Skip to main content
Erschienen in: Journal of Endocrinological Investigation 7/2014

01.07.2014 | Position Statement

Medical treatment in gender dysphoric adolescents endorsed by SIAMS–SIE–SIEDP–ONIG

verfasst von: A. D. Fisher, J. Ristori, E. Bandini, S. Giordano, M. Mosconi, E. A. Jannini, N. A. Greggio, A. Godano, C. Manieri, C. Meriggiola, V. Ricca, D. Dettore, M. Maggi, Italian GnRH analogs study ONIG group

Erschienen in: Journal of Endocrinological Investigation | Ausgabe 7/2014

Einloggen, um Zugang zu erhalten

Abstract

Purpose

Despite international guidelines being available, not all gender clinics are able to face gender dysphoric (GD) youth population needs specifically. This is particularly true in Italy. Centers offering specialized support are relatively few and a commonly accepted Italian approach to GD youth has still not been defined. The aim of the present Position Statement is to develop and adhere to Italian guidelines for treatment of GD adolescents, in line with the “Dutch Approach”, the Endocrine Society (ES), and the World Professional Association for Transgender Health (WPATH) guidelines.

Methods

An in-depth brainstorming on the application of International guidelines in the Italian context was performed by several dedicated professionals.

Results

A staged approach, combining psychological support as well as medical intervention is suggested. In the first phase, individuals requesting medical help will undergo a psycho-diagnostic procedure to assess GD; for eligible adolescents, pubertal suppression should be made available (extended diagnostic phase). Finally, from the age of 16 years, cross-sex hormonal therapy can be added, and from the age of 18 years, surgical sex reassignment can eventually be performed.

Conclusions

The current inadequacy of Italian services offering specialized support for GD youth may lead to negative consequences. Omitting or delaying treatment is not a neutral option. In fact, some GD adolescents may develop psychiatric problems, suicidality, and social marginalization. With access to specialized GD services, emotional problems, as well as self-harming behavior, may decrease and general functioning may significantly improve. In particular, puberty suppression seems to be beneficial for GD adolescents by relieving their acute suffering and distress and thus improving their quality of life.
Fußnoten
1
For a full account of sex and gender development see Giordano, S. (2012). Children with Gender Identity Disorder, a clinical, ethical and legal analysis. London and New York: Routledge
.
 
