on the quality of statistical analysis. Behaviour Research and Therapy. 2008; 46(2): 270-281.CrossRefPubMed
Metadaten
Titel
Computer-based HIV adherence promotion interventions: a systematic review
Translation Behavioral Medicine
verfasst von
Kasey R. Claborn
Anne Fernandez
Tyler Wray
Susan Ramsey
Publikationsdatum
01.09.2015
Verlag
Springer US
Erschienen in
Translational Behavioral Medicine / Ausgabe 3/2015
Print ISSN: 1869-6716
Elektronische ISSN: 1613-9860
DOI
https://doi.org/10.1007/s13142-015-0317-0

Weitere Artikel der Ausgabe 3/2015

Translational Behavioral Medicine 3/2015 Zur Ausgabe