nach oben

Tumor Biology

Erschienen in:

01.06.2014 | Review

Anti-tumor activities of matrine and oxymatrine: literature review

verfasst von: Yan Liu, Yang Xu, Weidan Ji, Xiaoya Li, Bin Sun, Quangen Gao, Changqing Su

Erschienen in: Tumor Biology | Ausgabe 6/2014

Einloggen, um Zugang zu erhalten

Abstract

Matrine (MT) and oxymatrine (OMT), two kinds of alkaloid components found in the roots of Sophora species, have various pharmacological activities and are demonstrated to have anti-inflammatory, anti-allergic, anti-virus, anti-fibrotic, and cardiovascular protective effects. They are recently proved to have anti-cancer potentials, such as inhibiting cancer cell proliferation, inducing cell cycle arrest, accelerating apoptosis, restraining angiogenesis, inducing cell differentiation, inhibiting cancer metastasis and invasion, reversing multidrug resistance, and preventing or reducing chemotherapy- or radiotherapy-induced toxicity when combined with other chemotherapeutic drugs. In this review, we summarize the recent investigations regarding the anti-cancer activities and possible molecular targets of MT and OMT for cancer prevention and treatment in order to provide clues and references for further study.

Cai XZ, Huang WY, Qiao Y, Du SY, Chen Y, Chen D, et al. Inhibitory effects of curcumin on gastric cancer cells: a proteomic study of molecular targets. Phytomedicine. 2013;20:495–505.CrossRefPubMed

Bishayee A, Politis T, Darvesh AS. Resveratrol in the chemoprevention and treatment of hepatocellular carcinoma. Cancer Treat Rev. 2010;36:43–53.CrossRefPubMed

Liu TY, Tan ZJ, Jiang L, Gu JF, Wu XS, Cao Y, et al. Curcumin induces apoptosis in gallbladder carcinoma cell line GBC-SD cells. Cancer Cell Int. 2013;13(1):64.PubMedCentralCrossRefPubMed

Wang S, Yu S, Shi W, Ge L, Yu X, Fan J, et al. Curcumin inhibits the migration and invasion of mouse hepatoma Hca-F cells through down-regulating caveolin-1 expression and epidermal growth factor receptor signaling. IUBMB Life. 2011;63(9):775–82.PubMed

Saleem M, Murtaza I, Tarapore RS, Suh Y, Adhami VM, Johnson JJ, et al. Lupeol inhibits proliferation of human prostate cancer cells by targeting beta-catenin signaling. Carcinogenesis. 2009;30(5):808–17.PubMedCentralCrossRefPubMed

Saleem M, Maddodi N, Abu Zaid M, Khan N, bin Hafeez B, Asim M, et al. Lupeol inhibits growth of highly aggressive human metastatic melanoma cells in vitro and in vivo by inducing apoptosis. Clin Cancer Res. 2008;14(7):2119–27.CrossRefPubMed

Funaya N, Haginaka J. Matrine- and oxymatrine-imprinted monodisperse polymers prepared by precipitation polymerization and their applications for the selective extraction of matrine-type alkaloids from Sophora flavescens Aiton. J Chromatogr A. 2012;1248:18–23.CrossRefPubMed

Lai JP, He XW, Jiang Y, Chen F. Preparative separation and determination of matrine from the Chinese medicinal plant Sophora flavescens Ait by molecularly imprinted solid-phase extraction. Anal Bioanal Chem. 2003;375:264–9.PubMed

Liu JY, Hu JH, Zhu QG, Li FQ, Wang J, Sun HJ. Effect of matrine on the expression of substance P receptor and inflammatory cytokines production in human skin keratinocytes and fibroblasts. Int Immunopharmacol. 2007;7:816–23.CrossRefPubMed

10.

Sun J, Mao J, Liu X, Wang Y, Sun Y, He Z. Separation and mechanism elucidation for six structure-like matrine-type alkaloids by micellar liquid chromatography. J Sep Sci. 2009;32:2043–50.CrossRefPubMed

11.