Literatur
1.
Zurück zum Zitat American Psychiatric Association (2013) Diagnostic and statistical manual of mental disorders, Fifth Edition: DSM-5 tm. Washington, DC American Psychiatric Association (2013) Diagnostic and statistical manual of mental disorders, Fifth Edition: DSM-5 tm. Washington, DC
2.
Zurück zum Zitat Dèttore D, Ristori J, Antonelli P, Bandini E, Fisher AD, Villani S, de Vries A, Steensma T, Cohen-Kettenis P (2014) Gender dysphoria in adolescents: the need for a shared assessment protocol and the proposal of the AGIR protocol. J Psychopathol in press Dèttore D, Ristori J, Antonelli P, Bandini E, Fisher AD, Villani S, de Vries A, Steensma T, Cohen-Kettenis P (2014) Gender dysphoria in adolescents: the need for a shared assessment protocol and the proposal of the AGIR protocol. J Psychopathol in press
3.
Zurück zum Zitat Godano A, Maggi M, Jannini EA, Meriggiola MC, Ghigo E, Todarello O, Lenzi A, Manieri C (2009) SIAMS-ONIG Consensus on hormonal treatment in gender identity disorders. J Endocrinol Invest 32:857–864PubMedCrossRef Godano A, Maggi M, Jannini EA, Meriggiola MC, Ghigo E, Todarello O, Lenzi A, Manieri C (2009) SIAMS-ONIG Consensus on hormonal treatment in gender identity disorders. J Endocrinol Invest 32:857–864PubMedCrossRef
4.
Zurück zum Zitat Fisher AD, Bandini E, Ricca V, Ferruccio N, Corona G, Meriggiola MC, Jannini EA, Manieri C, Ristori J, Forti G, Mannucci E, Maggi M (2010) Dimensional profiles of male to female gender identity disorder: an exploratory research. J Sex Med 7:2487–2498PubMed Fisher AD, Bandini E, Ricca V, Ferruccio N, Corona G, Meriggiola MC, Jannini EA, Manieri C, Ristori J, Forti G, Mannucci E, Maggi M (2010) Dimensional profiles of male to female gender identity disorder: an exploratory research. J Sex Med 7:2487–2498PubMed
5.
Zurück zum Zitat Bandini E, Fisher AD, Ricca V, Ristori J, Meriggiola MC, Jannini EA, Manieri C, Corona G, Monami M, Fanni E, Galleni A, Forti G, Mannucci E, Maggi M (2011) Childhood maltreatment in subjects with male-to-female gender identity disorder. Int J Impot Res 23:276–285PubMedCrossRef Bandini E, Fisher AD, Ricca V, Ristori J, Meriggiola MC, Jannini EA, Manieri C, Corona G, Monami M, Fanni E, Galleni A, Forti G, Mannucci E, Maggi M (2011) Childhood maltreatment in subjects with male-to-female gender identity disorder. Int J Impot Res 23:276–285PubMedCrossRef
6.
Zurück zum Zitat Caldarera A, Pfäfflin F (2011) Transsexualism and sex reassignment surgery in Italy. Int J Transgenderism 13:26–36CrossRef Caldarera A, Pfäfflin F (2011) Transsexualism and sex reassignment surgery in Italy. Int J Transgenderism 13:26–36CrossRef
7.
Zurück zum Zitat Meriggiola MC, Jannini EA, Lenzi A, Maggi M, Manieri C (2010) Endocrine treatment of transsexual persons: an Endocrine Society clinical practice guideline: commentary from an European perspective. Eur J Endocrinol 162:831–833PubMedCrossRef Meriggiola MC, Jannini EA, Lenzi A, Maggi M, Manieri C (2010) Endocrine treatment of transsexual persons: an Endocrine Society clinical practice guideline: commentary from an European perspective. Eur J Endocrinol 162:831–833PubMedCrossRef
8.
Zurück zum Zitat Imbimbo C, Verze P, Palmieri A, Longo N, Fusco F, Arcaniolo D, Mirone V (2009) A report from a single institute’s 14-year experience in treatment of male-to-female transsexuals. J Sex Med 6:2736–2745PubMedCrossRef Imbimbo C, Verze P, Palmieri A, Longo N, Fusco F, Arcaniolo D, Mirone V (2009) A report from a single institute’s 14-year experience in treatment of male-to-female transsexuals. J Sex Med 6:2736–2745PubMedCrossRef
9.
Zurück zum Zitat Madeddu F, Prunas A, Hartmann D (2009) Prevalence of axis II disorders in a sample of clients undertaking psychiatric evaluation for sex reassignment surgery. Psychiatr Q 80:261–267PubMedCrossRef Madeddu F, Prunas A, Hartmann D (2009) Prevalence of axis II disorders in a sample of clients undertaking psychiatric evaluation for sex reassignment surgery. Psychiatr Q 80:261–267PubMedCrossRef
10.
Zurück zum Zitat Fisher AD, Bandini E, Casale H, Ferruccio N, Meriggiola MC, Gualerzi A, Manieri C, Jannini EA, Mannucci E, Monami M, Stomaci N, Delle Rose A, Susini T, Ricca V, Maggi M (2013) Sociodemographic and clinical features of gender identity disorder: an Italian multicentric evaluation. J Sex Med 10:408–419PubMedCrossRef Fisher AD, Bandini E, Casale H, Ferruccio N, Meriggiola MC, Gualerzi A, Manieri C, Jannini EA, Mannucci E, Monami M, Stomaci N, Delle Rose A, Susini T, Ricca V, Maggi M (2013) Sociodemographic and clinical features of gender identity disorder: an Italian multicentric evaluation. J Sex Med 10:408–419PubMedCrossRef
11.
Zurück zum Zitat Bandini E, Fisher Castellini G, Lo Sauro C, Lelli L, Meriggiola MC, Casale H, Benni L, Ferruccio N, Faravelli C, Dèttore D, Maggi M, Ricca V (2013) Gender identity disorder and eating disorders: similarities and differences in terms of body uneasiness. J Sex Med 10:1012–1023PubMedCrossRef Bandini E, Fisher Castellini G, Lo Sauro C, Lelli L, Meriggiola MC, Casale H, Benni L, Ferruccio N, Faravelli C, Dèttore D, Maggi M, Ricca V (2013) Gender identity disorder and eating disorders: similarities and differences in terms of body uneasiness. J Sex Med 10:1012–1023PubMedCrossRef
12.
