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Journal of Endocrinological Investigation

Erschienen in:

01.12.2017 | Original Article

The relationship between circulating adiponectin, leptin and vaspin with bone mineral density (BMD), arterial calcification and stiffness: a cross-sectional study in post-menopausal women

verfasst von: N. Tanna, K. Patel, A. E. Moore, D. Dulnoan, S. Edwards, G. Hampson

Erschienen in: Journal of Endocrinological Investigation | Ausgabe 12/2017

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Abstract

Objective

To explore the relationship between circulating adiponectin, leptin and vaspin with bone mineral density (BMD), arterial stiffness and vascular calcification in post-menopausal women. We hypothesised that adipokines produced by adipose tissue may be mediators of bone and cardiovascular disease (CVD) and explain, in part, the observed association between osteoporosis and CVD.

Design

We studied 386 ambulant community dwelling postmenopausal women aged (mean [SD] 61 [6.4] years). BMD at the lumbar spine, femoral neck (FN), and total hip (TH), body composition; fat mass (FM) and lean mass (LM) as well as abdominal aortic calcification (AAC) were determined by dual energy X-ray absorptiometry. Pulse wave velocity (PWV) and augmentation index, markers of arterial stiffness were measured. Fasting adiponectin, leptin and vaspin were quantified in serum.

Results

A positive independent association was observed between vaspin and BMD at the FN (p = 0.009), TH (p = 0.037) in the whole study population adjusted for confounders including age, FM, LM and lifestyle variables. Using the same model, a negative association was seen between adiponectin and BMD at the FN in women with osteoporosis (p = 0.043). Serum adiponectin was significantly higher in women with fractures (20.8 [9.3] µg/ml compared to those without (18.5 [8.6] µg/ml, p = 0.018) and associated with a significant increased risk of fracture (HR 1.032, 95% CI 1.003–1.063, p = 0.032). Leptin was not associated with BMD or fracture risk after adjustment. Adiponectin was independently associated with AAC (p = 0.007) and significantly higher in women with AAC scores > 1; (19.2[9.2]) compared to those with no or low AAC scores (<1); 16.8 [8.0], p = 0.018). In adjusted analyses, PWV velocity was positively associated with circulating vaspin (p = 0.039) and AI was negatively associated with serum leptin (p = 0.002).

Conclusion

Adiponectin, leptin, vaspin are related to markers of bone and vascular health and may contribute to the observed association between osteoporosis and CVD.

Lampropoulos CE, Papaioannou I, D’Cruz DP (2012) Osteoporosis–a risk factor for cardiovascular disease? Nat Rev Rheumatol 8(10):587–598CrossRefPubMed

von der Recke P, Hansen MA, Hassager C (1999) The association between low bone mass at the menopause and cardiovascular mortality. Am J Med 106(3):273–278CrossRefPubMed

Buckens CF, de Jong PA, Verkooijen HM, Verhaar HJ, Mali WP, van der Graaf Y et al (2015) Vertebral fractures on routine chest computed tomography: relation with arterial calcifications and future cardiovascular events. Int J Cardiovasc Imaging 31(2):437–445CrossRefPubMed

Vassalle C, Mazzone A (2016) Bone loss and vascular calcification: A bi-directional interplay? Vascul Pharmacol 86:77–86CrossRefPubMed

Evenepoel P, D’Haese P, Brandenburg V (2015) Sclerostin and DKK1: new players in renal bone and vascular disease. Kidney Int 88(2):235–240CrossRefPubMed

Reid IR (2008) Relationships between fat and bone. Osteoporos Int 19(5):595–606CrossRefPubMed

Armstrong ME, Cairns BJ, Banks E, Green J, Reeves GK, Beral V et al (2012) Different effects of age, adiposity and physical activity on the risk of ankle, wrist and hip fractures in postmenopausal women. Bone 50(6):1394–1400CrossRefPubMedPubMedCentral

Premaor MO, Pilbrow L, Tonkin C, Parker RA, Compston J (2010) Obesity and fractures in postmenopausal women. J Bone Miner Res 25(2):292–297CrossRefPubMed

Ebong IA, Goff DC Jr, Rodriguez CJ, Chen H, Bluemke DA, Szklo M et al (2013) The relationship between measures of obesity and incident heart failure: the multi-ethnic study of atherosclerosis. Obesity (Silver Spring) 21(9):1915–1922

10.