Guzman JR, Koo JS, Goldsmith JR, Muhlbauer M, Narula A, Jobin C. Oxymatrine prevents NF-kappaB nuclear translocation and ameliorates acute intestinal inflammation. Sci Rep. 2013;3:1629.PubMedCentralCrossRefPubMed

12.

Cao YG, Jing S, Li L, Gao JQ, Shen ZY, Liu Y, et al. Antiarrhythmic effects and ionic mechanisms of oxymatrine from Sophora flavescens. Phytother Res. 2010;24:1844–9.CrossRefPubMed

13.

Yang Y, Xiu J, Zhang X, Zhang L, Yan K, Qin C, et al. Antiviral effect of matrine against human enterovirus 71. Molecules. 2012;17:10370–6.CrossRefPubMed

14.

Chai NL, Fu Q, Shi H, Cai CH, Wan J, Xu SP, et al. Oxymatrine liposome attenuates hepatic fibrosis via targeting hepatic stellate cells. World J Gastroenterol. 2012;18:4199–206.PubMedCentralCrossRefPubMed

15.

Li XM, Brown L. Efficacy and mechanisms of action of traditional Chinese medicines for treating asthma and allergy. J Allergy Clin Immunol. 2009;123:297–306. quiz 7-8.PubMedCentralCrossRefPubMed

16.

Liu H, Sun Y, Gao Y, Chen F, Xu M, Liu Z. The analgesic effect and mechanism of the combination of sodium ferulate and oxymatrine. Neurochem Res. 2010;35:1368–75.CrossRefPubMed

17.

Kan QC, Zhu L, Liu N, Zhang GX. Matrine suppresses expression of adhesion molecules and chemokines as a mechanism underlying its therapeutic effect in CNS autoimmunity. Immunol Res. 2013;56:189–96.CrossRefPubMed

18.

Zhang J, Li Y, Chen X, Liu T, Chen Y, He W, et al. Autophagy is involved in anticancer effects of matrine on SGC-7901 human gastric cancer cells. Oncol Rep. 2011;26:115–24.PubMed

19.

Zhang Y, Zhang H, Yu P, Liu Q, Liu K, Duan H, et al. Effects of matrine against the growth of human lung cancer and hepatoma cells as well as lung cancer cell migration. Cytotechnology. 2009;59:191–200.PubMedCentralCrossRefPubMed

20.

Li LQ, Li XL, Wang L, Du WJ, Guo R, Liang HH, et al. Matrine inhibits breast cancer growth via miR-21/PTEN/Akt pathway in MCF-7 cells. Cell Physiol Biochem. 2012;30:631–41.CrossRefPubMed

21.

Zhang JQ, Li YM, Liu T, He WT, Chen YT, Chen XH, et al. Antitumor effect of matrine in human hepatoma G2 cells by inducing apoptosis and autophagy. World J Gastroenterol. 2010;16:4281–90.PubMedCentralCrossRefPubMed

22.

Chen H, Zhang J, Luo J, Lai F, Wang Z, Tong H, et al. Antiangiogenic effects of oxymatrine on pancreatic cancer by inhibition of the NF-kappaB-mediated VEGF signaling pathway. Oncol Rep. 2013;30:589–95.PubMed

23.

Jin H, Sun Y, Wang S, Cheng X. Matrine activates PTEN to induce growth inhibition and apoptosis in V600EBRAF harboring melanoma cells. Int J Mol Sci. 2013;14:16040–57.PubMedCentralCrossRefPubMed

24.

Zhang S, Zhang Y, Zhuang Y, Wang J, Ye J, Zhang S, et al. Matrine induces apoptosis in human acute myeloid leukemia cells via the mitochondrial pathway and Akt inactivation. PloS One. 2012;7:e46853.PubMedCentralCrossRefPubMed

25.

Zhang L, Wang T, Wen X, Wei Y, Peng X, Li H, et al. Effect of matrine on HeLa cell adhesion and migration. Eur J Pharmacol. 2007;563:69–76.CrossRefPubMed

26.

Yan F, Liu Y, Wang W. Matrine inhibited the growth of rat osteosarcoma UMR-108 cells by inducing apoptosis in a mitochondrial-caspase-dependent pathway. Tumour Biol. 2013;34:2135–40.CrossRefPubMed

27.