Zurück zum Zitat Fisher AD, Castellini G, Bandini E, Casale H, Fanni E, Benni L, Ferruccio N, Meriggiola MC, Manieri C, Gualerzi A, Jannini E, Oppo A, Ricca V, Maggi M, Rellini AH (2013) Cross-sex hormonal treatment and body uneasiness in individuals with gender dysphoria. J Sex Med. doi:10.1111/jsm.12413 Fisher AD, Castellini G, Bandini E, Casale H, Fanni E, Benni L, Ferruccio N, Meriggiola MC, Manieri C, Gualerzi A, Jannini E, Oppo A, Ricca V, Maggi M, Rellini AH (2013) Cross-sex hormonal treatment and body uneasiness in individuals with gender dysphoria. J Sex Med. doi:10.​1111/​jsm.​12413
14.
Zurück zum Zitat Green R (1974) Sexual identity conflict in children and adults. Basic Books, New York Green R (1974) Sexual identity conflict in children and adults. Basic Books, New York
15.
Zurück zum Zitat Freund K, Langevin R, Satterberg J, Steiner B (1977) Extension of the gender identity scale for males. Arch Sex Behav 6:507–519PubMedCrossRef Freund K, Langevin R, Satterberg J, Steiner B (1977) Extension of the gender identity scale for males. Arch Sex Behav 6:507–519PubMedCrossRef
16.
Zurück zum Zitat Smith YL, Van Goozen SH, Kuiper AJ, Cohen-Kettenis PT (2005) Sex reassignment: outcomes and predictors of treatment for adolescent and adult transsexuals. Psychol Med 35:89–99PubMedCrossRef Smith YL, Van Goozen SH, Kuiper AJ, Cohen-Kettenis PT (2005) Sex reassignment: outcomes and predictors of treatment for adolescent and adult transsexuals. Psychol Med 35:89–99PubMedCrossRef
17.
Zurück zum Zitat Zucker KJ, Mitchell JN, Bradley SJ, Tkachuk J, Cantor JM, Allin SM (2006) The recalled childhood gender identity/gender role questionnaire: psychometric properties. Sex Roles 54:469–483CrossRef Zucker KJ, Mitchell JN, Bradley SJ, Tkachuk J, Cantor JM, Allin SM (2006) The recalled childhood gender identity/gender role questionnaire: psychometric properties. Sex Roles 54:469–483CrossRef
18.
Zurück zum Zitat Cohen-Kettenis PT, Pfäfflin F (2010) The DSM diagnostic criteria for gender identity disorder in adolescents and adults. Arch Sex Behav 39:499–513PubMedCrossRef Cohen-Kettenis PT, Pfäfflin F (2010) The DSM diagnostic criteria for gender identity disorder in adolescents and adults. Arch Sex Behav 39:499–513PubMedCrossRef
19.
Zurück zum Zitat Di Ceglie D, Sturge C, Sutton A (1998) Gender identity disorders in children and adolescents: Guidance for management (Council Report CR63). Royal College of Psychiatrists, London Di Ceglie D, Sturge C, Sutton A (1998) Gender identity disorders in children and adolescents: Guidance for management (Council Report CR63). Royal College of Psychiatrists, London
20.
Zurück zum Zitat Meyer W, Boockting WO, Cohen-Kettenis P, Coleman E, Di Ceglie D, Devor H, Gooren L, Hage JJ, Kirk S, Kuiper B, Laub D, Lawrence A, Menard Y, Patton J, Schaefer L, Webb A, Wheeler CC (2002) Standards of care of the Harry Benjamin International Gender Dysphoria Association, Sixth Version. J Psychol Hum Sex 13:1–30CrossRef Meyer W, Boockting WO, Cohen-Kettenis P, Coleman E, Di Ceglie D, Devor H, Gooren L, Hage JJ, Kirk S, Kuiper B, Laub D, Lawrence A, Menard Y, Patton J, Schaefer L, Webb A, Wheeler CC (2002) Standards of care of the Harry Benjamin International Gender Dysphoria Association, Sixth Version. J Psychol Hum Sex 13:1–30CrossRef
21.
Zurück zum Zitat Coleman E, Bockting W, Botzer M, Cohen-Kettenis P, DeCuypere G, Feldman J, Fraser L, Green J, Knudson G, Meyer WJ, Monstrey S, Adler RK, Brown GR, Devor AH, Ehrbar R, Ettner R, Eyler E, Garofalo R, Karasic DH, Lev AI, Mayer G, Meyer-Bahlburg H, Hall BP, Pfäfflin F, Rachlin K, Robinson B, Schechter LS, Tangpricha V, van Trotsenburg M, Vitale A, Winter S, Whittle S, Wylie KR, Zucker K (2011) Standards of care for the health of transsexual, transgender, and gender-nonconforming people, version 7. Int J Transgenderism 13:165–232CrossRef Coleman E, Bockting W, Botzer M, Cohen-Kettenis P, DeCuypere G, Feldman J, Fraser L, Green J, Knudson G, Meyer WJ, Monstrey S, Adler RK, Brown GR, Devor AH, Ehrbar R, Ettner R, Eyler E, Garofalo R, Karasic DH, Lev AI, Mayer G, Meyer-Bahlburg H, Hall BP, Pfäfflin F, Rachlin K, Robinson B, Schechter LS, Tangpricha V, van Trotsenburg M, Vitale A, Winter S, Whittle S, Wylie KR, Zucker K (2011) Standards of care for the health of transsexual, transgender, and gender-nonconforming people, version 7. Int J Transgenderism 13:165–232CrossRef
22.
Zurück zum Zitat Hembree WC, Cohen-Kettenis P, Delemarre-van de Waal HA, Gooren LJ, Meyer WJ 3rd, Spack NP, Tangpricha V, Montori VM (2009) Endocrine treatment of transsexuals persons: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 94:3132–3154PubMedCrossRef Hembree WC, Cohen-Kettenis P, Delemarre-van de Waal HA, Gooren LJ, Meyer WJ 3rd, Spack NP, Tangpricha V, Montori VM (2009) Endocrine treatment of transsexuals persons: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab 94:3132–3154PubMedCrossRef
23.
Zurück zum Zitat Steensma TD, Biemond R, de Boer F, Cohen-Kettenis PT (2011) Desisting and persisting gender dysphoria after childhood: a qualitative follow-up study. Clin Child Psychol Psychiatry 16:499–516PubMedCrossRef Steensma TD, Biemond R, de Boer F, Cohen-Kettenis PT (2011) Desisting and persisting gender dysphoria after childhood: a qualitative follow-up study. Clin Child Psychol Psychiatry 16:499–516PubMedCrossRef