Mitchell GF, Guo CY, Benjamin EJ, Larson MG, Keyes MJ, Vita JA et al (2007) Cross-sectional correlates of increased aortic stiffness in the community: the Framingham Heart Study. Circulation 115(20):2628–2636CrossRefPubMed

11.

Kershaw EE, Flier JS (2004) Adipose tissue as an endocrine organ. J Clin Endocrinol Metab 89(6):2548–2556CrossRefPubMed

12.

Pepe J, Cipriani C, Cilli M, Colangelo L, Minisola S (2016) Adipokines and bone metabolism: an interplay to untangle. J Endocrinol Invest 39(11):1359–1361CrossRefPubMed

13.

Biver E, Salliot C, Combescure C, Gossec L, Hardouin P, Legroux-Gerot I et al (2011) Influence of adipokines and ghrelin on bone mineral density and fracture risk: a systematic review and meta-analysis. J Clin Endocrinol Metab 96(9):2703–2713CrossRefPubMed

14.

Richards JB, Valdes AM, Burling K, Perks UC, Spector TD (2007) Serum adiponectin and bone mineral density in women. J Clin Endocrinol Metab 92(4):1517–1523CrossRefPubMed

15.

Napoli N, Pedone C, Pozzilli P, Lauretani F, Ferrucci L, Incalzi RA (2010) Adiponectin and bone mass density: the InCHIANTI study. Bone 47(6):1001–1005CrossRefPubMedPubMedCentral

16.

Liu Y, Song CY, Wu SS, Liang QH, Yuan LQ, Liao EY (2013) Novel adipokines and bone metabolism. Int J Endocrinol 2013:895045PubMedPubMedCentral

17.

Kajimura D, Lee HW, Riley KJ, Arteaga-Solis E, Ferron M, Zhou B et al (2013) Adiponectin regulates bone mass via opposite central and peripheral mechanisms through FoxO1. Cell Metab 17(6):901–915CrossRefPubMedPubMedCentral

18.

Oshima K, Nampei A, Matsuda M, Iwaki M, Fukuhara A, Hashimoto J et al (2005) Adiponectin increases bone mass by suppressing osteoclast and activating osteoblast. Biochem Biophys Res Commun 331(2):520–526CrossRefPubMed

19.

Williams GA, Wang Y, Callon KE, Watson M, Lin JM, Lam JB et al (2009) In vitro and in vivo effects of adiponectin on bone. Endocrinology 150(8):3603–3610CrossRefPubMed

20.

Zhu X, Jiang Y, Shan PF, Shen J, Liang QH, Cui RR et al (2013) Vaspin attenuates the apoptosis of human osteoblasts through ERK signaling pathway. Amino Acids 44(3):961–968CrossRefPubMed

21.

Kamio N, Kawato T, Tanabe N, Kitami S, Morita T, Ochiai K et al (2013) Vaspin attenuates RANKL-induced osteoclast formation in RAW264.7 cells. Connect Tissue Res 54(2):147–152CrossRefPubMed

22.

Mattu HS, Randeva HS (2013) Role of adipokines in cardiovascular disease. J Endocrinol 216(1):T17–T36CrossRefPubMed

23.

Cao Y, Tao L, Yuan Y, Jiao X, Lau WB, Wang Y et al (2009) Endothelial dysfunction in adiponectin deficiency and its mechanisms involved. J Mol Cell Cardiol 46(3):413–419CrossRefPubMed

24.

