Erschienen in:
01.02.2011 | Commentary
Promise and pitfalls of the Immunochip
verfasst von:
Adrian Cortes, Matthew A Brown
Erschienen in:
Arthritis Research & Therapy
|
Ausgabe 1/2011
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Abstract
Genomewide association studies (GWAS) have proven a powerful hypothesis-free method to identify common disease-associated variants. Even quite large GWAS, however, have only at best identified moderate proportions of the genetic variants contributing to disease heritability. To provide cost-effective genotyping of common and rare variants to map the remaining heritability and to fine-map established loci, the Immunochip Consortium has developed a 200,000 SNP chip that has been produced in very large numbers for a fraction of the cost of GWAS chips. This chip provides a powerful tool for immunogenetics gene mapping.