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Tumor Biology
Erschienen in: Tumor Biology 6/2016

30.12.2015 | Original Article

Expression of microRNA-452 via adenoviral vector inhibits non-small cell lung cancer cells proliferation and metastasis

verfasst von: Yongsheng Zhang, Lu Han, Jian Pang, Yang Wang, Fan Feng, Qiyu Jiang

Erschienen in: Tumor Biology | Ausgabe 6/2016

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Abstract

The microRNA miR-452 has been shown to function as a tumor suppressor. However, the cellular mechanism and potential application of miR-452-mediated cancer suppression remain great unknown. This study aims to identify how miR-452 acts in regulating non-small cell lung cancer (NSCLC) proliferation and metastasis. Expression of miR-452 via adenoviral (Ad) vector inhibits the proliferation, invasion, and migration of NSCLC cells A549 or H460. Our data also shows that miR-452 down-regulates the expression of Bmi-1 as well as pro-survival or anti-apoptosis regulators Survivin, cIAP-1, and cIAP-2. By such gene interference, miR-452 modulates NSCLC cell epithelial–mesenchymal transition (EMT) and further disrupts their migration and invasion. Moreover, miR-452 blocks the activation of PI3K/AKT pathway, which is also required for EMT process. These data reveal that miR-452 treatment could be a novel target or strategy for NSCLC treatment.
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Metadaten
Titel
Expression of microRNA-452 via adenoviral vector inhibits non-small cell lung cancer cells proliferation and metastasis
verfasst von
Yongsheng Zhang
Lu Han
Jian Pang
Yang Wang
Fan Feng
Qiyu Jiang
Publikationsdatum
30.12.2015
Verlag
Springer Netherlands
Erschienen in
Tumor Biology / Ausgabe 6/2016
Print ISSN: 1010-4283
Elektronische ISSN: 1423-0380
DOI
https://doi.org/10.1007/s13277-015-4725-z

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