24.
Zurück zum Zitat Steensma TD, McGuire JK, Kreukels BP, Beekman AJ, Cohen-Kettenis PT (2013) Factors associated with desistence and persistence of childhood gender dysphoria: a quantitative follow-up study. J Am Acad Child Adolesc Psychiatry 52:582–590PubMedCrossRef Steensma TD, McGuire JK, Kreukels BP, Beekman AJ, Cohen-Kettenis PT (2013) Factors associated with desistence and persistence of childhood gender dysphoria: a quantitative follow-up study. J Am Acad Child Adolesc Psychiatry 52:582–590PubMedCrossRef
25.
Zurück zum Zitat de Vries AL, Steensma TD, Doreleijers TA, Cohen-Kettenis PT (2011) Puberty suppression in adolescents with gender identity disorder: a prospective follow-up study. J Sex Med 8:2276–2283PubMedCrossRef de Vries AL, Steensma TD, Doreleijers TA, Cohen-Kettenis PT (2011) Puberty suppression in adolescents with gender identity disorder: a prospective follow-up study. J Sex Med 8:2276–2283PubMedCrossRef
26.
Zurück zum Zitat Giordano S (2012) Children with gender identity disorder, a clinical, ethical and legal analysis. Routledge, London and New York Giordano S (2012) Children with gender identity disorder, a clinical, ethical and legal analysis. Routledge, London and New York
27.
Zurück zum Zitat Delemarre-Van de Waal HA, Cohen-Kettenis PT (2006) Clinical management of gender identity disorders in adolescents: a protocol on psychological and pediatric endocrinology aspects. Eur J Endocrinol 155:S131–S137CrossRef Delemarre-Van de Waal HA, Cohen-Kettenis PT (2006) Clinical management of gender identity disorders in adolescents: a protocol on psychological and pediatric endocrinology aspects. Eur J Endocrinol 155:S131–S137CrossRef
29.
Zurück zum Zitat Spack NP, Edwards-Leeper L, Feldman HA, Leibowitz S, Mandel F, Diamond DA, Vance SR (2012) Children and adolescents with gender identity disorder referred to a pediatric medical center. Pediatrics 129:418–425PubMedCrossRef Spack NP, Edwards-Leeper L, Feldman HA, Leibowitz S, Mandel F, Diamond DA, Vance SR (2012) Children and adolescents with gender identity disorder referred to a pediatric medical center. Pediatrics 129:418–425PubMedCrossRef
30.
Zurück zum Zitat Grossman AH, D’Augelli AR (2007) Transgender youth and life-threatening behaviors. Suicide Life Threat Behav 37:527–537PubMedCrossRef Grossman AH, D’Augelli AR (2007) Transgender youth and life-threatening behaviors. Suicide Life Threat Behav 37:527–537PubMedCrossRef
31.
Zurück zum Zitat Skagerberg E, Parkinson R, Carmichael P (2013) Self-harming thoughts and behaviors in a group of children and adolescents with gender dysphoria. Int J Transgenderism 14:86–92CrossRef Skagerberg E, Parkinson R, Carmichael P (2013) Self-harming thoughts and behaviors in a group of children and adolescents with gender dysphoria. Int J Transgenderism 14:86–92CrossRef
32.
Zurück zum Zitat Di Ceglie D, Freedman D, McPherson S, Richardson P (2002) Children and adolescents referred to a specialist gender identity developmental service: clinical features and demographic characteristics. Int J Transgenderism 6:1 Di Ceglie D, Freedman D, McPherson S, Richardson P (2002) Children and adolescents referred to a specialist gender identity developmental service: clinical features and demographic characteristics. Int J Transgenderism 6:1
34.
Zurück zum Zitat Achenbach TM, Rescorla LA (2001) Manual for the ASEBA school-age forms and profiles. Burlington: VT: University of Vermont, Research Centre for Children, Youth and Families Achenbach TM, Rescorla LA (2001) Manual for the ASEBA school-age forms and profiles. Burlington: VT: University of Vermont, Research Centre for Children, Youth and Families
35.
Zurück zum Zitat Frigerio A, Cattaneo C, Cataldo MG, Schiatti A, Molteni M, Battaglia M (2004) Behavioral and emotional problems among Italian children and adolescents aged 4 to 18 years as reported by parents and teachers. Eur J Psychol Assess 20:124–133CrossRef Frigerio A, Cattaneo C, Cataldo MG, Schiatti A, Molteni M, Battaglia M (2004) Behavioral and emotional problems among Italian children and adolescents aged 4 to 18 years as reported by parents and teachers. Eur J Psychol Assess 20:124–133CrossRef
36.
Zurück zum Zitat Di Ceglie D (2012) Internalising and externalising behaviours in a group of young people with gender dysphoria. Unpublished manuscript, Gender Identity Development Service, The Tavistock and Portman NHS Foundation Trust, Tavistock Centre, London, England Di Ceglie D (2012) Internalising and externalising behaviours in a group of young people with gender dysphoria. Unpublished manuscript, Gender Identity Development Service, The Tavistock and Portman NHS Foundation Trust, Tavistock Centre, London, England
37.
Zurück zum Zitat Zucker KJ, Bradley SJ, Owen-Anderson A, Kibblewhite SJ, Wood H, Singh D, Choi K (2012) Demographics, behavior problems, and psychosexual characteristics of adolescents with gender identity disorder or transvestic fetishism. J Sex Marital Ther 38:151–189PubMedCrossRef Zucker KJ, Bradley SJ, Owen-Anderson A, Kibblewhite SJ, Wood H, Singh D, Choi K (2012) Demographics, behavior problems, and psychosexual characteristics of adolescents with gender identity disorder or transvestic fetishism. J Sex Marital Ther 38:151–189PubMedCrossRef