Ramasamy K, Agarwal R. Multitargeted therapy of cancer by silymarin. Cancer Lett. 2008;269:352–62.PubMedCentralCrossRefPubMed

28.

Liang CZ, Zhang JK, Shi Z, Liu B, Shen CQ, Tao HM. Matrine induces caspase-dependent apoptosis in human osteosarcoma cells in vitro and in vivo through the upregulation of Bax and Fas/FasL and downregulation of Bcl-2. Cancer Chemother Pharmacol. 2012;69:317–31.CrossRefPubMed

29.

Zhao B, Li B, Bai S, Shen L, Ren R, Jonas JB, et al. Effects of matrine on proliferation and apoptosis of cultured retinoblastoma cells. Graefes Arch Clin Exp Ophthalmol. 2012;250:897–905.CrossRefPubMed

30.

Xing Y, Yan F, Liu Y, Liu Y, Zhao Y. Matrine inhibits 3 T3-L1 preadipocyte differentiation associated with suppression of ERK1/2 phosphorylation. Biochem Biophys Res Commun. 2010;396:691–5.CrossRefPubMed

31.

Yu HB, Zhang HF, Li DY, Zhang X, Xue HZ, Zhao SH. Matrine inhibits matrix metalloproteinase-9 expression and invasion of human hepatocellular carcinoma cells. J Asian Nat Prod Res. 2011;13:242–50.CrossRefPubMed

32.

Wang YP, Zhao W, Xue R, Zhou ZX, Liu F, Han YX, et al. Oxymatrine inhibits hepatitis B infection with an advantage of overcoming drug-resistance. Antiviral Res. 2011;89:227–31.CrossRefPubMed

33.

Sun Q, Ma W, Gao Y, Zheng W, Zhang B, Peng Y. Meta-analysis: therapeutic effect of transcatheter arterial chemoembolization combined with compound kushen injection in hepatocellular carcinoma. Afr J Tradit Complement Altern Med. 2012;9:178–88.PubMedCentralPubMed

34.

Luo C, Zhu Y, Jiang T, Lu X, Zhang W, Jing Q, et al. Matrine induced gastric cancer MKN45 cells apoptosis via increasing pro-apoptotic molecules of Bcl-2 family. Toxicology. 2007;229:245–52.CrossRefPubMed

35.

Dai ZJ, Gao J, Ji ZZ, Wang XJ, Ren HT, Liu XX, et al. Matrine induces apoptosis in gastric carcinoma cells via alteration of Fas/FasL and activation of caspase-3. J Ethnopharmacol. 2009;123:91–6.CrossRefPubMed

36.

Yu P, Liu Q, Liu K, Yagasaki K, Wu E, Zhang G. Matrine suppresses breast cancer cell proliferation and invasion via VEGF-Akt-NF-kappaB signaling. Cytotechnology. 2009;59:219–29.PubMedCentralCrossRefPubMed

37.

Song G, Luo Q, Qin J, Wang L, Shi Y, Sun C. Effects of oxymatrine on proliferation and apoptosis in human hepatoma cells. Colloids Surf B: Biointerfaces. 2006;48:1–5.CrossRefPubMed

38.

Zou J, Ran ZH, Xu Q, Xiao SD. Experimental study of the killing effects of oxymatrine on human colon cancer cell line SW1116. Chin J Dig Dis. 2005;6:15–20.CrossRefPubMed

39.

Zhang S, Qi J, Sun L, Cheng B, Pan S, Zhou M, et al. Matrine induces programmed cell death and regulates expression of relevant genes based on PCR array analysis in C6 glioma cells. Mol Biol Rep. 2009;36:791–9.CrossRefPubMed

40.

Ling Q, Xu X, Wei X, Wang W, Zhou B, Wang B, et al. Oxymatrine induces human pancreatic cancer PANC-1 cells apoptosis via regulating expression of Bcl-2 and IAP families, and releasing of cytochrome c. J Exp Clin Cancer Res. 2011;30:66.PubMedCentralCrossRefPubMed

41.