Maahs DM, Ogden LG, Kinney GL, Wadwa P, Snell-Bergeon JK, Dabelea D et al (2005) Low plasma adiponectin levels predict progression of coronary artery calcification. Circulation 111(6):747–753CrossRefPubMed

25.

Johansen NB, Vistisen D, Brunner EJ, Tabak AG, Shipley MJ, Wilkinson IB et al (2012) Determinants of aortic stiffness: 16-year follow-up of the Whitehall II study. PLoS ONE 7(5):e37165CrossRefPubMedPubMedCentral

26.

Dekker JM, Funahashi T, Nijpels G, Pilz S, Stehouwer CD, Snijder MB et al (2008) Prognostic value of adiponectin for cardiovascular disease and mortality. J Clin Endocrinol Metab 93(4):1489–1496CrossRefPubMed

27.

Zachariah JP, Hwang S, Hamburg NM, Benjamin EJ, Larson MG, Levy D et al (2016) Circulating adipokines and vascular function: cross-sectional associations in a community-based cohort. Hypertension 67(2):294–300PubMed

28.

Soderberg S, Ahren B, Jansson JH, Johnson O, Hallmans G, Asplund K et al (1999) Leptin is associated with increased risk of myocardial infarction. J Intern Med 246(4):409–418CrossRefPubMed

29.

Sawicka M, Janowska J, Chudek J (2016) Potential beneficial effect of some adipokines positively correlated with the adipose tissue content on the cardiovascular system. Int J Cardiol 222:581–589CrossRefPubMed

30.

Hampson G, Edwards S, Conroy S, Blake GM, Fogelman I, Frost ML (2013) The relationship between inhibitors of the Wnt signalling pathway (Dickkopf-1(DKK1) and sclerostin), bone mineral density, vascular calcification and arterial stiffness in post-menopausal women. Bone 56(1):42–47CrossRefPubMed

31.

Spangenberg A, Maghsoodi N, Dulnoan D, Moore AE, Edwards S, Frost ML et al (2016) Bone mineral density and body composition are associated with circulating angiogenic factors in post-menopausal women. Calcif Tissue Int 99(6):608–615CrossRefPubMedPubMedCentral

32.

Vlachopoulos C, Aznaouridis K, Stefanadis C (2010) Prediction of cardiovascular events and all-cause mortality with arterial stiffness: a systematic review and meta-analysis. J Am Coll Cardiol 55(13):1318–1327CrossRefPubMed

33.

Tomiyama H, Yamashina A (2010) Non-invasive vascular function tests: their pathophysiological background and clinical application. Circ J 74(1):24–33CrossRefPubMed

34.

Terzoudis S, Malliaraki N, Damilakis J, Dimitriadou DA, Zavos C, Koutroubakis IE (2016) Chemerin, visfatin, and vaspin serum levels in relation to bone mineral density in patients with inflammatory bowel disease. Eur J Gastroenterol Hepatol 28(7):814–819CrossRefPubMed

35.

Assadi M, Salimipour H, Akbarzadeh S, Nemati R, Jafari SM, Bargahi A et al (2011) Correlation of circulating omentin-1 with bone mineral density in multiple sclerosis: the crosstalk between bone and adipose tissue. PLoS ONE 6(9):e24240CrossRefPubMedPubMedCentral

36.

Hida K, Wada J, Eguchi J, Zhang H, Baba M, Seida A et al (2005) Visceral adipose tissue-derived serine protease inhibitor: a unique insulin-sensitizing adipocytokine in obesity. Proc Natl Acad Sci USA 102(30):10610–10615CrossRefPubMedPubMedCentral

37.

Aguirre GA, De Ita JR, de la Garza RG, Castilla-Cortazar I (2016) Insulin-like growth factor-1 deficiency and metabolic syndrome. J Transl Med 14:3CrossRefPubMedPubMedCentral

38.