38.
Zurück zum Zitat de Vries AL, Cohen-Kettenis PT (2012) Clinical management of gender dysphoria in children and adolescents: the Dutch approach. J Homosex 59:301–320PubMedCrossRef de Vries AL, Cohen-Kettenis PT (2012) Clinical management of gender dysphoria in children and adolescents: the Dutch approach. J Homosex 59:301–320PubMedCrossRef
39.
Zurück zum Zitat de Vries A, Cohen-Kettenis PT, Delemarre-Van de Waal H (2006) Clinical management of gender dysphoria in adolescents. Int J Transgenderism 9:83–94CrossRef de Vries A, Cohen-Kettenis PT, Delemarre-Van de Waal H (2006) Clinical management of gender dysphoria in adolescents. Int J Transgenderism 9:83–94CrossRef
40.
Zurück zum Zitat Cohen-Kettenis PT, Delemarre-Van de Waal HA, Gooren LJG (2008) The treatment of adolescent transsexuals: changing insights. J Sex Med 5:1892–1897PubMedCrossRef Cohen-Kettenis PT, Delemarre-Van de Waal HA, Gooren LJG (2008) The treatment of adolescent transsexuals: changing insights. J Sex Med 5:1892–1897PubMedCrossRef
41.
Zurück zum Zitat Lev AI (2004) Transgender emergence-therapeutic guidelines for working with gender-variant people and their families. The Haworth Clinical Practice Press, New York-London-Oxford Lev AI (2004) Transgender emergence-therapeutic guidelines for working with gender-variant people and their families. The Haworth Clinical Practice Press, New York-London-Oxford
43.
Zurück zum Zitat Heger S, Müller M, Ranke M, Schwarz H, Waldhauser F, Partsch C, Sippell WG (2006) Long-term GnRH agonist treatment for female central precocious puberty does not impair reproductive function. Mol Cell Endocrinol 254–255:217–220PubMedCrossRef Heger S, Müller M, Ranke M, Schwarz H, Waldhauser F, Partsch C, Sippell WG (2006) Long-term GnRH agonist treatment for female central precocious puberty does not impair reproductive function. Mol Cell Endocrinol 254–255:217–220PubMedCrossRef
44.
Zurück zum Zitat Lazar L, Meyerovitch J, de Vries L, Phillip M, Lebenthal Y (2013) Treated and untreated women with idiopathic precocious puberty: long-term follow-up and reproductive outcome between the third and fifth decades. Clin Endocrinol. doi:10.1111/cen.12319 Lazar L, Meyerovitch J, de Vries L, Phillip M, Lebenthal Y (2013) Treated and untreated women with idiopathic precocious puberty: long-term follow-up and reproductive outcome between the third and fifth decades. Clin Endocrinol. doi:10.​1111/​cen.​12319
45.
Zurück zum Zitat Feuillan PP, Jones JV, Barnes K, Oerter-Klein K, Cutler GB Jr (1999) Reproductive axis after discontinuation of gonadotropin-releasing hormone analog treatment of girls with precocious puberty: long-term follow-up comparing girls with hypothalamic hamartoma to those with idiopathic precocious puberty. J Clin Endocrinol Metabol 84:44–49CrossRef Feuillan PP, Jones JV, Barnes K, Oerter-Klein K, Cutler GB Jr (1999) Reproductive axis after discontinuation of gonadotropin-releasing hormone analog treatment of girls with precocious puberty: long-term follow-up comparing girls with hypothalamic hamartoma to those with idiopathic precocious puberty. J Clin Endocrinol Metabol 84:44–49CrossRef
46.
Zurück zum Zitat Heger S, Partsch CJ, Sippell WG (1999) Long-term outcome after depot gonadotropin-releasing hormone agonist treatment of central precocious puberty: final height, body proportions, body composition, bone mineral density, and reproductive function. J Clin Endocrinol Metabol 84:4583–4590 Heger S, Partsch CJ, Sippell WG (1999) Long-term outcome after depot gonadotropin-releasing hormone agonist treatment of central precocious puberty: final height, body proportions, body composition, bone mineral density, and reproductive function. J Clin Endocrinol Metabol 84:4583–4590
47.
Zurück zum Zitat De Sutter P (2007) Reproduction and fertility issues for transpeople. In: Ettner R, Monstrey S, Eyler AE (eds) Principles of transgender medicine and surgery. Haworth Press, New York, pp 209–221 De Sutter P (2007) Reproduction and fertility issues for transpeople. In: Ettner R, Monstrey S, Eyler AE (eds) Principles of transgender medicine and surgery. Haworth Press, New York, pp 209–221
48.
Zurück zum Zitat Wierckx K, Stuyver I, Weyers S, Hamada A, Agarwal A, De Sutter P, T’Sjoen G (2012) Sperm freezing in transsexual women. Arch Sex Behav 41:1069–1071PubMedCrossRef Wierckx K, Stuyver I, Weyers S, Hamada A, Agarwal A, De Sutter P, T’Sjoen G (2012) Sperm freezing in transsexual women. Arch Sex Behav 41:1069–1071PubMedCrossRef
49.
Zurück zum Zitat Wylie KR, Fung R, Boshier C, Rotchell M (2009) Recommendations of endocrine treatment for patients with gender dysphoria. Sex Relat Ther 24:175–187CrossRef Wylie KR, Fung R, Boshier C, Rotchell M (2009) Recommendations of endocrine treatment for patients with gender dysphoria. Sex Relat Ther 24:175–187CrossRef
50.
Zurück zum Zitat Kreukels BPC, Cohen-Kettenis PT (2011) Puberty suppression in gender identity disorder: the Amsterdam experience. Nat Rev Endocrinol 7:466–472PubMedCrossRef Kreukels BPC, Cohen-Kettenis PT (2011) Puberty suppression in gender identity disorder: the Amsterdam experience. Nat Rev Endocrinol 7:466–472PubMedCrossRef
51.