Liu XS, Jiang JK, Jiao XY, Wu YE, Lin JH. Matrine-induced apoptosis in leukemia U937 cells-involvement of caspases activation and MAPK-independent pathways. Planta Med. 2006;72:501–6.CrossRefPubMed

42.

Liu TY, Song Y, Chen H, Pan SH, Sun XY. Matrine inhibits proliferation and induces apoptosis of pancreatic cancer cells in vitro and in vivo. Biol Pharm Bull. 2010;33:1740–5.CrossRefPubMed

43.

Ma L, Wen S, Zhan Y, He Y, Liu X, Jiang J. Anticancer effects of the Chinese medicine matrine on murine hepatocellular carcinoma cells. Planta Med. 2008;74:245–51.CrossRefPubMed

44.

Wang L, You Y, Wang S, Liu X, Liu B, Wang J, et al. Synthesis, characterization and in vitro anti-tumor activities of matrine derivatives. Bioorg Med Chem Lett. 2012;22(12):4100–2.CrossRefPubMed

45.

Shi C, Yu L, Yang F, Yan J, Zeng H. A novel organoselenium compound induces cell cycle arrest and apoptosis in prostate cancer cell lines. Biochem Biophys Res Commun. 2003;309:578–83.CrossRefPubMed

46.

Zhao JF, Xie GR, Li XM, Chen WT, Sun ML, Fang Z, et al. Effect of Matrine on cell cycle and human telomerase reverse transcriptase of human salivary adenoid cystic carcinoma. Hua Xi Kou Qiang Yi Xue Za Zhi. 2010;28:234–40.PubMed

47.

Zhang Z, Wang X, Wu W, Wang J, Wang Y, Wu X, et al. Effects of matrine on proliferation and apoptosis in gallbladder carcinoma cells (GBC-SD). Phytother Res. 2012;26:932–7.CrossRefPubMed

48.

Harbour JW, Dean DC. The Rb/E2F pathway: expanding roles and emerging paradigms. Genes Dev. 2000;14:2393–409.CrossRefPubMed

49.

Jiang H, Hou C, Zhang S, Xie H, Zhou W, Jin Q, et al. Matrine upregulates the cell cycle protein E2F-1 and triggers apoptosis via the mitochondrial pathway in K562 cells. Eur J Pharmacol. 2007;559:98–108.CrossRefPubMed

50.

Degterev A, Boyce M, Yuan J. A decade of caspases. Oncogene. 2003;22:8543–67.CrossRefPubMed

51.

Spencer SL, Sorger PK. Measuring and modeling apoptosis in single cells. Cell. 2011;144:926–39.PubMedCentralCrossRefPubMed

52.

Zhang Y, Sun S, Chen J, Ren P, Hu Y, Cao Z, et al. Oxymatrine induces mitochondria dependent apoptosis in human osteosarcoma MNNG/HOS cells through inhibition of PI3K/Akt pathway. Tumour Biol. 2013. doi:10.1007/s13277-013-1223-z.

53.

Bröker LE, Kruyt FAE, Giaccone G. Cell death independent of caspases: a review. Clin Cancer Res. 2005;11:3155–62.CrossRefPubMed

54.

Zheng SY, Li DC, Zhang ZD, Zhao J, Ge JF. Adenovirus-mediated FasL gene transfer into human gastric carcinoma. World J Gastroenterol. 2005;11:3446–50.PubMedCentralCrossRefPubMed

55.

Tan CH, Qian XQ, Jia RD, Wu M, Liang ZQ. Matrine induction of reactive oxygen species activates p38 leading to caspase-dependent cell apoptosis in non-small cell lung cancer cells. Oncol Rep. 2013;30:2529–35.PubMed

56.

Song MQ, Zhu JS, Chen JL, Wang L, Da W, Zhu L, et al. Synergistic effect of oxymatrine and angiogenesis inhibitor NM-3 on modulating apoptosis in human gastric cancer cells. World J Gastroenterol. 2007;13:1788–93.PubMedCentralCrossRefPubMed

57.

