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Journal of Endocrinological Investigation

Erschienen in:

01.07.2014 | Original Article

Osteocalcin levels are inversely associated with Hba1c and BMI in adult subjects with long-standing type 1 diabetes

verfasst von: Ernesto Maddaloni, Luca D’Onofrio, Angelo Lauria, Anna Rita Maurizi, Rocky Strollo, Andrea Palermo, Nicola Napoli, Silvia Angeletti, Paolo Pozzilli, Silvia Manfrini

Erschienen in: Journal of Endocrinological Investigation | Ausgabe 7/2014

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Abstract

Purpose

Diabetic osteopathy is an upcoming complication of diabetes characterized by osteoporosis, increased risk for bone fractures and alterations in bone metabolism. Osteocalcin (OC) is a bone-specific protein produced by osteoblasts involved in the regulation of glucose and energy metabolism. The aim of this study is to determine whether OC serum levels are correlated with metabolic control in adult subjects with type one diabetes mellitus (T1DM).

Methods

A cross-sectional study was conducted on 93 subjects (51 men) with mean age, disease duration and body mass index (BMI) of 39.9 ± 12.3, 17.2 ± 12.6 years and 24.5 ± 3.4 kg/m², respectively. Blood samples were drawn to measure levels of hemoglobin A1c (HbA1c), OC, 25-OH vitamin D and PTH.

Results

Significant inverse correlations were found between OC and HbA1c (r = −0.295, P = 0.004) and between OC and BMI (r = −0.218, P = 0.037). These correlations were confirmed also among men in the analyses by gender [HbA1c vs OC: r = −0.363, P = 0.009; BMI vs OC: r = −0.291, P = 0.043], and similar but nonsignificant trends were confirmed among women. A significant difference in mean OC was also found between the lowest and the highest HbA1c tertile (22.3 ± 10.0 vs 16.9 ± 8.0 ng/mL, P = 0.025).

Conclusions

These data show that in T1DM of long duration, OC serum levels are inversely associated with HbA1c and BMI, supporting the hypothesis that a poor glycemic control can affect osteoblast function.

International Diabetes Federation Guidelines (2011) Diabetes in childhood and adolescence

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Titel: Osteocalcin levels are inversely associated with Hba1c and BMI in adult subjects with long-standing type 1 diabetes
verfasst von: Ernesto Maddaloni
Luca D’Onofrio
Angelo Lauria
Anna Rita Maurizi
Rocky Strollo
Andrea Palermo
Nicola Napoli
Silvia Angeletti
Paolo Pozzilli
Silvia Manfrini
Publikationsdatum: 01.07.2014
Verlag: Springer International Publishing
Erschienen in: Journal of Endocrinological Investigation / Ausgabe 7/2014
Elektronische ISSN: 1720-8386
DOI: https://doi.org/10.1007/s40618-014-0092-7

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Abstract

Purpose

Methods

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Conclusions

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