Zurück zum Zitat Giordano S (2007) Gender atypical organization in children and adolescents: ethic-legal issues and a proposal for new guidelines. Int J Children’s Rights 15:365–390CrossRef Giordano S (2007) Gender atypical organization in children and adolescents: ethic-legal issues and a proposal for new guidelines. Int J Children’s Rights 15:365–390CrossRef
52.
Zurück zum Zitat Edwards-Leeper L, Spack NP (2012) Psychological evaluation and medical treatment of transgender youth in an interdisciplinary “Gender Management Service” (GeMS) in a Major Pediatric Center. J Homosex 59:321–336PubMedCrossRef Edwards-Leeper L, Spack NP (2012) Psychological evaluation and medical treatment of transgender youth in an interdisciplinary “Gender Management Service” (GeMS) in a Major Pediatric Center. J Homosex 59:321–336PubMedCrossRef
53.
Zurück zum Zitat Delemarre-van de Waal HA (2013) Early Medical Intervention in Adolescents with Gender Dysphoria. In: Kreukels BPC, Steensma TD, de Vries ALC (eds.) Gender Dysphoria and Disorders of Sex Development. Springer New York Heidelberg Dordrecht London, pp 193–203 Delemarre-van de Waal HA (2013) Early Medical Intervention in Adolescents with Gender Dysphoria. In: Kreukels BPC, Steensma TD, de Vries ALC (eds.) Gender Dysphoria and Disorders of Sex Development. Springer New York Heidelberg Dordrecht London, pp 193–203
54.
Zurück zum Zitat Delemarre-van de Waal HA (2004) Application of gonadotropin releasing hormone in hypogonadotropic hypogonadism–diagnostic and therapeutic aspects. Eur J Endocrinol 151:89–94CrossRef Delemarre-van de Waal HA (2004) Application of gonadotropin releasing hormone in hypogonadotropic hypogonadism–diagnostic and therapeutic aspects. Eur J Endocrinol 151:89–94CrossRef
55.
Zurück zum Zitat Manasco PK, Pescovitz OH, Feuillan PP, Hench KD, Barnes KM, Jones J, Hill SC, Loriaux DL, Cutler JRGB (1988) Resumption of puberty after long term lutenizing hormone-releasing hormone treatment of central precocious puberty. J Clin Endocrinol Metabol 67:368–372CrossRef Manasco PK, Pescovitz OH, Feuillan PP, Hench KD, Barnes KM, Jones J, Hill SC, Loriaux DL, Cutler JRGB (1988) Resumption of puberty after long term lutenizing hormone-releasing hormone treatment of central precocious puberty. J Clin Endocrinol Metabol 67:368–372CrossRef
56.
Zurück zum Zitat Cohen-Kettenis PT, van Goozen SHM (1997) Sex reassignment on adolescent transsexuals: a follow-up study. J Am Acad Child Adolesc Psychiatry 36:263–271PubMedCrossRef Cohen-Kettenis PT, van Goozen SHM (1997) Sex reassignment on adolescent transsexuals: a follow-up study. J Am Acad Child Adolesc Psychiatry 36:263–271PubMedCrossRef
57.
Zurück zum Zitat Smith YL, van Goozen SHM, Cohen-Kettenis PT (2001) Adolescents with gender identity disorder who were accepted or rejected for sex reassignment surgery: a prospective follow-up study. J Am Acad Child Adolesc Psychiatry 40:472–481PubMedCrossRef Smith YL, van Goozen SHM, Cohen-Kettenis PT (2001) Adolescents with gender identity disorder who were accepted or rejected for sex reassignment surgery: a prospective follow-up study. J Am Acad Child Adolesc Psychiatry 40:472–481PubMedCrossRef
58.
Zurück zum Zitat Cohen-Kettenis PT, Pfäfflin F (2003) Transgenderism and intersexuality in childhood and adolescence. Sage Publications, Making Choices. London Cohen-Kettenis PT, Pfäfflin F (2003) Transgenderism and intersexuality in childhood and adolescence. Sage Publications, Making Choices. London
59.
Zurück zum Zitat de Vries AL (2010) Gender dysphoria in adolescents: mental health and treatment evaluation. Doctoral dissertation, VU University, Amsterdam de Vries AL (2010) Gender dysphoria in adolescents: mental health and treatment evaluation. Doctoral dissertation, VU University, Amsterdam
60.
Zurück zum Zitat Cohen-Kettenis PT, Schagen SE, Steensma TD, de Vries AL, Delemarre-van de Waal HA (2011) Puberty suppression in a gender-dysphoric adolescent: a 22-year follow-up. Arch Sex Behav 40:843–847PubMedCentralPubMedCrossRef Cohen-Kettenis PT, Schagen SE, Steensma TD, de Vries AL, Delemarre-van de Waal HA (2011) Puberty suppression in a gender-dysphoric adolescent: a 22-year follow-up. Arch Sex Behav 40:843–847PubMedCentralPubMedCrossRef
61.
Zurück zum Zitat Bertelloni S, Dati E, Baroncelli GI (2008) Disorders of sex development: hormonal management in adolescence. Gynecol Endocrinol 24:339–346PubMedCrossRef Bertelloni S, Dati E, Baroncelli GI (2008) Disorders of sex development: hormonal management in adolescence. Gynecol Endocrinol 24:339–346PubMedCrossRef
63.
Zurück zum Zitat Buvat J, Maggi M, Guay A, Torres LO (2013) Testosterone deficiency in men: systematic review and standard operating procedures for diagnosis and treatment. J Sex Med 10:245–284PubMedCrossRef Buvat J, Maggi M, Guay A, Torres LO (2013) Testosterone deficiency in men: systematic review and standard operating procedures for diagnosis and treatment. J Sex Med 10:245–284PubMedCrossRef
64.
Zurück zum Zitat Han TS, Bouloux PM (2010) What is the optimal therapy for young males with hypogonadotropic hypogonadism? Clin Endocrinol (Oxf) 72:731–737CrossRef Han TS, Bouloux PM (2010) What is the optimal therapy for young males with hypogonadotropic hypogonadism? Clin Endocrinol (Oxf) 72:731–737CrossRef
65.