Jin Y, Hu J, Wang Q, Li Z, Chen Y. Effects of oxymatrine on the apoptosis of human esophageal carcinoma Eca109 cell line and its mechanism. J Huazhong Univ of Sci Technolog Med Sci. 2008;28:314–6.CrossRef

58.

Maheshwari RK, Singh AK, Gaddipati J, Srimal RC. Multiple biological activities of curcumin: a short review. Life Sci. 2006;78:2081–7.CrossRefPubMed

59.

Lee TH, Seng S, Sekine M, Hinton C, Fu Y, Avraham HK, et al. Vascular endothelial growth factor mediates intracrine survival in human breast carcinoma cells through internally expressed VEGFR1/FLT1. PLoS Med. 2007;4:e186.PubMedCentralCrossRefPubMed

60.

North S, Moenner M, Bikfalvi A. Recent developments in the regulation of the angiogenic switch by cellular stress factors in tumors. Cancer Lett. 2005;218:1–14.CrossRefPubMed

61.

Qu F, Cui YR, Xu J. Anttumor effects of matrine on murine hepatocarcinoma cell line H22 and the mechanism. Anti-tumor Pharmacy (China). 2011;1:374–8.

62.

Hlobilkova A, Ehrmann J, Knizetova P, Krejci V, Kalita O, Kolar Z. Analysis of VEGF, Flt-1, Flk-1, nestin and MMP-9 in relation to astrocytoma pathogenesis and progression. Neoplasma. 2009;56:284–90.CrossRefPubMed

63.

Park JH, Jeong YJ, Park KK, Cho HJ, Chung IK, Min KS, et al. Melittin suppresses PMA-induced tumor cell invasion by inhibiting NF-kappaB and AP-1-dependent MMP-9 expression. Mol Cells. 2010;29:209–15.CrossRefPubMed

64.

Liu XY, Fang H, Yang ZG, Wang XY, Ruan LM, Fang DR, et al. Matrine inhibits invasiveness and metastasis of human malignant melanoma cell line A375 in vitro. Int J Dermatol. 2008;47:448–56.CrossRefPubMed

65.

Levy-Adam F, Ilan N, Vlodavsky I. Tumorigenic and adhesive properties of heparanase. Semin Cancer Biol. 2010;20:153–60.PubMedCentralCrossRefPubMed

66.

Li H, Tan G, Jiang X, Qiao H, Pan S, Jiang H, et al. Therapeutic effects of matrine on primary and metastatic breast cancer. Am J Chin Med. 2010;38:1115–30.CrossRefPubMed

67.

Kundu M, Thompson CB. Autophagy: basic principles and relevance to disease. Annu Rev Pathol. 2008;3:427–55.CrossRefPubMed

68.

Yang ZJ, Chee CE, Huang S, Sinicrope FA. The role of autophagy in cancer: therapeutic implications. Mol Cancer Ther. 2011;10:1533–41.PubMedCentralCrossRefPubMed

69.

Liang XH, Jackson S, Seaman M, Brown K, Kempkes B, Hibshoosh H, et al. Induction of autophagy and inhibition of tumorigenesis by beclin 1. Nature. 1999;402:672–6.CrossRefPubMed

70.

Wang Z, Zhang J, Wang Y, Xing R, Yi C, Zhu H, et al. Matrine, a novel autophagy inhibitor, blocks trafficking and the proteolytic activation of lysosomal proteases. Carcinogenesis. 2013;34:128–38.CrossRefPubMed

71.

Cohen SB, Graham ME, Lovrecz GO, Bache N, Robinson PJ, Reddel RR. Protein composition of catalytically active human telomerase from immortal cells. Science. 2007;315:1850–3.CrossRefPubMed

72.

Basu N, Skinner HG, Litzelman K, Vanderboom R, Baichoo E, Boardman LA. Telomeres and telomere dynamics: relevance to cancers of the GI tract. Expert Rev Gastroenterol Hepatol. 2013;7:733–48.PubMedCentralCrossRefPubMed

73.

