Erschienen in:
01.07.2014 | Research Article
RETRACTED ARTICLE: Relationships between PTEN
gene mutations and prognosis in glioma: a meta-analysis
verfasst von:
Wei-Zhong Xiao, Dong-Hua Han, Fei Wang, Yong-Qian Wang, You-Hou Zhu, Yi-Fang Wu, Ning-Tao Liu, Ji-Yong Sun
Erschienen in:
Tumor Biology
|
Ausgabe 7/2014
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Abstract
We conducted a meta-analysis in order to investigate the relationships between
PTEN gene mutations and the prognosis in
glioma. The following electronic databases were searched for relevant articles
without any language restrictions: Web of Science (1945 ~ 2013), the Cochrane
Library Database (Issue 12, 2013), PubMed (1966 ~ 2013), EMBASE (1980 ~ 2013),
CINAHL (1982 ~ 2013), and the Chinese Biomedical Database (CBM) (1982 ~ 2013).
Meta-analyses were conducted using the STATA software (Version 12.0, Stata
Corporation, College Station, Texas USA). Hazard ratio (HR) with its corresponding
95 % confidence interval (95%CI) was calculated. Six independent cohort studies with
a total of 357 glioma patients met our inclusion criteria. Our meta-analysis results
indicated that glioma patients with PTEN gene
mutations exhibited a significantly shorter overall survival (OS) than those without
PTEN gene mutations (HR = 3.66,
95%CI = 2.02 ~ 5.30, P < 0.001).
Ethnicity-stratified subgroup analysis demonstrated that PTEN gene mutations were closely linked to poor prognosis in glioma
among Americans (HR = 3.72, 95%CI = 1.72 ~ 5.73, P < 0.001), while similar correlations were not observed among
populations in Sweden, Italy, and Malaysia (all P > 0.05). Our meta-analysis provides direct and strong evidences for
the speculation of PTEN gene mutations’
correlation with poor prognosis of glioma patients.