Zurück zum Zitat Poomthavorn P, Suphasit R, Mahachoklertwattana P (2011) Adult height, body mass index and time of menarche of girls with idiopathic central precocious puberty after gonadotropin-releasing hormone analogue treatment. Gynecol Endocrinol 27:524–528PubMedCrossRef Poomthavorn P, Suphasit R, Mahachoklertwattana P (2011) Adult height, body mass index and time of menarche of girls with idiopathic central precocious puberty after gonadotropin-releasing hormone analogue treatment. Gynecol Endocrinol 27:524–528PubMedCrossRef
66.
Zurück zum Zitat Drobac S, Rubin K, Rogol AD, Rosenfield RL (2006) A workshop on pubertal hormone replacement options in the United States. J Pediatr Endocrinol Metab 19:55–64PubMedCrossRef Drobac S, Rubin K, Rogol AD, Rosenfield RL (2006) A workshop on pubertal hormone replacement options in the United States. J Pediatr Endocrinol Metab 19:55–64PubMedCrossRef
67.
Zurück zum Zitat Davenport ML (2010) Approach to the patient with Turner syndrome. J Clin Endocrinol Metab 95:1487–1495PubMedCrossRef Davenport ML (2010) Approach to the patient with Turner syndrome. J Clin Endocrinol Metab 95:1487–1495PubMedCrossRef
68.
Zurück zum Zitat Bondy CA, Turner Syndrome Study Group (2007) Care of girls and women with Turner syndrome: a guideline of the Turner Syndrome Study Group. J Clin Endocrinol Metab 92:10–25PubMedCrossRef Bondy CA, Turner Syndrome Study Group (2007) Care of girls and women with Turner syndrome: a guideline of the Turner Syndrome Study Group. J Clin Endocrinol Metab 92:10–25PubMedCrossRef
69.
Zurück zum Zitat Kelly JJ, Rajkovic IA, O’Sullivan AJ, Sernia C, Ho KK (1993) Effects of different oral estrogen formulations on insulin-like growth factor-I, growth hormone and growth hormone binding protein in post-menopausal women. Clin Endocrinol 39:561–567CrossRef Kelly JJ, Rajkovic IA, O’Sullivan AJ, Sernia C, Ho KK (1993) Effects of different oral estrogen formulations on insulin-like growth factor-I, growth hormone and growth hormone binding protein in post-menopausal women. Clin Endocrinol 39:561–567CrossRef
70.
Zurück zum Zitat Yigit S, Onyirimba M, Gendreau P, Lerer T, Rubin K (2004) Effect of transdermal versus oral estradiol on growth factors and markers of bone turn-over in young adults with Turner Syndrome: a pilot study. J Bone Miner Res 19:S320 Yigit S, Onyirimba M, Gendreau P, Lerer T, Rubin K (2004) Effect of transdermal versus oral estradiol on growth factors and markers of bone turn-over in young adults with Turner Syndrome: a pilot study. J Bone Miner Res 19:S320
71.
Zurück zum Zitat O’Sullivan AJ, Crampton LJ, Freund J, Ho KK (1998) The route of estrogen replacement therapy confers divergent effects on substrate oxidation and body composition in postmenopausal women. J Clin Invest 102:1035–1040PubMedCentralPubMedCrossRef O’Sullivan AJ, Crampton LJ, Freund J, Ho KK (1998) The route of estrogen replacement therapy confers divergent effects on substrate oxidation and body composition in postmenopausal women. J Clin Invest 102:1035–1040PubMedCentralPubMedCrossRef
72.
Zurück zum Zitat Vehkavaara S, Silveira A, Hakala-Ala-Pietilä T, Virkamäki A, Hovatta O, Hamsten A, Taskinen MR, Yki-Järvinen H (2001) Effects of oral and transdermal estrogen replacement therapy on markers of coagulation, fibrinolysis, inflammation and serum lipids and lipoproteins in postmenopausal women. Thromb Haemost 85:619–625PubMed Vehkavaara S, Silveira A, Hakala-Ala-Pietilä T, Virkamäki A, Hovatta O, Hamsten A, Taskinen MR, Yki-Järvinen H (2001) Effects of oral and transdermal estrogen replacement therapy on markers of coagulation, fibrinolysis, inflammation and serum lipids and lipoproteins in postmenopausal women. Thromb Haemost 85:619–625PubMed
73.
Zurück zum Zitat Möller B, Schreier H, Li A, Romer G (2009) Gender identity disorder in children and adolescents. Curr Probl Pediatr Adolesc Health Care 39:117–143PubMedCrossRef Möller B, Schreier H, Li A, Romer G (2009) Gender identity disorder in children and adolescents. Curr Probl Pediatr Adolesc Health Care 39:117–143PubMedCrossRef
74.
Zurück zum Zitat Spack N (2008) An endocrine perspective on the care of transgender adolescents. Presented at the 55th annual meeting of the American Academy of Child and Adolescent Psychiatry, 28 October–2 November 2008 Spack N (2008) An endocrine perspective on the care of transgender adolescents. Presented at the 55th annual meeting of the American Academy of Child and Adolescent Psychiatry, 28 October–2 November 2008
75.
Zurück zum Zitat Cohen-Kettenis PT, Steensma TD, de Vries AL (2011) Treatment of adolescents with gender dysphoria in the Netherlands. Child Adolescent Psychiatr Clin N Am 20:689–700CrossRef Cohen-Kettenis PT, Steensma TD, de Vries AL (2011) Treatment of adolescents with gender dysphoria in the Netherlands. Child Adolescent Psychiatr Clin N Am 20:689–700CrossRef
Metadaten
Titel
Medical treatment in gender dysphoric adolescents endorsed by SIAMS–SIE–SIEDP–ONIG
verfasst von
A. D. Fisher
J. Ristori
E. Bandini
S. Giordano
M. Mosconi
E. A. Jannini
N. A. Greggio
A. Godano
C. Manieri
C. Meriggiola
V. Ricca
D. Dettore
M. Maggi
Italian GnRH analogs study ONIG group
Publikationsdatum
01.07.2014
Verlag
Springer International Publishing
Erschienen in
Journal of Endocrinological Investigation / Ausgabe 7/2014
Elektronische ISSN: 1720-8386
DOI
https://doi.org/10.1007/s40618-014-0077-6