Liu HQ, Liu SL, Wang H, Xie XY, Chen XL, Zhang XM, et al. Genomic amplification of the human telomerase gene (hTERC) associated with human papillomavirus is related to the progression of uterine cervical dysplasia to invasive cancer. Diagn Pathol. 2012;7:1–8.CrossRef

74.

Zhang LP, Jiang JK, Tam JW, Zhang Y, Liu XS, Xu XR, et al. Effects of Matrine on proliferation and differentiation in K-562 cells. Leuk Res. 2001;25:793–800.CrossRefPubMed

75.

Fukuchi Y, Yamato K, Kawamura C, Ikeda Y, Kizaki M. p27KIP1 and GATA-1 are potential downstream molecules in activin A-induced differentiation and apoptosis pathways in CML cells. Oncol Rep. 2006;16:1099–103.PubMed

76.

Inoue N, Yahagi N, Yamamoto T, Ishikawa M, Watanabe K, Matsuzaka T, et al. Cyclin-dependent kinase inhibitor, p21WAF1/CIP1, is involved in adipocyte differentiation and hypertrophy, linking to obesity, and insulin resistance. J Biol Chem. 2008;283:21220–9.PubMedCentralCrossRefPubMed

77.

He S, Liu F, Xie Z, Zu X, Xu W, Jiang Y. P-Glycoprotein/MDR1 regulates Pokemon gene transcription through p53 expression in human breast cancer cells. Int J Mol Sci. 2010;11:3309–51.PubMedCentralPubMed

78.

Colabufo NA, Berardi F, Cantore M, Contino M, Inglese C, Niso M, et al. Perspectives of P-glycoprotein modulating agents in oncology and neurodegenerative diseases: pharmaceutical, biological, and diagnostic potentials. J Med Chem. 2010;53:1883–97.CrossRefPubMed

79.

Chai S, To KK, Lin G. Circumvention of multi-drug resistance of cancer cells by Chinese herbal medicines. Chin Med. 2010;5:26.PubMedCentralCrossRefPubMed

80.

Zhang J, Tang AZ. Reversal effect of matrine on drug resistance of human nasopharyngeal carcinoma cell line. Zhong Yao Cai. 2012;35(12):1989–94.PubMed

81.

Liu F, Liu SY, He SN, Xie ZH, Zu XY, Jiang YY. Survivin transcription is associated with P-glycoprotein/MDR1 overexpression in the multidrug resistance of MCF-7 breast cancer cells. Oncol Rep. 2010;23:1469–75.CrossRefPubMed

82.

Luo SX, Deng WY, Wang XF, Lu HF, Han LL, Chen BB, et al. Molecular mechanism of indirubin-3′-monoxime and matrine in the reversal of paclitaxel resistance in NCI-H520/TAX25 cell line. Chin Med J (Enql). 2013;126:925–9.

83.

Gao HY, Li GY, Lou MM, Li XY, Wei XY, Wang JH. Hepatoprotective effect of matrine salvianolic acid B salt on carbon tetrachloride-induced hepatic fibrosis. J Inflamm (Lond). 2012;9:16.CrossRef

84.

Hu ST, Tang Y, Shen YF, Ao HH, Bai J, Wang YL, et al. Protective effect of oxymatrine on chronic rat heart failure. J Physiol Sci. 2011;61:363–72.CrossRefPubMed

85.

Xu W, Lin H, Zhang Y, Chen X, Hua B, Hou W, et al. Compound Kushen Injection suppresses human breast cancer stem-like cells by down-regulating the canonical Wnt/beta-catenin pathway. J Exp Clin Cancer Res. 2011;30:103.PubMedCentralCrossRefPubMed

86.

Shao Q. The recent effect of radiotherapy combined with compound kushen injection for esophageal cancer. Radiother Oncol. 2011;99:S372–3.CrossRef

87.

Lao Y. Clinical study on effect of matrine injection to protect the liver function for patients with primary hepatic carcinoma after trans-artery chemo-embolization (TAE). Zhong Yao Cai. 2005;28:637–8.PubMed

88.

