01.03.2014 | Original Article
Plasma Homocysteine level and its clinical correlation with type 2 diabetes mellitus and its complications
Erschienen in: International Journal of Diabetes in Developing Countries | Ausgabe 1/2014
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Homocysteine (Hcys) has been implicated to be associated with diabetes and its complications. To study the association of plasma Hcys with diabetes complications (cardiovascular disease [CVD], cerebrovascular disease [CBVD], peripheral vascular disease [PVD], nephropathy, retinopathy and neuropathy). 316 type 2 diabetic patients were enrolled for the study. Plasma Hcys was done by Chemiluminescence Micropart assay. Elevated plasma Hcys correlated significantly with duration of the disease, CVD, CBVD, PVD, Nephropathy, Retinopathy and Neuropathy showed significant association with abnormal plasma Hcys level. Total cholesterol and triglyceride was significantly associated with abnormal plasma Hcys level. However Hb1Ac, LDL and HDL did not show significant correlation. Plasma Hcys level can be considered as an early marker of progression of diabetes and its complications.
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