Weitere Artikel der Ausgabe 7/2014

Journal of Endocrinological Investigation 7/2014 Zur Ausgabe

Endocrinology and Art

Orazio Marinali (1643–1720)

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Notfall-TEP der Hüfte ist auch bei 90-Jährigen machbar

26.04.2024 Hüft-TEP Nachrichten

Ob bei einer Notfalloperation nach Schenkelhalsfraktur eine Hemiarthroplastik oder eine totale Endoprothese (TEP) eingebaut wird, sollte nicht allein vom Alter der Patientinnen und Patienten abhängen. Auch über 90-Jährige können von der TEP profitieren.

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

25.04.2024 Hypotonie Nachrichten

Wenn unter einer medikamentösen Hochdrucktherapie der diastolische Blutdruck in den Keller geht, steigt das Risiko für schwere kardiovaskuläre Ereignisse: Darauf deutet eine Sekundäranalyse der SPRINT-Studie hin.

Bei schweren Reaktionen auf Insektenstiche empfiehlt sich eine spezifische Immuntherapie

Insektenstiche sind bei Erwachsenen die häufigsten Auslöser einer Anaphylaxie. Einen wirksamen Schutz vor schweren anaphylaktischen Reaktionen bietet die allergenspezifische Immuntherapie. Jedoch kommt sie noch viel zu selten zum Einsatz.

Therapiestart mit Blutdrucksenkern erhöht Frakturrisiko

25.04.2024 Hypertonie Nachrichten

Beginnen ältere Männer im Pflegeheim eine Antihypertensiva-Therapie, dann ist die Frakturrate in den folgenden 30 Tagen mehr als verdoppelt. Besonders häufig stürzen Demenzkranke und Männer, die erstmals Blutdrucksenker nehmen. Dafür spricht eine Analyse unter US-Veteranen.

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.