Zhang XL, Xu HR, Chen WL, Chu NN, Li XN, Liu GY, et al. Matrine determination and pharmacokinetics in human plasma using LC/MS/MS. J Chromatogr B Analyt Technol Biomed Life Sci. 2009;877:3253–6.CrossRefPubMed

89.

Yue PF, Yuan HL, Li XY, Yang M, Zhu WF. Process optimization, characterization and evaluation in vivo of oxymatrine-phospholipid complex. Int J Pharm. 2010;387:139–46.CrossRefPubMed

90.

Ruan J, Liu J, Zhu D, Gong T, Yang F, Hao X, et al. Preparation and evaluation of self-nanoemulsified drug delivery systems (SNEDDSs) of matrine based on drug-phospholipid complex technique. Int J Pharm. 2010;386:282–90.CrossRefPubMed

91.

Fan R, Liu R, Ma R, Bi K, Li Q. Determination of oxymatrine and its active metabolite matrine in human plasma after administration of oxymatrine oral solution by high-performance liquid chromatography coupled with mass spectrometry. Fitoterapia. 2013;89:271–7.CrossRefPubMed

92.

Wu XL, Hang TJ, Shen JP, Zhang YD. Determination and pharmacokinetic study of oxymatrine and its metabolite matrine in human plasma by liquid chromatography tandem mass spectrometry. J Pharml Biomed Anal. 2006;41(3):918–24.CrossRef

93.

Kennedy DA, Seely D. Clinically based evidence of drug-herb interactions: a systematic review. Expert Opin Drug Saf. 2010;9(1):79–124.CrossRefPubMed

94.

Hu MJ, Zeng H, Wu YL, Zhang YP, Zhang S, Qiao MM, et al. Synergistic effects of matrine and 5-fluorouracil on tumor growth of the implanted gastric cancer in nude mice. Chin J Dig Dis. 2005;6(2):68–71.CrossRefPubMed

95.

Yang CL, Liu SS, Ma YG, Liu YY, Xue YX, Huang B. The influence of intraoperative pleural perfusion with matrine-cisplatin or cisplatin on stromal cell-derived factor-1 in non-small cell lung cancer patients with subclinical pleural metastasis. Med Oncol. 2012;29(2):574–81.CrossRefPubMed

Titel: Anti-tumor activities of matrine and oxymatrine: literature review
verfasst von: Yan Liu
Yang Xu
Weidan Ji
Xiaoya Li
Bin Sun
Quangen Gao
Changqing Su
Publikationsdatum: 01.06.2014
Verlag: Springer Netherlands
Erschienen in: Tumor Biology / Ausgabe 6/2014
Print ISSN: 1010-4283
Elektronische ISSN: 1423-0380
DOI: https://doi.org/10.1007/s13277-014-1680-z

Springer Medizin

Anti-tumor activities of matrine and oxymatrine: literature review

Abstract

Neu im Fachgebiet Onkologie

Adjuvante Immuntherapie verlängert Leben bei RCC

Alectinib verbessert krankheitsfreies Überleben bei ALK-positivem NSCLC

Bei Senioren mit Prostatakarzinom auf Anämie achten!

ICI-Therapie in der Schwangerschaft wird gut toleriert

Update Onkologie

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 6/2014

Bone morphogenetic protein 2 inhibits hepatocellular carcinoma growth and migration through downregulation of the PI3K/AKT pathway

Common genetic variants on FOXE1 contributes to thyroid cancer susceptibility: evidence based on 16 studies

CGB activates ERK and AKT kinases in cancer cells via LHCGR-independent mechanism

Dihydroartemisinin induces apoptosis in colorectal cancer cells through the mitochondria-dependent pathway

High sensitivity of touch imprint cytology in young patients with invasive lobular carcinoma of the breast

Genetic association between ERCC5 rs17655 polymorphism and lung cancer risk: evidence based on a meta-analysis

Neu im Fachgebiet Onkologie

Adjuvante Immuntherapie verlängert Leben bei RCC

Alectinib verbessert krankheitsfreies Überleben bei ALK-positivem NSCLC

Bei Senioren mit Prostatakarzinom auf Anämie achten!

ICI-Therapie in der Schwangerschaft wird gut toleriert

Update Onkologie