Locatelli V, Bianchi VE (2014) Effect of GH/IGF-1 on bone metabolism and osteoporsosis. Int J Endocrinol 2014:235060CrossRefPubMedPubMedCentral

39.

Mpalaris V, Anagnostis P, Anastasilakis AD, Goulis DG, Doumas A, Iakovou I (2016) Serum leptin, adiponectin and ghrelin concentrations in post-menopausal women: Is there an association with bone mineral density? Maturitas 88:32–36CrossRefPubMed

40.

Johansson H, Oden A, Lerner UH, Jutberger H, Lorentzon M, Barrett-Connor E et al (2012) High serum adiponectin predicts incident fractures in elderly men: osteoporotic fractures in men (MrOS) Sweden. J Bone Miner Res 27(6):1390–1396CrossRefPubMed

41.

Araneta MR, von Muhlen D, Barrett-Connor E (2009) Sex differences in the association between adiponectin and BMD, bone loss, and fractures: the Rancho Bernardo study. J Bone Miner Res 24(12):2016–2022CrossRefPubMedPubMedCentral

42.

Modder UI, Roforth MM, Hoey K, McCready LK, Peterson JM, Monroe DG et al (2011) Effects of estrogen on osteoprogenitor cells and cytokines/bone-regulatory factors in postmenopausal women. Bone 49(2):202–207CrossRefPubMedPubMedCentral

43.

Steffes MW, Gross MD, Lee DH, Schreiner PJ, Jacobs DR Jr (2006) Adiponectin, visceral fat, oxidative stress, and early macrovascular disease: the Coronary Artery Risk Development in Young Adults Study. Obesity (Silver Spring) 14(2):319–326CrossRef

44.

Choi SH, Kwak SH, Lee Y, Moon MK, Lim S, Park YJ et al (2011) Plasma vaspin concentrations are elevated in metabolic syndrome in men and are correlated with coronary atherosclerosis in women. Clin Endocrinol (Oxf) 75(5):628–635CrossRef

45.

Karbek B, Bozkurt NC, Topaloglu O, Aslan MS, Gungunes A, Cakal E et al (2014) Relationship of vaspin and apelin levels with insulin resistance and atherosclerosis in metabolic syndrome. Minerva Endocrinol 39(2):99–105PubMed

46.

Dimova R, Tankova T (2015) The role of vaspin in the development of metabolic and glucose tolerance disorders and atherosclerosis. Biomed Res Int 2015:823481CrossRefPubMedPubMedCentral

47.

Matsuda K, Teragawa H, Fukuda Y, Nakagawa K, Higashi Y, Chayama K (2003) Leptin causes nitric-oxide independent coronary artery vasodilation in humans. Hypertens Res 26(2):147–152CrossRefPubMed

48.

Garonna E, Botham KM, Birdsey GM, Randi AM, Gonzalez-Perez RR, Wheeler-Jones CP (2011) Vascular endothelial growth factor receptor-2 couples cyclo-oxygenase-2 with pro-angiogenic actions of leptin on human endothelial cells. PLoS ONE 6(4):e18823CrossRefPubMedPubMedCentral

49.

Al Mheid I, Patel R, Murrow J, Morris A, Rahman A, Fike L et al (2011) Vitamin D status is associated with arterial stiffness and vascular dysfunction in healthy humans. J Am Coll Cardiol 58(2):186–192CrossRefPubMedPubMedCentral

Titel: The relationship between circulating adiponectin, leptin and vaspin with bone mineral density (BMD), arterial calcification and stiffness: a cross-sectional study in post-menopausal women
verfasst von: N. Tanna
K. Patel
A. E. Moore
D. Dulnoan
S. Edwards
G. Hampson
Publikationsdatum: 01.12.2017
Verlag: Springer International Publishing
Erschienen in: Journal of Endocrinological Investigation / Ausgabe 12/2017
Elektronische ISSN: 1720-8386
DOI: https://doi.org/10.1007/s40618-017-0711-1

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Abstract

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